Hosting of sulfamethoxazole in Cuban natural clays
L. Lazo1, L. Valdés2, L. C. de Ménorval3, A. Rivera1
1
Zeolites Engineering Laboratory, Institute of Materials Science and Technology
(IMRE), University of Havana, Cuba; 2Department of Pharmacy, Institute of Pharmacy
and Food (IFAL), University of Havana, Cuba; 3Institut Charles Gerhardt Montpellier,
Equipe Agrégats, Interface, et Materiaux pour l'Energie (AIME), Université
Montpellier, France
*Corresponding authors: aramis@imre.oc.uh.cu
Clays are commonly used as controlled release systems due to their ion
exchange and adsorbing properties. In this work, the ability to incorporate
sulfamethoxazole (SMX) as model drug in two natural Cuban clays bentonite
and palygorskite is studied in order to evaluate their potential as drug carriers
in the pharmaceutical industry. Different parameters (pH dependent, initial
drug concentration, and temperature and interaction time) were investigated
with the aim to optimize the drug intercalation. The solid obtained was
characterized using XRD and IR. Although both clays have different structural
characteristics ”flexibility” for the bentonite and “rigidity” for
the
palygorskite, the SMX amount incorporated is very similar. The SMX
incorporation is pH-dependent, and the best results were found at acid pH. It
was also confirmed that the drug incorporation increases with the increment of
drug initial concentration, and it is independent from the temperature.
Preliminary release studies suggested a low chemical affinity of SMX to clays.