Supplemental: Tables [2] Figures [2]
Table 1s. Early Postoperative Morbidity (N= 27)
Descriptor
Number (%)
Median Length of Stay (range), days
6 (3-15)
Re-hospitalization Events1
7 (26%)
Post-operative Grade 3 Complications
7 (26%)
Anastomotic leak, intestinal
1 (3.7%)
Bowel perforation/necrosis
1 (3.7%)
Catheter-related infection
1 (3.7%)
Fluid collection (non-infectious)
2 (7.4%)
Hemorrhage
1 (3.7%)
Other (nausea/infection)
1 (3.7%)
Other Infections
17
1 (3.7%)
re-hospitalization events in 6 patients; one patient had 2 re-hospitalizations.
Table 2s. Safety: Adjuvant Therapy with Gemcitabine (N= 26)
Toxicity
I.
Grade 2
Grade 3
Hematologic
Anemia
11 (42%)
Leukopenia
12 (46%)
3 (12%)
Neutropenia (neutrophils)
9 (35%)
12 (46%)
Coagulopathy (INR)
II.
1 (4%)
Biochemical
AST/ ALT elevation
2 (8%)
Hyperbilirubinemia
1 (4%)
Hypoalbuminemia
6 (23%)
Electrolyte abnormalities1
Hyperglycemia
III.
4 (15%)
10 (38%)
2 (8%)
Gastrointestinal
Abdominal pain
2(8%)
Grade 4
Grade 5
Diarrhea
2 (8%)
Flatulence
1 (4%)
Nausea/vomiting
2 (8%)
Small bowel obstruction
IV.
1 (4%)
Other
Anorexia
1 (4%)
Dehydration
1 (4%)
Fatigue
2 (8%)
Fever
1 (4%)
Hypertension
1 (4%)
Infection with normal neutrophils
1 (4%)
Infection with neutropenia
Phlebitis
Syncope
1Includes
1 (4%)
1 (4%)
1 (4%)
1 (4%)
1 (4%)
hypokalemia, hyperkalemia and hypophosphatemia.
Figure 1s. Kaplan-Meier Recurrence- Free Survival (N= 27)1
1Recurrence-free
survival was calculated from the time of surgery for N= 27 who underwent
surgery.
Median recurrence-free survival: 22 months, 95% CI 11 to 27 months.
Figure 2s: Kaplan-Meier Disease-Specific Survival (N= 38)1
1Disease-specific
survival analysis: Four patients were censored at date of death (3 early
fatalities and one additional patient died of complications following hip surgery without
confirmed recurrence)
Disease-specific survival: 30.6 months (95% CI 19 months to NA)
Figure 3s: Overall Survival by Resection vs No Resection
Comparing patients who underwent surgical resection to those that did not undergo surgical
resection, P-value = 0.0006.