Supplementary Table 6: The impact of the gene-gene interaction between OCT2 c.808 (G>T)
and MATE1 g.-66 T>C on the secretory clearance of metformin.
OCT2 c.808 (G>T)
Mean CLsec (L/h)
c.808 GG
c. 808 GT
c.808TT
P
21.4 (18.2-25.1)
27.8 (23.4-33.1)*
37.6 (27.2-51.9)**
0.005
(n=8)
(n=7)
(n=2)
24.3 (21.1-27.9)
21.6 (18.4-25.4)■
21.5 (16.5-28.0)
(n=11)
(n=8)
(n=3)
26.4 (21.6-32.4)
26.5 (21.6-32.5)
g. -66 TT
MATE1 g.-66 T>C
g. -66 TC
g. -66 CC
p
0.294
0.451
-
(n=5)
(n=5)
0.160
0.029
0.027
Supplementary Table 6. The impact of the gene-gene interaction between OCT2 c.808 (G>T) and
MATE1 g.-66 T>C on the secretory clearance of metformin evaluated using parametric multiple
regression and adjusted for the individual glomerular filtration rates. All data are presented as
geometric means with 95% confidence intervals. CLsec, secretory clearance. In individuals
homozygous for the g.-66 T>C wildtype, metformin secretory clearance was significantly increased
for the individuals either heterozygous or homozygous for the c.808 (G>T) variant * P=0.017and **
P=0.003. In individuals heterozygous for the c.808 (G>T) variant, metformin secretory clearance
was significantly reduced for the individuals heterozygous and homozygous for the g.-66 T>C
variant. ■ P= 0.022. P= 0.008.