Correlation between Biotechnology and its Effects on Society Biology Partnership Identifying Information: (Group Members and Schools, Title of Lesson, Length in Minutes, Course Level) David Woods, Janece Campbell, Travis Moore; Correlation between biotechnology and its effects on society; 52 minute class period; Biology I Motivation: 1. Teacher will show a video on Huntington’s disease involving karyotyping and genetics 2. Bell Ringer Question: Would you marry or have a child with someone that could or you knew had undesirable traits within their genetic code. 3. Students will answer the following questions to determine a diagnostic I. Students will be asked if they think they should be karyotyped before they are allowed to apply for a marriage certificate. II. Construct a punnet square with parents having the code Hh and hh. III. Based on your punnet square constructed, what is the percentage chance of the child getting Huntington’s disease? IV. Analyze the question above and identify the odds of the child not inheriting Huntington’s disease. Needed Materials & Set-Up: Video shown from youtube.com: https://www.youtube.com/watch?v=JzAPh2v-SCQ Disease Huntington’s DNA Paternity Testing Simulation 114, $75.00 http://www.edvotek.com/114 Follow instructions according to the DNA Paternity Testing Simulation 114 Student Practice Sheet “Probability of Genetics Disease”; See attached sheet Student Note Taking sheet “Keys to Genes”; See attached sheet Class is broken down into groups of 4 Page 1 of 5 Correlation between Biotechnology and its Effects on Society Biology Partnership Outcomes Dimensions of K-12 Science Education Standards: Scientific and engineering practices: 3: Obtaining, evaluating, and communicating information. Crosscutting concepts: 1: Patterns, 7:Stability and change Disciplinary Core ideas: ETS2: Links among engineering, technology, science, and society Next Generation Sunshine State Standards: SC.912.L.16.1: Use Mendel’s laws of segregation and independent assortment to analyze patterns of inheritance. SC.912.L.16.10: Evaluate the impact of biotechnology on the individual, society and the environment, including medical and ethical issues. Content Literacy Standards: Writing Standards: Write informative/explanatory texts to examine and convey complex ideas, concepts, and information clearly and accurately through the effective selection, organization, and analysis of content. Specific Learning Outcomes: Page 2 of 5 Correlation between Biotechnology and its Effects on Society Biology Partnership Students will be able to accurately identify patterns of inheritance in 80% of punnet squares using the given alleles. Students will be able to correctly determine the percent of children inheriting a genetic disorder/disease from 80% of the punnet squares Presentation and Participation: Behavior: Lecture Assign genetic samples to each group of students Answer Questions on Bell Ringer Class discussion. Cognitive: Demonstration Teacher will run gel electrophoresis on sample parent and child dna and compare it against a baseline. Behavior: lecture (continue) Lead class discussion in review over: Dominate/ recessive traits path of inheritance Punnet squares and Pedigree lines Review Vocab: Genotype: what is expressed in the alleles/ an organism’s allele pairs? Example Hh Phenotype: observable characteristic that is expressed as a result of an allele pair. (What you see or what disorder they inherit. Pedigree royal Families recessive sex linked Hemophilia “explain” Applied Genetics chapter in book Link applied genetics back to the opening bell ringer By asking the question would knowing peoples genetic make-up before having children with them be a form of selective breeding Discussion in inbreeding Are there any pro/ cons of selective breeding? What I any moral implications might there be? Explain gel-electrophoresis/ check the tank and see how it is going Cognitive: Summarizing and note taking Page 3 of 5 Correlation between Biotechnology and its Effects on Society Biology Partnership Students will be provided a structured note taking sheet to put key terms and ideas in. Application/Process: Debate Students will be asked to construct a debate about whether they think they should do DNA testing on their children while they are in the womb. Other: Practice Students will practice the punnet squares for possible percentage outcome of dominant and recessive traits. Questions: (3 higher order—analysis, synthesis, evaluation) 1. Based on the information provided in class, would you still marry/ have children with someone has undesirable traits in their genetic code. 2. Construct a punnet square with parents having the code Hh and hh. 3. Based on your punnet square constructed, what is the percentage chance of the child getting Huntington’s disease? 4. Analyze the question above and identify the odds of the child not inheriting Huntington’s disease. 5. Based on the laboratory experiment run in the class, which is the Dad of the child? Reflection: Students will answer questions on selective breeding worksheet and will be graded and returned the next day. Answer key for Questions: 1. Answers will vary h h H Hh Hh h hh hh 2. Child has a 50% change of getting Huntington’s 3. The child has a high probability of getting Huntington’s based on the percentage 4. Parent 2 Safety: Students have been reviewed safety procedures prior to coming to class the day before. Teacher will give a quick demonstration during demonstration activity on possible safety problems. Teacher needs to be aware of all possible electrical safety concerns and keep care. Make sure students are aware that Page 4 of 5 Correlation between Biotechnology and its Effects on Society Biology Partnership teacher is running the lab and shouldn’t crowd lab. Safety reminders will be given when the students first walk in to lab. The students could bump into each as they move around the classroom. The students could get cut if they break a test tube. It is possible that some of the students could be allergic to the agar. Teacher should warn students of possible staining of clothing with blue dye Transformative: (Accommodations for at least 2 special needs students) There is 1 ESE student in the class having learning disabilities, he will be provided a longer time to complete the Selective breeding worksheet. Any students with ESOL will be provided the worksheet in digital form to translate to their native language. Students with hearing and visual disabilities will be provided digital forms of the lesson to read to them as well as show bigger print. Utilize: Students will possibly need re-teaching on pedigree examples. If it is unclear how DNA traits match with a parent and child, a reteach example will be given as a motivation tool in the next lesson. If more than 10% of students fail to correctly complete the punnet square, I will reteach this concept by providing another sample of a genetic disorder. Page 5 of 5