SYLLABUS
Pathomorphology
Pathology is a science which combines the basis fields of medicine and clinical medicine. Pathology is
a study of causes, mechanisms, course and consequences of the disease. The pathology is classically
divided into general and organ pathology. Proper clinical diagnosis is based on clear understanding
etiology, pathogenesis, morphological and functional changes in specific diseases processes.
The pathology course includes lectures, and tutorials. During tutorials and lectures cell injury and cell
death, inflammations, hemodynamic disorders, neoplasms, genetic and environmental diseases will
be discussed first. Next the changes of diseases in particular systems will be discussed. Each of the
pathology issues will be illustrated by guided and self-performed microscopic slides studies. After 4
week pathology course students are obligated to pass written test exam to obtain a credit for whole
pathology course.
Teachers:
Prof. Andrzej Marszałek MD, PhD
Łukasz Szylberg MD, PhD
Joanna Maciejewska MD
Natalia Skoczylas-Makowska MD
Contact:
- natalia.makowska@vp.pl
- asia_bielsk@wp.pl
- l.szylberg@cm.umk.pl
- magdaw@cm.umk.pl
I.
Department of Clinical Pathomorphology Collegium Medicum Nicolaus Copernicus
University, Skłodowskiej-Curie 9, 85-094 Bydgoszcz
II.
Head of the unit: Prof. Andrzej Marszałek MD, PhD
III.
Faculty of Medicine, Medical Program, 3rd year
IV.
Course coordinator: Natalia Skoczylas-Makowska, MD
V.
Form of classes: lectures, tutorials
VI.
Form of crediting: Exam, 13 ECTS points
VII.
Number of hours: Lectures – 64 hours, Tutorials – 96 hours
VIII.
Aim of the course
After completing the pathology course student has to know causes, pathomechanisms, clinical course
and consequences of the disease and understand morphological and functional changes in specific
diseases processes.
IX. Topics of tutorials (THE SCHEDULE FROM PATHOMORPHOLOGY INCLUDING A LIST OF SLIDES)
X. Topics of lectures
IX. THE SCHEDULE FROM PATHOMORPHOLOGY INCLUDING A LIST OF SLIDES.
I WEEK
1. Monday: Introduce to pathology + autopsy
Łukasz Szylberg MD, PhD
Topics:









Legal issue related to autopsy and to the pathologist.
Rules of writing a pathological diagnosis.
Audiovisual presentation of autopsy techniques
Autopsy demonstration with discussion of autopsy techiques.
Signs of death.
Autopsy techniques for haed, neck, chest, abdominal and pelvis examination.
Autopsy in special cases – e.g. emphysema, embolisms, poisoning etc.
Practical performed by students.
Neonatal autopsy techniques
2. Tusday:
a) Adaptive changes. Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Atrophy, hyperplasia, hypertrophy, metaplasia – definition, division, causes, examples
 Dystrophic and metastatic calcification
 Fatty change and cellular swelling
 Necrosis – definition, types, morphology
Topics of tutorials:
 Adaptive changes
 Intracellular accumulations
 Pathologic calcification
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
Brown atrophy of the heart
atrophia fusca myocardii
Cardiac muscle hypertrophy
(hypertrophia musculi cordis)
Endometrial hyperplasia
(hyperplasia glandularis endometrii)
Vacuolar degeneration (hydropic change) of hepatocytes
(degeneratio parenchymatosa hepatis)
Epidermal hyperkaratosis
(hyperkeratosis epidermis)
Corpus albicans ovarii
Liquefactive necrosis (brain encephalomalacia)
(necrosis colliquativa; na przykładzie rozmiękania mózgu
[encephalomalatio cerebri])
Coagulative necrosis (liver and lung tuberculosis)
(necrosis coagulativa; na przykładzie: gruźlicy płuc i wątroby
[tuberculosis pulmonum et hepatis])
146
138,150
085, 085a,
085c, 085d
134
135
143
152
026
b) Hemodynamic disorders. Łukasz Szylberg, MD, PhD
Topics to prapare:
 Pulmonary thrombosis
 Infarction pale and red
 Hyperemia passive
Topics of tutorials:
 Edema
 Hyperemia
 Embolism
 Thrombosis
 Hemmorhage
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
9.
Hemorrhagic cerebral infarction
(focus haemorrhagicum cerebri)
Hemosiderosis whitish ovarian body
(haemosisderosis corporis albicantis ovarii)
Passive congestion of liver
(hyperaemia passiva hepatis)
Chronic venous stasis in the lungs
(venostasis chronica pulmonum)
Pale infarction of kidney
(infarctus pallidus renis)
Hemorrhagic intestinal infartion
(infarctus haemorrhagicus intestini)
Adhering thrombus
(thrombosis parietalis)
Recanalization of thrombus
(thrombosis recanalisatus)
Pulmonary edema
127, 133
154 + żelazo
155
153, 157
059
160
097, 193
233
062/256
3. Wensday: Chronic and acute inflammation. Joanna Maciejewska, MD
Topics to prapare:
 Definition of acute and chronic inflammation
 Characteristics of cells and processes with their participation in acute and chronic
inflammation.
 Outcome of acute inflammation
 systemic and local symptoms of acute inflammation
 Granulomatous inflammation - definition
 Types of granulomas
Topics of tutorials:
 Morphology of inflammation
 Vascular changes in acute inflammation
 Lymphatic vessels and lymph nodes in acute inflammation
 Pathogenesis, morphology and clinical changes in syphilis and tuberculosis
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
Lymphnode sinus histiocytosis
(histiocytosis lymphonoduli)
Nonspecyfic lymphadenitis
Lymphonodulitis reactiva
Fibrinoid necrosis on the example of chronic peptic ulcer
(degeneratio fibrinoidea; na przykładzie przewlekłego wrzodu
trawiennego żołądka [ulcus chronicum pepticum ventriculi])
Lung abscess
(abscessus pulmonis)
Serum acute appendicitis, appendicitis with lymphoid follicles
hyperplasia, suppurative appendicitis, gangrenous appendicitis
(appendicitis; [acuta serosa] [follicularis], [purulenta],
[phlegmonosa], [gangrenosa],[obliterativa])
meningitis purulenta
Miliary tuberculosis of lung
(tuberculosis miliaris pulmonis)
Adrenal tuberculosis
(tuberculosis glandulae suprarenalis)
Tuberculous meningitis
(meningitis tuberculosa)
Lymph node sarcoidosis
(sarcoidosis lymphonoduli)
Leprosy
(lepra)
Inflammatory granulation tissue, foreign body reaction
(granulatio, granuloma)
188
Scarring after myocardial infarction
Cicatrisatio post infarctum myocardii)
069
226
144
034
262, 027,
266, 268
167
025
151
102
111
229
4. Thursday: Diseases of immunity. Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Organ changes in systemic lupus erythematosus, rheumatoid arthritis, amyloidosis.
 Polyarteritis nodosa
Topics of tutorials:
 Systemic lupus erythematosus
 Scleroderma
 Rheumatoid arthritis
 Inflammatory myopathies
 Sjogren syndrome
 Vasculitides
Slides:
1.
2.
3.
4.
5.
6.
7.
Renal amyloidosis
(amyloidosis renis)
Rheumatoid nodule
(nodulus rheumathoideus)
Rheumatoid arthritis
(ang. rheumatoid artritis)
Periarteritis nodosa
(polyarteritis nodosa)
Sclerodermia
(scleroderma localisata)
Lupus erythematosus – renal changes
(lupus erythematosus)
Helictotrichon
(oxyuriasis)
077 +
amyloid
174
082
124
173, 196
Włókna
sprężyste
033, PAS
276
5. Friday: Neoplasms. Joanna Maciejewska, MD
Topics to prapare:
 Morphological and clinical characteristic of benign and malignant neoplasms.
 Precancerous lesions.
 Metaplasia.Dysplasia.
 Carcinoma in situ.
 Microinvasion and early cancer.
 Pareneoplastic syndromes and kachexia
 Grading i stading.
 Tumor markers.
Topics of tutorials:
 Abnormal differentiation and maturation of tissues.
 Intraepithelial neoplasia.
 Benign epithelial neoplasms
 Malignant and locally malignant tumors.
 Epidemiology and diagnostic of neoplasms.
 Clinical features of neoplasms.
Slides:
1.
2.
3.
4.
5.
6.
Epidermal actinic keratoses
(keratosis senilis)
Lichen sclerosus; (kraurosis)
Benign mammary dysplasia
(mastopathia fibroso-cystica; dysplasia benigna mammae)
Seborrheic skin whart
(verruca seborrhoica)
Eversion in the cylindrical epithelium of the vaginal cervix,
glandular erosion of the vaginal cervix
(ectropion)
Neoplasia intraepithelialis cervicalis CINI/ LSIL
(neoplasia intraepithelialis cervicalis; ang. CIN – cervical
intraepithelial neoplasia) CIN I/ LSIL
177
168
050, 179
243
237
178
7.
Neoplasia intraepithelialis cervicalis CIN III/HSIL
176
8.
Bowen’diseases
(morbus Boweni)
Basal cell carcinoma of the skin
(carcinoma basocellulare cutis)
Squamous cell carcionoma of the skin
(carcinoma planoepitheliale/ carcinoma sinocellulare cutis)
Urothelial carcinoma of the bladder
(carcinoma urotheliale)
Colorectal adenocarcinoma
(adenocarcinoma coli)
Lipoma
(lipoma)
Liposarcoma
(liposarcoma)
Astrocytoma
(astrocytoma)
Glioblastoma multiforme
(glioblastoma multiforme)
Sarcoma synoviale – lung metastasis
(sarcoma synoviale)
166
9.
10.
11.
12.
13.
14.
15.
16.
17.
II WEEK
1. Monday : Pathology of the gastrointestinal tract. Łukasz Szylberg.MD, PhD
Topics to prapare:
 Gastritis.
 Peptic chronic ulcer.
 Colon cancer – morphologic and clinical features
Topics of tutorials:
 Congenital anomalies of gastrointestinal tract
 Esophagitis and tumors of esophagus
 Inflammation of gastrointestinal tract
 Peptic ulcer disease
 Neoplasms of stomach
 Intestinal vascular disease
 Diverticular disease
 Intestinal obstruction
 Tumors of the large and small intestine
110
022
186
279
195
049
053, 244
204, 260
214
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Ulcerative colitis
(colitis ulcerosa)
Crohn disease
(morbus Lesniowski-Crohn; także: ileitis terminali, ang: Crohn
disease)
Celiac disease
(celiakia)
Adenomatous polyp of the sigmoid colon
(polypus adenomatosus)
Gastric adenocarcionoma
(adenocarcinoma ventriculi)
Mucous degeneration on the example of mucinous
adenocarcionoma
Carcinoid of the appendix
(carcinoidum appendicis)
Colorectal leyomyosarcoma
(leyomyosarcoma coli)
Hemorrhagic intestinal infarction
(infractus haemorrhagicus intestini)
Barret esophagus
003, 008
228
165
042
041
068 + śluz
270
006
160
283
2. Tusday: Pathology of the liver, bile ducts and pancreas. Łukasz Szylberg, MD, PhD
Topics to prapare:
 Patterns of hepatic injury
 Acute and chronic viral hepatitis
 Drug and toxin-induced liver disease.
 Cirrhosis.
 Hemochromatosis
 Primary sclerosing choalngitis
 Circulatory disorders
 Malignant tumors of liver
 Cholelithiasis
 Acute pancreatitis
Topics of tutorials:
 Infectieous disorders
 Autoimmune hapatitis
 Alcoholic liver disease.
 Insufficiency of liver.
 Impaired blood flow into and through the liver.
 Metabolic liver diseases
 Cholestasis and disorders of the intrahepatic bile ducts
 Nodules and tumors of liver
 Fine and core needle biopsy
 Cholecystitis
 Tumors of the gallbladder
 Pancreatitis
 Neoplasms of pancreas
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
Intrahepatic cholestasis
(stasis bilis intrahepatica)
Viral hepatitis
(hepatitis viralis)
Alcoholic cirrhosis
(cirrhosis hepatis alcoholica)
Postinflammatory cirrhosis
(cirrhosis hepatis postinfectiosa)
Centrilobular necrosis
(necrosis centrolobularis hepatis)
Liver cancer
(carcinoma hepatocellulare)
Cholecystitis
(cholecystits)
Gallbladder cancer infiltrating the liver
148
227
105,
Masson,
vanGiesson
162
070
277
280
269
3 Wensday.: Pathology of the respiratory tract part I. Joanna Maciejewska, MD
Topics to prapare:
 Pneumonia – morphology and clinical features
 Pulmonary vascular diseases
 Chronic obturative disorders of lung.
 Pathology changes in pleura
Topics of tutorials:
 Etiology, pathogenesis, division and morphology mouth, throat, nose and trachea mucosa
inflammations
 Bronchiectases
 Pneumonia – etiology, pathogenesis, morphology
 Pneumoconioses
 Obturative and restrictive disease of lung
 Cor pulmonale
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
Pulmonary artery embolism
(embolia thrombotica ramorum arteriae pulmonalis)
Hemorrhagic lung infarction
(infarctus haemorrhagicus pulmonis)
Lobar pneumonia
(pneumonia lobaris)
Bronchopneumonia
(bronchopneumonia)
Chronic bronchitis
(bronchitis chronica)
Fungal pulmonary infection
(pneumonia mycotica)
Mixed salivary gland tumor
(tumor mixtus; edenoma pleomorphum)
Pnemoconioses
(pneumoconioses)
156
060
198
067, 058
076
115
031
272
4. Thursday: Pathology of the respiratory tract part II. Joanna Maciejewska, MD
Topics to prapare:
 Lung cancer
 Cancer of larynx
 Malignant tumors of the salivary glands
 Nosopharyngeal cancer
Topics of tutorials:
 Precancerous lesions and neoplasms of respiratory tract (including nasal cavity, larynx,
trachea, bronchus, pleura)
Slides:
1.
2.
3.
4.
5.
Squamous cell lung cancer
(carcinoma planoepitheliale pulmonis)
Lung adenocarcinoma
(adenocarcinoma pulmonis)
Lung small cell carcionoma
(carcinoma microcellulare pulmonis)
Laryngeal squamous cell carcinoma
(carcinoma planoepitheliale laryngis)
Bronchial carcinoid and carcinoid of the appendix.
(carcinoidum bronchit et appendicis) (barw.chromograniną A)
5 Friday.: Childhood and infancy diseases. Łukasz Szylberg, MD
Topics to prapare:
 Neonatal respiratory distress syndrome
 Fetal hydrops
 Necrotizing enterocolitis
 Wilms tumor
 Neuroblastoma
 Rethinoblastoma
 Rhabdomyosarcoma
Topics of tutorials:
 Congenital anomalies
 Respiratory distress syndrome
 Tumors of infancy and childhood
 Prasotic infections
245
046
040
210
090, 249
Slides:
1.
2.
3.
4.
5.
6.
7.
!! TEST
Testicular hypoplasia
(hypoplasia testis)
Neonatal respriratory distress syndrome
(membranae hyalinae pulmonum)
Trichinosis
(trichinellosis)
Echonococcosis
(echinococcosis cystica pulmonum)
Cerebral toxoplasmosis
toxoplasmosis cerebri)
Craniopharyngioma
(craniopharyngeoma)
Retinoblastoma
(retinoblastoma)
(exercises 1-10 and lectures 1,2)
145
159
164
106
139, PAS
208
202
III WEEK
1. Monday : Pathology of heart and vascular diseases Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Morphology of infarction
 Hypertensive heart disease
 Bacterial endocarditis
Topics of tutorials:
 Atherosclerosis
 Aneurysms and varicoses
 Ischemic heart disease
 Myocardial infarction
 Right sided heart failure
 Endocarditis
Slides
1.
Arteriosclerosis
(arterioclerosis centralis)
2.
Arteriosclerosis of renal arteries
(renes arteriosclerotici)
3.
Myocardial infarction
(infractus myocardii)
4.
Myocardial scarring
(cicatrisatio postinfractosa myocardii)
5.
Heart valve endocarditis
(endocarditis valvularis)
6.
Fibrinous pericarditis
(pericarditis fibrinoidea)
7.
Acute myocarditis
(myocarditis acuta)
8.
Hemorrhoids
(varices haemorrhoidales ani)
9.
Hemangioma
(haemangioma)
128, 131,
132
212 +PAS
255
069
216
096
163, 250
251
099
2. Tusday : Pathology of the urinary tract. Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Nephritic syndrome
 Acute and chronić pyelonephritis
 Vascular lesions in benign and malignant hypertension
 Urolithiasis
 Hydronephrosis
 Renal cel carcinoma
 Urothelial carcinoma of bladder
Topics of tutorials:
 Nephritic syndrome and associated glomerulonephritis
 Tubulointestinal nephritis induced by grugs and toxins
 Nefropatia poanalgetyczna.
 Acute tubular necrosis
 Diseases of blood vessels
 Cystic diseases of kidney
 Tumors of the kidney and urinary tract
Slides:
1.
2.
3.
4.
5.
6.
7.
Changes in diebetic kidney
(degeneratio glycogenica renum)
glomerulosclerosis intercapillaris
Glomerular sclerosis
(glomerulonephritis sclerosans)
Pyelonephritis
(pyelonephritis)
Renal cell carcinoma
(carcinoma clarocellulare renis)
Urothelial carcinoma of the bladder
(carcinoma urotheliale)
Kidney transplant – rejection
(ang. Kidney rejection)
092,
glikogen
030, PAS
169, PAS
199, PAS
002, 247,
PAS
186
273, PAS
3. Wensday: Hemopathology. Joanna Maciejewska, MD
Topics to prapare:
 Reactive lymphadenitis
 Definition of lymphoma and leukemia
 Clinical manifestations of proliferative diseases of the lymphatic system
 Hodgkin lymphoma – definition, types, morphology, clinical manifestation
Topics of tutorials:
 Non-neoplastic diseases of lymphatic system
 Hematological malignances – leukemias and lymphomas
 Neoplasms of histiocytes
Slides:
1.
2.
acute myelogenous leukemia; AML
Lymphoma
063
180,183
3.
4.
5.
6.
7.
8.
(lymphoma malignum)
Hodgkin lymphoma, lymphocyte depletion type
Hodgkin lymphoma, mixed cellularity type
Hodgkin lymphoma, nodular sclerosis type
Multiple myeloma
(myeloma multiplex)
Solitary myeloma- rib tumor
(plasmocytoma; plasma cel myeloma)
Disseminated Intravascular Coagulation DIC
(microangipatia thrombotica, ang. DIC)
220
089
007
055
231
211
4 Thursday.: Pathology of the endocrine system. Łukasz Szylberg, MD
Topics to prapare:
 Graves diseases
 Hashimoto thyroiditis
 Neoplasms of the thyroid
 Pheochromocytoma
 Neuroblastoma
Topics of tutorials:
 Morphological causes of hypothalamic-pituitary axis failure
 Morphological causes of failure of anterior and posterior lobe of the pituitary gland
 Nowotwory przedniego płata przysadki mózgowej
 Tumors of the anterior pituitary gland
 Parathyroid glands – hyperparathyroidism and hypoparathyroidism
 Thyroiditis
 Benign and malignant tumors of thyroid
 Acute and chronić adrenal insufficiency
 Adrenocortical neoplasms
 Neoplasms of adrenal medulla
 Morfologiczne przyczyny niewydolności części endokrynnej trzustki
 Diabetes - pathogenesis and morphology
 Pancreatic endocrine neoplasms
 Multiple endocrine neoplasia syndromes
Slides:
1.
2.
3.
4.
5.
6.
7.
Diffuse toxic goiter
(degeneratio colloidea glandulae thyreoideae)
Lymphocytic thyroiditis
(thyreoiditis lymphocytaria)
Invasive thyroiditis with fibrosis
(struma Riedl)
Thyroid adenoma
(adenoma glandulae thyroideae)
Papillary carcinoma of thyroid gland
(carcinoma papillare glandulae thyroideae)
Follicular carcinoma of thyroid gland
(carcinoma folliculare glandulae thyroideae)
Parathyroid carcinoma
141
175
189
021
035
274
281
(carcinoma glandulae parathyroideae)
5. Friday: Pathology of the female reproductive system, part I Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Cervical neoplasia
 Risk factors in cervical carcinoma and carcinoma of the endometrium
 Carcinoma of the endometrium – pathogenesis, morphology and clinical aspects
 Leiomyomas of uterus
Topics of tutorials:
 Neoplasms and inflammations of cervix
 Neoplasms and inflammations of uterus
 Endometriosis
 Dysfunctional endometrial bleeding
Slides:
1.
2.
3.
Invasive cervical cancer
(carcinoma colli uteri)
Uterine adenocarcionoma
(adenocarcinoma endometrii)
Purulent salpingitis
(salipingitis purulenta)
101
010
038
IV WEEK
1. Monday: Pathology of the female reproductive system part II. Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Tumors of ovary epithelium
Topics of tutorials:
 Inflammations and neoplasms of ovaries
 Inflammation and neoplasms of fallopian tube
Slides:
1.
2.
3.
Simple ovary cyst
(cystis simplex ovarii)
Ovary cystadenoma
(cystadenocarcinoma ovarii)
Ovary cystadenocarcinoma
(cystadenoma ovarii)
2 Tusday.:
a) Pathology of the breast Łukasz Szylberg, MD, PhD
Topics to prapare:
 Fibroadenoma – morphology and clinical featurs
 Phyllodes tumor - morphology and clinical featurs
142
019
181
 Histioklinika brodawczaka wewnątrzprzewodowego
 Breast cancer - morphology and clinical featurs
Topics of tutorials:
 Inflammation of the breast
 Fibrocystic changes and prolifarative disease of breast
 Benign neoplasms of breast
 Malignant neoplasms in situ and infiltrate
 Stromal tunors
Slides:
1.
2.
3.
Infiltrating ductal carcinoma of the breast
(carcinoma ductale invasivum mammae)
Mucinous carcinoma
(carcinoma gelatinosum mammae)
Intraductal papilloma of the breast
(papilloma intraductale mammae)
048
219, śluz
224
b) Pathology of the skin. Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Basal cel carcinoma and squamous cel carcinoma of the skin – morphology and clinical
features
 Melanocytic nevus
 Melanoma – morphology, pathogenesis and clinial characteristic
Topics of tutorials:
 Neoplasms and tumor-like conditions of the skin
Slides:
1.
2.
Pigmented nevus
(nevus pigmentosus)
Melanoma malignum
(melanoma malignum)
109
122, 057,
242
melanina
3 Wensday.: Pathology of the male genital system. Natalia Skoczylas-Makowska, MD
Topics to prapare:
 Neoplasms of testis – morphology and clinical features
 Prostate – adenocarcinoma and hyperplasia
Topics of tutorials:
 Congenital anomalies and tumors of penis
 Congenital anomalies, vascular disturbances and tumors of testis
 Tumors of prostatę and prostatic benign enlargement
Slides:
1.
2.
3.
4.
Embryonal carcinoma of testis
(carcinoma embrionalne testis)
Seminoma (seminoma)
(seminoma)
Benign prostatic hyperplasia
(hyperplasia nodularis prostatae)
Prostate cancer
(carcinoma prostatae)
051, 230
271
264
282
4. Thursday: Central nervous system Joanna Maciejewska, MD
Topics to prapare:
 Bacterial meningitidis – causes, morphology
 Cerebral infarction
 Glial neoplasms of CNS
Topics of tutorials:
 Trauma of central nervous system
 Edema and hernation
 Cerebrovascular diseases
 Infections
Slides:
1.
2.
3.
4.
5.
6.
7.
8.
Neurilemmoma, Schwannoma
(neurilemmoma; Schwannoma)
Malignant epipheral nerve sheat tumor
184
Oligodenroglioma
(oligodenroglioma)
Ependymomoma
(ependymoma)
Ganglion cells tumor
(ganglioneurocytoma)
209
Meningioma
(meningeoma)
meningeoma malignum
Medulloblastoma
(medulloblastoma)
5. Friday: Classes in the laboratory. Sections.
!! TEST (exercises 11-20 and lectures 3,4)
045
206
235,
Masson,
vanGiesson
246
074
207
Practical skill chart in Pathology
Year of study ……… group ……….
Academic year …………………….
After graduation Pathomorphology course student should:
Type of practical skills
Know the pathological terms and the knowledge of the
basic mechanism of cell and tissue damage
Describe the processes of regeneration of tissues and
organs
Recognize the pathological images of diseases of the
immune system, genetic diseases, infectious and
environmental disorders
Define the clinical course of specific and nonspecific
inflammation
Know the etiology of hemodynamic, progressive and
regressive changes,
Recognize the pathological images of diseases of the
immune system, genetic diseases, infectious and
environmental disosders
Recognize the pathological images of childhood
diseases
Know the issues of specific organ pathology, images of
macro-and microscopic, and clinical course of
pathological changes in various organs
Replace and pathogens internal and external,
modifiable and unmodifiable
Replace the clinical forms of the most common
diseases of particular organs and systems, metabolic
diseases and disorders of water-electrolyte and acidbase
Be able to link images of tissue and organ damage with
symptoms of the diseases, a history and results of
laboratory determinations and to describe the
consequences of developing lesions to adjacent organs
topographically
Analyze the phenomenon of reactive, defensive and
adaptive control and disturbance caused by an
etiological factor
date
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Comments
Lectures:
1. Introduction to pathology. Pathology as a basis for therapeutic decisions. Apoptosis.
Processes of cel aging.
2. Basics of immunopathology. Amyloidosis. Sarcoidosis.
3. Molecular basis of carcinogenesis and correlation with morphological image. Morphological
features of tumor-host reaction.
4. Morphological characteristics: thromboembolic disease, shock, and disseminated
intravascular coagulation syndrome (DIC). Haemorrhagic diathesis. Anemia.
5. Pathology of genetically determined diseases.
6. Pathology of environmental diseases.
7. Pathology of infectious diseases (with discussion about hepatitis)
8. Pathology of heart and vascular part 1 (congenital heart disease, pericarditis, myocarditis,
etiopathogenesis of atherosclerosis)
9. Pathology of the heart and blood vessels part 2 (vasculitis, neoplasms of the heart and blood
vessels).
10. Pathology of interstitial lung diseases. Atypical pneumonia.
11. Pathology of oral cavity and esophagous
12. pathology of the upper respiratory tract. Tumors of salivary gland and larynx.
13. Non-neoplastic diseases of the lymphatic system. Pathology of the spleen and thymus.
Classification system of proliferative diseases.
14. Test includes lectures 4-14
15. Idiopathic inflammatory bowel disease.
16. Pathology of glomerulonephritis - general issues.
17. Pathology of the vulva and vagina. Non-neoplastic gynecological pathology.
18. Pathology of pregnancy and placenta. Pathology of the fetus and newborn.
19. Pathology of the genitourinary system (malformations, inflammation, and cancer of penis).
Pathology of sexually transmitted diseases.
20. The pathology of selected diseases of the breast (inflammatory, proliferative lesions of the
breast, selected aspects of the molecular basis of breast cancer and their significance).
21. Pathology in daily practice - clinical cases.
22. Pathogenesis and histopathology of diabetes.
23. Pathology of endocrine system. Neuroendocrine tumors.
24. pathology of inflammatory skin diseases. Bullous skin disorders.
25. Pathology non-neoplastic diseases of the muscles, joints, and bones.
26. Aspects of soft tissue pathology
27. Malformations of the central nervous system.
28. The pathology of selected diseases of the nervous system (CNS viral infections, spongiform
encephalopathies, primary myelin diseases and neurodegenerative diseases).
29. Pathology in daily practice - clinical cases.
30. Test includes lectures 16-30