Table S2
DRP1K38A OP in primary
hippocampal neurons
-Reduces dendritic mitochondria content.
DRP1 OP in primary
hippocampal neurons
-Increases dendritic mitochondria content.
DRP1 mutant
Drosophila NMJ
DRP1K38A OP in primary
hippocampal neurons
-Drastic reduction in synaptic mitochondria content.
DRP1 OP in primary
hippocampal neurons
DRP1 RNAi in primary
hippocampal neurons
DRP1 OP in primary
hippocampal neurons
DRP1K38A OP in primary
hippocampal neurons
DRP1-/- in primary
forebrain neurons.
DRP1 OP in primary
hippocampal neurons
DRP1K38A OP in primary
hippocampal neurons
DRP1S656A OP in primary
hippocampal neurons
lacking endogenous DRP1
DRP1S656D OP in primary
hippocampal neurons
lacking endogenous DRP1
OPA1 RNAi
in primary cortical neurons
-Reduces the number of axonal mitochondria.
-Prevents the augmentation of axonal mitochondria
induced by OP of the Bcl2 family member Bcl-XL.
-Increases the number of axonal mitochondria.
-Potentiates the augmentation of axonal mitochondria
induced by Bcl-XL OP.
-Reduces mitochondrial content in neurites and in
spines.
-Increases mitochondrial content in neurites.
-Reduces the number and plasticity of dendritic spines.
-Reduces the quantity of a post-synaptic marker (PSD95).
-Reduces the number of functional presynaptic boutons.
-No effect on dendritic arborisation.
-Increases the number and plasticity of dendritic spines.
-Increases the quantity of a post-synaptic marker (PSD95).
-Increases the number of functional presynaptic boutons.
-No effect on dendritic arborisation.
-No effect on basal neurotransmission.
-Defect in mobilizing synaptic vesicles reserve pool.
-Reduces the quantity of a pre-synaptic marker (synaptophysin).
-Prevents the augmentation of a pre-synaptic marker (synaptophysin)
induced by Bcl-XL OP.
-Increases the quantity of a pre-synaptic marker (synaptophysin).
-Prevents the augmentation of a pre-synaptic marker (synaptophysin)
induced by Bcl-XL over-expression.
-Reduces the number of dendritic spines.
Li 2004
-Reduces the number of dendritic spines.
Wang 2009
-Reduces mitochondrial content in neurites.
-Reduction of the mitochondrial content in neurites
and spines.
-Decreases dendritic mitochondrial area.
-Decreases m∆
-Increases dendritic mitochondrial area.
Li 2004
Versterken 2005
Li 2008
Li 2008
Wang 2009
Wang 2009
-Reduction of neurites number and branching.
-Reduction of a pre-synaptic marker (synaptophysin).
-Decreases dendritic outgrowth.
-Increases synaptic density.
-Increases dendritic outgrowth.
-Decreases synaptic density.
-Mimicking dephosphorylation of DRP1 by neuronal PP2A increases
synaptic density.
Ishihara 2009
-Pseudo-phosphorylation of DRP1 by PKA increases
dendritic mitochondrial area.
-Pseudo-phosphorylation of DRP1 by PKA decreases synapses density.
Dickey 2011
-Reduces dendritic mitochondrial content.
-Decreases mitochondrial respiratory complexes,
mtDNA and m∆ levels.
-Reduces pre- and post synaptic markers (Synaptophysin, synapsin,
PSD95) quantities and synapses number.
-Reduces neurites length. No effect on neurites number.
This study
-Mimicking dephosphorylation of DRP1 by neuronal
PP2A decreases dendritic mitochondrial area.
OP = Overproduction. NMJ = Neuromuscular Junction. m∆ = mitochondrial membrane potential.
Dickey 2011
Dickey 2011
Dickey 2011