Date - 國立中興大學食品暨應用生物科技學系

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國立中興大學 103 學年度第一學期食品暨應用生物科技學系碩專班二年級專題討論
Title:Development of curcumin nanocrystal: Physical aspects
Paper From:Journal of Pharmaceutical Sciences
Impact factor:3.007
Speaker :游振偉(19)
Student ID: 5102043016
Date: 2014 /12/ 28
Moderator :陳玉琴
1. Introduction
Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses
diverse pharmacologic effects. It is practically insoluble in water at acidic or neutral pH
but soluble in alkali. This study is to enhance the dissolution rate of a poorly
water-soluble drug, curcumin, by fabricating nanocrystals using high-pressure
homogenization. Four polymer stabilizers[polyvinyl alcohol (PVA), polyvinyl
pyrrolidone (PVP), D-α-tocopherol polyethylene glycol 1000 succinate (TPGS),
carboxymethylcellulose sodium salt] and one low molecular weight surfactants
[sodium dodecyl sulfate (SDS) ] were investigated with nanocrystals size, surface
charge, shape and morphology, thermal property, crystallinity and a short-term stability
storing at 4°C and room temperature. The mean particle diameter was between 500 and
700 nm which produced by PVA, PVP, TPGS, and SDS. However, PVP is the most
efficient polymer to stabilize curcumin nanoparticle. Curcumin nanocrystals provide
excellent physicochemical properties such as enhanced kinetic solubility in water and
improved physical stability. The superior physicochemical properties of curcumin
nanocrystals should overcome the absorption problem in the gastrointestinal tract and
increase the bioavailability.
2. Materials and methods
3. Results and discussion
3.1 After homogenization 20 cycles, the size increased in the order of:
TPGS<SDS<PVP < PVA <Na-CMC. SDS as well dispersing, fast diffusing
low-molecular weight surfactant should reveal the best performance in the
nanoparticle production.
3.2 The magnitude of the zeta potential gives an indication of the potential stability of
the colloidal system. SDS-stabilized and Na-CMC-stabilized nanosuspension has
the highest ZP value.
3.3 Particle size of the PVP nanoparticles was drastically decreased from microscale to
nanoscale (±400 nm).
3.4 DSC and X-ray diffraction were used to study the crystalline state of Curcumin
nanocrystals. Homogenization process did not change the crystallinity of curcumin.
3.5 The nanosuspensions stabilized with PVA, PVP, and TPGS are stable over period of
30 days at both storage conditions. SDS-stabilized and Na-CMC-stabilized leading
to particle aggregation.
4. Conclusion:
PVA, PVP, TPGS, and SDS were succesfully to produced nanocrystals of curcumin
with the particle size in the range of 500–700 nm. Na-CMC which indicating presence
of aggregates is not sufficient to stabilize aqueous curcumin nanosuspensions. PVA,
PVP, and TPGS showed similar performance in preserving the nanosuspension stability.
Based on these physicochemical studies, curcumin nanocrystals provide excellent
physicochemical properties such as increased dissolution velocity, enhanced kinetic
solubility in water and improved physical stability.
5. References
5.1 Kinetic solubility and dissolution velocity of rutin nanocrystals.
Mauludin R, Müller RH, Keck CM. 2009.
5.2 Lipid nanocarriers for dermal delivery of lutein: Preparation, characterization,
stability and performance.
Mitri, R. Shegokar, S. Gohla, C. Anselmi, R.H. Müller 2011
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