Additional file 1: Table S1. Significant pathways obtained upon the application of the clipper
method on KEGG pathways as implemented in the Graphite Web program to the CRC dataset.
Pathway
Adherens junction
Measles
Toll-like receptor signaling pathway
Vascular smooth muscle contraction
Viral myocarditis
Acute myeloid leukemia
Glutamatergic synapse
Pathogenic Escherichia coli infection
Prostate cancer
Circadian entrainment
Dopaminergic synapse
Epstein-Barr virus infection
Salivary secretion
Pancreatic secretion
Cell adhesion molecules (CAMs)
Chronic myeloid leukemia
Gap junction
Hepatitis B
Shigellosis
Jak-STAT signaling pathway
Hepatitis C
Fructose and mannose metabolism
Huntington's disease
Serotonergic synapse
Cholinergic synapse
NF-kappa B signaling pathway
Salmonella infection
Cell cycle
GABAergic synapse
Natural killer cell mediated cytotoxicity
Neuroactive ligand-receptor interaction
Nicotinate and nicotinamide metabolism
Oocyte meiosis
Antigen processing and presentation
Dilated cardiomyopathy
Glycerophospholipid metabolism
HIF-1 signaling pathway
Leukocyte transendothelial migration
Colorectal cancer
Influenza A
Retrograde endocannabinoid signaling
Leishmaniasis
Apoptosis
Herpes simplex infection
Gastric acid secretion
RIG-I-like receptor signaling pathway
African trypanosomiasis
alphaMean
0
0
0
0
0
0
0.01
0
0
0
0.01
0
0.01
0
0.05
0
0
0.01
0.05
0
0.01
0.02
0.02
0.04
0
0.01
0.07
0
0.05
0
0.08
0.02
0.05
0
0.01
0
0
0
0.01
0
0.03
0
0
0
0.01
0
0.01
alphaVar
0
0
0
0
0
0.01
0
0.01
0.01
0.02
0.01
0.02
0.01
0.03
0
0.05
0.05
0.04
0
0.06
0.06
0.05
0.06
0.04
0.09
0.08
0.02
0.1
0.05
0.1
0.02
0.09
0.06
0.12
0.11
0.12
0.12
0.12
0.12
0.14
0.11
0.16
0.17
0.18
0.18
0.19
0.2
Cocaine addiction
Adipocytokine signaling pathway
Long-term depression
Osteoclast differentiation
Tight junction
Amyotrophic lateral sclerosis (ALS)
Progesterone-mediated oocyte maturation
mTOR signaling pathway
Prion diseases
Bacterial invasion of epithelial cells
Carbohydrate digestion and absorption
Pentose phosphate pathway
Glioma
Melanoma
Small cell lung cancer
B cell receptor signaling pathway
Inositol phosphate metabolism
ECM-receptor interaction
Bladder cancer
Alzheimer's disease
Amino sugar and nucleotide sugar metabolism
Morphine addiction
Fc gamma R-mediated phagocytosis
Axon guidance
Insulin signaling pathway
Pertussis
Thyroid cancer
Wnt signaling pathway
Fc epsilon RI signaling pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Neurotrophin signaling pathway
TGF-beta signaling pathway
Toxoplasmosis
Endometrial cancer
NOD-like receptor signaling pathway
Endocrine and other factor-regulated calcium reabsorption
VEGF signaling pathway
ErbB signaling pathway
0.04
0
0.03
0.01
0
0.05
0.02
0
0.01
0.01
0
0.25
0
0.02
0.02
0.03
0.04
0
0.04
0
0
0.01
0
0
0.01
0
0.02
0
0.02
0.62
0
0
0
0
0
0.03
0.05
0
0.17
0.22
0.19
0.21
0.22
0.17
0.21
0.23
0.22
0.23
0.25
0.03
0.29
0.27
0.27
0.27
0.27
0.33
0.3
0.36
0.38
0.41
0.43
0.46
0.49
0.52
0.52
0.55
0.57
0
0.62
0.63
0.66
0.68
0.71
0.71
0.72
0.92