TUDOR ALEXANDRU FULGA, PhD
Weatherall Institute of Molecular Medicine
Radcliffe Department of Medicine, University of Oxford
JR Hospital, Oxford OX3 9DS
Tel: +44 1865 222 811
Email: tudor.fulga@imm.ox.ac.uk
EDUCATION
PhD European Molecular Biology Laboratory (EMBL)
B.Sc. Faculty of Biology, University of Bucharest
1998 – 2001
1992 – 1997
RESEARCH POSITIONS
WIMM - University of Oxford
Harvard Medical School
Harvard Medical School, BWH
European Molecular Biology Laboratory
Institute of Biochemistry, Bucharest
MRC Senior Research Fellow
Instructor in Cell Biology
Postdoctoral Fellow
PhD/Bridging postdoctoral fellow
Research assistant
2011- present
2008 - 2011
2004 - 2007
1998 - 2003
1996 - 1998
TEACHING POSITIONS
Harvard University
Harvard University
Harvard University
Harvard University
Teaching fellow (MCB 54)
Teaching fellow (MCB 52)
Teaching fellow (MCB 54)
Teaching fellow (MCB 54)
2010-2011
2006-2007
2005-2006
2004-2005
FELLOWSHIPS AND AWARDS
MRC Senior Research Fellow
HMS/HSMD Postdoctoral Fellow Travel Award
Faculty of 1000 associate faculty member
Keystone Symposia Scholarship
BWH/HMS Award for outstanding achievement in science research
John Douglas French Alzheimer's Foundation Postdoctoral Fellowship Harvard University Award of Distinction in Teaching
Best Poster Prize – Santa Cruz Conference on Developmental Biology
Louis Jeantet EMBL PhD Fellowship for East Europe
FEBS Course Fellowship
FEBS Course Fellowship
2011-2016
2010
2009-present
2008
2007
2006 - 2008
2005
2002
1998-2002
1997
1996
PUBLICATIONS
1. Tudor A. Fulga#, Elizabeth M. McNeill, Richard Binari, Julia Yelick, Alexandra Blanche,
Matthew Booker, Michael Schnall-Levin, Yong Zhao, Todd DeLucca, Fernando Bejarano, Zhe
Han, Eric C. Lai, Dennis Wall, Norbert Perrimon#, David Van Vactor#. Unbiased screening by
conditional competitive inhibition reveals novel functions of conserved Drosophila miRNAs during
development and adult behaviour. (2014) Developmental Cell, Revision. # Corresponding author
2. Jennifer Y. Tan, Keith W. Vance, Miguel A. Varela, Tamara Sirey, Lauren M. Watson, Helen J.
Curtis, Martina Marinello, Sandro Alves, Bruno Steinkraus, Sarah Cooper, Tatyana Nesterova, Neil
Brockdorff, Tudor A. Fulga, Alexis Brice, Annie Sittler, Peter L. Oliver, Matthew J. Wood, Chris P.
Ponting and Ana C. Marques. Crosstalking noncoding RNAs contribute to cell-specific
neurodegeneration in Spinocerebellar ataxia type 7. (2014) Nature Structural & Molecular
Biology. In press.
3. Andrew Bassett, Ghows Azzam, Lucy Wheatley, Charlote Tibbit, Timothy Rajakumar, Simon
McGowan, Nathan Stanger, Philip Andrew Ewels, Stephen Taylor, Chris P. Ponting, Ji-Long Liu,
Tatjana Sauka-Spengler, Tudor A. Fulga. Understanding functional miRNA-target interactions in
vivo by site-specific genome engineering. (2014) Nature Comm. In press.
4. Katharine J. Marler, Philipp Suetterlin, Asha Dopplapudi, Aine Rubikaite, Jihad Adnan, Nicola
A. Maiorano, Andrew S. Lowe, Ian D. Thompson, Manav Pathania, Angelique Bordey, Tudor
Fulga, David L. Van Vactor, Robert Hindges and Uwe Drescher (2014) BDNF Promotes Axon
Branching of Retinal Ganglion Cells via miRNA-132 and p250GAP. Journal of Neuroscience,
34(3):969-79.
5. Wanhe Li, Mike Cressy, Hongtao Qin, Tudor Fulga, David Van Vactor, and Josh Dubnau
(2013) microRNA-276a functions in Ellipsoid Body and Mushroom Body neurons for naive and
conditioned olfactory avoidance in Drosophila. Journal of Neuroscience, 33(13):5821-33.
6. Fernando Bejarano, Diane Bortolamiol-Becet, Qi Dai, Kailiang Sun, Abil Saj, Yu-Ting Chou,
David R. Raleigh, Kevin Kim, Jianquan Ni, Joshua W. Hagen, Hong Duan, Jr-Shiuan Yang, Tudor
A. Fulga, David Van Vactor, Norbert Perrimon and Eric C. Lai (2012) A genomewide transgenic
resource for conditional expression of Drosophila microRNAs. Development, 139(15):2821-31.
7. Manavendra Pathania, Juan Torres-Reveron, Lily Yan, Tomoki Kimura, Tiffany V. Lin, Valerie
Gordon, Zhao-Qian Teng, Xinyu Zhao, Tudor A. Fulga, David Van Vactor, Angélique Bordey
(2012) miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and
Survival of Newborn Olfactory Bulb Neurons. PLos One, 7(5):e38174.
8. Vikram Khurana, Paola Merlo, Brian DuBoff, Tudor A. Fulga, Katherine A. Sharp, Shelag D.
Campbell, Jurgen Gotz and Mel B. Feany (2011) A critical neuroprotective role for an ATMdependent DNA damage checkpoint. Aging Cell, 11(2):360-2.
9. Vikram Khurana‡, Ilan Elson-Schwab‡, Tudor A. Fulga‡, Erin Mulkearns and Mel B Feany
(2010) Lysosomal proliferation is involved with caspase-cleavage of tau and promotes
neurodegeneration in a Drosophila model of tauopathy. PLoS Genetics, 15;6(7). ‡ Equal
contribution
10. Carlos M. Loya, David Van Vactor and Tudor A. Fulga (2010) Understanding neuronal
connectivity through the post-transcriptional toolkit. Genes and Development, 24(7):625-35
11. Carlos M. Loya, Cecilia S. Lu, David Van Vactor# and Tudor A. Fulga# (2009) Transgenic
microRNA inhibition with spatiotemporal specificity in intact organisms Nature Methods,
6(12):897-903. # Corresponding author
12. Howard Chia-Hao Chang, Douglas N. Dimlich, Takakazu Yokokura, Ashim Mukherjee, Mark
W. Kankel, Anindya Sen, Vasanthi Sridhar, Tudor A. Fulga, Anne C. Hart, David Van Vactor,
Spyros Artavanis-Tsakonas (2008) Modeling Spinal Muscular Atrophy in Drosophila PLoS ONE
15;3(9):e3209
13. Tudor A. Fulga# and David Van Vactor# (2008) Synapses and growth cones on two sides of a
highwire Neuron 57(3):339-44. # Corresponding author
14. Michelle L. Steinhilb, Dora Dias-Santagata‡, Tudor A. Fulga‡, Daniel L. Felch and Mel B.
Feany (2007) Tau phosphorylation sites work in concert to promote neurotoxicity in vivo Mol. Biol.
Cell 18(12):5060-8 ‡ Equal contribution
15. Ambra Bianco, Adam Cliffe, Minna Poukkula, Juliette Mathieu, Carlos M. Luque, Tudor A.
Fulga and Pernille Rørth (2007) Two distinct modes of guidance signaling during collective
migration. Nature 448 (7151):362-5.
16. Magali Periquet, Tudor Fulga, Liisa Myllykangas, Michael G. Schlossmacher and Mel B.
Feany (2007) Aggregated -synuclein mediates dopaminergic neurotoxicity in vivo. Journal of
Neuroscience 27 (12):3338-46
17. Dora Dias-Santagata, Tudor A. Fulga, Atanu Duttaroy and Mel B Feany (2007) Oxidative
stress mediates tau-induced neurodegeneration in Drosophila. J. Clin. Invest. 117 (1):236
18. Tudor A. Fulga#, Ilan Elson-Schwab, Vikram Khurana, Michelle L. Steinhilb, Tara L. Spires,
Bradley T. Hyman and Mel B. Feany# (2006) Abnormal bundling and accumulation of F-actin
mediates tau-induced neuronal degeneration in vivo. Nature Cell Biology, 9(2):139-48. #
Corresponding author
19. Vikram Khurana, Tudor A. Fulga and Mel B. Feany (2005) Senseless makes sense for SCA-1.
Nature Neuroscience (11):1422-4
20. Tudor A. Fulga and Pernille Rørth. (2002) Invasive cell migration is initiated by guided growth
of long cellular extensions. Nature Cell Biology 4(9):715-719
21. Martin R. Pool, Joachim Stumm, Tudor A. Fulga, Irmgard Sinning & Bernhard Dobberstein
(2002) Three stages in Signal Recognition Particle interaction with the Ribosome Science
297(5585):1345-8
22. Tudor A. Fulga, Irmgard Sinning, Bernhard Dobberstein & Martin R. Pool (2001) SR
coordinates Signal Sequence release from SRP with Ribosome binding to the Translocon. EMBO
J. 20(9):2338-47
23. Stefan E. Szedlacsek, Alexandru R. Aricescu, Tudor A. Fulga, L Renault & Axel Scheidig
(2001) Crystal structure of PTP-SL/BR7 catalytic domain:Implications for MAP kinase regulation. J
Mol Biol. 311(3):557-68
CURRENT GRANT SUPPORT
MRC Senior Research Fellowship 2011-2016
MRC Confidence in Concept Award 2013-2014
NDM/WT Research Fund Award
BBSRC Research Project Grant 2014-2016
£ 1,100,688
£ 80,640
£ 9,076
£ 482,987