SUPPLEMENTAL MATERIAL
Table 1. References and number of transplanted cases described in each single excluded study.
Reference
Trull AK, Parker J, Warren RE. IgG enzyme linked immunosorbent assay for diagnosis of
invasive aspergillosos: retrospective study over 15 years of transplant recipients. J Clin Pathol
1985;38:1045-1051. a,b
Wajaszczuk CPD, Dummer JS, Ho M, Van Thiel DH, Starzl TE, Iwatsuki S et al. Fungal infection
in liver transplant recipients. Transplantation 1985;40:347-353. b
Lie TS, Höfer M, Höhnke C, Krizek L, Kühnen E, Iwantscheff A et al. Aspergillosis following
liver transplantation as a hospital infection. Dtsch Med Wochenschr 1987;112:297-301. b
Cox KL, Ward RE, Furgiuele TL, Cannon RA, Sanders KD, Kurland G. Orthotopic liver
transplantation in patients with cystic fibrosis. Pediatrics 1987;80:571-574. b
Woods GL, Wood RP, Shaw BW Jr. Aspergillus endocarditis in patients without prior
cardiovascular surgery: report of a case in a liver transplant recipient and review. Rev Infect Dis
1989;11:263-272. b
Boon AP, O'Brien D, Adams DH. 10-year review of invasive aspergillosis detected at necroscopy.
J Clin Pathol 1991;44:452-454. b
Kusne S, Torre-Cisneros J, Mañez R, Irish W, Martin M, Fung J et al. Factors associated with
invasive lung aspergillosis and the significance of positive aspergillus culture after liver
transplantation. J Infect Dis 1992;166:1379-1383. a,b
Torre-Cisneros J, Lopez OL, Kusne S, Martinez AJ, Starzl TE, Simmons RL et al. CNS
aspergillosis in organ transplantation: a clinicopathological study. J Neurol Neurosurg Psychiatry
1993;56:188-193. b
Singh N, Mieles L, Yu VL, Gayowski T. Invasive aspergillosis in liver transplant recipients:
association with candidemia and consumption coagulopathy and failure of prophylaxis with lowdose amphotericin B. Clin Infect Dis 1993;17:906-908. a,b
Blanloeil Y, François T, Germaud P, Le Conte P, Morin O, Michel P et al. Invasive aspergillosis
in surgical intensive care patients. Ann Fr Anesth Reanim 1993; 12:379-384. b
Collins LA, Samore MH, Roberts MS, Luzzati R, Jenkins RL, Lewis WD et al. Risk factors for
invasive fungal infections complicating orthotipic liver transplantation. J Infect Dis
1994;170:644-652. b
Boes B, Bashir R, Boes C, Hahn F, McConnell JR, McComb R. Central nervous system
aspergillosis. Analysis of 26 patients. J Neuroimaging 1994;4:123-129. a,b
Couetil JP, Houssin DP, Soubrane O, Chevalier PG, Dousset BE, Loulmet D et al. Combined
lung and liver transplantation in patients with cystic fibrosis. J Thorac Cardiovasc Surg
1995;110:1415-1423. a,b
Tollemar J, Höckerstedt K, Ericzon BG, Jalanko H, Ringdén O. Liposomal amphotericin B
prevents invasive fungal infections in liver transplant recipients. A randomized, placebocontrolled study. Transplantation 1995;59:45-50. a,b
Brown RS Jr, Lake JR, Katzman BA, Ascher NL, Somberg KA, Emond JC et al. Incidence and
significance of aspergillosis culture following liver and kidney transplantation. Transplantation
1996;61:666-669. b
Hunt KE, Glasgow BJ. Aspergillus endophtalmitis. An unrecognised endemic disease in
orthotopic liver transplantation. Ophtalmology 1996;103:757-767. b
Singh N, Arnow PM, Bonham A, Dominguez E, Paterson DL, Pankey GA et al. Invasive
aspergillosis in liver transplant recipients in the 1990s. Transplantation 1997;64:716-720. b
N of cases of IA
4
6
3
1
1
12
33
13
3
2
1
8
2
1
21
7
25
Boniver V, de Leval L, Daenen G, Honoré P, Davin C, Hardy N et al. Anatomo-clinical
correlation. A case of invasive pulmonary aspergillosis. Rev Med Liege 1998;53:592-596. b
Singh N, Gayowski T, Wagener MM, Marino IR. Pulmonary infiltrates in liver transplant
recipients in the intensive care. Transplantation 1999; 67:1138-1144. a,b
1
3
Jeffrey GP, Brind AM, Ormonde DG, Frazer CK, Ferguson J, Bell R et al. Management of biliary
tract complications following liver transplantation. Aust N Z J Surg 1999;69:717-722. b
1
Rabkin JM, Oroloff SL, Corless CL, Benner KG, Flora KD, Rosen HR et al. Association of fungal
infection and increased mortality in liver transplant recipients. Am J Surg 2000;179:426-430. a,b
4
Duchini A, Redfield DC, McHutchison JG, Brunson ME, Pockros PJ. Aspergillosis in liver
transplant recipients: successful treatment and improved survival using a multistep approach.
South Med J 2002;95:897-899. b
Ergin F, Arslan H, Azap A, Demirhan B, Karakayali H, Haberal M. Invasive aspergillosis in
solid organ transplantation: report of eight cases and review of literature. Transpl Int
2003;16:280-286. a
Singh N, Avery RK, Munoz P, Pruett TL, Alexander B, Jacobs R et al. Trends in risk profiles for
and mortality associated with invasive aspergillosis among liver transplant recipients. Clin Infect
Dis 2003;36:46-52. b
Liu ZW, Zou WL, Zhu XD, Zhang XL, Liu Y, Shen ZY. Clinical analysis of aspergillosis in
orthotopic liver transplant recipients. Zhonghua Gan Zang Bing Za Zhi 2005;13:171-174. b
7
4
40
17
Castroagudín JF, Pontón C, Bustamante M, Otero E, Martínez J, Tomé S et al. Prospective
interventional study to evaluate the efficacy and safety of liposomal amphotericin B as
prophylaxis of fungal infections in high-risk liver transplant recipients. Transplant Proc
2005;37:3965-3967. b
2
Trullas JC, Cervera C, Benito N, de la Bellacasa JP, Agustí C, Rovira M et al. Invasive pulmonary
aspergillosis in solid organ and bone marrow transplant recipients. Transplant Proc
2005;37:4091-4093. a,b
11
Singh N, Pruett TL, Houston S, Muñoz P, Cacciarelli TV, Wagener MM et al. Invasive
aspergillosis in the recipient of liver retransplantation. Liver Transplant 2006;12:1205-1209. a,b
Son JM, Jee WH, Jung CK, Kim SI, Ha KY. Aspergillus spondylodiscitis in the cervicothoraco-lumbar-spine in a immmunocompromised patient: a case report. Korean J Radiol
2007;8:448-451. a
67
1
Rosenhagen M, Feldhues R, Schmidt J, Hoppe-Tichy T, Geiss HK. A risk profile for invasive
aspergillosis in liver transplant recipients 2. Infection 2009;37:313-319. a
10
Rubio E, Jimenez M, Alvira LG, Lucena JL, Arrieta FM, Chaparro MD et al. Influence of
infection by aspergillosis in arterial complications after liver transplantation: evolution and results
in 670 transplant. Transplant Proc 2011;43:751-752. b
4
a
: Lack of outcome;
: Lack of more than 50% of the characteristics (study variables included date of publication, gender,
age, underlying disease, the presence of kidney failure, a previous liver transplantation, the time of
appearance of IA after transplantation, sites involved clinically, the type of Aspergillus spp., and the
antifungal treatment).
b
Table 2. Study variables considered for patients included in this study.
Variable
Date of publication
Gender
Age
Underlying hepatic disease
Kidney failure
Retransplantation
Time of diagnosis
Type of diagnosis
Sites clinically involved
Species of Aspergillus
Antifungal treatement
Outcome
N
431
111
103
73
24
289
89
260
168
92
59
280
%
100
26
24
17
6
67
21
60
39
21
14
65