By: Amy Marston, Abby Drees, Bobby Wachtel, and Yianni Troupes
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Thyroid –Stimulating Hormone is produced
by the pituitary gland

Thyroid-Stimulating Hormone is peptide
based, as shown it needs a receptor and
cannot pass through
the membrane

The second messenger for TSH is cyclic AMP

After a phosphorylation cascade occurs, TSH
stimulates a change in the thyroid cell’s DNA
so that it begins to produce the hormone
“thyroxine”
The result of this pathway is a negative feedback loop
 When the body needs more heat
or experiences low thyroxin
levels, TRH is released from the
hypothalamus which stimulates
the release of TSH from the anterior
pituitary which then stimulates
the release of thyroxin from the
thyroid gland which increases
metabolism and brings the body
back to homeostasis.

Grave’s Disease: An autoimmune disease where the
body makes an antibody called TSI that mimics TSH,
and causes the thyroid to make too much thyroid
hormone.
 This “hyperthyroidism” can result in a metabolism
that is too high, and can result in weight loss,
weakness, and even heart problems.
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