Principal Investigator/Program Director (Last, First, Middle):
Quiñones-Hinojosa, Alfredo
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Alfredo Quiñones-Hinojosa
Associate Professor Of Neurological Surgery and
Oncology, Cellular and Molecular Medicine and
Neuroscience
eRA COMMONS USER NAME
AQUINON2
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of California, Berkeley, CA
Harvard Medical School, Boston, MA
University of California, San Francisco
University of California, San Francisco
University of California, San Francisco, CA
DEGREE
(if applicable)
B.A. (High honors)
M.D. (Cum laude)
Postdoctoral
YEAR(s)
1991-94
1994-99
1999-2000
2003-04
2000-05
FIELD OF STUDY
Psychology
Neuroscience
General Surgery
Stem Cell Biology
Neurosurgery
A. Personal Statement
I am an Associate Professor of Neurosurgery and Oncology at the Johns Hopkins University School of Medicine. At Johns
Hopkins, I lead the Brain Tumor Stem Cell Laboratory at Johns Hopkins Neurosurgery Department. I study brain tumors from
an imaging, clinical and basic science perspective to improve patient safety and maximize the efficacy of current treatments for
brain tumors. I am an expert in brain cancer and have interests in preventing brain tumor cell migration. For this research
proposal, I will be mentoring Mr. Joshua Bakhsheshian (along with Dr. Andre Levchenko from Biomedical Engeneering
as a co-mentor), a 2nd year medical student, in identifying the cell responsible for tumor recurrence, and if these cells are
under the guidance EGF proteins. It is my goal for Joshua to reach the aims outlined in his research proposal and develop
the appropriate skills to become an independent physician-scientist who will be a leader in the field of Neuro-Oncology.
Positions and Honors
Positions and Employment
1993-94
Ford Baccalaureate Fellow and Honor’s Research Scholar, UC Berkeley.
1994-96
Predoctoral Fellow, Harvard Medical School, Department of Neurobiology
1997-99
Howard Hughes Fellow, Harvard Medical School
2003-04
Postdoctoral Fellow, Developmental and Stem Cell Biology, University of California, San Francisco,
2004-05
Chief Resident in Neurosurgery, University of California, San Francisco
2005Director of Neurosurgical Oncology, Johns Hopkins University School of Medicine, Bayview Hospital
2005-07
Assistant Professor of Neurosurgery and Oncology, Johns Hopkins University School of Medicine (JHUSOM)
and Sidney Kimmel Comprehensive Cancer Center (SKCCC)
2007Assistant Professor of Neuroscience and Cellular and Molecular Medicine, JHUSOM
2008Associate Professor, Neurosurgery, Oncology, Neuroscience, Cellular Molecular Medicine, JHU and SKCCC
2009Director Neurosurgical Pituitary Center, JHUSOM
Other Experience and Professional Memberships
1996●American Medical Association; ●Society for Neuroscience
1998●American Association for the Advancement of Science; ●Society for Experimental Biology and Medicine
2001●American Association of Neurological Surgeons (AANS); ●Congress of Neurological Surgeons (CNS)
2004●Editorial Board “Neurosurgery” Journal
2006●American College of Surgeons (ACS); ●American Association for Cancer Research (AACR); ●American Brain
Tumor Association (ABTA); ●American Society for Clinical Oncology (ASCO)
2008Editorial Board in the following Journals: ●Journal of Oncology; ●Annals of Surgical Oncology; ●World
Neurosurgery; ●World Journal of Stem Cells
Selected Honors
2004
●Alpha Omega Alpha; ●AANS Bittner Award for Research in Neurooncology; ●NIH F32 Grant Recipient.
2005
Topic Editors: Charles Liu & A Quiñones-Hinojosa “Stem Cell Opportunities in Neurosurgery”. Neurosurgical
Focus 2005 29:3; ●Harvard Medical School Harold Amos Invited Lecture;●UCSF Neurosurgery Naffziger Award;
PHS 398/2590 (Rev. 11/09)
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Principal Investigator/Program Director (Last, First, Middle):
2006
2007
2008
2009
2010
2011
Quiñones-Hinojosa, Alfredo
●AAMC Herbert Nickens Award; ●HSF Hall of Fame Induction. ●NIH Loan Repayment Program; ● NIH KO8
grant; ●ASCO Developmental Award: ●ACS Franklin Martin Faculty Award; ●Hopkins Passano Physician
Award; ●AANS Young Clinician Award. ●HHMI Physician Scientist Award
●Topic Editors: A Quiñones-Hinojosa & Nader Sanai. “Stem Cells in Neurosurgery” Neurosurgical Clin of
North America, Jan 2007; ● AANS Young Clinician Award; ●Robert Wood Johnson Foundation Award; ●Popular
Science Magazine Brilliant 10 Scientists Award; ●The Johns Hopkins Richard J. Otenasek, Teaching Award
●UC Davis Distinguished Dean’s Lecture; ●Alpha Omega Alpha Visiting Professor, Mount Sinai School of
Medicine; ●Merage Foundation National Leadership in Science and Medicine Award; ●Daily Record Health Care
Heroes Award; ●Olender Foundation American Hero Award ●Yale Medical School Commencement Speaker
●Honorary Professor at the University of the Americas, Quito, Ecuador
●Community Colleges Distinguished Alumni Award; ●Distinguished Speaker at University of Texas, PanAmerican; ●Key Note Speaker Texas Association of School Administrators
●Healthcare Heroes finalist ●American Association of Community Colleges Outstanding Alumni Award
●Ruth L. Kirschstein National Research Service Award Distinguished speaker ●Stevenson University
Convocation Keynote Speaker ● Nifty Fifty scientist at USA Science & Engineering Festival
● Martinez and Townsel Endowed Lecture at the Marine Biological Laboratory ●Honorary Doctor of Human
Letters and Commencement Speaker, Southern Vermont University
C. Selected Peer-reviewed Publications (Selected from 176 peer-reviewed publications)
Most relevant to the current application
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Tzeng SY, Guerrero-Cázares H, Martinez EE, Sunshine JC, Quiñones-Hinojosa A, Green JJ. Non-viral gene delivery
nanoparticles based on Poly(β-amino esters) for treatment of glioblastoma. Biomaterials. 2011 Apr 30.
Ying M, Wang S, Sang Y, Sun P, Lal B, Goodwin CR, Guerrero-Cazares H, Quinones-Hinojosa A, Laterra J, Xia S.
“Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition”. Oncogene. 2011 Mar 7.
Ying M, Sang Y, Li Y, Guerrero-Cazares H, Quinones-Hinojosa A, Vescovi AL, Eberhart CG, Xia S, Laterra J. “Kruppellike family of transcription factor 9, a differentiation-associated transcription factor, suppresses notch1 signaling and
inhibits glioblastoma-initiating stem cells.” Stem Cells. 2011 Jan;29(1):20-31.
Hughes SA, Achanta P, Ho AL, Duenas VJ, Quinones-Hinojosa A. Biological Horizons for targeting brain malignancy.
Advances in experimental medicine and biology 2010 Vol.671, Pages:93-104.
Shah A, Garzon-Muvdi T, Mahajan R, Duenas VJ, and A Quinones-Hinojosa, “Animal Models of Neurological
Disease”, Adv Exp Med Biol. 2010;671:23-40.
Garzón-Muvdi T, Quiñones-Hinojosa A. Neural stem cell niches and homing: recruitment and integration into
functional tissues. ILAR J. 2009;51(1):3-23.
Frazier JL, Johnson MW, Burger PC, Weingart JD, Quinones-Hinojosa A. Rapid malignant transformation of
low-grade astrocytomas; report of 2 cases and review of the literature. Surg. Neurol. 2009 Aug 6.
Chaichana, K., Guerrero-Cazares, H., Capilla-Gonzalez, V., Zamora-Berridi, G., Achanta, P., Gonzalez-Perez, O., Jallo,
G.I., Garcia-Verdugo, J.M., Quinones-Hinojosa, A. Intra-operatively obtained human tissue: Protocols and techniques for
the study of neural stem cells. Journal of Neuroscience Methods (2009).
Guerrero-Cázares H, Chaichana KL, Quiñones-Hinojosa A. Neurosphere culture and human organotypic model
to evaluate brain tumor stem cells. Methods Mol Biol. 2009;568:73-83. Zaidi HA, Kosztowski TA, QuinonesHinojosa A, “Origins and Clinical Implications of the Brain Tumor Stem Cell Hypothesis.” Journal of NeuroOncology, Spring 2009.
Kostowski TA, Zaidi HA, Quinones-Hinojosa A. “Applications of Neural and Mesenchymal Stem Cells in the
Treatment of Gliomas,” Expert Review of Anticancer Therapy, 2009.
N Sanai, AD Tramontin, A Quiñones-Hinojosa, NM Barbaro, N Gupta, S Kunwar, MT Lawton, MW McDermott,
AT Parsa, JM Garcia-Verdugo, MS Berger, A Alvarez-Buylla. “Unique astrocyte ribbon in adult human brain
contains neural stem cells but lacks chain migration”. Nature. 2004 Feb 19;427(6976):740-4.
Gonzalez-Perez O, Guerrero-Cazares H, Quiñones-Hinojosa A. “Targeting of deep brain structures with
microinjections for delivery of drugs, viral vectors, or cell transplants”. J Vis Exp. 2010 Dec 1;(46). pii: 2082. doi:
10.3791/2082.
Chaichana K, Kosztowski T, Niranjan A, Olivi A, Weingart J, Laterra J, Brem H, Quiñones-Hinojosa A. “Prognostic
Significance of Contrast-Enhancing Anaplastic Astrocytomas in Adults”. Journal of Neurosurgery, 2010.
PHS 398/2590 (Rev. 11/09)
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Principal Investigator/Program Director (Last, First, Middle):
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Quiñones-Hinojosa, Alfredo
Achanta P, Sedora NI, Roman BS, Quiñones-Hinojosa A. Gliomagenesis and the Use of Neural Stem Cells in
Brain Tumor Treatment. Anticancer Agents Med Chem. 2010 Feb 25.
Gonzalez-Perez O, Quiñones-Hinojosa A. Dose-dependent effect of EGF on migration and differentiation of adult
subventricular zone astrocytes. Glia. 2010 Feb 25.
D. Research Support
Ongoing Research Support
 Project Number: RO1 107999
Project Period: 6/1/10 – 5/31/15
P.I.: Alfredo Quinones-Hinojosa
Role on Project: Principal Investigator
Project Title: Role of NKCC1 on Brain Tumor Stem Cell Migration after EGF and Slit-2 Stimulation
Source: NIH/NINDS RO1
 Project Number: RO1 CA161210
Project Period: 7/1/11 – 6/31/16
P.I.: Jef Boeke
Role on Project: Co-Investigator
Project Title: Retrotransposon Instability in Glioblastoma Multiforme
Source: NIH/NCI RO1
 Project Number: 107017
Project Period: 7/1/09-6/30/12
P. I.: John Laterra and Alfredo Quinones-Hinojosa
Role on Project: Co-Principal Investigator
Project Title: The biology and therapeutic targeting of brain cancer stem cells
Source: The James S. McDonnell Foundation
 Project Number: TEDCO
Project Period: 7/01/10-6/30/12
P.I.: George Ricuarte
Role in Project: Co-Investigator
Project Title: Stem Cell Transplantation in Non-human Primates with Parkinsonism
Source: Maryland Stem Cells Research Fund (TEDCO)
 Project Number: NYSTEM
Project Period: 09/01/2010-08/31/13
P.I.: Steven Goldman
Role in Project: Co-Investigator
Project title: Atlas of gene expression by progenitor cells of the human brain and its tumors
Source: NYSTEM
 Project Number:
Project Period: 10/1/2008 to 12/30/2012
P.I.: Jay Pillai
Role in Project: Co-Investigator
Project title: Comparison of Utility of Different Functional MRI Language Paradigms for Effective Presurgical Mapping
of Eloquent Cortex
Source: Siemens
 Project Number: Chordoma Foundation
Project Period: 12/1/11-1/1/13
P.I.: Alfredo Quinones-Hinojosa
Role on Project: Principal Investigator
Project Title: Cancer Stem Cells in Chordoma: Implications for Tumorigenesis and Treatment
Source: The Chordoma Foundation
Partial List of Completed Research Support
1/1/08-1/1/12
RWJ 102690
P.I.: Alfredo Quinones-Hinojosa
Role on Project: Principal Investigator
Project Title: Neural and Cancer Stem Cells: Study of Migration and Transformation
Source: The Robert Wood Johnson Foundation/Harold Amos Medical Faculty Development Program
8/1/06-12/31/11
HHMI 905675
P.I.: Alfredo Quinones-Hinojosa
Role on Project: Principal Investigator
Project Title: Migration of Human Neural Stem Cells and their Transformation to Cancer Stem Cells
PHS 398/2590 (Rev. 11/09)
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Principal Investigator/Program Director (Last, First, Middle):
Quiñones-Hinojosa, Alfredo
Source: Howard Hughes Medical Institute Physician-Scientist Award
7/1/06-6/30/11
1K08NS055851
P.I.: Alfredo Quinones-Hinojosa
Role on Project: Principal Investigator
Project Title: Migration of Human Neural Stem Cells In Vitro and In Vivo
Source: NIH/NINDS
6/1/08-5/31/11
Maryland Stem Cell Technology Development Corporation 104544
P. I.: John Laterra and Alfredo Quinones-Hinojosa
Role on Project: Co-Principal Investigator
Project Title: Molecular Mechanisms of Tumor-Propagation by Human Glioblastoma Stem Cells
6/30/08-6/29/11
Maryland Stem Cell Technology Development Corporation 104268
P.I.: Alfredo Quinones-Hinojosa
Role on project: Principal Investigator
Project Title: Characterization of Anti-Glioma Response and Migratory Patterns of IL-12 Secreting Human Mesenchymal Stem
Cells
6/01/09 – 5/31/11
Maryland Stem Cell Technology Development Corporation 106743
P.I.: Tomas Garzon-Muvdi
Role on Project: Co-Principal Investigator
Project Title: Role of the Interaction between Cation-Chloride cotransporters and EGF and PDGF in Migration of Brain Tumor
Stem Cells
6/01/2009-6/31/2011 Maryland Stem Cell Technology Development Corporation 106916
P.I.: Ahmed Moyheldin
Role on Project: Co-Principal Investigator
Project Title: The effects of hypoxic adaptation and signaling on cancer stem cell growth and invasion
7/01/09-6/30/11
Maryland Stem Cell Technology Development Corporation 106273
P.I.: Mihoko Kai and Alfredo Quinones-Hinojosa
Role on Project: Co-Principal Investigator
Project Title: DNA Damage Response in Glioblastoma Stem Cells
7/01/08 - 6/30/10
Maryland Stem Cell Technology Development Corporation
Quinones-Hinojosa (Co-P.I.)
Migration of Human Brain Tumor Stem Cells in Response to Slit Proteins
6/30/08 - 6/29/10
Maryland Stem Cell Technology Development Corporation
P. I.: Andre Levchenko
Quinones-Hinojosa (Co-P.I.)
Control of Human Neural Stem Cell Survival, Proliferation and Differentiation Using Novel Micro and Nano Fluidic Platforms
7/1/06-6/30/09
American Society of Clinical Oncology (ASCO) Foundation Award
Quinones-Hinojosa (P.I.)
Migration of Human Neural Stem Cells In Vitro and In Vivo
7/1/06-6/30/09
Children’s Cancer Foundation
Quinones-Hinojosa (P.I.)
Isolation, Characterization, Migration, and Transformation to Cancer Stem Cells of Human Pediatric Subventricular Zone
Neural Stem Cells
4/1/06-3/31/09
Brain Tumor Founder Collaborative
Quinones-Hinojosa (Co-P.I.)
Tumor Stem Cell-Based Drug Discovery for Adult and Pediatric Glioma
PHS 398/2590 (Rev. 11/09)
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