C-1 NS 207 – ORGANIC CHEMISTRY Full Course Title: Organic Chemistry Organska Hemija Course Code: NS207 Course Level/BiH cycle: I cycle; 2ndyear ECTS credit value: 6 ECTS Student work-load: For the whole semester (numbers are represented in hours) Lectures Tutorial / Practical training/discussions Individual learning TOTAL 40 10 50 100 Expected workload! Length: FALL 2015 Faculty/School/Department: FENS, Genetics and Bioengineering Course leader: Jasmin Šutković Contact details: Office: Office hours: F3-24 Monday 14-16 Wednesday 14-16 Any time you find me! e-mail: jsutkovic@ius.edu.ba Phone: +38733957187 Site: IUS A building , A F2.13 for Monday lecture and A F1.11 for Wednesday lecture. Host Study Program: Genetic and Bioengineering Course status: Program course - required Pre-requisites: Chemistry Access restrictions: No Assessment: Lectures,Homework’s,Attendance, Quizzes, Project, Midterm exams and Final Exam Date validated: October, 2015 This course shall teach the students to acquire knowledge about the nature and its compositions. In order to accomplish this, the following objectives will be achieved: To build a basic knowledge of the structure of organic compounds To understand the function of organic molecules in the cell. Use of organic compounds in daily life To analyse scientific concepts and think critically To review the importance and relevance of chemistry in our everyday lives To be able to utilize the methods of science as a logical means of problem solving Course aims: 1 C-1 Learning outcomes: Indicative syllabus content: Learning delivery: Assessment Rationale: Assessment Weighting: Essential Reading: Our goal is to teach the students the fundamental concepts of organic and biological chemistry and in this way illustrate how chemistry explains many aspects of everyday life. Thekey feature is the use of molecular art to illustrate and explain common phenomena we encounter every day.Students will be given enough detail to understand basic concepts, such as how the natural and synthetic organic compounds are synthesized and these compounds affect our daily life. Introduction to organic chemistry, atoms and atomic theories, Chemical compounds and their chemical reactions.How to Write a Formula for an Ionic Compounds and how to name a Covalent Molecule. Alkanes, unsaturated organic compounds,Organic Compounds That Contain Oxygen, Halogen, or Sulfur, aldehydes, ketones, chemistry of lipids. Carbohydrates, proteins and nucleic acids. Lectures and in class tutorials. Assessment concept is based on continuous work with students during the semester. Evaluation method is based on giving points for each activity, homework assignments, quizand midterm examination during semester, as well as on final exam. Quiz 2x 20% Midterm exam 20% Project 10% Homework’s (5x) Attendance Final exam 10% 5% Required , more than 70% 35% Total 100% Janice G. Smith, 2010. General, Organic, and Biological Chemistry, McGraw-Hill, ISBN 978-0-07302657-2 Bruice, P. K. 2010, Essential Organic Chemistry, Pearson ISBN 10:0-321-64416-6 Recommended readings: Intranet web reference: Important notes: Check with the lecturer for more references. Virtual book:https://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/intro1.htm Attendance policy: Absence from lectures shall not exceed 30%. Students who exceed the limits with medical or emergency excuse acceptable and approved by the Dean of the relevant faculty shall not be allowed to take the final examination and shall receive a mark zero for this course Course policy: During examination (quiz, midterm and final exam) students are allowed to use calculators and accessories approved by the course lecturer. MOBILE PHONESare strictly prohibited during the exams. Coming late to the class is not accepted(lateness will be evaluated as absent).Student are not allowed to disturb (talk, eat ,etc...) during the classes. Academic Dishonesty: Cheating and plagiarism is prohibited. However, who tries to cheat and plagiaries will receive one warning but ifshe/he continues to do so it will result in the expulsion from the class and receive 0 points for that particular exam. Cheating includes, but is not limited to: Giving or receiving unauthorized assistance during an examination; Obtaining unauthorized information about an examination before it is given; Using inappropriate or unallowable sources of information during an examination; Falsifying data in experiments and other research; Altering the record of any grades Altering answers after an examination has been submitted; Falsifying any official University record; or, Misrepresenting the facts in order to obtain exemptions from course requirements. 2 C-1 Grading policy: GRADE S IUS GRADES PERCEN T Weight coefficient of IUS grades A (10) A 95-100% 4.0 A- 91-94% 3.7 B+ 88-90% 3.3 B 85-87% 3.0 B- 81-84% 2.7 C+ 78-80% 2.3 C 75-77% 2.0 C- 70-74% 1.7 D+ 65-69% 1.3 E (6) D 55-64% 1.0 F (5) F < 55 0.0 B (9) C (8) D(7) Quality assurance: Quality assurance Through regular monitoring and control of the assistants the process of continuous work of students should be achieved. The entire written and oral request from student will be carefully evaluated by the responsible course holder and through discussion with other professor and course assistance decisions will be made. Quality of the course will be achieved through continues homework assignments and tutorials. Course schedule: 3 C-1 Week Date/Classroom 1 7.10.2015 No No No 1. Elements 2. Structure of the Atom (13-14h, AF2.13) 3. Isotopes 4. The Periodic Table 14.10.15 5. Electronic Structure (11-13h, AF1.11) 6. Electronic Configurations 7. Electronic Configurations and the Periodic Table 1. Relate the location of an element inthe periodic table to its electronic configuration No lab activities No 32-65 3 Chemical compounds properties Tutorialsduring and binding. It is important to the lectures understand their structure and naming. Additionally Hydrocarbon organic chemicals will be introduced, their properties and use in everyday life. Focus on health & medicine: covalent drugs and medical products Homework 1 93-120 Introduction lecture Class activities Readings Learning (Book objectives (After page this lesson student number) will be able to : Syllabi review (11-13h, AF1.11) 2 Topics to be covered Problems/ Lab activities Assignments (Homework) 12.10.15 19.10.15 Covalent Bonding and the Periodic Table; Focus on the Human Body: Covalent (13-14h, AF2.13) Molecules and the Cardiovascular System; Lewis Structures; Drawing Lewis Structures 21.10.15 ; Multiple Bonds;Exceptions to the Octet (11-13h, AF1.11) Rule; Elements in Group 3A Elements in the Third Row ;Resonance; Drawing Resonance Structures; Focus on the Environment: Ozone ;Naming Covalent Compounds; Molecular Shape; Two Groups Around an Atom etc;Focus on Health & Medicine: Covalent Drugs and Medical Products 2.Draw an electron-dot symbol for anAtom 3.Use the periodic table to predict therelative size and ionization energy of elements 1.Identify an element by its symbol and classify it as a metal, nonmetal, or metalloid 2. Describe the basic parts of an atom 3. Distinguish isotopes and calculate atomic weight 4. Describe the basic features of periodic table 5. Understand the electronic structure of an atom 6. Write an electronic configuration for an element 1.Recognize the bonding characteristics of covalent compounds 2.Draw Lewis structures for covalent compounds 3. Draw resonance structures for some ions and molecules 4.Name covalent compounds that contain two types of elements 5. Use electronegativity to determine whether a bond is polar or nonpolar 6.Determine whether a 4 C-1 molecule is polar or nonpolar 4 26.10.15 Introduction to Organic Chemistry. (13-14h, AF2.13) Characteristic Features of Organic (11-13h, AF1.11) Compounds; Shapes of Organic Molecules; Drawing Organic Molecules; Functional Groups; Properties of Organic Compounds Alkanes 5 28.10.15 2.11.15 Focus on health & medicine: Vitamins Focus on Environment: (13-14h, AF2.13) Introduction Combustion. Fossil Fuels 4.11.15 (11-13h, AF1.11) Simple Alkanes; An Introduction to Nomenclature; Alkane Nomenclature; Cycloalkanes Tutorials during the lectures Tutorials during No the lectures No 322-354 355-378 1.Recognize the characteristic features of organic compounds 2.Predict the shape around atoms in organic molecules 3.Use shorthand methods to draw organic molecules 4.Recognize the common functional groups and understand their importance 5. Distinguish organic compounds from ionic inorganic compounds 6. Determine whether an organic compound is polar or nonpolar 7.Determine solubility properties of organic compounds 8.Determine whether a vitamin is fat 1.Identify and draw acyclic alkanes and cycloalkanes 2.Identify constitutional isomers 3.Name alkanes using the IUPAC system of nomenclature 4. Predict the physical properties of alkanes 5.Write equations for the complete and incomplete combustion of alkanes 5 C-1 6 9.11.15 Monday (Quiz 1) (13-14h, AF2.13) Wednesday 11.11.15 (11-13h,AF1.11) Unsaturated hydrocarbons. Alkenes and Alkynes;Nomenclature of Alkenes and Alkynes; Cis–Trans Isomers; Interesting Alkenes in Food and Medicine;Aromatic Compounds; Nomenclature of Benzene Derivatives; Reactions of Aromatic Compounds FOCUS ON HEALTH & MEDICINE: Tutorials during Homework 2 the lectures 379-417 Tutorials during No the lectures 418-448 Reactions of Alkenes Margarine or Butter? Polymers—The Fabric of ModernSociety: Aromatic Drugs, Sunscreens, andCarcinogens: Phenols as Antioxidants 7 16.11.15 (13-14h, AF2.13) 18.11.15 (11-13h, AF1.11) 8 Organic compounds that contain oxygen, halogen, or sulfur. FOCUS ON HEALTH & MEDICINE: Structure and Properties of Alcohols. Ethanol, the Most Widely Nomenclature of Alcohols; Interesting Alcohols; Reactions of Alcohols; Structure and Properties of Ethers; Alkyl Halides; Organic Compounds That Contain Sulfur Abused Drug Ethers as Anesthetics 23.11.15 Monday (13-14h, AF2.13) (Project assignments and preparations) 25.11.15 Wednesday (Non-Working Day) National Day of BiH (Non-Working Day) 1.Identify the three major types of unsaturated hydrocarbons—alkenes, alkynes, and aromatic compounds 2.Name alkenes, alkynes, and substituted benzenes 3.Recognize the difference between constitutional isomers and stereoisomers, as well as identify cis and trans isomers 4. Identify saturated and unsaturated fatty acids and predict their relative melting points 1.Identify alcohols, ethers, alkyl halides, and thiols 2. Classify alcohols and alkyl halides as 1°, 2°, or 3° 3.Determine the properties of alcohols, ethers, alkyl halides, and thiols 4.Give basic names for alcohols, ethers, alkyl halides, and thiols 5.Draw the products of the dehydrationof alcohols 6 C-1 9 30.11.15 (13-14h, AF2.13) 2.12.15 (11-13h, AF1.11) Monday: Aldehydes and Ketone Structure and Bonding FOCUS ON HEALTH & MEDICINE: Physical Properties; Reactions of Aldehydes and Ketones; Reduction of Aldehydes and Ketones; Acetal Formation Interesting Aldehydes and Ketones Wednesday (2.12.2015): MIDTERM EXAM Tutorials during Homework 3 the lectures FOCUS ON THE HUMAN BODY The Chemistry of Vision Midterm exam will include lecture 1 to 7. 10 Lipids Fatty Acids; Introduction to Lipids;Waxes; (13-14h, AF2.13) Triacylglycerol’s—Fats and Oils; Hydrolysis of Triacylglycerol’s; Phospholipids; Cell 9.12.15 Membranes 7.12.15 (11-13h,AF1.11) FOCUS ON HEALTH & MEDICINE: Cholesterol, the Most Prominent Steroid; Steroid Hormones FOCUS ON HEALTH & MEDICINE: Fat-Soluble Vitamins FOCUS ON HEALTH & MEDICINE: Prostaglandins and Leukotrienes Tutorials during the lectures No 473-502 1.Identify the characteristics of aldehydes and ketones 2.Name aldehydes and ketones 3.Give examples of useful aldehydes and ketones 4.Draw the products of oxidation reactions of aldehydes 5.Draw the products of reduction reactions of aldehydes and ketones 6.Understand the basic reactions involved in vision 7. Identify and prepare hemiacetalsand acetals. 579-607 1.Classify fatty acids and describe the relationship between melting point and the number of double bonds 2.Draw the structure of a wax and identify the carboxylic acid and alcohol components 3. Describe the difference between a fat and an oils 4. Identify the two major classes of phospholipids 5. Describe the structure of a cell membrane, as well as different mechanisms of transport across the membrane 6.Describe the relationship between blood cholesterol level and cardiovascular disease 7. Define what a hormone is and list several examples of steroid hormones 7 C-1 8.Identify fat-soluble vitamins 11 14.12.15 QUIZ 2 (14.12.2015) (13-14h, AF2.13) Carbohydrates 16.12.15 (11-13h,AF1.11) 12 Monosaccharide’s; The Cyclic Forms of Monosaccharide’s; Reduction and Oxidation of Monosaccharide’s; Disaccharides; Polysaccharides Amino acids, proteins and enzymes Introduction; Amino Acids; Acid–Base (13-14h, AF2.13) Behaviour of Amino Acids; Peptides; Proteins 23.12.15 Protein Hydrolysis and Denaturation; (11-13h,AF1.11) Enzymes 21.12.15 FOCUS ON THE HUMAN BODY: Useful Carbohydrate Derivatives Tutorials during FOCUS ON THE HUMAN BODY: the lectures Blood Type FOCUS ON THE HUMAN BODY: Tutorials during Biologically Active Peptides the lectures FOCUS ON THE HUMAN BODY: Common Proteins FOCUS ON HEALTH & MEDICINE: Using Enzymes to Diagnose and Treat Diseases Homework 4 608-643 No 644-681 1 Identify the three major types of carbohydrates 2.Recognize the major structural features of monosaccharaides 3.Draw the cyclic forms of monosaccharide’s 4.Draw reduction and oxidation products of monosaccharaides 5.Recognize the major structural features of disaccharides 6.Describe the characteristics of cellulose, starch, and glycogen 7.Give examples of some carbohydrate derivatives that contain amino groups, amides, or carboxylate anions 8.Describe the role that carbohydrates play in determining blood type 1.Describe the acid–base properties of amino acids 2. Draw simple peptides from individual amino acids, and label the Nand C-terminal amino acids 3. Give examples of simple biologically active peptides 4.Describe the characteristics of the primary, secondary, tertiary, and quaternary structure of proteins 5.Describe protein denaturation 6. Describe the main 8 C-1 features of enzymes 7.Describe the use of enzymes. Nucleic acids and protein synthesis FOCUS ON HEALTH & Nucleosides and Nucleotides; MEDICINE: Viruses (13-14h, AF2.13) Nucleic Acids; The DNA Double Helix; Replication; RNA; Transcription; The 30.12.15 Genetic Code; Translation and Protein (11-13h,AF1.11) Synthesis; Mutations and Genetic Diseases; Recombinant DNA 13 28.12.15 14 4.1.16 (13-14h, AF2.13) Project presentation by students Tutorials during the lectures Homework 5 682-717 1.Draw the structure of nucleosides and nucleotides 2.Draw short segments of the nucleic acids DNA and RNA 3.Describe the basic features of the DNA double helix4.Outline the main steps of replication 5. List the three types and functions of RNA molecules 6.Explain the process of transcription 7. Describe the basic elements of the genetic code 8. Explain the process of translation Each student will present his/her topic in front the classmates. 6.1.16 (11-13h,AF1.11) 18.1.2016 - 29.1.2016 FINAL EXAM PERIOD Prepared by senior assistant Jasmin Šutković October 6, 2015 9