First Name
Brandon
Middle Initial
P
Last Name
Brown
Degree
MD, MA
Address
705 Riley Hospital Drive Suite 1053
Indianapolis, Indiana 46202
United States
Phone Number
(317) 948-6303
Fax
(317) 944-2920
Email
brpbrown@iupui.edu
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Investigator/Applicant Brandon
First Name
Investigator/Applicant P
Name MI
Investigator/Applicant Brown
Last Name
Investigator/Applicant MD, MA
Degree
Investigator/Applicant
Name Address
705 Riley Hospital Drive Suite 1053
Indianapolis, IN 46202
United States
Investigator/Applicant (317) 948-6303
Name Phone Number
Investigator/Applicant brpbrown@iupui.edu
Name Email
Title
Quantitative Renal Ultrasonography in the Diagnosis of Congenital
Hydronephrosis: Assessment of Urologic Repair and Correlation with Conventional
Ultrasound
Abstract of Proposed Research Plan (300 words)
Congenital hydronephrosis secondary to urinary tract obstruction remains an important cause of pediatric
morbidity due to urinary tract infections, pain and kidney stones, as well as partial or complete loss of
renal function in severe cases. In addition, the evaluation and treatment of this condition often results in
significant pediatric exposure to ionizing radiation via repeated nuclear medicine renal imaging. While
conventional ultrasound (US) offers subjective assessment of the degree of dilatation of the obstructed
urinary tract, any changes to the renal parenchyma are often not recognized until irreversible damage has
occurred, as seen with cortical thinning. This research proposal aims to evaluate the emerging imaging
technology of quantitative US elastography as applied to the pediatric kidney in cases of congenital
hydronephrosis. In particular, the quantitative US technique we propose to use will allow for assessment of
changes to the renal parenchyma secondary to urinary tract obstruction. Further, US elastography used as
surveillance for patients with severe (grade III-IV) hydronephrosis will allow for identification of those
patients who will most benefit from surgical correction, and will also allow for identification of changes to
the renal parenchyma after surgical repair. Accuracy of this quantitative US imaging technique will be
compared with the qualitative degree of hydronephrosis as assessed by conventional US imaging. We will
also compare quantitative US elastography with the effects on renal function as determined via nuclear
medicine renal imaging. This study is relevant because our results can help improve the diagnostic
accuracy of current tools and decrease the dose of radiation to which children being investigated for
hydronephrosis are subjected. In the future, we hope to evaluate the cost effectiveness of incorporating US
elastography in clinical protocols.
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and bibliography
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Resources and Environment:
Riley Hospital for Children is the only nationally ranked children’s hospital in the State of Indiana, and is
home to the #2 Pediatric Urology program in nation as determined by US News and World Report. Our
Pediatric Radiology Department is centrally located in the hospital and immediately adjacent to the Riley
Outpatient Center. Riley recently opened a new 10-story 675,000 square foot Simon Family Tower
expansion and became the only Pediatric Level I trauma center in the state. Our pediatric radiology
department has eight general pediatric radiologists, one pediatric interventionalist, and two pediatric
neuroradiologists in addition to having pediatric radiology fellows and rotating residents.
Major Equipment:
We will perform all imaging at Riley Hospital for Children in Indianapolis, IN. The following dedicated
ultrasound machine is housed in our hospital's main radiology department, and will be utilized for all of
the research imaging:
Transabdominal ultrasound images of each kidney will be acquired using a commercially available Siemens
S3000 imaging system (Siemens Medical Solutions USA, Issaquah, WA) utilizing a curvilinear array probe.
Ultrasound shear wave speed measurements will be made using the Siemens VirtualTouch IQTM analysis
tool (http://www.healthcare.siemens.com/ultrasound/tissue-strain-analytics/virtual-touch-iq) available
on the S3000 imaging system.
Additional Information:
This research project will be performed in coordination with the IUPUI Research Center for Quantitative
Renal Imaging, which is located on the campus of the Indiana University School of Medicine in
Indianapolis, IN. This center's mission is to develop, implement, and disseminate innovative quantitative
imaging methods designed to diagnose kidney disease and evaluate efficacy of therapeutic interventions.
Its 3 main goals:
1) Identifying, developing, and implementing innovative imaging methods that provide quantitative
imaging biomarkers for assessing and inter-relating renal structure, function, hemodynamics and
underlying tissue microenvironmental factors contributing to kidney disease.
2) Establishing an environment that facilitates and encourages interdisciplinary collaborations among
investigators, helps advance the research careers of junior faculty, and offers research support to
investigators focused on developing and utilizing innovative quantitative imaging methods in support of
kidney disease research.
3) Providing a resource to inform the greater research and healthcare communities of advances in
quantitative renal imaging and its potential for enhanced patient management and care.
Award Payee First
John
Name
Award Payee Last
Talbott
Name
Award Payee
BS
Degree
Award Payee Address
Office of Research Administration - Dept 78867 PO Box 78000
Detroit, Michigan 48278-0867
United States
Award Payee Phone
(317) 278-3473
Number
Award Payee Email
spon2@iupui.edu
Grant Administrator's
Jean
First Name
Grant Administrator's
Last Name
Mercer
Grant Administrator's
BS
Degree
Grant Administrator's
Address
980 Indiana Avenue Room 2232
Indianapolis, Indiana 46202
United States
Grant Administrator's
(317) 278-3473
Phone Number
Grant Administrator's
spon2@iupui.edu
Email
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