Summary Points S1 What was already known - Tablet computers are becoming more and more popular for a variety of clinical or clinical related tasks. - Tablet computers will likely be used by a majority of American physicians in the near future. - Touchscreen operated mobile devices potentially facilitate the distribution of pathogens. - Disinfection of these devices with a leaky, non-protected case does not seem to be straightforward. 1 What this study has added - Tablet computers get severely contaminated with various, partially potentially pathogenic bacteria during usage in a clinical setting. - Microbial contamination of the tablet computer can be significantly reduced by wrapping the device with a customized single-use plastic bag. - Wrapping hardly impairs operability or user satisfaction of touchscreen operated devices. 11 % of the patients reported problems with the functionality of the touchscreen. These patients indicated that they had never used a touchscreen operated device (tablet computer, smartphone, etc.) before. - 81 % of the patients rated the availability of a tablet computer during the waiting period as “very good”. 2