Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Janet M. Oliver
Regents’ Professor and Harvey Chair of Pathology
eRA COMMONS USER NAME
joliver
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as
nursing, and include postdoctoral training.)
DEGREE
INSTITUTION AND LOCATION
(if
YEAR(s)
FIELD OF STUDY
applicable)
University of Adelaide, Australia
B. Sc
1966
Biochemistry/Zoology
Flinders University of South Australia
B. Sc Hons
1967
Biochemistry
University of Alberta, Edmonton, Canada
M. Sc
1969
Biochemistry
London University, London, UK
Ph D
1972
Biochemistry
Harvard Medical School, Boston, MA
Post Doc
1973
Cell Physiology
Personal Statement
Dr. Oliver is Director of the Cell Pathology Division in the UNM Department of Pathology and Associate
Director for Professional Development and Partnerships in the UNM Cancer Center. She is the co-Director of
two Center grants for interdisciplinary research and training, the New Mexico Spatiotemporal Modeling Center
(stmc.health.unm.edu) and the New Mexico Cancer Nanotechnology Training Center (cntc.unm.edu). The
Centers are administered through the UNMCC and provide research support and training for faculty,
postdoctoral fellows and graduate students working in the CC research programs.
Positions
1973 - 1983
Assistant to Full Professor, Depts. of Physiology & Pathology, U. of Connecticut Health Center
1983 - Present Professor, Department of Pathology, University of New Mexico Health Sciences Center
1984 - 1990
Director, UNM/LANL Graduate Program in Cell and Molecular Biology and Biophysics
1987 - 1994
Director, The Center for Structural Biology, University of New Mexico School of Medicine
1990 - Present Associate Director for Research, UNM Cancer Research and Treatment Center
1992 - 2010
PI and Director, American Cancer Society Institutional Research Grant (ACS IRG) program
1996 - 2000
PI and Director, NIH/NCRR Institutional Development Award (IDeA)
2002 – 2012 PI and Director, NIH/NIGMS National Center for Systems Biology/New Mexico Center for the
Spatiotemporal Modeling of Cell Signaling
2002-present Professor, Department of Biology, University of New Mexico
2010 – present Co-PI and Co-Director (with A. Datye), NCI Cancer Nanotechnology Training Center
Honors
1972-1973
Leukemia Society of America Postdoctoral Fellowship
1977-1982
American Cancer Society Faculty Research Award
1993-1994
ACS Scholar Award
1996-Present UNM Regents’ Professor
2002
UNM SOM Excellence in Research and Leadership Award
2002-2004
Associate Editor, Journal of Immunology
2006
Distinguished Alumnus Award, Flinders University of South Australia
2010
Elected Fellow of the American Association for the Advancement of Science (AAAS)
2011
Appointed Frederick H. Harvey Chair of Pathology
Fifteen Selected Publications (from more than 160)
1. Hutchcroft JE, Geahlen RL, Deanin GG and Oliver JM. FcRI-mediated tyrosine phosphorylation and
activation of the 72 kDa protein-tyrosine kinase, PTK72/Syk, in RBL-2H3 rat tumor mast cells. Proc Natl
Acad Sci 1992; 89: 9107-9111.
2. Ortega EM, Lara M, Lee I, Santana C, Martinez AM, Pfeiffer JR, Lee RJ, Wilson BS and Oliver JM. Lyn
dissociation from phosphorylated FcRI subunits: a new regulatory step in the FcRI signaling cascade
revealed by studies of FcRI dimer signaling activity. J Immunol 1999;162: 176-185.
PHS 398/2590 (Rev. 11/07)
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Principal Investigator/Program Director (Last, First, Middle):
3. Wilson BS, Pfeiffer JR, Surviladze Z, Gaudet EA and Oliver JM. 2001. High resolution mapping of mast cell
membranes reveals primary and secondary domains of FcRI and LAT. J Cell Biol 2001; 154: 645-658.
4. Youssef LA, Wilson BS and Oliver JM. Proteasome-dependent regulation of Syk tyrosine kinase
expression in human basophils. J Allergy Clin Immunol 2002; 110: 366-373.
5. Wilson BS, Steinberg SL, Leiderman K, Pfeiffer JR, Surviladze Z, Zhang J, Samelson LE, Yang LH, Kotula
PG, and Oliver JM. Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in
native membranes. Mol Biol Cell 2004; 15: 2580-2592.
6. Frankel DJ, Pfeiffer JR, Oliver JM, Wilson BS and Burns AR. FcRI signaling domains observed as distinct
topographic features on the inside of mast cell membranes. Biophys J 2006; 90: 2404–2413.
7. Torigoe C, Faeder JR, Oliver JM and Goldstein B. Kinetic proofreading of ligand-FcRI interactions persists
beyond LAT phosphorylation. J Immunol 2007;178: 3530 - 3535.
8. Zhang, J, SL Steinberg, BS Wilson, JM Oliver and LR Williams. Markov random field modeling of the
spatial distribution of proteins on cell membranes. Bull Math. Biol. 2008; 70: 297-321.
9. Andrews, NL, KA Lidke, JR. Pfeiffer, AR Burns, BS Wilson, JM Oliver, and DS Lidke. Actin restricts FcεRI
diffusion and facilitates antigen-induced receptor immobilization. Nature Cell Biol. 2008; 10: 955-963.
10. Andrews, NL, JR Pfeiffer, AM Martinez, DM Haaland, RW Davis, T Kawakami, JM Oliver, BS Wilson and
DS Lidke. Small, Mobile FcεRI Receptor Aggregates Are Signaling Competent. Immunity 2009:31:469–479.
11. Radhakrishnan, K, J Edwards, D Lidke, T Jovin, B Wilson, and J Oliver. Sensitivity Analysis Predicts that
the ERK-pMEK Interaction Regulates ERK Nuclear Translocation. IET Systems Biology 3: 329-341 2009.
12. Carroll-Portillo, A, K Spendier, J Pfeiffer, G Griffiths, H Li, JM Oliver, D Lidke, J Thomas, BS Wilson and J
Timlin. FcεRI Membrane Dynamics upon Binding Mobile or Immobile Ligands on Surfaces: Formation of a
Mast Cell Synapse. J Immunol. 2010: 184:1328-38.
13. Wilson, BS, J.M. Oliver, D.S. Lidke. Spatiotemporal signaling in mast cells. In: Mast Cell Biology,
Contemporary and Emerging Topics, Editors, Dean Metcalfe and Alasdair Gilfillan. Landes BioScience and
Springer Science. 2011; 716: 91-106.
14. Espinoza, FA, JM Oliver, BS Wilson, SL Steinberg. Using Hierarchical Clustering and Dendrograms to
Quantify the Clustering of Membrane Proteins. Bull. Math. Biol. 2012:74; 190-211.
15. Espinoza, FA, MJ Wester, JM Oliver, BS Wilson, NL Andrews, DS Lidke and SL Steinberg. Insights Into
Cell Membrane Microdomain Organization from Live Cell Single Particle Tracking of the IgE High Affinity
Receptor FcεRI of Mast Cells. Bull. Math. Biol. 2012: 74; 1857-1911.
Research Support
NIH P50GM085273 (Wilson, Oliver)
8/1/09-7/31/14
New Mexico Center for the Spatiotemporal Modeling of Cell Signaling
This grant established the tenth NIGMS National Center for Systems Biology. Oliver was the Founding PI;
leadership transitioned in January 2013 to B. Wilson who will lead the competing renewal. Oliver is now co-PI.
The Center’s overall goal is to integrate quantitative biochemical measurement, novel imaging technologies
and computational modeling to better understand membrane microdomain organization and the role of
membrane protein mobility in the regulation of complex signaling pathways in immune and cancer cells.
NIH R25CA153825 (Oliver, Datye)
9/1/10-8/31/15
Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Center
This multi-PI plan grant is for support of interdisciplinary graduate student and postdoc training in
nanotechnology with applications to cancer.
PHS 398/2590 (Rev. 11/07)
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Biographical Sketch Format Page