Dr. SHILADITYA SENGUPTA
Division of Bioengineering and Environmental Health
Massachusetts Institute of Technology
77 Massachusetts Avenue, Rm. 16-561
Cambridge, MA 02139
Tel: 617 253-7666
shiladit@mit.edu
EDUCATION
Department of Pharmacology, University of Cambridge, Cambridge, UK
PhD in Pharmacology (Since October 1998)
Expected in 2001; submitting thesis in July 2001.
All India Institute of Medical Sciences, Delhi, India
MSc (Faculty of Medical Sciences) Pharmacology (1996 - 1998)
Class: First
All India Institute of Medical Sciences, Delhi, India
BSc Hons in Human Biology & Pharmacology (1992 - 1996)
Class: First
AWARDS / SCHOLARSHIPS / GRANTS
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ASPET Graduate Student Travel Award from the American Society for
Pharmacology and Experimental Therapeutics, for attending Experimental Biology
(2001)
Eddington Travel Grant awarded by Trinity College to attend the International
Congress of Pharmacology and Therapeutics, New Delhi (1999)
Glaxo Travel Grant awarded by the Department of Pharmacology, University of
Cambridge, to attend the International Congress of Pharmacology and Therapeutics,
New Delhi (1999)
Nehru Cambridge Scholarship and Trinity Overseas Fees Bursary (1998-2001)
Overseas Research Scholarship award from the Committee of Vice-Chancellors and
Principals of the Universities of the United Kingdom (1998-2001)
British Chevening Scholarship awarded by the FCO, UK and British Council (19981999)
Council of Scientific and Industrial Research, HRD, Govt. of India, Full Foreign
Travel Grant to attend XIII International Congress of Pharmacology at Munchen,
Germany (1998)
Govt. of India, Ministry of Science and Technology, Foreign Travel Grant to attend
XIII International Congress of Pharmacology at Munchen, Germany (1998)
Geeta Mittal Gold Medal and Book Prize for best research work in basic oncology,
awarded by the All India Institute of Medical Sciences (1997)
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Summer Research Fellowship awarded by the All India Institute of Medical Sciences
(1995)
PUBLICATIONS
Original Research Papers in Refereed Journals
Reviews / Book Chapters
Original Research Papers in Refereed Journals
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Sengupta S, Toh S A, Sellers L A, Zhang H T, Wong RNS, Yeung H W, Fan T P-D.
Angiogenesis is promoted by ginsenoside Rg1 through the NOSIII
pathway. FASEBJ, 2001; 15(5):A943.
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Sengupta S, Tyagi P, Chandra S, Kochupillai V, Gupta S K. Encapsulation in
Cationic Liposomes Enhances Antitumour Efficacy and Reduces the Toxicity of
Etoposide, a Topo-Isomerase II Inhibitor.Pharmacology. 2001; 62(3):163-71.
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Sengupta S, Gherardi E, Fan T-P D. Hepatocyte growth factors/scatter factor
(HGF/SF) accelerates angiogenesis in sponge implants in mice: modulation by LNAME and NS 398. Br.J.Pharmacol 2000 (In press).
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Sengupta S, Tyagi P, Velpandian T, Gupta Y K, Gupta S K. Etoposide encapsulated
in positively charged liposomes: pharmacokinetic studies in mice and formulation
stability studies.Pharmacological Research. 2000; 42:459-464.
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Tyagi P, Sengupta S, Velpandian T, Gupta Y K, Kochupillai V, Gupta S K.
Evaluation of the Antitumour Activity of Liposomal Formulations of Etoposide
Against Choriocarcinoma Xenografts in Balb/c nu/nu Mice. Pharm. Pharmacol.
Commun. 1999;5:595-598.
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Sengupta S, Sanyal M, Kochupillai V, Gupta S K. Expression of Inducible and
Neuronal Nitric Oxide Synthase in 20-Methyl Cholanthrene (20-MCA) Induced
Fibrosarcoma. Indian Journal of Pharmacology 1999;31:315-318.
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Gupta SK, Bhardwaj RK, Tyagi P, Sengupta S, Velpandian T. Anti-inflammatory
activity and pharmacokinetic profile of a new parenteral formulation of
nimesulide. Pharmacological Research 1999;39:137-141.
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Sengupta S, Velpandian T, Sapra P, Sanyal M, Gupta S K. Etoposide encapsulated
long circulating liposomes: improved antitumor efficacy with reduced adverse
effects. Naunyn Schmiedeberg's Arch Pharmacol. 1998; 358 (Suppl 2); R 531.
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Velpandian T, Mathur P, Sengupta S, Gupta S K. Preventive Effect of Chyavanprash
Against Steroid Induced Cataract in the Developing Chick Embryo. Phytother. Res.
1998;12:320-323.
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Sengupta S, Velpandian T, Sapra P, Mathur P, Gupta S K. Comparative Analgesic
Efficacy of Nimesulide and Diclofenac Gels after Topical Application on the
Skin. Skin Pharmacol Appl Skin Physiol 1998;11:273-278.
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Sengupta S, Velpandian T, Kabir SR, Gupta S K. Analgesic efficacy and
pharmacokinetics of topical nimesulide gel in healthy human volunteers: double-blind
comparison with piroxicam, diclofenac and placebo. Eur J Clin Pharmacol
1998;54:541-547.
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Gupta S K, Velpandian T, Sengupta S, Mathur P, Sapra P. Influence of Piperine on
Nimesulide Induced Antinociception. Phytother. Res. 1998;12:266-269.
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Gupta S K, Velpandian T, Mathur P, Sengupta S. Comparative Analgesic Activity of
Nimesulide and Diclofenac by Intramuscular Route: Correlation with
Pharmacokinetic Profile of Nimesulide.Pharmacology 1998;56:137-143.
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Gupta S K, Prakash J, Awor L, Joshi S, Velpandian T, Sengupta S. Antiinflammatory activity of topical nimesulide gel in various experimental
models. Inflamm Res 1996;45:590-592.
Reviews / Book Chapters
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Sengupta S. Cyclooxygenase-2: a new therapeutic target. Indian Journal of
Pharmacology 1999;31:322-332..
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Sengupta S, Fan T-P D. 'Immunity' and 'Auto-immune diseases' in Oxford
Companion of the body, Oxford University Press. (In press)
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Sengupta S, Gupta S K. "Angiogenesis: Concepts and research methodologies" in Ed.
S.K.Gupta, Pharmacology and Therapeutics in the New Millennium, Narosa
Publishing House.
INVITED LECTURES
Sengupta S, Damon B, Richard W, Gherardi E, Fan TP D. Hepatocyte growth factor/scatter
factor (HGF/SF) and wound healing angiogenesis: mechanistic studies. International
Congress on frontiers in Pharmacology and Therapeutics in 21st century, 1st - 4th Dec,
1999, New Delhi, India.
PATENTS
UK Patent filed for a new steroidal compound that promotes angiogenesis and woundhealing. Assignee: University of Cambridge.
TEACHING EXPERIENCE
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1998-2001: Supervisor of pharmacology for students of medicine /vet / natural
sciences, at Trinity College, University of Cambridge. This involves teaching
undergraduate pharmacology to groups of students, setting question papers,
evaluating answers and writing evaluation reports of students.
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1998-2001: Demonstrator of practical undergraduate pharmacology for part IB
students, at the Department of Pharmacology, University of Cambridge.
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1999-2000: Supervised three part II-students on their final year research projects
involving (i) the effects of angiostatin and combretastatin on vascular and nonvascular cells, (ii) pharmacological characterisation of huang-qin, a TCM for asthma
(paper communicated to J Pharm Pharmacol) and (iii) elucidating thesignal
transduction for angiogenic effects of Rg1 (a novel compound).
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1996-1998: Participated in post-graduate teaching programme at the Department of
Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
BUSINESS / INDUSTRIAL EXPERIENCE
Founder of ANGIOMICS, an angiogenesis-based novel drug-discovery company. The
concept recently won a prize at the Cambridge University Entrepreneurs' annual 50K
business development competition, and is now in negotiations with venture capitalists for
first round funding.
MEMBERSHIPS / FELLOWSHIPS
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Life member of the Indian Pharmacological Society.
Member of the American Society for Pharmacology and Experimental Therapeutics.
Member of the Society for Experimental Biology and Medicine, USA.
Fellow of the Cambridge Commonwealth Society.
OFFICES HELD
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Student Member, Curriculum-reform committee, All India Institute of Medical
Sciences. 1997-98.
General secretary, Society for Young Scientists, All India Institute of Medical
Sciences. 1996-97.
Student Member, Dean's committee, All India Institute of Medical Sciences. 1996-97.