OTHER DRUGS KEY POINTS Over the last decade, the number of performance and image enhancing drugs detected at the Australian border has increased 751.6 per cent, with the 10 356 detections in 2012–13 the highest number on record. The number of national steroid seizures and arrests continued to increase in 2012–13 and are the highest number on record. There was a record 509 tryptamine detections at the Australian border in 2012–13. There was a record 277 anaesthetic detections at the Australian border in 2012–13. The 565 national hallucinogen arrests reported in 2012–13 is the highest number on record. ANABOLIC AGENTS AND OTHER SELECTED HORMONES Other drugs and substances—collectively referred to in this report as ‘other drugs’—are being increasingly recognised as part of Australia’s illicit drug market. This chapter focuses on the main drugs and substances in this category: anabolic agents and other selected hormones, tryptamines, anaesthetics, pharmaceuticals, drug analogues and new psychoactive substances and other drugs not elsewhere classified. MAIN FORMS Anabolic agents and selected hormones are commonly referred to as performance and image enhancing drugs (PIEDs). The Australian Standard Classification of Drugs of Concern distinguishes four classes of substances as anabolic agents and selected hormones: anabolic androgenic steroids (AAS) beta-2-agonists other anabolic agents and selected hormones peptide hormones, mimetics and analogues (ABS 2011). ANABOLIC-ANDROGENIC STEROIDS (AAS), BETA-2-AGONISTS AND OTHER ANABOLIC AGENTS AND SELECTED HORMONES AAS, commonly referred to as steroids, are synthetic variants of the male sex hormone testosterone. ‘Anabolic’ refers to the muscle-building effects of the drug, while ‘androgenic’ refers to their masculinising effects. AAS may be derived from natural sources, but can also be synthetically manufactured for therapeutic use in human and veterinary treatment. AAS are used in the treatment of diseases that reduce lean muscle mass, including cancer and acquired immunodeficiency syndrome (AIDS) and conditions of steroid deficiency, such as delayed puberty. In addition to use in treatment, AAS are also used to enhance image and sports performance (NIDA 2012). Illicit Drug Data Report 2012–13 97 The World Anti-Doping Agency (WADA) categorises anabolic agents as either AAS or other anabolic agents. Both AAS and other anabolic agents are prohibited substances under the World Anti-Doping Code 2013 Prohibited List (WADA 2012). AAS are commonly administered by injection, orally, or via cream, gel or skin patches. Side effects of AAS use may include extreme mood swings, mania, depression, paranoia, delusions, impaired judgement, organ damage—including cardiovascular damage—high blood pressure and blood clots. Male-specific effects of use may include shrinkage of the testicles, reduced sperm-count or infertility, development of breasts and increased risk of prostate cancer. Female-specific effects of use may include the growth of facial hair, menstrual problems and baldness (Ip et al. 2012; NIDA 2012). The use of beta-2-agonists is prohibited under the World Anti-Doping Code 2013 Prohibited List, with the exception of specific asthma treatments and related doses administered via inhalation. Beta-2-agonists in aerosol form are commonly used in the treatment of asthma to relax muscles in the airway. However, when taken into the bloodstream, they may have anabolic effects. Beta-2-agonists, such as clenbuterol, may be used either alone or in conjunction with other substances to promote muscle definition and growth (anabolic effect) and decrease body fat (catabolic effect). The most frequently reported side effects associated with the use of beta-2-agonists include increased body temperature, nausea, headaches, insomnia, tremors and cardiovascular conditions. The misuse of beta-2-agonists may also lead to muscle cramps, palpitations and nervousness (NDARC 2005; NDARC 2006; USADA 2013; WADA 2012). AAS and other anabolic agents commonly used in Australia are outlined in Table 25. TABLE 25: AAS and other anabolic agents commonly used in Australia Drug name Potential effects Brand name Forms AAS—Anabolic Used to increase muscle mass through increased retention of protein Deca-durabolin, Anadrol-50, Oxandrin Ampoule, vial, prepacked syringe, tablet AAS—Androgenic Used to increase muscle mass by increasing male sex hormone levels Depo-testosterone, Sustanon, Androil Testocaps Vial, ampoule, prepacked syringe, capsule Beta-2-agonists (including clenbuterol) Commonly used to treat asthma, however when taken into the blood-stream increases muscle mass by mimicking the effects of adrenaline and nonadrenaline Bricanyl, Ventolin, Spiropent (clenbuterol) and Ventipulmin (clenbuterol) Ampoule, rotacap, inhaler, nebuliser, tablet PEPTIDE HORMONES, MIMETICS AND ANALOGUES While AAS remain widely used, the PIEDs market has evolved to include an ever-expanding range of substances which manipulate the body’s hormonal system. These substances, which include peptide hormones, mimetics1 and analogues, may provide similar effects to AAS and are considered by users to be new generation PIEDs. Hormones are vital for the effective functioning of the human body and are naturally produced. Synthetic mimetics and analogues of these naturally occurring hormones have been developed to assist in the treatment of a number of medical conditions, with some diverted for non-medical use as a consequence of their performance enhancing effects. 1 Substances that are chemically different, but which mimic the pharmacological effects of a particular substance. Illicit Drug Data Report 2012–13 98 While peptides can be used on their own to promote muscle growth, these substances are also used in combination with anabolic steroids to maintain muscle gains. Peptide hormones which have potential performance enhancing properties are listed in the World Anti-Doping Code 2013. These include erythropoietin (EPO), human growth hormone (hGH), insulin-like growth factors (IGF-1), gonadotrophins (such as luteinising hormone [LH] and human chorionic gonadotrophin [hCG]), insulins and other growth factors affecting muscle, tendon or ligament proteins (ASADA 2013).2 EPO is a synthetic hormone, which stimulates bone marrow to produce more red blood cells and increases oxygen-absorption, thereby improving endurance and increasing metabolism and muscular healing. Side effects of EPO use may include increased risk of thrombosis in the heart, lungs and/or brain. Users of hCG may seek to decrease their body fat and improve brain activity. The use of hCG may boost natural testosterone production after a long AAScycle and may serve as a masking agent to avoid testing positive to other substances. Side effects of hCG use may include gynaecomastia, depression, irritability and headaches. Side effects of hGH use may include increases in the size of the jaw, chin, fingers, hands, toes, feet, nose, cheekbone and internal organs (NADA 2012; NDS 2006; NSW Health 2013; USADA 2013). Peptide hormones, mimetics and analogues are generally administered via injection, nasal spray or orally. Despite potentially serious side effects, individuals continue the non-medical use of both natural and synthetic hormones. Side effects of hormone use vary and may be particular to the hormone used. For example, effects of EPO use may include increased blood pressure, convulsions, influenza-like symptoms, skin reactions, thrombosis, heart attack and stroke. Effects of hGH use may include low blood sugar, fluid retention, inadequate thyroid function, heart damage, impotence, premature ageing and death. Effects of hCG use may include over-stimulation of the hormonal system, acne, tiredness, mood changes, fluid retention, hair loss, enlargement of the prostate, heart disease, liver disease and infertility (Kanayama & Pope 2012; NDS 2006; Stenman 2009; UNODC 2013a). Peptide hormones, mimetics and analogues commonly used in Australia are listed in Table 26. TABLE 26: Peptide hormones, mimetics and analogues commonly used in Australia Drug name Potential effects Brand name Forms Erythropoietin (EPO) Increases endurance and recovery from anaerobic exercise Eprex, Aranesp Ampoule, pre-packed syringe Human chorionic gonadotrophin (hCG) Used to manage the side effects of AAS use such as gynaecomastiaa and shrinking testicles APL, Pregnyl, Profasi, Novarel, Repronex Vial, ampoule Human growth hormone (hGH) Used to increase muscle size and strength Norditropin, NorditropinSimpleXx, Genotropin, Humatrope, Saizen, Scitropi Penset, vial, auto injector cartridge Insulin Used because of the perception that it contributes to increased muscle bulkb NovoRapid, Apidra, Humalog, Hypurin Neutral, Actrapid, Humulin R, Protaphane, NovoMix 30 Vial, penset, pre-packed syringe 2 For a substance or method to be prohibited, it must meet at least two of the following three conditions: potential to enhance or does enhance performance in sport, potential to risk the athlete’s health and/or the World AntiDoping Agency has determined that the substance or method violates the spirit of sport (ASADA 2013). Illicit Drug Data Report 2012–13 99 a. b. Drug name Potential effects Brand name Forms Pituitary and synthetic gonadotrophins Used to overcome the side effects of AAS use or as a masking agent Clomid, Bravelle Ampoule, tablet Insulin-like Growth Factor Used to increase muscle bulk and reduce body fat Increlex Vial Corticotrophins Used because of its antiinflammatory properties and for mood elevating effects Synacthen Depot Ampoule Anti-oesterones Used to manage the side effects of AAS use such as gynaecomastiaa Nolvadex Tablet The development of breast-like tissue in males. There is no scientific evidence of this. INTERNATIONAL TRENDS There is no regulation on the production and trafficking of PIEDs in some parts of the world. Pharmaceuticals diverted from the licit market to the illicit market, combined with the growing number of unregulated online pharmacies, continue to ensure direct supply and unlimited access to PIEDs (Paoli 2012). International open source reports indicate that countries such as China, India, Pakistan, Thailand and some Eastern European countries are primary source countries for PIEDs, with numerous production sites and well-established trafficking routes. According to open source reporting, China and India are the fastest growing suppliers of PIEDs to the international market (ACMD 2010; SMH 2012). In 2012, the European Journal of Crime reported that networks of producers and traders— which includes athletes’ support personnel and representatives of national sport federations and governing bodies—may supply PIEDs to some athletes and non-competitive users, such as fitness centres and dietary supplements shops (Paoli 2012). The global PIEDs market is supplied by a range of methods, including legal and illegal importation and domestic diversion from the legitimate market (Marcley et al. 2013). Due to the varying legal status of PIEDs internationally, producers can manufacture and stockpile PIEDs in countries where they are unregulated and utilise online websites to reach the global market (Paoli 2012). In the United States of America (US), anabolic steroids are primarily imported illegally, but are also diverted from legitimate sources, either through theft or inappropriate prescribing (US DEA 2011). Increased intelligence sharing and collaboration between international law enforcement agencies and other government bodies will continue to support WADA in their efforts to detect and deter the use of PIEDs by professional athletes (ADF 2013a; Paoli 2012; WADA 2012). DOMESTIC TRENDS AUSTRALIAN BORDER SITUATION The Australian Customs and Border Protection Service continues to disrupt the movement of PIEDs3 into Australia. 3 PIEDs detected by the Australian Customs and Border Protection Service includes the following: anabol, dianabol, androstenedione, norandrostenedione, chronic gonadotrophins, clomiphenes, dehydroepiandrosterone Illicit Drug Data Report 2012–13 100 The number of PIEDs detected at the Australian border has continued to increase since 2004–05. The total number of PIEDs detected at the Australian border increased by 18.7 per cent this reporting period, from 8 726 in 2011–12 to 10 356 in 2012–13, with the 10 356 detections the highest number on record (see Figure 50). In this reporting period, there were 1 054 detections of clenbuterol, a common beta-2-agonist. FIGURE 50: Number of performance and image enhancing drug detections at the Australian border, 2003–04 to 2012–13 (Source: Australian Customs and Border Protection Service) 12000 10000 Number 8000 6000 4000 2000 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 Despite a 42.2 per cent decrease in the number of steroid detections this reporting period, from 6 126 in 2011–12 to 3 543 in 2012–13, the 3 543 steroid detections in 2012–13 is the third highest number reported in the last decade (see Figure 51). Hormone detections increased 162.0 per cent, from 2 600 in 2011–12 to 6 813 in 2012–13, the highest number reported in the last decade (see Figure 51). (DHEA), prasterone, erythropoietin, GH releasing hormones, somatorelines, methandienone, methandrostenelone, nandrolone, oxymetholone, stanozolol, hGH, somatropin/s and testosterone. Illicit Drug Data Report 2012–13 101 FIGURE 51: Number of performance and image enhancing drug detections, by category, at the Australian border, 2003–04 to 2012–134 (Source: Australian Customs and Border Protection Service) Hormones Steroids 8000 7000 6000 5000 4000 3000 2000 1000 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 4 From 2011–12, DHEA detections have been incorporated into steroid detection numbers. All the data contained in Figure 51 has been updated to reflect this change to enable direct comparison across the decade. Illicit Drug Data Report 2012–13 102 IMPORTATION METHODS Similar to previous reporting periods, parcel post was the most commonly detected method of importation by number, accounting for 88.2 per cent of PIED detections at the Australian border in 2012–13 (see Figure 52). There were 973 detections of clenbuterol this reporting period, which were primarily detected in the postal stream. FIGURE 52: Number of performance and image enhancing drug detections at the Australian border, as a proportion of total detections, by method of importation, 2012–13 (Source: Australian Customs and Border Protection Service) Air cargo (7.2%) Air passenger/crew (4.6%) Parcel post (88.2%) Sea Cargo (<0.1%) EMBARKATION POINTS In 2012–13, a total of 70 countries were identified as embarkation points for PIEDs detected at the Australian border, compared with 63 in 2011–12. The prominent embarkation points for PIEDs this reporting period were the US, China and Thailand, accounting for 62.9 per cent of the total number of PIED detections in 2012–13. Other major embarkation points this reporting period include Hong Kong, United Kingdom (UK), Canada, India, Turkey, Greece and Moldova. There were a total of 24 embarkation points identified for clenbuterol in 2012–13. DOMESTIC MARKET INDICATORS According to the 2010 National Drug Strategy Household Survey (NDSHS), 0.1 per cent of the Australian population aged 14 years or older reported recent5 non-medical steroid use (AIHW 2011). According to the Australian Needle and Syringe Program Survey (ANSPS), the prevalence of respondents reporting PIEDs as the drug last injected increased, from 5 per cent in 2011 to 7 per cent in 2012. In 2012, of the respondents who recently initiated6 injecting drug use, 55 per cent reported PIEDs as the last drug injected. Among males who were new initiates to injecting, the proportion of those reporting PIEDs as the last drug injected increased, from 53 per cent in 2011 to 68 per cent in 2012. Reported figures of use specific to the states and territories varied, with the prevalence of injecting PIEDs increasing 5 6 In the NDSHS, ‘recent use’ refers to reported use in the 12 months preceding interview. Less than 3 years since first injection. Illicit Drug Data Report 2012–13 103 in New South Wales and Queensland. In those states, prevalence increased from 2 per cent in 2008 to 12 per cent in 2012 and from 1 per cent in 2008 to 11 per cent in 2012 respectively. The reported prevalence of injecting PIEDs was stable at 2 per cent or less in all other states and territories (Iversen and Maher 2013). In a 2012 national study of regular injecting drug users, the proportion of respondents reporting steroid use at some stage in their lifetime decreased, from 8 per cent in 2011 to 6 per cent in 2012. In the same study, the proportion of respondents reporting recent7 use remained stable at 2 per cent. In a 2012 national study of regular ecstasy users, the proportion of respondents reporting steroid use at some stage in their lifetime decreased, from 4 per cent in 2011 to 2 per cent. In the same study, the proportion of respondents reporting recent steroid use also decreased, from 2 per cent in 2011 to 1 per cent in 2012. Early findings from the 2013 study indicate the proportion of recent steroid users has decreased to less than 1 per cent (NDARC 2013; Sindicich & Burns 2013; Stafford & Burns 2013). PRICE National law enforcement data on the price of PIEDs is limited. In 2012–13, the price for a single 10 millilitre vial of testosterone ranged between $120 and $250, with a per vial price of between $140 and $190 for 10 vials reported in Queensland. Prices reported per vial in Queensland for larger quantities ranged between $130 and $180 for 20 vials and between $110 and $160 for 50 vials. In 2012–13, the price for a 10 millilitre vial of anabolic steroids ranged between $230 and $300, with a per vial price of $140 for 10 vials reported in Queensland. Prices reported per vial in Queensland for larger quantities were $180 for 20 vials and $160 for 50 vials. AVAILABILITY Access to PIEDs is facilitated by purchases on the internet. According to the 2010 NDSHS, 1.0 per cent of the Australian population aged 14 years or older was offered or had the opportunity to use steroids in the 12 months preceding interview, compared to 1.3 per cent in 2007. The 20–29-year-old age group reported the highest proportion at 2.0 per cent (AIHW 2011). SEIZURES AND ARRESTS In 2012–13, the number of national steroid seizures increased by 59.1 per cent, from 208 in 2011–12 to 331 in 2012–13, with the 331 seizures this reporting period the highest number on record. While the weight of national steroid seizures decreased 44.2 per cent this reporting period, from 33.7 kilograms in 2011–12 to 18.8 kilograms in 2012–13, it is the second highest weight reported in the last decade (see Figure 53). The term ‘recent use’ in the regular injecting drug user and regular ecstasy user studies refers to reported use in the 6 months preceding interview. 7 Illicit Drug Data Report 2012–13 104 FIGURE 53: National steroid seizures, by number and weight 2003–04 to 2012–13 40 Weight 350 Number 35 300 250 25 200 20 150 15 Number Weight (kg) 30 100 10 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 0 2005–06 0 2004–05 50 2003–04 5 New South Wales continues to account for the greatest proportion of national steroid seizures, accounting for 47.4 per cent of the number and 31.9 per cent of the weight national steroid seizures this reporting period. South Australia reported the highest percentage change in both the number and weight of steroid seizures in 2012–13 (see Table 27). TABLE 27: Number, weight and percentage change of national steroid seizures, 2011–12 to 2012–13 Number State/Territorya New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory Australian Capital Territory 2011–12 144 8 28 1 5 0 12 10 208 Weight (grams) 2012–13 157 18 57 31 13 0 14 41 331 % change 2011–12 2012–13 % change 9.0 125.0 103.6 3 000.0 160.0 26 898 5 985 216 31 236 0 315 60 6 020 2 677 4 618 3 373 102 0 816 1 280 18 886 -77.6 -55.3 2 038.0 10 780.6 -56.8 0 159.0 2 033.3 -44.0 0 16.7 310.0 59.1 Total 33 741 a. Includes seizures by state/territory police and AFP for which a valid seizure weight was recorded. National steroid arrests have been increasing since 2005–06. This reporting period, national steroid arrests increased 29.4 per cent, from 511 in 2011–12 to 661 in 2012–13, the highest number on record. Consumer arrests accounted for 77.0 per cent of national steroid arrests this reporting period, with Tasmania and the Australian Capital Territory reporting more provider than consumer arrests (see Figure 54). Illicit Drug Data Report 2012–13 105 FIGURE 54: Number of national steroid arrests, 2003–04 to 2012–13 Total Consumer Provider 700 600 Number 500 400 300 200 100 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 In 2012–13, New South Wales, South Australia and the Australian Capital Territory reported a decrease in steroid arrests (see Table 28). Over the last decade, Queensland has continued to account for the highest proportion of national steroid arrests, accounting for 59.3 per cent of arrests in 2012–13. Tasmania reported the greatest percentage increase in steroid arrests this reporting period, however, the number of arrests remains low. TABLE 28: Number and percentage change of national steroid arrests, 2011–12 and 2012–13 Arrests a State/Territory New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory Australian Capital Territory Total 2011–12 41 62 296 10 65 8 11 18 2012–13 39 88 392 8 101 13 14 6 % change -4.9 41.9 32.4 -20.0 55.4 62.5 27.3 -66.7 511 661 29.4 a. The arrest data for each state and territory includes AFP data. Illicit Drug Data Report 2012–13 106 TRYPTAMINES MAIN FORMS Tryptamines are hallucinogenic substances that act upon the central nervous system, distorting mood, thought and perception. Some are found naturally in a variety of flowering plants, leaves, seeds and in spore-forming plants such as psilocybin-containing mushrooms, while others, such as lysergic acid diethylamide (LSD) and diethyltryptamine, are synthetically manufactured (EMCDDA 2013a; UNODC 2011a). Tryptamine use may cause hallucinations—seeing, hearing, smelling, tasting or touching non-existent objects or existing ones in a distorted way. Other short-term effects of use may include decreased ability to make sensible judgements and recognise common danger, thus making users susceptible to accidents and injury. Long-term use may lead to dissociative experiences—a psychiatric disorder characterised by a reversible amnesia relating to personal identity (AIC 2011; NIDA 2009; UNODC 2013a). The following section will cover the two common tryptamines illicitly used in Australia: lysergic acid diethylamide (LSD)—a synthetic drug—and psilocybin, a substance found in various species of mushrooms. LYSERGIC ACID DIETHYLAMIDE (LSD) LSD is manufactured from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains. Often referred to as ‘acid’, LSD is among the most potent mood-changing chemicals, with only a small amount needed to cause visual hallucinations and distortions, known as ‘trips’. LSD is normally produced as a tartrate salt, which is colourless, odourless and water soluble. LSD is available in paper squares, sugar cubes, tablets and liquid form. LSD is most commonly sold on impregnated, single dose squares of blotting paper called tabs. Usually taken orally, other methods of LSD administration include snorting, injecting, smoking and shelving8 (NIDA 2009; Sindicich & Burns 2012). Short-term effects of LSD use may include extreme emotional swings, fear, panic and paranoia. Long-term effects of LSD use may include ‘flashbacks’,9 impaired memory and concentration and increased potential risk of mental illness10 (ADF 2013b). PSILOCYBIN-CONTAINING MUSHROOMS Psilocybin is a chemical with hallucinogenic properties that is found in certain species of mushrooms, often referred to as ‘magic mushrooms’, which affect the central nervous system and alters a person’s mood, thinking and behaviour. Grown in the forests of Victoria, New South Wales and some areas of Queensland and Western Australia, the most commonly consumed varieties of psilocybin-containing mushrooms in Australia are psilocybe cubensis (‘gold tops’), psilocybe subaeruginosa and copelandia cyanescens (‘blue meanies’) and psilocybe semilanceata (‘liberty caps’) (Cunningham 2008; WA DAO 2005). Also known as ‘shafting’, the drug is inserted into the anus or the vagina to avoid irritation to the user’s stomach. Users may experience recurrences of certain aspects of drug experiences, referred to as flashbacks. Flashbacks can persist in some users and lead to a condition known as hallucinogen persisting perceptual disorder. 10 Mental illness may include prolonged psychosis, depression and personality disruption in users with a predisposition to the condition. 8 9 Illicit Drug Data Report 2012–13 107 Hallucinogenic mushrooms are available fresh, treated or preserved, or in powder or capsule form. Usually sold as dried mushrooms, they can be eaten raw, brewed as a tea or combined with other foods to mask their bitter taste. The potency of hallucinogenic mushrooms varies and is dependant on species, growing conditions, harvest period and form (EMCDDA 2013a). Visually distinguishing between psilocybin-containing mushrooms and poisonous varieties is difficult. Therefore, accidental consumption of poisonous mushrooms may occur and result in permanent liver damage or death. Short-term effects of psilocybin-containing mushroom use may include drowsiness, paranoia and panic attacks. Long-term effects may include impaired memory and increased risk of mental illness (NDARC 2012; NIDA 2009). INTERNATIONAL TRENDS According to the 2013 United Nations report on the challenge of new psychoactive substances, psilocin, psilocybin, diethyltryptamine hydrochloride (DET), dimethyltryptamine (DMT) and etryptamine are the only tryptamines under international control (listed in Schedule I of the 1971 Convention). While psilocybin-containing mushrooms continue to be harvested, tryptamines are also synthesised to mimic the effects of psilocybin (UNODC 2013a; UNODC 2013b). According to the 2013 European Drug Report, the prevalence of LSD and hallucinogenic mushroom use in Europe has remained relatively low and stable for a number of years (EMCDDA 2013b). According to the 2011 National Survey on Drug Use and Health, 23 million people in the US population aged 12 years and older had used LSD in their lifetime (DEA 2013). Key findings on adolescent drug use in the US in 2012 reported that LSD use has decreased considerably and no longer accounts for the greatest proportion of reported hallucinogen use, with increases in the reported use of psilocybin. Of the students in years 8, 10 and 12 involved in the study, the year 12 students reported the highest proportion of hallucinogen use, both within their lifetime and in the past year, with reported use exceeding that reported for other illicit drugs including MDMA, methylamphetamine, cocaine and heroin (Johnston et al. 2013). Internationally, there is limited reporting available on the scale of cultivation of psilocybin-containing mushrooms. According to media reporting, in September 2012, approximately 62 kilograms of psychedelic mushrooms was seized in Ohio. Believed to be the largest mushroom seizure in the state, the seizure had an estimated value of US$3.1 million (Dungjen 2012). DOMESTIC TRENDS AUSTRALIAN BORDER SITUATION LSD and psilocybin-containing mushrooms are the most common tryptamines detected at the Australian border. This reporting period the number of tryptamine detections at the Australian border increased by 258.5 per cent, from 142 in 2011–12 to 509 in 2012–13, the highest number on record. Detections in this reporting period include—but is not limited to— 344 LSD detections and 123 psilocybin-containing mushroom detections (see Figure 55). Illicit Drug Data Report 2012–13 108 FIGURE 55: Number of tryptamine detections at the Australian border, 2003–04 to 2012–13 (Source: Australian Customs and Border Protection Service) 600 500 Number 400 300 200 100 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 IMPORTATION METHOD The postal stream continues to account for the greatest number of tryptamine detections at the Australian border. In 2012–13, of the 509 tryptamine border detections, 505 detections were in the postal stream. Of these, 489 detections weighed less than 100 grams each. All of the psilocybin mushroom detections this reporting period occurred in the postal stream. Of the 344 LSD detections in 2012–13, all but 4 were in the postal stream. EMBARKATION POINTS In 2012–13, a total of 19 countries were identified as embarkation points for tryptamines detected at the Australian border, compared with 8 countries in 2011–12. The Netherlands accounted for 73.9 per cent of the number of tryptamine detections this reporting period. Other major embarkation points in 2012–13 include the US, Spain, the UK, Canada, Germany, Brazil, China, Israel and Poland. Canada accounted for 35.2 per cent of LSD detections in 2012–13, with 121 detections. Of the 123 psilocybin-containing mushroom detections, 63 were from the Netherlands and 38 from Canada, which accounted for 82.1 per cent of psilocybin-containing mushroom detections this reporting period. Other major embarkation points in 2012–13 include the US, Germany, the UK and Israel. DOMESTIC MARKET INDICATORS According to the 2010 NDSHS, 8.8 per cent of the Australian population aged 14 years or older reported using hallucinogens at least once in their lifetime. In the same survey, 1.4 per cent reported recent use of hallucinogens, the first increase reported since 1998 (AIHW 2011). In a 2012 national study of regular injecting drug users, 65 per cent of respondents reported having used hallucinogens at some stage in their lifetime, which remained consistent with figures reported in 2011. In the same study, the proportion of respondents reporting recent use of hallucinogens decreased, from 8 per cent in 2011 to 6 per cent in 2012. LSD and mushrooms were the most common hallucinogens used (Stafford & Burns 2013). Illicit Drug Data Report 2012–13 109 In a 2012 national study of regular ecstasy users, the proportion of respondents reporting the use of mushrooms at some stage in their lifetime increased marginally, from 70 per cent in 2011 to 71 per cent in 2012. In the same study, the proportion of respondents reporting recent LSD use decreased, from 46 per cent in 2011 to 34 per cent in 2012. This is the lowest percentage reported since 2003. The proportion of respondents reporting the recent use of mushrooms also decreased, from 29 per cent in 2011 to 27 per cent in 2012. Early findings from the 2013 study indicate the proportion of respondents reporting recent mushroom use remained unchanged at 27 per cent, while the proportion of respondents reporting recent LSD use increased to 43 per cent. This is the second highest proportion reported since 2003 (NDARC 2013; Sindicich & Burns 2013; Stafford & Burns 2013).11 PRICE In 2012–13, law enforcement data on the price of psilocybin-containing mushrooms was unavailable. Nationally, the price per tab of LSD ranged between $10 and $50 in 2012–13. In a 2012 study of regular ecstasy users, respondents reported the median price per tab of LSD ranged between $15 and $22.50 nationally. Early findings from the 2013 study indicate a price range of between $15 and $32.50 (NDARC 2013; Sindicich & Burns 2013).12 AVAILABILITY According to the 2010 NDSHS, 3.7 per cent of the population had been offered or given the opportunity to use hallucinogens in the 12 months preceding interview. The proportion was higher in the 18–19 year (11.7 per cent) and 20–29 year age groups (11.0 per cent) (AIHW 2011). In a 2012 national study of regular injecting drug users, 65 per cent of respondents reported using hallucinogens in their lifetime, which remained consistent with figures reported in 2011. However, only 6 per cent reported recent use of hallucinogens, a decrease from 8 per cent in 2011. LSD and mushrooms were the most common hallucinogens used (Stafford & Burns 2013). In a 2012 national study of regular ecstasy users, of the respondents able to comment on the availability of LSD in Australia, 63 per cent reported LSD as being easy or very easy to obtain, compared with 73 per cent in 2011. Early findings from the 2013 study indicate there has been an increase in availability of LSD, with 67 per cent of respondents reporting LSD as easy or very easy to obtain. There are no figures on the availability of psilocybin-containing mushrooms (NDARC 2013; Sindicich & Burns 2013). SEIZURES AND ARRESTS In 2012–13, the number of national hallucinogen seizures increased by 11.9 per cent, from 285 in 2011–12 to 319 in 2012–13, the highest number reported in the last decade. The weight of national hallucinogen seizures decreased by 84.7 per cent, from 23.5 kilograms in 2011–12 to 3.6 in 2012–13 and is the lowest weight reported since 2008–09 (see Figure 56). 11 In response to the difficulties experienced by smaller states and territories in recruiting regular ecstasy users, the recruitment criteria was broadened in 2012 to include recent use of any psychostimulant. As such, caution should be exercised when comparing to previous reporting periods. 12 Due to the small numbers of respondents providing price comment in the study (n<10), these findings should be interpreted with caution. Illicit Drug Data Report 2012–13 110 FIGURE 56: National hallucinogen seizures, by number and weight, 2003–04 to 2012–13 25 Weight 350 Number 300 250 15 200 150 10 Number Weight (kg) 20 100 5 50 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 0 2003–04 0 Since 2005–06, New South Wales has accounted for the greatest proportion of national hallucinogen seizures, accounting for 62.4 per cent of the number and 66.5 per cent of the weight of national seizures in 2012–13. New South Wales, Victoria, Tasmania and the Australian Capital Territory reported an increase in the number of hallucinogen seizures this reporting period, while Queensland and Tasmania were the only states or territories to report an increase in seizure weight, increasing from 224 grams in 2011–12 to 278 grams, and 0 grams to 31 grams respectively in 2012–13 (see Table 29). TABLE 29: Number, weight and percentage change of national hallucinogen seizures, 2011–12 to 2012–13 Number State/Territorya New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory Australian Capital Territory Total 2011–12 163 41 21 3 50 0 7 0 285 Weight (grams) 2012–13 199 52 20 2 36 2 7 1 319 % change 2011–12 2012–13 22.1 26.8 -4.8 -33.3 -28.0 – 0.0 – 11.9 7 492 5 338 224 365 10 137 0 2 0 23 558 2 444 524 278 32 364 31 2 0 3 675 % change -67.4 -90.2 24.1 -91.2 -96.4 – 0.0 – -84.4 a. Includes seizures by state/territory police and AFP for which a valid seizure weight was recorded. Figure 57 illustrates the number of national hallucinogen arrests since 2003–04. Over the last decade, hallucinogen arrests have increased 355.6 per cent, from 124 in 2003–04 to 565 in 2012–13, the highest number on record. In 2012–13, consumer arrests accounted for 78.2 per cent of national hallucinogen arrests. However, South Australia and Tasmania reported more hallucinogen provider than consumer arrests this reporting period. Illicit Drug Data Report 2012–13 111 FIGURE 57: Number of national hallucinogen arrests, 2003–04 to 2012–13 Total Consumer Provider 600 Number 500 400 300 200 100 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 In 2012–13, the number of hallucinogen arrests increased 16.7 per cent, from 484 in 2011–12 to 565 in 2012–13 (see Table 30). Queensland continues to account for the greatest proportion of national hallucinogen arrests, accounting for 35.9 per cent of national arrests in 2012–13. TABLE 30: Number and percentage change of national hallucinogen arrests, 2011–12 to 2012–13 Arrests State/Territorya New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory Australian Capital Territory Total 2011–12 127 56 192 11 91 3 3 1 2012–13 157 70 203 16 111 3 4 1 % change 23.6 25.0 5.7 45.5 22.0 0.0 33.3 0.0 484 565 16.7 a. The arrest data for each state and territory includes AFP data. Illicit Drug Data Report 2012–13 112 ANAESTHETICS MAIN FORMS Originally developed for medical and veterinary use, a number of anaesthetics are diverted for illicit use. The following section will cover ketamine hydrochloride (ketamine) and gamma-hydroxybutyrate (GHB), two common illicitly used anaesthetics. KETAMINE Ketamine hydrochloride, commonly referred to as K, Super K, Special K and Vitamin K, is a white crystalline powder, structurally and pharmacologically similar to phencyclidine (PCP). Used as an anaesthetic by veterinarians and medical professionals, it is used illicitly for its sedative and hallucinogenic effects. Classed as a dissociative anaesthetic, it induces feelings of detachment and ‘out of body experiences’, with higher doses producing full anaesthesia. Ketamine is commonly sold in three forms—powder, tablet and liquid—and is often swallowed, snorted or injected. It can also be combined with other substances, such as cannabis or tobacco and smoked (DEA 2012; NSW Health 2012). Short-term effects of ketamine use may include general aches and pains, poor coordination, amnesia, impaired judgement and disorientation. Long-term effects of ketamine use may include reduced ability to concentrate, personality and mood changes, depression and bladder conditions.13 Use of ketamine in combination with depressant drugs such as alcohol, heroin or tranquillisers, may result in vital organ-failure (ADF 2013c; Curcio 2012; DoHA 2010). GAMMA-HYDROXYBUTYRATE (GHB) AND RELATED SUBSTANCES GHB—also known as fantasy, grievous bodily harm or GBH, liquid ecstasy and blue nitro—is found naturally in the body in small quantities and may be synthetically produced. First synthesised in 1960, GHB was originally developed as an anaesthetic due to its ability to rapidly permeate the blood–brain barrier and cause sleepiness. GHB acts as a central nervous system depressant, slowing messages travelling between the brain and the rest of the body (ADF 2013d; NSW Health 2006; Roll et al. 2012; WHO 2012). GHB is readily manufactured from its precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD). Both GBL and 1,4-BD metabolise into GHB in the body and are used as industrial solvents in industrial chemical processes, including the production of polymers. GHB use may promote growth hormone production, as such GHB may be used by some individuals to aid in fat reduction and muscle-building. GHB use may also enhance euphoria and facilitate sexual assault. High doses and regular use of GHB can lead to tolerance and—if discontinued—withdrawal symptoms. Users of stimulants such as amphetamines and ecstasy may use GHB to alleviate the effects of these stimulants. The competing effects of stimulant and depressant drugs may lead to a cycle of dependence (ADF 2013b; WHO 2012). GHB may appear as a colourless or bright blue liquid— which is bitter or salty-tasting—less commonly a crystal powder, and is usually sold in small bottles or vials. GHB is typically administered orally (swallowed) or intravenously (injected) (ADF 2013b; WHO 2012). 13 Ketamine use has been linked to cystitis, which can lead to blood in urine, incontinence, severe pain and kidney failure. Illicit Drug Data Report 2012–13 113 The effects of GHB use appear to vary greatly according to the amount used, with increased risk of overdose as a consequence of the small dosage units. Effects may include hallucinations, tremors, decreased body temperature, blackouts, memory lapses, seizures, respiratory failure, coma or death. The possible presence of solvents or heavy-metal contaminants in GHB also pose additional health risks to users (NSW Health 2006; Roll et al. 2012; WHO 2012). The risk of overdose increases when GHB is mixed with alcohol. Overdose may result in respiratory depression, rapid onset of drowsiness, muscle spasms, movement and speech impairments, memory loss and vomiting (NSW Health 2006). INTERNATIONAL TRENDS Global seizures of ketamine remained stable in 2012. According to UNODC reporting, many of the seized tablets sold as 3,4-methylenedioxymethylamphetamine (MDMA, commonly referred to as ‘ecstasy’) in East and South-East Asia contain a variety of other psychoactive substances such as ketamine. According to media reporting, India remains a large manufacturer of ketamine, which is smuggled to the expanding South-East Asia market in liquid, powder and capsule form (Tan 2012). According to a health report the number of users of ‘club drugs’—including ketamine, methylamphetamine, GBL and mephedrone— seeking treatment increased, from 4 656 in 2005–06 to 6 486 in 2011 (NTA 2012). According to UNODC reporting, in New Zealand, GHB/GBL is often sold with methylamphetamine and marketed to assist with the come-down effects related to amphetamine-type-stimulants (ATS) use (UNODC 2012; UNODC 2013c). DOMESTIC TRENDS AUSTRALIAN BORDER SITUATION Anaesthetic detections at the Australian border include only GHB, GBL and ketamine detections. In 2012–13, the number of anaesthetics detected at the Australian border increased by 161.3 per cent, from 106 in 2011–12 to 277 in 2012–13, the highest number on record. The total number of GHB and GBL detections increased by 66.0 per cent, from 47 in 2011–12 to 78 in 2012–13, which consisted of 4 GHB detections and 74 GBL detections. The total number of ketamine detections increased 237.3 per cent this reporting period, from 59 in 2011–12 to 199 in 2012–13 (see Figure 58). Illicit Drug Data Report 2012–13 114 FIGURE 58: Number of anaesthetic detections at the Australian border, 2003–04 to 2012–13 (Source: Australian Customs and Border Protection Service) 300 250 Number 200 150 100 50 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 IMPORTATION METHODS The postal stream continues to account for the greatest number of anaesthetic border detections, accounting for 90.2 per cent of detections in 2012–13 (see Figure 59). FIGURE 59: Number of anaesthetic detections at the Australian border, as a proportion of total detections, by method of importation, 2012–13 (Source: Australian Customs and Border Protection Service) Air cargo (8.7%) Air passenger/crew (1.1%) Parcel post (90.2%) In 2012–13, 98.5 per cent of the number of ketamine detections at the Australian border occurred in the postal stream. Of these, 99.4 per cent weighed less than 100 grams (see Figure 60). Illicit Drug Data Report 2012–13 115 FIGURE 60: Number of ketamine detections at the Australian border, as a proportion of total detections, by method of importation, 2012–13 (Source: Australian Customs and Border Protection Service) Air passenger/crew (1.5%) Parcel post (98.5%) In 2012–13, parcel post accounted for 68.9 per cent of the number of border detections of GHB and GBL, followed by air cargo with 31.1 per cent (see Figure 61). FIGURE 61: Number of GHB and GBL detections at the Australian border, as a proportion of total detections, by method of importation, 2012–13 (Source: Australian Customs and Border Protection Service) Air cargo (31.1%) Parcel post (68.9%) Illicit Drug Data Report 2012–13 116 EMBARKATION POINTS In 2012–13, a total of 21 countries were identified as embarkation points for anaesthetics detected at the Australian border, compared with 17 countries in 2011–12. By number, the primary embarkation point was the UK, which accounted for 32.1 per cent of the number of anaesthetic detections at the Australian border in 2012–13. Other prominent embarkation points by number this reporting period were the Netherlands, Poland, Canada, Germany, Thailand, India, Lithuania, Belgium and Ireland. By number, Poland was the primary embarkation point for GHB and GBL with 21 detections, which accounted for 26.9 per cent of the number of detections. Other major embarkation points identified for GHB and GBL detections this reporting period by number were Thailand, the UK, China, Lithuania, the Netherlands, Singapore and Germany. In 2012–13, a total of 18 countries were identified as embarkation points for ketamine detected at the Australian border, compared with 13 countries in 2011–12. By number, the UK was the primary embarkation point, accounting for 39.2 per cent of ketamine detections at the Australian border in 2012–13. Other major embarkation points by number for ketamine detections this reporting period included the Netherlands, Canada, Germany, India, Belgium, Ireland, Spain, Taiwan and the US. DOMESTIC MARKET INDICATORS According to the 2010 NDSHS, 1.4 per cent of the Australian population aged 14 years or older reported using ketamine at least once in their lifetime. In the same survey, 0.8 per cent reported using GHB at least once in their lifetime. The proportion of the population aged 14 years or older reporting recent use of ketamine and GHB was 0.2 per cent and 0.1 per cent respectively (AIHW 2011). In a 2012 national study of regular ecstasy users, the proportion of respondents reporting ketamine use in their lifetime decreased, from 42 per cent in 2011 to 39 per cent in 2012. The proportion of respondents reporting recent ketamine use decreased, from 16 per cent in 2011 to 14 per cent in 2012. Early findings from the 2013 study indicate the proportion of respondents reporting recent ketamine use has increased to 19 per cent (NDARC 2013; Sindicich & Burns 2013; Stafford & Burns 2013). In the same 2012 study, the proportion of respondents reporting GHB use in their lifetime decreased from 22 per cent in 2011 to 21 per cent in 2012. In 2012, reported recent GHB use remained low at 7 per cent. Early findings from the 2013 study indicate the proportion of respondents reporting recent GHB use has decreased to 6 per cent (NDARC 2013; Sindicich & Burns 2013; Stafford & Burns 2013). PRICE Law enforcement price data for ketamine is limited. Consistent with prices reported in 2011–12, the price for a gram of ketamine in New South Wales ranged between $50 and $180 in 2012–13 and between $150 and $200 in Queensland. The price of a single ketamine tablet this reporting period ranged between $25 and $50 in Queensland, with $50 per tablet reported in the Northern Territory. Nationally, the price for 1–1.5 millilitres of GHB/GBL ranged between $3 and $25 in 2012–13, with the price per litre ranging between $2 000 and $5 000. Illicit Drug Data Report 2012–13 117 PURITY According to a study of regular ecstasy users, the perceived purity of ketamine is reported as high. In 2012, 6 per cent of respondents were able to comment on the perceived purity of ketamine, of which 60 per cent reported the purity of ketamine as high, compared with 63 per cent in 2011 (Sindicich & Burns 2013).14 AVAILABILITY According to the 2010 NDSHS, 1.1 per cent of the population had been offered or given the opportunity to use ketamine and 1.0 per cent GHB in the 12 months preceding interview. These figures are consistent with those reported in the 2007 survey (AIHW 2011). In a 2012 national study of regular ecstasy users, 6 per cent of respondents were able to comment on the availability of ketamine. Of these, 45 per cent reported ketamine as easy to very easy to obtain, a decrease from 52 per cent in 2011. Early findings from the 2013 study indicate this has increased to 69 per cent, however, the number of respondents able to comment remains low and findings should be interpreted with caution. In the same 2012 study, 27 respondents were able to comment on the availability of GHB. Of these, 59 per cent reported GHB as easy to very easy to obtain, an increase from 47 per cent in 2011. Early findings from the 2013 study indicate the proportion of respondents reporting the availability of GHB as easy to very easy to obtain increased to 75 per cent (NDARC 2013; Sindicich & Burns 2013). 14 As very small numbers (n=27) of the national sample commented on characteristics of the ketamine market, results should be interpreted with caution. Illicit Drug Data Report 2012–13 118 PHARMACEUTICALS MAIN FORMS Produced for legitimate medical use, many pharmaceutical drugs are diverted to the illicit market. The illicit pharmaceutical market encompasses the use of prescription pharmaceuticals that is inconsistent with their intended use or directions—including, but not limited to intentional misuse and overuse (also referred to as non-medical use)—and diversion from the legitimate market. Opioid analgesics and benzodiazepines are the most commonly misused pharmaceuticals in Australia (PHAA 2010; Sweeney 2007). Pharmaceuticals are obtained for illicit personal use through various methods including: family and friends with legitimate access stolen, altered or forged prescriptions feigning symptoms theft from surgeries or pharmacies doctor-shopping15 threatening general practitioners purchases over the internet poor prescription practices, such as prescribing larger than required quantities health practitioners self-prescribing or otherwise misappropriating through their work (ADF 2013e; DCPC 2007). The Australian Government subsidises numerous pharmaceuticals through the Pharmaceutical Benefits Scheme (PBS).16 With the increased availability of pharmaceuticals comes an increase in the potential for their misuse. The use of pharmaceutical drugs for non-medical purposes can have potentially dangerous effects and may lead to addiction, poisoning, disease and death (PHAA 2010). Dependence on the non-medical use of pharmaceuticals may occur following medical treatment for a physical or emotional trauma, or as a consequence of self-medication. Other reasons for the non-medical use of pharmaceuticals include being for the treatment of an underlying drug dependency problem, dealing with withdrawal symptoms, illicit drug substitution and/or for the enhancement of other drugs (AIC 2009). This section will focus on the pharmaceutical drugs most commonly used for non-medical purposes in Australia: benzodiazepines and opioids. ‘Doctor-shopping’ refers to presenting to numerous doctors for the purpose of obtaining multiple prescriptions to deal with non-existent or exaggerated symptoms. 16 The PBS is a federally funded government program which subsidises the cost of a broad range of medicines for most medical conditions and was established to ensure Australians have affordable access to pharmaceutical medicines. 15 Illicit Drug Data Report 2012–13 119 BENZODIAZEPINES Benzodiazepines slow the activity of the central nervous system and the messages sent and received by the brain. Most commonly prescribed to relieve insomnia, anxiety and panic attacks, the desired effects of benzodiazepine use include relaxation, calmness and relief from anxiety. The use of benzodiazepines—even when its use is consistent with the intended directions at therapeutic level—may cause a range of harms to the user, such as cognitive impairment, dependence and depression. Benzodiazepines may be misused to 'come down' from the effects of stimulants, such as amphetamines or cocaine, to enhance the effects of other depressant drugs, or as a substitute for drugs of choice when they are unavailable (ADF 2013f; Nielsen & Thompson 2008). Benzodiazepines are among the most prescribed drugs in Australia. The most common forms of benzodiazepines are tablets and capsules, which are stamped with their proprietary name. Benzodiazepines can also be injected, which increases injection-related harms and mortality (Nielsen & Thompson 2008; PBAC 2007). Use of low to moderate doses of benzodiazepines may lead to confusion, impaired motor coordination, loss of appetite and nausea. Higher doses may result in impaired judgement, difficulty in thinking clearly, memory loss, mood swings and aggressive behaviour. Shortterm effects of use may include drowsiness, memory loss and confusion. Long-term effects of benzodiazepine use may include developing a tolerance to the drug, vomiting, panic attacks and paranoia during withdrawal from dependent use. The combined effects of benzodiazepines and other depressant drugs, such as alcohol or heroin, increase the risk of overdose and fatalities (ADF 2013f; AIC 2009; Bradvik et al. 2007; DCPC 2007; Partanen et al. 2009). The main forms of benzodiazepine pharmaceuticals are listed in Table 31. TABLE 31: Main forms of commonly used benzodiazepine pharmaceuticals Pharmaceutical type Trade name User names Alprazolam Zanax, Alprazolam, Tafil, Farmapram, Asolan, Traxil, Niravam Zanies, Zans, Blues, Quad Bars, Totem Poles, Z Bars Bromazepam Lexotan Clonazepam Rivotril Diazepam Valium, Ducene, Antenex, Propam Flunitrazepam Rohypnol, Hypnodorm Rohies, Roofies Nitrazepam Mogadon, Alodorm, Dormican, Nitepam Moggies Oxazepam Serepax, Murelax, Alepam, Benzotran Sarahs Temazepam Normison, Temaze, Euhypnos Footballs, Normies OPIOIDS The term ‘opioids’ describes a class of drugs derived from the opium poppy and includes synthetic substances with similar pain relieving properties. Opioid pharmaceuticals are commonly prescribed for pain management and the treatment of heroin and other opioid addiction. Illicit Drug Data Report 2012–13 120 The most common opioids used to treat pain include codeine, morphine and oxycodone. The misuse of opioids may result in tolerance and dependence17 and instances of psychiatric conditions. Indicators of dependence include a strong desire to take the substance, limited control over its use and the need to increase dosage quantities to achieve the desired effect. Opioid withdrawal symptoms may include joint and muscle pain, nausea and vomiting, abdominal cramps and irritability (Degenhardt 2013; SA Health 2011). Available in tablet, capsule and liquid form, side effects of opioid use include drowsiness, nausea and depressed respiration. The injection of opioids may be linked to the transmission of blood-borne viruses, such as hepatitis B and C and human immunodeficiency virus (HIV) and other injection-related infections, such as collapsed veins and abscesses. Opioid overdose is more likely to occur when it is combined with other central nervous system depressants, when the method of administration is injection, or if the user is experiencing a change in tolerance levels. Methadone and buprenorphine are the two main pharmaceuticals used in the treatment of opioid dependence (ADF 2011; ADF 2013e). Common opioid pharmaceuticals are listed in Table 32. TABLE 32: Main forms and effects of commonly used opioid pharmaceuticals Pharmaceutical type Trade name User names Comments Morphine MS Contin, Anamorph, Kapanol, Morphalgin M, monkey, morph, Miss Emma, dreamer, hard stuff, greys Main component of opium; powerful narcotic analgesic Codeine Panadine Forte, Codral Forte, Dymadon Forte, Codalgin Forte, Mersyndol Forte An extract of opium which is not as strong as morphine Oxycodone Oxycontin, Endone, Wxynorm, Oxy, oxies, O.Cs, Percocet, Roxidcodone, Tylox, oxycottons, oxy 80s, Percodan hillbilly heroin, roxies, percs A semi-synthetic opioid analgesic similar to morphine Fentanyl Durogesic, Actiq (lozenge), Fenpatch, Denpax An opioid analgesic more potent than morphine, with a rapid onset and short duration Pethidine Peth Synthetic narcotic analgesic, similar to morphine but shorter lasting Methadone (or physeptone when in tablet form) Meth, Done, Metho Synthetic narcotic analgesic used in the treatment of opioid dependence; predominantly provided in syrup form to patients Beup, mud Used to treat withdrawal from heroin and employed in maintenance treatment to block the effects of other opioids Buprenorphine Subutex, Temgesic 17 Drug dependence is defined by the International Classification of Diseases 10th Revision (ICD-10) as the presence of three or more indicators of dependence for at least a month within the previous year (Degenhardt et al. 2013). Illicit Drug Data Report 2012–13 121 INTERNATIONAL TRENDS All regions in the world continue to report high levels of the non-medical use of tranquillisers, sedatives and non-prescription pharmaceutical opioids. Poly drug users may use single-use tranquillisers, such as benzodiazepines, to enhance the effects of heroin. According to the UNODC, the non-medical use of codeine-containing cough medicines and suppressants continues unabated (UNODC 2013c). According to US reporting, the non-medical use of prescription drugs is increasing at a greater rate than that of other illicit drugs (Clinton Foundation 2013). The National Drug Intelligence Centre assesses that the non-medical use of controlled prescription and overthe-counter pharmaceutical drugs ranks second only to that of cannabis. Prescription drugs commonly used for non-medical purposes include opioid pain relievers, stimulants for treating Attention Deficit Hyperactivity Disorder and medication for treating anxiety disorders. Across all age groups (14 years and over) within the US, the number of deaths associated with prescription painkillers exceeds that of all other illicit drugs (NIDA 2013). According to the International Narcotic Control Board, Central American countries have reported the non-medical use of pharmaceutical preparations that contain stimulants, as well as of prescription stimulants. East and South-East Asian countries have also reported the trafficking in and non-medical use of prescription drugs and over-the-counter pharmaceutical preparations containing internationally controlled substances of concern. South Africa has reported high levels of non-medical use of prescription drugs (mainly benzodiazepines, analgesics, codeine preparations and sedative-hypnotics) (INCB 2013). The 2011 European School Project on Alcohol and Other Drugs survey found that the lifetime prevalence of non-prescription use of tranquillizers or sedatives among students remained relatively stable between 1995 and 2011, at about 7 to 8 per cent (INCB 2013). Licensed internet pharmacies provide accessible, convenient and private services to consumers. However, there are also illegal internet pharmacies that typically sell a variety of medications, which may pose health and safety risks to the user. These include access to unapproved drugs, legal prescription drugs dispensed without a valid prescription, products that are marketed with fraudulent health claims, or counterfeit pharmaceuticals. DOMESTIC TRENDS AUSTRALIAN BORDER SITUATION Prescription pharmaceuticals are primarily imported by individuals without criminal intent. Pharmaceuticals continue to be purchased over the internet due to the anonymity afforded to purchasers without a prescription and the lower cost. Pharmaceutical border detections in 2012–13 include benzodiazepines and opioids. While the number of pharmaceutical detections at the Australian border decreased by 13.9 per cent this reporting period, from 1 337 in 2011–12 to 1 151 in 2012–13, it is the third highest number on record. The majority of these were benzodiazepines. The number of benzodiazepine detections decreased this reporting period, from 1 298 in 2011–12 to 1 056 in 2012–13. The total number of pharmaceutical opioid detections doubled this reporting period, increasing from 39 in 2011–12 to 79 in 2012–13. Oxycodone was the primary pharmaceutical opioid detected at the Australian border in 2012–13, accounting for 60.7 per cent of the total number of detections. Other pharmaceutical opioids detected this reporting period were morphine, buprenorphine and methadone (see Figure 62). Illicit Drug Data Report 2012–13 122 FIGURE 62: Number of pharmaceutical detections at the Australian border, 2003–04 to 2012–13 (Source: Australian Customs and Border Protection Service) 1600 1400 Number 1200 1000 800 600 400 200 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 IMPORTATION METHODS The postal stream continues to account for the greatest number of pharmaceutical detections. In 2012–13, the postal stream accounted for 57.1 per cent of the number pharmaceutical detections, followed by air passenger/crew at 36.3 per cent (see Figure 63). FIGURE 63: Number of pharmaceutical detections at the Australian border, as a proportion of total detections, by method of importation, 2012–13 (Source: Australian Customs and Border Protection Service) Air cargo (3.7%) Air passenger/crew (36.3%) Parcel post (57.1%) Sea cargo (2.9%) Illicit Drug Data Report 2012–13 123 EMBARKATION POINTS In 2012–13, a total of 60 countries were identified as embarkation points for pharmaceuticals detected at the Australian border, compared with 55 countries in 2011–12. Thailand was the prominent embarkation point, accounting for 19.5 per cent of the number of pharmaceutical detections in 2012–13. Other major embarkation points this reporting period by number were India, Singapore, Malaysia, the UK, Romania, South Africa, Indonesia, the US and Pakistan. In 2012–13, a total of 58 countries were identified as embarkation points for benzodiazepines detected at the Australian border. Thailand was the prominent embarkation point, accounting for 20.2 per cent of the number of benzodiazepine detections in 2012–13. Pakistan was the prominent embarkation point by number for opioid detections at the Australian border this reporting period, accounting for 13.9 per cent of detections in 2012–13. DOMESTIC MARKET INDICATORS According to the 2010 NDSHS, 4.2 per cent of the Australian population aged 14 years or older reported recent non-medical18 use of any pharmaceuticals, the first increase reported since 199819 (AIHW 2011). According to the ANSPS, pharmaceutical opioids (including morphine and oxycodone) were the third most commonly reported class of drug last injected nationally over the period 2008 to 2012. The prevalence of PIEDs injection increased in New South Wales, from 2 per cent in 2008 to 12 per cent in 2012, and in Queensland, from 1 per cent in 2008 to 11 per cent in 2012, and was stable at 2 per cent or less in all other jurisdictions. Consistent with previous years, pharmaceutical opioids were the drug most commonly injected in the Northern Territory (70 per cent) and Tasmania (40 per cent) in 2012. In the same study, methadone was reported as the last drug injected by less than 10 per cent of the ANSPS respondents over the period 2008 to 2012, with a decline in prevalence observed over this period (Iversen 2013). In a 2012 national study of regular injecting drug users, the proportion of respondents reporting recent use of any of benzodiazepine decreased, from 69 per cent in 2011 to 64 per cent 2012, with 62 per cent of respondents reporting swallowing as the main route of administration. In the same study, 50 per cent of respondents reported recent use of any form of illicit benzodiazepine.20 The proportion of respondents reporting recent illicit morphine use decreased, from 39 per cent in 2011 to 38 per cent in 2012 and remained the most commonly injected pharmaceutical opioid (NDARC 2013). The same 2012 study showed variation between states and territories, with the Northern Territory and Tasmania reporting the highest illicit use of morphine—locations where heroin is traditionally reported as being difficult to obtain. In 2012, the proportion of respondents reporting recent illicit use of oxycodone increased, from 32 per cent in 2011 to 35 per cent in 2012. Figure 64 shows the reported recent use of various pharmaceutical drugs in 2012 by a regular injecting drug user population (Stafford & Burns 2013). The NDSHS relates use for non-medical purposes to ‘ways that induced or enhanced a drug experience, enhanced performance or were for cosmetic purposes’. 19 According to the NDSHS, pharmaceuticals include: pain-killers/analgesics, tranquillisers, steroids, methadone or buprenorphine and/or other opioids. 20 Refers to/includes sublingual administration of buprenorphine (trade name Subutex) and buprenorphinenaloxone (trade name Suboxone). 18 Illicit Drug Data Report 2012–13 124 FIGURE 64: Proportion of a regular injecting drug user population reporting recent use of illicit pharmaceuticals, by type of pharmaceuticals, 2012 (Source: National Drug and Alcohol Research Centre) 100 90 Recent use (%) 80 70 60 50 40 30 20 10 Pharm. stimulants Oxycodone Morphine Methadone Buprenorphine Benzodiazepines 0 In a 2012 national study of regular ecstasy users, the proportion of respondents reporting the recent illicit use of benzodiazepines decreased, from 34 per cent in 2011 to 26 per cent. In the same study, the proportion of respondents reporting the recent illicit use of opiates also decreased, from 14 per cent in 2011 to 9 per cent in 2012. Figure 65 shows the recent reported illicit use of various pharmaceuticals in 2012 by a regular ecstasy drug user population (Sindicich & Burns 2013). FIGURE 65: Proportion of a regular ecstasy drug user population reporting recent use of illicit pharmaceuticals, by type of pharmaceutical, 2012 (Source: National Drug and Alcohol Research Centre) 100 90 70 60 50 40 30 20 10 Pharm. stimulants Other opiates Methadone Buprenorphine 0 Benzodiazepines Recent use (%) 80 Illicit Drug Data Report 2012–13 125 Research on drug use among police detainees in Australia incorporates a self-report survey and voluntary urinalysis. The self-report survey indicates drug use in the 12 months preceding interview. In contrast to other illicit drugs, the proportion of detainees testing positive for opiates or benzodiazepines exceeds that for self reported use. In 2012–13, the proportion of detainees testing positive21 for benzodiazepine use decreased, from 22.6 per cent in 2011–12 to 20.0 per cent in 2012–13, as did the self-reported use of benzodiazepines, which decreased, from 13.1 per cent in 2011–12 to 12.2 per cent in 2012–13 (see Figure 66). FIGURE 66: Proportion of detainees testing positivea for benzodiazepines compared with self-reported use, 2003–04 to 2012–13b (Source: Australian Institute of Criminology) Urinalysis Self reporting 25 Proportion (%) 20 15 10 5 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 a. Urine was collected in only two sites during the fourth quarter of 2012. b. Figures reported for 2012–13 reflects data collected in the third and fourth quarter of 2012 only. The proportion of detainees testing positive22 for opiate use decreased this reporting period, from 15.0 per cent in 2011–12 to 14.0 per cent in 2012–13. The self-reported use of methadone also decreased, from 9.8 per cent in 2011–12 to 7.8 per cent in 2012–13 (see Figure 67).23 21 Benzodiazepines and their metabolites can be detected in urine on average 2 to 14 days after administration (Makkai 2000). 22 Opiates and their metabolites can be detected in urine on average 2 to 3 days after administration (Makkai 2000). 23 The self-report DUMA survey does not differentiate between use of opiates and methadone, with the self-report question includes use of ‘illegal morphine/street/methadone/homebake or other illegal opiates’ (AIC 2012–13). Illicit Drug Data Report 2012–13 126 FIGURE 67: Proportion of detainees testing positivea for opiates compared with self-reported use of methadone, 2003–04 to 2012–13b (Source: Australian Institute of Criminology) Urinalysis Self reporting 20 18 Proportion (%) 16 14 12 10 8 6 4 2 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 a. Urine was collected in only two sites during the fourth quarter of 2012. b. Figures reported for 2012–13 reflect data collected in the third and fourth quarter of 2012 only. PRICE Law enforcement price data for pharmaceuticals obtained for non-medical use is limited. In 2012–13, the price for a 60 milligram tablet of Oxycontin was $60. In a 2012 national study of regular injecting drug users, the median price for 40 milligrams of oxycodone was $30, an increase from $22.50 in 2011 and ranged between $20 in New South Wales and $40 in Tasmania (Stafford & Burns 2013).24 AVAILABILITY According to a 2012 national study of regular injecting drug users, of the respondents able to comment on the availability of illicit oxycodone, 68 per cent reported it as easy or very easy to obtain, compared with 61 per cent in 2011. The proportion of respondents reporting illicit morphine as easy or very easy to obtain in 2012 remained stable at 72 per cent (Stafford & Burns 2012; Stafford & Burns 2013). SEIZURES Following decreases in the number of national other opioid seizures in 2010–11 and 2011–12, the number of seizures increased 24.1 per cent this reporting period, from 83 in 2011–12 to 103 in 2012–13. Following a spike in the weight of national other opioid seizures in 2010–11, the weight of national other opioid seizures has continued to decrease, from 26.6 kilograms in 2011–12 to 6.1 kilograms in 2012–13 (see Figure 68). 24 South Australia, Queensland, the Australian Capital Territory and the Northern Territory had small numbers reporting (n<10). Illicit Drug Data Report 2012–13 127 FIGURE 68: National other opioid seizures, by number and weight, 2003–04 to 2012–13 250 Weight 350 Number 300 250 150 200 150 100 Number Weight (kg) 200 100 50 50 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 0 2003–04 0 Despite reporting a decrease in the number and weight of other opioid seizures in 2012–13, New South Wales continues to account for the majority of national other opioid seizures, accounting for 46.6 per cent of the number and 62.2 per cent of the weight of seizures this reporting period. In 2012–13, Tasmania reported the greatest percentage increase in the number of other opioid seizures, while Queensland reported the greatest percentage increase in weight (see Table 33). TABLE 33: Number, weight and percentage change of national other opioid seizures, 2011–12 and 2012–13 Number State/Territorya New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory Australian Capital Territory Total 2011–12 42 10 6 6 7 1 0 11 83 Weight (grams) 2012–13 48 13 16 0 4 17 0 5 103 % change 2011–12 14.3 30.0 166.7 -100.0 -42.9 1 600.0 0 -54.5 24.1 2012–13 18 004 7 809 5 772 19 0 0 8 26 617 3 823 1 672 385 0 8 244 0 15 6 147 % change -78.8 -78.6 7 600.0 -100.0 -57.9 – 0 87.5 -76.9 a. Includes seizures by state/territory police and AFP for which a valid seizure weight was recorded. Illicit Drug Data Report 2012–13 128 DRUG ANALOGUES SUBSTANCES (DANPS) AND NEW PSYCHOACTIVE MAIN FORMS Drug analogues and new25 psychoactive substances (DANPS), is an umbrella term referring to substances that mimic, or are intended to mimic, the effects of illegal drugs and which are marketed as alternatives to controlled drugs. DANPS have been present in Australia and overseas since at least the mid-2000s and are often referred to as novel substances, novel psychotropic substances, emerging psychoactive substances, analogues, mimetics, legal highs, new synthetics, herbal highs or designer drugs (UNODC 2011b; UNODC 2013b). A wide range of DANPS are available to users. According to the UNODC, the number of potential synthetic drug derivatives is technically unlimited. Three United Nations Conventions provide a framework for controlling the production, trade and possession of over 240 psychoactive substances, with the number of DANPS exceeding that of other illicit drugs regulated by these conventions or treaties. These so-called ‘legal highs’26 or mimetics have become the drug of choice for some illicit drug users (EMCDDA 2013b; Lancet 2013; UNODC 2013b). The marketing of DANPS as legal alternatives to controlled substances—including methylamphetamine, MDMA and cannabis—may be interpreted by prospective users as being safe to consume or less harmful than illicit drugs. As many of these substances are novel, there is limited research or knowledge about the short or long-term health consequences of DANPS use, the risk of dependence, possible effects of use in combination with other drugs, or potential fatal dosage levels. Some identified short-term effects associated with DANPS use include dilated pupils, hypertension, hyperventilation, paranoia, agitation, hyperthermia, tremors and seizures (Arnold 2013; UNODC 2013a). Two groups of DANPS that receive considerable public attention are synthetic cannabinoids and cathinones, in particular 4-methylmethcathinone (4-MMC). This section will cover these two groups in more detail. SYNTHETIC CANNABINOIDS Many synthetic cannabinoids27 were synthesised with the aim of using them in laboratory research as potential treatments for conditions such as nausea and glaucoma, or for their anti-inflammatory and analgesic properties. In 2012, the European Union’s Early Warning System (EWS) was notified of 73 new psychoactive substances, of which 30 were synthetic cannabinoids. Synthetic cannabinoids mimic the effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive substance in cannabis. While some synthetic cannabinoids share a chemical structure similar to THC, the vast majority identified to date have no structural relationship to THC. With the exception of a small number of substances which have very limited legitimate uses, the vast majority of identified substances have no legitimate industrial, scientific or medicinal application (ADF 2013h; Bretteville-Jensen et al. 2013; EMCDDA 2013c; TGA 2011). Use of the term ‘new’ does not necessarily refer to a new invention—as many DANPS may have been synthesised years or decades ago—rather that they have recently emerged on the market. 26 Use of the term ’legal high’ may not reflect the true legal status of these substances under Australian legislation. 27 Scientifically, these are known as cannabimimetics due to the way the compounds mimic cannabis like behaviour. The commonly used term ‘synthetic cannabinoids’ has been used to avoid confusion and remain consistent with existing public terminology. 25 Illicit Drug Data Report 2012–13 129 Synthetic cannabinoids are typically dissolved in a solvent and sprayed onto dried plant material for use. As a consequence of the way in which synthetic cannabinoids are produced, there may be great variation both within and between the finished products. Synthetic cannabinoids are primarily smoked (via a pipe, in a cigarette or joint or blunt, or by using a hookah or water pipe or bong). Administration via vaporisation, in addition to oral and rectal ingestion has also been reported. Synthetic cannabinoids are sold on the internet or in various specialised shops and typically contain 1–3 grams of dried plant matter in a foil sachet, often labelled as a smoking mixture, herbal blend or incense. Synthetic cannabinoids are marketed under various brand names, which include Kronic, Spice, K2 and Northern Lights. Although a number of plant-based ingredients may be listed on the packaging, scientific testing has found that many of these are not actually present (ADF 2013g; Bretteville-Jensen et al. 2013; NCPIC 2013; NSW Health 2011). Users of synthetic cannabinoids may experience elevated mood, relaxation and altered perceptions. Short-term effects of synthetic cannabinoid use may include fatigue, headaches, disorientation, hallucinations, tachycardia, hypertension, agitation, panic attacks, anxiety and depression. Long-term effects use may include an increased risk of heart attack (as a consequence of high blood pressure and reduced blood supply to the heart). Synthetic cannabinoids also have carcinogenic potential, which may put users at risk of developing chronic bronchitis and lung cancer, and may precipitate the development of psychosis in patients with a history of mental illness. According to UNODC reporting, several cases of severe toxicity and deaths have been associated with synthetic cannabinoid use (ADF 2013h; Bretteville-Jensen et al. 2013; TGA 2011; UNODC 2013a). Synthetic cannabinoids form part of the illicit drug market in Australia. Since 2011, some Australian states and territories have introduced new regulations to ban synthetic cannabinoids. From 1 May 2012, nine groups of synthetic cannabinoids were included within Schedule 9 (Prohibited Substance) in the Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) (Poison Standard) (ADF 2013h, AG 2012).28 On 29 May 2013, the Commonwealth prescribed eight synthetic cannabinoids as border controlled drugs under the Criminal Code Act 1995.29 The list of border controlled drugs is found in the Criminal Code Regulations 2002. 4-MMC (4-METHYLMETHCATHINONE) Developed as an antidepressant, 4-MMC was first synthesised in 1929, however its strong addictive potential stopped it from being used for medical purposes. An illicit drug market for 4-MMC was established in the last decade after it was ‘rediscovered’ in 2003 (Bretteville-Jensen 2013; UNODC 2013a). 4-MMC, also known as mephedrone, is an analogue designed to mimic cathinone, which is a controlled drug. 4-MMC is a central nervous system stimulant, which increases the synaptic30 concentrations of neurotransmitters, such as dopamine, serotonin, and norepinephrine.31 Common street names for 4-MMC include ‘meph’, ‘meow’, ‘miaow-miaow’, ‘m-cat’, ‘drone’, ‘bubbles’ or ‘kitty cat’. 4-MMC is commonly marketed or mislabelled as bath salts, plant food or hoover freshener (ADF 2013i; Bretteville-Jensen et al. 2013; Sindicich & Burns 2013; Wood & Dargan 2012). 28 See the Initiatives chapter for further information. Many synthetic cannabinoids (including the eight added to the border controlled drug list) also appear on the Customs (Prohibited Import) Regulations 1956, and are therefore subject to a range of licensing and permit requirements for import/export of these substances. 30 A synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another cell (neural or otherwise). 31 Both a hormone and a neurotransmitter. 29 Illicit Drug Data Report 2012–13 130 Powder is the most common form of 4-MMC. It is available in tablet or capsule form. It can be snorted, swallowed, or dissolved for oral/rectal use or intramuscular/intravenous injection. The most common route of administration of 4-MMC is snorting (Sindicich & Burns 2013). Users report that 4-MMC produces a similar experience to amphetamines, MDMA or cocaine. Reported short term effects of 4-MMC use include dilated pupils, tremors or convulsions, insomnia, anxiety, paranoia, hypertension and breathing difficulties. Long-term effects of use may lead to memory deterioration, hallucinations, delusions, erratic behaviour, anxiety, paranoia and depression (Brunt et al. 2011; UNODC 2013a; Winstock et al. 2010). INTERNATIONAL TRENDS DANPS are a global phenomenon, with all regions of the world virtually reporting simultaneous activity related to this market. Over the past few years, there has been unprecedented growth in the number, type and availability of DANPS, however reliable data on the scope and nature of this market is limited to some extent. Between 2005 and 2011, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) EWS reported one new substance per week, with two-thirds of all reported DANPS either synthetic cannabinoids or synthetic cathinones (EMCDDA 2013b; Forensic Science Review 2013). Studies report numerous sales occur via the internet, with suppliers using the internet to promote their products. Both users and sellers value the impersonal and implied low-risk transaction method stemming from online purchases. The low price of synthetic cannabinoids and cathinones—compared to some other illicit drugs—and the ease of transaction, for both users and sellers, creates potential for market expansion (Forensic Science Review 2013). In Europe, clandestine laboratories producing DANPS sell direct to users via the internet, or through legitimate stores. In order to avoid detection by law enforcement or other regulatory bodies, suppliers may also deceptively label these substances as not for human consumption and market the substances in a variety of packaging, purporting them to be bath salts, plant food, research chemicals or fertiliser (Forensic Science Review 2013). According to the International Narcotics Control Board, many DANPS suppliers are based in China or India, with domestic manufacture also reported by countries in Europe, the Americas and other parts of Asia (INCB 2013). The UNODC reported the number of synthetic cathinones seizures remained stable in 2012 (UNODC 2013b). In June 2013, the US DEA announced a 1 500 kilogram seizure of synthetic cannabinoids and cathinones manufactured in India and China, intended for the US and Australian markets (Knight 2013). The United Arab Emirates seized 126 parcel consignments, totalling 23.5 kilograms of synthetic cannabinoids (Spice) over an eight month period in 2012 (UNODC 2013c). In January 2013, Egypt reported increasing seizures of synthetic cannabinoids (Voodoo) originating in Europe and trafficked through Libya (UNODC 2013c). There is no standard national or international approach to addressing the issue of DANPS. Many countries have adopted broad legislative approaches for controlling DANPS through the use of analogue and generic terms, temporary and emergency procedures and alternative non-drug specific legislation, such as consumer protection legislation. The US has enacted laws to target analogue compounds. Although not making synthetic drugs illegal, Sweden can seize them under the Destruction Act and the UK uses Temporary Drug Class Orders to ban new substances—usually effective within a month—while formal legislative change is enacted (Policing and Practice Journal 2013). Illicit Drug Data Report 2012–13 131 Illicit Drug Data Report 2012–13 132 In 2013, New Zealand introduced the Psychoactive Substances Act 2013, making it illegal to import, manufacture, sell or supply psychoactive substances without a licence. The burden of proof is now placed on the manufacturers and distributors to prove that their products present low risk for human use before they can be granted a licence (NZG 2013). DOMESTIC TRENDS AUSTRALIAN BORDER SEIZURES DANPS comprise synthetic cannabinoids, substituted cathinones, analogues of amphetamine type-stimulants, as well as novel and obscure research chemicals. The main characteristic of these drugs is the diversity and large number of substances involved. DANPS are sourced from within large groups of chemical compounds, which complicate their regulation and may enable vendors to evade regulatory mechanisms by adjusting the chemical composition of their products. DANPS are increasingly seized at the Australian border, mainly in air cargo parcels and the international mail stream. Border regulation of DANPS is complex due to many new and emerging substances not being covered under current legislation. Their presumptive identification also poses challenges as current trace detection tools may not currently be calibrated to detect the thousands of drugs which potentially fall under this category. Shipments encountered at the Australian border are either personal use quantities that are purchased online and delivered by mail, or larger shipments intended for resale. Shipments intended for resale comprise either a large number of retail doses, mostly of synthetic cannabinoids, packaged as ready-to-use smoking mixtures, or bulk active agents in kilogram quantities, mainly from China. DANPS have low active dose thresholds such as 3–6 mg for synthetic cannabinoids, and 0.1–0.4 mg for the exceptionally dangerous NBOMe group compounds, which have been associated with fatalities in Australia and other countries. DANPS, which are sold in Australia at low prices per dose, have the potential to generate criminal profits in excess of those obtained from trafficking more established illicit drugs, such as heroin and cocaine, although at present the DANPS market does not compare in size with more traditional illicit drug markets. Although the breadth of new substances appearing on the market is very large, and some appear only sporadically, the Australian Federal Police (AFP) Forensic Drug Intelligence (FDI) team, in consultation with the National Measurement Institute (NMI), has identified the following categories of DANPS: amphetamine-type substances cathinone-type substances synthetic cannabinoids tryptamine-type substances others. Among the many different compounds detected and reported since 2006–07, some have been more common than others in terms of the weight of material seized and/or the overall number of seizures. These have included 4-MMC, N,N-dimethylamphetamine (DMA), 1-benzylpiperazine (BZP) and 3-trifluoromethylphenylpiperazine (TFMPP). Illicit Drug Data Report 2012–13 133 Over the reporting periods, analysis of DANPS has included amphetamine-type substances, novel cathinone-type substances, synthetic cannabinoids, novel tryptamine-type substances, novel 2C-type substances and novel piperazine-type substances. Analysis of border seizures containing DANPS indicates that while the number of seizures decreased in 2012–13, the weight of seizures containing DANPS more than doubled (see Figure 69).32 FIGURE 69: Number and weight of seizures selected for further analysis and found to contain novel substances and drug analogues, 2006–07 to 2012–13 (Source: Australian Federal Police, Forensic Drug Intelligence) 80 150 60 100 40 50 20 0 0 2012–13 200 2011–12 100 2010–11 250 2009–10 120 2008–09 300 2007–08 140 Number Number 350 2006–07 Weight (kg) Weight Since 2008–09, novel cathinone-type substances have accounted for the highest proportion of the number of seizures in this subset. In 2012–13, novel cathinone-type substances accounted for 44.6 per cent of analysed seizures containing novel substances, followed by novel amphetamine-type substances (17.9 per cent), novel 2C-type substances (16.1 per cent), novel piperazine-type substances (10.7 per cent), synthetic cannabinoids (8.9 per cent) and novel tryptamine-type substances (1.8 per cent). Following a spike in the weight of DANPS seized in 2010–1133 and the notable decrease in the weight of DANPS seized in 2011–12, the weight of analysed seizures increased by 139.3 per cent in 2012–13. Novel piperazine-type substances accounted for 41.8 per cent of the weight of novel substance seizures, followed by novel cathinone-type substances (35.1 per cent), novel amphetamine-type substances (19.6 per cent), synthetic cannabinoids (3.4 per cent) and novel tryptamine-type substances (<0.1 per cent). DOMESTIC MARKET INDICATORS In a 2012 national study of regular ecstasy users, the proportion of respondents reporting recent 4-MMC use decreased, from 14 per cent in 2011 to 5 per cent in 2012. Swallowing (62 per cent), followed by snorting (48 per cent), were the most common methods of administration, with minimal reporting of injecting. Early findings from the 2013 study indicate 32 The data in Figure 69 refers only to seizures made by the AFP, examined by AFP crime scene teams, sampled and subsequently confirmed to contain a novel substance by the NMI. Seizure data does not represent all AFP seizures of DANPS during these periods. 33 The spike in the weight of DANPS seized in 2010–11 was due to 3 large seizures containing novel amphetamine-type substances, which accounted for approximately 82 per cent of the weight of novel substances seized in that reporting period. Illicit Drug Data Report 2012–13 134 the proportion of respondents reporting recent use has increased to 6 per cent (NDARC 2013; Sindicich & Burns 2013). In the same 2012 study, the proportion of respondents reporting recent use of synthetic cannabinoids increased, from 6 per cent in 2011 to 15 per cent of in 2012. Early findings from the 2013 study indicate the proportion of respondents reporting recent use has increased to 16 per cent (NDARC 2013; Sindicich & Burns 2013). PRICE National law enforcement price data for DANPS, including 4-MMC and synthetic cannabinoids is limited. In 2012–13, the price of a tablet/capsule of 4-MMC in Tasmania the price was $30, with the price in Queensland ranging between $20 and $50. Nationally, the price for 3 grams of synthetic cannabinoids in 2012–13 ranged between $50 and $95. DOMESTIC SEIZURES Technical challenges exist for law enforcement agencies in identifying DANPS. Due to the dynamic nature of this market, data systems have limited capacity to accurately record and readily extract seizure and arrest data, with many of these drugs reported as ‘other drugs’. As a result, monitoring and reporting on national trends of these drugs is limited. Since 2007–08, jurisdictions have indicated an increase in the number and weight of DANPS seized. Key categories of seized substances include amphetamine-type substances, cathinone-type substances and synthetic cannabinoids. Illicit Drug Data Report 2012–13 135 OTHER AND UNKNOWN NOT ELSEWHERE CLASSIFIED (NEC) DRUGS Data of national other and unknown NEC drug arrests and seizures capture drugs and substances outside the other specific drug categories contained in the Illicit Drug Data Report (IDDR). This category covers a range of substances including precursors, anaesthetics, DANPS, pharmaceuticals and drugs not elsewhere classified. Substances in this category are likely to change between reporting periods. Data limitations are further discussed in the Statistics chapter. Over the last decade, the number of national other and unknown NEC drug seizures increased 425.0 per cent, from 1 367 in 2003–04 to 7 177 in 2012–13. By comparison, the weight of seizures has fluctuated over the last decade, increasing 1 089.2 per cent, from 185 kilograms in 2003–04 to 2 200 kilograms in 2012–13. This reporting period the number of other and unknown NEC drug seizures increased 32.9 per cent, from 5 399 in 2011–12 to 7 177 in 2012–13, while the weight of seizures decreased 83.6 per cent, from 13 451.5 kilograms in 2011–12 to 2 200.0 kilograms in 2012–13. The significant decrease in the weight of related seizures between the 2011–12 and 2012–13 reporting periods is a direct consequence of a single 11–tonne seizure of hypophosphorous acid in 2011–12, a reagent chemical used in the manufacture of methylamphetamine (see Figure 70). FIGURE 70: National ‘Other and unknown—not elsewhere classified’ drug seizures, by number and weight, 2003–04 to 2012–13 Weight 8000 Number 7000 12000 6000 Weight (kg) 14000 10000 5000 8000 4000 6000 3000 4000 2000 2000 1000 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 0 2003–04 0 Number 16000 New South Wales accounted for the greatest proportion of national other and unknown NEC drug seizures this reporting period, accounting for 43.5 per cent of the number and 29.8 per cent of the weight. Queensland, Western Australia and Northern Territory reported notable increases in the weight of other and unknown NEC drug seizures this reporting period, with their combined seizure weight accounting for 52.6 per cent of the weight of national seizures in 2012–13 (see Table 34). Illicit Drug Data Report 2012–13 136 TABLE 34: Number, weight and percentage change of national other and unknown NEC drug seizures, 2011–12 and 2012–13 Number State/Territorya New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory 2011–12 Weight (grams) 2012–13 % change 2011–12 2012–13 3 122 32.4 12 687 524 655 050 461 663 43.8 338 274 371 678 9.9 1 192 1 258 5.5 135 277 486 917 259.9 2 358 Australian Capital Territory % change -94.8 21 32 52.4 15 532 13 926 -10.3 996 1 704 71.1 36 484 90 523 148.1 132 158 19.7 3 651 1 807 -50.5 209 211 1.0 233 264 578 715 148.1 30 29 -3.3 1 585 1 444 -8.9 Total 5 399 7 177 32.9 13 451 591 2 200 060 -83.6 a. Includes seizures by state/territory police and AFP for which a valid seizure weight was recorded. b. Please note that kava seizures in the Northern Territory may constitute a significant proportion of the number and weight of other and unknown NEC seizures within a given reporting period. As such, care should be taken when interpreting these results. Over the last decade, the number of national other and unknown NEC drug arrests has increased 47.7 per cent, from 8 444 in 2003–04 to 12 469 in 2012–13, the highest number reported in the last decade. Since 2003–04, consumer arrests have accounted for over 70 per cent of national other and unknown NEC drug arrests, accounting for 72.9 per cent of arrests in this reporting period (see Figure 71). FIGURE 71: Number of national ‘Other and unknown—not elsewhere classified’ drug arrests, 2003–04 to 2012–13 Total Consumer Provider 14000 12000 Number 10000 8000 6000 4000 2000 2012–13 2011–12 2010–11 2009–10 2008–09 2007–08 2006–07 2005–06 2004–05 2003–04 0 Queensland continues to account for the greatest proportion of national other and unknown NEC drug arrests, accounting for 31.6 per cent of arrests in 2012–13. This reporting period South Australia reported the highest percentage increase in other and unknown NEC drug arrests (see Table 35). Illicit Drug Data Report 2012–13 137 TABLE 35: Number and percentage change of national other and unknown NEC drug arrests, 2011–12 and 2012–13 Arrests State/Territorya New South Wales Victoria Queensland South Australia Western Australia Tasmania Northern Territory Australian Capital Territory Total 2011–12 1 714 2 417 3 558 154 2 104 477 178 3 2012–13 1 706 3 182 3 945 801 2 439 345 51 0 % change -0.5 31.7 10.9 420.1 15.9 -27.7 -71.3 -100.0 10 605 12 469 17.6 a. The arrest data for each state and territory includes AFP data. Illicit Drug Data Report 2012–13 138 NATIONAL IMPACT The other drugs category includes a wide range of drugs and substances. In 2012–13, there was a record 10 356 detections of PIEDs at the Australian border. The number of embarkation points identified for PIED detections increased 11.1 per cent this reporting period, from 63 countries in 2011–12 to 70 countries in 2012–13. The postal stream continues to account for the greatest proportion of the number of detected PIEDs, with China and Thailand the prominent embarkation points for the number of PIEDs detected at the Australian border in 2012–13. While the weight of national steroid seizures decreased this reporting period, it is the second highest weight reported in the last decade. In 2012–13, the number of national steroid seizures and arrests increased and are the highest on record. New South Wales continues to account for the greatest proportion of both the number and weight of national steroid seizures, while Queensland continues to account for the greatest proportion of national steroid arrests. While consumer arrests continue to account for the greatest proportion of national steroid arrests, in 2012–13, Tasmania and the Australian Capital Territory reported more provider arrests than consumer arrests. There was a record 509 detections of tryptamines at the Australian border in 2012–13, the majority of which relate to LSD detections. The number of embarkation points identified for tryptamines detections increased 137.5 per cent this reporting period, from 8 countries in 2011–12 to 19 countries in 2012–13. The postal stream continues to account for the greatest proportion of the number of tryptamine detections, with the Netherlands the prominent embarkation point for tryptamine detections at the Australian border in 2012–13. Nationally, the weight of hallucinogen seizures decreased to 3.6 kilograms, the lowest weight reported since 2008–09. Despite this decrease, the number of national hallucinogen seizures continued to increase and is the highest reported in the last decade. New South Wales continues to account for the greatest proportion of both the number and weight of national hallucinogen seizures, with Queensland continuing to account for the greatest proportion of national hallucinogen arrests. While consumer arrests continue to account for the greatest proportion of national hallucinogen arrests, South Australia and Tasmania reported more provider arrests than consumer arrests. There was a record 277 detections of anaesthetics at the Australian border in 2012–13, the majority of which relate to ketamine detections. The number of embarkation points identified for anaesthetic detections at the Australian border increased 23.5 per cent, from 17 countries in 2011–12 to 21 countries in 2012–13. The postal stream continues to account for the greatest proportion of the number of anaesthetic detections, with the UK the prominent embarkation point by number for anaesthetic detections at the Australian border in 2012–13. While the number of pharmaceutical detections at the Australian border decreased in 2012–13, it is the third highest number reported in the last decade. The majority of detections this reporting period were benzodiazepines. The number of embarkation points identified for pharmaceuticals detected at the Australian border increased 9 per cent, from 55 countries in 2011–12 to 60 countries in 2012–13. The postal stream continues to account for the greatest proportion of the number of pharmaceutical detections. Thailand was the prominent embarkation point for the number of benzodiazepines detected at the Australian border in 2012–13, with Pakistan the prominent embarkation point for the number of opioid detections. Illicit Drug Data Report 2012–13 139 The most prevalent DANPS available in the Australian illicit drug market in 2012–13 were novel piperazine-type substances, novel cathinone-type substances, novel amphetaminetype substances and synthetic cannabinoids. While the number of analysed border seizures containing DANPS in 2012–13 decreased 56.3 per cent, the weight of seizures more than doubled. In this reporting period, novel cathinone-type substances accounted for the majority of analysed border seizures by number, while novel piperazine-type substances accounted the greatest proportion of the weight of seizures. The number of national other and unknown NEC drug seizures continued to increase this reporting period, with the 7 177 seizures in 2012–13 the highest number reported in the last decade. The weight of national seizures decreased considerably in 2012–13, a direct consequence of the 11 tonne seizure of hypophosphorous acid in 2011–12. New South Wales accounted for the greatest proportion of the number and weight of national other and unknown NEC drug seizures this reporting period. 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