Cellular Uptake Mechanism of Paclitaxel
Nanocrystals Determined by Confocal Imaging and
Kinetic Measurement
Yan Chen1,2 and Tonglei Li 2*
1
Department of Pharmaceutical Science, School of Pharmacy, Second Military Medical
University, Shanghai, 200433, China
2
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West
Lafayette, Indiana, USA
Supporting Information
1
Figure S1. Particle size measurement by DLS of PTX-NCs after crystallization (A) and
homogenization (B).
2
Figure S2. Confocal image of KB cells treated by SRB solution at 3 hours. Nuclei and lysosomes
were dyed as blue and red, respectively. Scale bar: 10 μm.
3
Figure S3. Flow cytometric analysis of folate receptors of KB cells (blue) with IgG (red) as the
control.
4