Identification
eFigure 1. Study flow diagram showing the study selection process
Records identified through
database searching
(n = 2452)
Additional records identified
through other sources
(n = 16)
Screening
Records after duplicates removed
(n = 2217)
Records excluded
(n = 2115)
Records screened
(n = 2217)
Eligibility
Full-text articles excluded (n = 88):
Full-text articles assessed
for eligibility
(n = 102)
Not overweight or obese adults (n=13)
[1-13];
Not GT/GTE supplementation, or not
GT/GTE alone (n=16) [14-29];
No data on blood pressure (n=25) [30-54];
Included
Studies included in
qualitative synthesis
(n = 14)
Not RCTs (n=5) [55-59];
Not placebo used as comparison (n=17)
[60-76];
Other reasons (12):
Studies included in
quantitative synthesis
(meta-analysis)
(n = 14)
— Duplicates (n=5) [77-81];
— Not oral GTE supplementation (n=1)
[82];
— Intervention duration less than one
week (n=6) [83-88].
1
eFigure 2. Risk of bias summary: review authors’ judgements about each risk of bias domain
for each included study.
2
eFigure 3. Risk of bias graph: review authors’ judgements about each risk of bias domain
presented as percentages across all included studies.
3
eFigure 4. Funnel plot to assess publication bias for effect of GT or GTE on SBP among
overweight and obese adults
4
eFigure 5. Funnel plot to assess publication bias for effect of GT or GTE on DBP among
overweight and obese adults
5
eTable. Summary of findings for Green tea or green tea extract compared to placebo for
Blood pressure among overweight and obese adults
Patient or population: Overweight and obese adults
Settings: Japan, China, Poland, Netherlands, UK, USA and Australia
Intervention: Green tea (GT) or green tea extract (GTE)
Comparison: Placebo
Outcomes
Illustrative comparative risks* (95% CI)
Assumed risk
Placebo
Corresponding risk
GT or GTE
Relative
effect
(95% CI)
No of
Participants
(studies)
Quality of the Comments
evidence
(GRADE)
The mean change in SBP
Change in SBP1
Follow-up: 3 weeks in the placebo groups
to 16 weeks
ranged from
8 lower to 0.79 higher
mmHg
The mean change in SBP
in the intervention groups
was
1.42 lower (2.47 to 0.36
lower) mm Hg
971
(14 studies)
⊕⊕⊝⊝2,3
low
The mean change in DBP
Change in DBP4
Follow-up: 3 weeks in the placebo groups
to 16 weeks
ranged from
4.1 lower to 2 higher
mmHg
The mean change in DBP
in the intervention groups
was
1.25 lower (2.32 to 0.19
lower) mmHg
971
(14 studies)
⊕⊕⊝⊝2,3
low
Quality of life
See comment5
Follow-up: 8 weeks
and 16 weeks,
respectively
See comment5
165
(2 study)
See comment6
Adverse events
See comment6
Follow-up: 3 weeks
to 16 weeks
See comment6
823
(11 studies)
⊕⊕⊕⊝
high
The dropout rate in the
placebo groups ranged
from
0% to 26%
971
(14 studies)
⊕⊕⊕⊕
high
The dropout rate in the
placebo groups ranged
from
0% to 18%
Treatment
discontinuation
Follow-up: 3 weeks
to 16 weeks
See
comment7
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence
interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval;
GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.
1 SBP:
systolic blood pressure;
2 High
risk of bias of incomplete outcome data and blinding, and unclear risk of bias such as allocation concealment and the
influence of funding;
6
3 Unexplained
heterogeneity;
4
DBP: diastolic blood pressure;
5
Only Two studies included. No difference in the effect on quality of life in one trial, while a higher score was observed only
on hedonic tone in another study;
6
No sufficient information retrieved;
7
No adverse events reported, or no significant difference found between intervention and placebo groups.
7
List of excluded studies
1.
Miller RJ, Jackson KG, Dadd T, Mayes AE, Brown AL, Lovegrove JA, Minihane AM: The impact of the
catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green
tea ingestion. Molecular nutrition & food research 2012, 56(6):966-975.
2.
Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney, Jr., J.F, Vita JA: Acute
EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease.
Journal of the American College of Nutrition 2007, 26(2):95-102.
3.
Freese R, Basu S, Hietanen E, Nair J, Nakachi K, Bartsch H, Mutanen M: Green tea extract decreases
plasma malondialdehyde concentration but does not affect other indicators of oxidative stress,
nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy females.
European journal of nutrition 1999, 38(3):149-157.
4.
Maron DJ, Lu GP, Cai NS, Wu ZG, Li YH, Chen H, Zhu JQ, Jin XJ, Wouters BC, Zhao J:
Cholesterol-lowering effect of a theaflavin-enriched green tea extract: A randomized controlled trial.
Archives of Internal Medicine 2003, 163(12):1448-1453.
5.
McMullen MK, Whitehouse JM, Shine G, Towell A: Habitual coffee and tea drinkers experienced
increases in blood pressure after consuming low to moderate doses of caffeine; these increases
were larger upright than in the supine posture. Food & function 2011, 2(3-4):197-203.
6.
Miyazaki R, Kotani K, Ayabe M, Tsuzaki K, Shimada J, Sakane N, Takase H, Ichikawa H, Yonei Y, Ishii K:
Minor effects of green tea catechin supplementation on cardiovascular risk markers in active older
people: A randomized controlled trial. Geriatrics and Gerontology International 2013, 13(3):622-629.
7.
Nagaya N, Yamamoto H, Uematsu M, Itoh T, Nakagawa K, Miyazawa T, Kangawa K, Miyatake K: Green
tea reverses endothelial dysfunction in healthy smokers. Heart (British Cardiac Society) 2004,
90(12):1485-1486.
8.
Oyama J, Maeda T, Kouzuma K, Ochiai R, Tokimitsu I, Higuchi Y, Sugano M, Makino N: Green tea
catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in
smokers. Circulation Journal 2010, 74(3):578-588.
9.
Princen HM, van Duyvenvoorde W, Buytenhek R, Blonk C, Tijburg LB, Langius JA, Meinders AE, Pijl H:
No effect of consumption of green and black tea on plasma lipid and antioxidant levels and on LDL
oxidation in smokers. Arteriosclerosis, Thrombosis & Vascular Biology 1998, 18(5):833-841.
10.
Young JF, Dragsted LO, Haraldsdottir J, Daneshvar B, Kall MA, Loft S, Nilsson L, Nielsen SE, Mayer B,
Skibsted LH et al: Green tea extract only affects markers of oxidative status postprandially: Lasting
antioxidant effect of flavonoid-free diet. British Journal of Nutrition 2002, 87(4):343-355.
11.
van het Hof KH, de Boer HS, Wiseman SA, Lien N, Westrate JA, Tijburg LB: Consumption of green or
black tea does not increase resistance of low-density lipoprotein to oxidation in humans. American
Journal of Clinical Nutrition 1997, 66(5):1125-1132.
12.
de Maat MP, Pijl H, Kluft C, Princen HM: Consumption of black and green tea had no effect on
inflammation, haemostasis and endothelial markers in smoking healthy individuals. European
journal of clinical nutrition 2000, 54(10):757-763.
13.
Sugihara N, Kishimoto Y, Saita E, Toyozaki M, Taguchi C, Kobayashi M, Niino H, Sagesaka Y, Tani M,
Kondo K: The effects of green tea catechin on ldl oxidation and endothelial function in healthy
subjects. 20th International Congress of Nutrition Granada Spain 2013, 63:1603.
14.
Kappus RM, Curry CD, McAnulty S, Welsh J, Morris D, Nieman DC, Soukup J, Collier SR: The effects of a
multiflavonoid supplement on vascular and hemodynamic parameters following acute exercise.
Oxidative medicine and cellular longevity 2011, 2011:210798.
8
15.
Kutan Fenercioglu A, Saler T, Genc E, Sabuncu H, Altuntas Y: The effects of polyphenol-containing
antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without
complications. Journal of endocrinological investigation 2010, 33(2):118-124.
16.
Outlaw J, Wilborn C, Smith A, Urbina S, Hayward S, Foster C, Wells S, Wildman R, Taylor L: Effects of
ingestion of a commercially available thermogenic dietary supplement on resting energy
expenditure, mood state and cardiovascular measures. Journal of the International Society of Sports
Nutrition 2013, 10(1):25.
17.
Quinlan P, Lane J, Aspinall L: Effects of hot tea, coffee and water ingestion on physiological
responses and mood: The role of caffeine, water and beverage type. Psychopharmacology 1997,
134(2):164-173.
18.
Quinlan PT, Lane J, Moore KL, Aspen J, Rycroft JA, O'Brien DC: The acute physiological and mood
effects of tea and coffee: The role of caffeine level. Pharmacology Biochemistry and Behavior 2000,
66(1):19-28.
19.
Rogers PJ, Smith JE, Heatherley SV, Pleydell-Pearce CW: Time for tea: mood, blood pressure and
cognitive performance effects of caffeine and theanine administered alone and together.
Psychopharmacology 2008, 195(4):569-577.
20.
Seifert JG, Nelson A, Devonish J, Burke ER, Stohs SJ: Effect of acute administration of an herbal
preparation on blood pressure and heart rate in humans. International Journal of Medical Sciences
2011, 8(3):192-197.
21.
Kreutzkamp B: Blood pressure lowering: Significant effects of cocoa but not from tea intake.
Medizinische Monatsschrift fur Pharmazeuten 2007, 30(8):309-310.
22.
van het Hof KH, Wiseman SA, Yang CS, Tijburg LB: Plasma and lipoprotein levels of tea catechins
following repeated tea consumption. Proceedings of the Society for Experimental Biology & Medicine
1999, 220(4):203-209.
23.
Belza A, Toubro S, Astrup A: The effect of caffeine, green tea and tyrosine on thermogenesis and
energy intake. European journal of clinical nutrition 2009, 63(1):57-64.
24.
Berube-Parent S, Pelletier C, Dore J, Tremblay A: Effects of encapsulated green tea and Guarana
extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure
and fat oxidation in men. British Journal of Nutrition 2005, 94(3):432-436.
25.
Rakic V, Beilin LJ, Burke V: Effect of coffee and tea drinking on postprandial hypotension in older
men and women. Clinical and Experimental Pharmacology and Physiology 1996, 23(6-7):559-563.
26.
Jalili T, Beisinger S, Quadros A, Rabovsky A: A mixture of grape seed and skin extract, green tea
extract, resveratrol, and quercetin reduces blood pressure in hypertensive subjects with metabolic
syndrome. Experimental Biology 2012, EB San Diego, CA United States 2012, 26.
27.
Vorster H, Jerling J, Oosthuizen W, Cummings J, Bingham S, Magee L, Mulligan A, Runswick S: Tea
drinking and haemostasis: A randomized, placebo-controlled, crossover study in free-living subjects.
Haemostasis 1996, 26(1):58-64.
28.
Smith AE, Lockwood CM, Moon JR, Kendall KL, Fukuda DH, Tobkin SE, Cramer JT, Stout JR:
Physiological effects of caffeine, epigallocatechin-3-gallate, and exercise in overweight and obese
women. Applied Physiology, Nutrition and Metabolism 2010, 35(5):607-616.
29.
Arazi H, Samami N, Kheirkhah J, Taati B: The Effect of Three Weeks Green Tea Extract Consumption
on Blood Pressure, Heart Rate Responses to a Single Bout Resistance Exercise in Hypertensive
Women. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of
Hypertension 2014.
9
30.
Crew KD, Ho KA, Brown P, Greenlee H, Bevers TB, Arun B, Sneige N, Hudis C, McArthur HL, Chang J et
al: Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling
in women with hormone receptor-negative breast cancer. J Hum Nutr Diet 2014.
31.
Garcia FA, Cornelison T, Nuno T, Greenspan DL, Byron JW, Hsu CH, Alberts DS, Chow HH: Results of a
phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with
persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia. Gynecol Oncol
2014, 132(2):377-382.
32.
Mielgo-Ayuso J, Barrenechea L, Alcorta P, Larrarte E, Margareto J, Labayen I: Effects of dietary
supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis,
cardiometabolic risk factors and liver function in obese women: randomised, double-blind,
placebo-controlled clinical trial. Br J Nutr 2014, 111(7):1263-1271.
33.
Roshdy E, Rajaratnam V, Maitra S, Sabry M, Allah AS, Al-Hendy A: Treatment of symptomatic uterine
fibroids with green tea extract: a pilot randomized controlled clinical study. International journal of
women's health 2013, 5:477-486.
34.
Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N,
Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S, Hongprapas P: Effectiveness of green tea
on weight reduction in obese Thais: A randomized, controlled trial. Physiology & behavior 2008,
93(3):486-491.
35.
Boschmann M, Thielecke F: The effects of epigallocatechin-3-gallate on thermogenesis and fat
oxidation in obese men: A pilot study. Journal of the American College of Nutrition 2007,
26(4):389S-395S.
36.
Chang AL, Egbert B, Munoz C, Janjua R, Rehmus W: A 2-year, double-blind, randomized,
placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic
appearance of photoaging skin. Journal of the American Academy of DermatologyConference: 67th
Annual Meeting of the American Academy of Dermatology, AAD San Francisco, CA United
StatesConference Start: 20090306 Conference End: 20090310Conference Publication: (varpagings)
2009, 60(3 SUPPL. 1):AB29.
37.
Domingo DS, Camouse MM, Hsia AH, Matsui M, Maes D, Ward NL, Cooper KD, Baron ED:
Anti-angiogenic effects of epigallocatechin-3-gallate in human skin. International journal of clinical
and experimental pathology 2010, 3(7):705-709.
38.
Hodgson JM, Croft KD, Mori TA, Burke V, Beilin LJ, Puddey IB: Regular ingestion of tea does not
inhibit in vivo lipid peroxidation in humans. Journal of Nutrition 2002, 132(1):55-58.
39.
Inami S, Takano M, Yamamoto M, Murakami D, Tajika K, Yodogawa K, Yokoyama S, Ohno N, Ohba T,
Sano J et al: Tea catechin consumption reduces circulating oxidized low-density lipoprotein.
International Heart Journal 2007, 48(6):725-732.
40.
Stendell-Hollis NR, Thomson CA, Thompson PA, Bea JW, Cussler EC, Hakim IA: Green tea improves
metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer
survivors. Journal of human nutrition and dietetics : the official journal of the British Dietetic
Association 2010, 23(6):590-600.
41.
Tinahones FJ, Rubio MA, Garrido-Sanchez L, Ruiz C, Gordillo E, Cabrerizo L, Cardona F: Green tea
reduces LDL oxidability and improves vascular function. Journal of the American College of Nutrition
2008, 27(2):209-213.
42.
Kristen AV, Lehrke S, Mereles D, Schnabel PA, Rocken C, Ehlermann P, Dengler TJ, Altland K, Katus HA:
Green tea reduces left ventricular myocardial mass in patients with transthyretin amyloidosis.
10
Journal of Heart and Lung TransplantationConference: 31st Annual Meeting and Scientific Sessions of
the International Society for Heart and Lung Transplantation, ISHLT San Diego, CA United
StatesConference Start: 20110413 Conference End: 20110(TRUNCATED) 2011, 30(4 SUPPL. 1):S193.
43.
Alexopoulos N, Vlachopoulos C, Baou K, Terentes-Printzios D, Aznaouridis K, Ioakeimidis N, Dima I,
Stefanadis C: The short-term effect of tea consumption on aortic stiffness and wave reflections.
American College of Cardiology 58th Annual Scientific Session and i2 Summit: Innovation in
Intervention Orlando, FL United States 2009, 53(10):A442.
44.
Hossein Zadeh MJ, Mohammadi S, Hossein Nejad A, Karimi M, Mirzaie K, Eshraghian MR: The effect of
green tea extract on serum visfatin consentration in patients with T2DM. 3rd International Congress
on Prediabetes and the Metabolic Syndrome Nice France 2009, 1:A285.
45.
Falsini B, Marangoni D, Salgarello T, Stifano G, Montrone L, Di Landro S, Guccione L, Balestrazzi E,
Colotto A: Effect of epigallocatechin-gallate on inner retinal function in ocular hypertension and
glaucoma: a short-term study by pattern electroretinogram. Graefes Archive for Clinical &
Experimental Ophthalmology 2009, 247(9):1223-1233.
46.
Hsu SP, Wu MS, Yang CC, Huang KC, Liou SY, Hsu SM, Chien CT: Chronic green tea extract
supplementation reduces hemodialysis-enhanced production of hydrogen peroxide and
hypochlorous acid, atherosclerotic factors, and proinflammatory cytokines. American Journal of
Clinical Nutrition 2007, 86(5):1539-1547.
47.
Janjua R, Munoz C, Gorell E, Rehmus W, Egbert B, Kern D, Chang ALS: A two-year, double-blind,
randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and
histologic appearance of photoaging skin. Dermatologic Surgery 2009, 35(7):1057-1065.
48.
Ryu OH, Lee J, Lee KW, Kim HY, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM: Effects of green
tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes
patients. Diabetes Research & Clinical Practice 2006, 71(3):356-358.
49.
Shen C.-L Chyu M.-C Pence BC, Yeh JK, Zhang Y, Felton CK, Doctolero S, Wang JS: Green tea
polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: Safety
and quality of life report. BMC Complementary and Alternative Medicine 2010, 10.
50.
Toolsee NA, Aruoma OI, Gunness TK, Kowlessur S, Dambala V, Murad F, Googoolye K, Daus D,
Indelicato J, Rondeau P et al: Effectiveness of green tea in a randomized human cohort: Relevance to
diabetes and its complications. BioMed Research International 2013, 2013.
51.
Batista GdAP, Cunha CL, Scartezini M, von der Heyde R, Bitencourt MG, Melo SFd: Prospective
double-blind crossover study of Camellia sinensis (green tea) in dyslipidemias. Arquivos brasileiros
de cardiologia 2009, 93(2):128-134.
52.
Maki KC, Reeves MS, Farmer M, Yasunaga K, Matsuo N, Katsuragi Y, Komikado M, Tokimitsu I, Wilder
D, Jones F: Green tea catechin consumption enhances exercise-induced abdominal fat loss in
overweight and obese adults. The Journal of nutrition 2009, 139(2):264-270.
53.
Kim W, Jeong MH, Cho SH, Yun JH, Chae HJ, Ahn YK, Lee MC, Cheng X, Kondo T, Murohara T et al:
Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells
in chronic smokers. Circulation Journal 2006, 70(8):1052-1057.
54.
Zheng JS, Yu Y, Yang J, Xu XJ, Hu XJ, Luo M, Li D: Postprandial effects of two Chinese liquors on
selected cardiovascular disease risk factors in young men. Acta Physiologica Hungarica 2013,
100(3):302-311.
55.
Chen TS, Liou SY, Wu HC, Tsai FJ, Tsai CH, Huang CY, Chang YL: Efficacy of epigallocatechin-3-gallate
and amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients. Journal of
11
Medicinal Food 2011, 14(7-8):718-723.
56.
Hirano R, Momiyama Y, Takahashi R, Taniguchi H, Kondo K, Nakamura H, Ohsuzu F: Comparison of
green tea intake in Japanese patients with and without angiographic coronary artery disease.
American Journal of Cardiology 2002, 90(10):1150-1153.
57.
Sung H, Min WK, Lee W, Chun S, Park H, Lee YW, Jang S, Lee DH: The effects of green tea ingestion
over four weeks on atherosclerotic markers. Annals of Clinical Biochemistry 2005, 42(Pt 4):292-297.
58.
Trudel D, Labbe DP, Araya-Farias M, Doyen A, Bazinet L, Duchesne T, Plante M, Gregoire J, Renaud MC,
Bachvarov D et al: A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a
maintenance therapy in women with advanced stage ovarian cancer. Gynecologic oncology 2013,
131(2):357-361.
59.
Kim HM, Kim J: The effects of green tea on obesity and type 2 diabetes. Diabetes and Metabolism
Journal 2013, 37(3):173-175.
60.
Fukino Y, Shimbo M, Aoki N, Okubo T, Iso H: Randomized controlled trial for an effect of green tea
consumption on insulin resistance and inflammation markers. Journal of nutritional science and
vitaminology 2005, 51(5):335-342.
61.
Mozaffari-Khosravi H, Ahadi Z, Barzegar K: The effect of green tea and sour tea on blood pressure of
patients with type 2 diabetes: A randomized clinical trial. Journal of Dietary Supplements 2013,
10(2):105-115.
62.
Nagao T, Hase T, Tokimitsu I: A green tea extract high in catechins reduces body fat and
cardiovascular risks in humans. Obesity (Silver Spring, Md) 2007, 15(6):1473-1483.
63.
Nagao T, Meguro S, Hase T, Otsuka K, Komikado M, Tokimitsu I, Yamamoto T, Yamamoto K: A
catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes.
Obesity (Silver Spring, Md) 2009, 17(2):310-317.
64.
Persson IA, Persson K, Hagg S, Andersson RG: Effects of green tea, black tea and Rooibos tea on
angiotensin-converting enzyme and nitric oxide in healthy volunteers. Public health nutrition 2010,
13(5):730-737.
65.
Vieira Senger AE, Schwanke CHA, Gomes I, Valle Gottlieb MG: Effect of green tea (Camellia sinensis)
consumption on the components of metabolic syndrome in elderly. Journal of Nutrition, Health and
Aging 2012, 16(9):738-742.
66.
Uto-Kondo H, Ayaori M, Kishimoto Y, Adachi T, Takiguchi S, Yakushiji E, Sasaki M, Komatsu T, Kondo K,
Ikewaki K: Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular
superoxide dismutase levels in men with metabolic syndrome: Link with LDL oxidizability.
International journal of food sciences and nutrition 2013, 64(4):407-414.
67.
Hori Y, Miyazawa K, Shimizu R, Sano M, Watanabe Y: Safety evaluation of excessive intake of green
tea containing F. Velutipes extracts on human study. Journal of Tokyo Medical University 2009,
67(1):52-59.
68.
Kajimoto O, Nakagawa S, Kajimoto Y, Takashiba M, Shimano K: Hypotensive effects and safety of tea
beverage containing peptide derived from sardine muscle hydrolyzate on high normal blood
pressure and mild hypertensive subjects. Japanese Pharmacology and Therapeutics 2005,
33(11):1127-1140.
69.
Kajimoto O, Nakagawa S, Kajimoto Y, Takashiba M, Shimano K: Evaluation of the safety in excess
administration of tea beverage containing peptide derived from sardine muscle hydrolyzate on
humans. Japanese Pharmacology and Therapeutics 2005, 33(11):1113-1125.
70.
Yang HY, Yang SC, Chao JC, Chen JR: Beneficial effects of catechin-rich green tea and inulin on the
12
body composition of overweight adults. British Journal of Nutrition 2012, 107(5):749-754.
71.
Belcaro G, Ledda A, Hu S, Cesarone MR, Feragalli B, Dugall M: Greenselect phytosome for borderline
metabolic syndrome. Evidence-based Complementary and Alternative Medicine 2013, 2013.
72.
Fukino Y, Ikeda A, Maruyama K, Aoki N, Okubo T, Iso H: Randomized controlled trial for an effect of
green tea-extract powder supplementation on glucose abnormalities. European journal of clinical
nutrition 2008, 62(8):953-960.
73.
Gordillo-Bastidas E, Yanez-Sanchez I, Panduro A, Martinez-Lopez E: Effect of moderate-fat diet
complemented with green tea on anthropometric and biochemical markers, and cardiovascular risk
in obese patients. 8th Annual World Congress on Insulin Resistance Diabetes and Cardiovascular
Disease, WCIRDC Los Angeles, CA United States 2011, 8(1):83-84.
74.
Miller RJ, Jackson KG, Dadd T, Mayes AE, Brown AL, Minihane AM: The impact of the
catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a
green tea extract. British Journal of Nutrition 2011, 105(8):1138-1144.
75.
Sone T, Kuriyama S, Nakaya N, Hozawa A, Shimazu T, Nomura K, Rikimaru S, Tsuji I: Randomized
controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and
cardiovascular disease risk factors. Food and Nutrition Research 2011, 55.
76.
Mousavi A, Vafa M, Neyestani T, Khamseh M, Hoseini F: The effects of green tea consumption on
metabolic and anthropometric indices in patients with Type 2 diabetes. Journal of research in
medical sciences : the official journal of Isfahan University of Medical Sciences 2013,
18(12):1080-1086.
77.
Basu A, Betts NM, Mulugeta A, Tong C, Newman E, Lyons TJ: Green tea supplementation increases
glutathione and plasma antioxidant capacity in adults with the metabolic syndrome. Nutrition
Research 2013, 33(3):180-187.
78.
Penugonda K, Sanchez K, Leyva M, Aston C, Lyons T, Basu A: Effect of green tea flavonoid
supplementation on features of metabolic syndrome (MeS). Experimental Biology 2009 (EB 2009)
New Orleans, LA United States 2009, 23 (S1.
79.
Szulinska M, Bogdanski P, Musialik K, Suliburska J: Beneficial influence of green tea extract
supplementation on blood pressure, insulin resistance, selected inflammatory markers and total
antioxidant status in patients with obesity related hypertension. 19th European Congress on Obesity,
ECO2012 Lyon France 2012, 5:197.
80.
Basu A, Sanchez K, Leyva MJ, Wu M, Betts NM, Aston CE, Lyons TJ: Green tea supplementation
affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome.
Journal of the American College of Nutrition 2010, 29(1):31-40.
81.
Diepvens K, Kovacs EM, Nijs IM, Vogels N, Westerterp-Plantenga MS: Effect of green tea on resting
energy expenditure and substrate oxidation during weight loss in overweight females. The British
journal of nutrition 2005, 94(6):1026-1034.
82.
Yamada H, Tateishi M, Harada K, Ohashi T, Shimizu T, Atsumi T, Komagata Y, Iijima H, Komiyama K,
Watanabe H et al: A randomized clinical study of tea catechin inhalation effects on
methicillin-resistant staphylococcus aureus in disabled elderly patients. Journal of the American
Medical Directors Association 2006, 7(2):79-83.
83.
Hodgson JM, Puddey IB, Burke V, Beilin LJ, Jordan N: Effects on blood pressure of drinking green and
black tea. Journal of hypertension 1999, 17(4):457-463.
84.
Vlachopoulos C, Alexopoulos N, Dima I, Aznaouridis K, Andreadou I, Stefanadis C: Acute effect of
black and green tea on aortic stiffness and wave reflections. Journal of the American College of
13
Nutrition 2006, 25(3):216-223.
85.
Alexopoulos N, Vlachopoulos C, Aznaouridis K, Baou K, Vasiliadou C, Pietri P, Xaplanteris P, Stefanadi E,
Stefanadis C: The acute effect of green tea consumption on endothelial function in healthy
individuals. European journal of cardiovascular prevention and rehabilitation : official journal of the
European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac
Rehabilitation and Exercise Physiology 2008, 15(3):300-305.
86.
Hodgson JM, Puddey IB, Croft KD, Burke V, Mori TA, Caccetta RA, Beilin LJ: Acute effects of ingestion
of black and green tea on lipoprotein oxidation. American Journal of Clinical Nutrition 2000,
71(5):1103-1107.
87.
Thielecke F, Rahn G, Bohnke J, Adams F, Birkenfeld AL, Jordan J, Boschmann M:
Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: A
pilot study. European journal of clinical nutrition 2010, 64(7):704-713.
88.
Randell RK, Hodgson AB, Lotito SB, Jacobs DM, Boon N, Mela DJ, Jeukendrup AE: No effect of 1 or 7 d
of green tea extract ingestion on fat oxidation during exercise. Medicine and science in sports and
exercise 2013, 45(5):883-891.
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