** Please complete and return to Shy Walker at swalker@phoenixchildrens.com
Study Title:
A Study to Evaluate the Safety and Tolerability of Aprepitant in Pediatric Patients for the Prevention of Post-
Operative Nausea and Vomiting
Study Purpose:
A Study for Children Scheduled for Surgery to evaluate prevention of post-operative nausea.
Study Summary:
Up to 42% of children experience nausea and vomiting after surgery. This condition is known as
PONV (post-operative nausea and vomiting). PONV can lead to reduced pain relief, dehydration, delayed healing of wounds, and prolonged recovery.
We are conducting a research study that is testing a drug used to prevent PONV.
Basic Eligibility Criteria:
Participants must be either:

Scheduled for a specific type of surgery (identified by the child’s health care provider)
OR
 Expected to be treated with an opioid-type of pain relief medication either during surgery or within the first 24 hours following a surgery.
Patients and their parents may also consider:
• Study medication is included in study participation
• Participation in a clinical trial could help lead to additional options for treating PONV in children
• There are risks associated with participating in a clinical trial. These risks will be reviewed with the parent and child before deciding to participate
Study Location(s):
Phoenix Children’s Hospital

Study Contact(s):
David Notrica, MD
Trauma Services
(602) 254-5561