Study questions
HRM Exam 1
Rose-Hellekant
1. Which of the following characteristics can be attributed to steroid hormones and their
receptors?
A. a small fraction of steroid hormone in the circulation is bound to carrier proteins
B. steroidogenic cells are noteworthy for their extensive rough endoplasmic reticulum
C. steroid hormone bound receptors act as transcription factors
D. steroid hormones are typically released from the parent cell by exocytosis
E. steroids typically have circulating short half lives of about 2-5 minutes
2. Dopamine antagonists used to treat schizophrenia may cause the secretion of this hormone
to increase:
A. corticotropin-releasing factor
B. prolactin
C. adrenocorticotropic hormone
D. somatomedin
E. thyrotropin-releasing hormone
3. A 52-year-old white female presents with fatigue, night sweats, heat intolerance and
intermittent shaking. She notes that she has lost over 10 pounds of body weight in the last 2
months without trying. On physical exam her blood pressure is 128/82, pulse is 112 and
temperature is 99.2 F, and she has a diffusely enlarged, smooth and tender region in the ventral
neck. Anti-thyroid peroxidase antibody (TPO-ab) and anti-thyroglobulin antibody (TB-ab) are
negative, but TSH stimulating immunoglobulin (TSIs) are elevated. What are the most likely
results of her thyroid stimulating hormone (TSH) and free T4 tests?
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A. TSH = 0.3 mU/L, free T4 =15 μg/dL
B. TSH = 3.5 mU/L, free T4 =2 μg/dL
C. TSH = 4 mU/L, free T4 =14 μg/dL
D. TSH = 0.2 mU/L, free T4=1 μg/dL
E. TSH = 7.0 mU/L, free T4 = 13 μg/dL
4. A 40-year-old Hispanic female patient is brought into the emergency room following collapse
after gardening in the high heat and humidity. On physical examination, brownish
hyperpigmentation of her cheeks is noted. Which of the following is most likely true in this
patient?
A. The patient should be treated with octreotide.
B. The patient has primary adrenal insufficiency.
C. The patient should be treated with β-endorphin.
D. The patient has secondary adrenal insufficiency.
E. The patient has Cushing disease.
5. The ACTH-regulated, rate-limiting step in steroid production in the adrenal gland results in the
production of which hormone:
A. cortisol
B. 11-deoxycorticosterone
C. dihydroepiandosterone
D. pregnenolone
E. aldosterone
6. Growth hormone and cortisol are similar in that:
A. both cause the utilization of fats for energy
B. both cause hyperglycemia
C. both have their secretion suppressed by somatostatin
D. both cause potassium conservation
E. both result in a positive nitrogen balance
7. Which glucose transporter is responsive to insulin?
A. GLUT1
B. GLUT2
C. GLUT3
D. GLUT4
E. GLUT7
8. Which of the following promotes insulin secretion?
A. fasting state
B. incretins
C. norepinephrine
D. growth hormone
E. insulin-like growth factor-1
Downing
9. The synthesis of which of the following hormones is best identified with chief (principal) cells?
A. adrenocorticotropic hormone (ACTH)
B. aldosterone
C. androgen
D. antidiuretic hormone (ADH or vasopressin)
E. calcitonin
F. epinephrine
G. estrogen
H. glucagon
I. glucocorticoids
J. growth hormone (GH)
K. insulin
L. luteinizing hormone (LH or ICSH)
M. melatonin
N. norepinephrine
O. oxytocin
P. pancreatic polypeptide
Q. parathyroid hormone (PTH)
R. prolactin
S. somatostatin
T. thyroid hormones (T3 and T4)
U. thyroid stimulating hormone (TSH)
10. Which of the following hormones could possibly be released from the cells indicated by the
arrows in the image above?
A. adrenocorticotropic stimulating hormone (ACTH)
B. calcitonin
C. insulin
D. parathyroid hormone (PTH)
E. prolactin (PRL)
Krafts
11. A 32-year-old female presents with hypertension, hyperglycemia, and depression. She is
found to have an ACTH-secreting pituitary tumor. Which of the following sets of laboratory
results fit this patient's diagnosis?
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A. cortisol 50 μg/dL; ACTH 5 pg/ml; no suppression with high-dose dexamethasone
B. cortisol 50 μg/dL; ACTH 200 pg/ml; suppression with high-dose dexamethasone
C. cortisol 1 μg/dL; ACTH 200 pg/ml; no suppression with high-dose dexamethasone
D. cortisol 50 μg/dL; ACTH 5 pg/ml; suppression with low-dose dexamethasone
E. cortisol 1 μg/dL; ACTH 200 pg/ml; suppression with high-dose dexamethasone
12. A 54-year-old female presents to her physician with a chief complaint of depression. She
reports she has unintentionally gained several pounds over the past month, and she's "always
cold." On physical examination she is bradycardic and has 2+ non-pitting edema in her lower
extremities. Which of the following is the most likely etiology of this disease?
A. Autoimmune destruction of thyroid tissue
B. Idiopathic replacement of thyroid tissue with fibrous tissue
C. Thyroid adenoma
D. Iodine deficiency
E. Thyroid carcinoma
13. A 62-year-old, otherwise-healthy male is found to have incidental hypercalcemia on routine
laboratory testing. Which of the following is the most likely cause?
A. Parathyroid hyperplasia
B. Parathyroid adenoma
C. Squamous cell carcinoma of the lung
D. Milk-alkali syndrome
E. Familial hyperparathyroidism
14. A 28-year-old female presents with episodes of severe headaches, sweating and heart
palpitations. When questioned regarding her family history, she relates that her father and two
cousins have had their thyroids removed. Her blood pressure is 150/110 mm Hg, and she says
she is having one of her "spells" at the moment. Which of the following is likely to be elevated in
this patient's urine?
A. Adrenocorticotropic hormone (ACTH)
B. Renin
C. Vanillylmandelic acid (VMA)
D. Glucose
E. Cortisol
Pearson
15. In evaluating a 27 y/o G2P2002 female in the postpartum period, the following would be
most consistent with a diagnosis of postpartum depression developing:
A. symptoms of feeling tearful and down beginning day 2-3 after birth
B. severe fatigue the week following delivery
C. feelings of doubt of being able to care for a baby that begin just prior to hospital discharge
D. sadness and anxiety that begin one month after delivery
E. difficulty managing daily tasks the first couple weeks home after delivery
ANSWERS
Rose-Hellekant
1. C
2. B
3. A
4. B
5. D
6. B
7. D
8. E
Downing
9. Q
10. E
Krafts
11. B
12. A
13. B
14. C
Pearson
15. D