Treatment of Allergic Rhinitis (Hay Fever) Allergic Rhinitis in general 1. ↑ vascular permeability due to vasodilation leading to a. Runny nose 1. Allergic rhinitis is having collection of symptoms which include a. Itchy b. Tearing eyes 2. Stimulation of sensory neuron leading to i. Nose a. Itching ii. Mouth b. Sneezing iii. Eyes b. Runny nose c. Sneezing 3. Hypersecretion of glandular tissues Distribution of Histamine receptors 1. H1 d. Tearing eyes a. Smooth muscle cells e. Nasal decongestion b. Endothelial cells 2. Due to hypersensitivity of nasal mucosa to allergens 2. H2 The fundamental cause of allergic rhinitis is release of histamine 3. H3 The released of histamine by Mast cells and Basophils will lead to a. Gastric parietal cells a. Central nervous system Drugs used in the treatment of Allergic Rhinitis 1. Anti-histamines a. 1st generation i. Diphenhydramine ii. Promethazine iii. Clorpheniramine b. 2nd generation i. Cetrizine ii. Loratadine c. Decongestants (A1 receptor agonist) i. Xylometazoline ii. Ephedrine d. Anti-inflammatory agents i. Beclomethasone Antihistamine Mechanism of Action Drugs/Infos 1st generation 2nd generation Diphehydramine Promethazine Cetrizine Loratadine Non – selective 1. Binds to a. H1 receptor b. H3 receptor (CNS) 2. Cross BBB 3. Thus causing sedation Shorter duration of action Selective 1. Binds to only H1 receptor 2. Thus, NOT causing any sedation Causing 4. CNS depression 5. Anticholinergic action a. Dry mouth b. Urinary retention 6. Alpha adrenergic blocking effect a. Orthostatic hypotension DOES NOT cause 1. CNS depression 2. Anticholinergic action 3. Alpha adrenergic blocking effect Longer duration of action 1. Blocks the H1 receptor of nasal mucosa leading to a. Vasoconstriction b. reduce in i. Swelling ii. Tearing iii. Capillary permeability iv. Runny nose Side Effects 1st Generation Causing 1. CNS depression 2. Anticholinergic action a. Dry mouth b. Urinary retention 3. Alpha adrenergic blocking effect Orthostatic hypotension 2nd generation Interaction with drugs metabolized by hepatic metabolism (CYP450 inhibitor) 1. Antifungal a. Ketonazole 2. Antibiotics a. Erythromycin 3. Prokinetics a. Cisapride Leading to cardiac arrhythmias Nasal Decongestion (A1 Receptor Agonist) Drugs/Infos Mechanism of Action Xylomethazoline Epherdrine 1. Binds to nasal blood vessel a1 adrenergic receptor leading to vasodilation 2. Which therefore will a. Reduce nasal mucosa swelling b. Reduce capillary permeability Anti-inflammatory Agents (Intranasal Glucocorticoid) Drugs/Infos Mechanism of Action Beclamethasone Info 1. Given intranasal 1. Inhibits Phospholipase A2 in which involve in the formation of Arachidonic Acid; precursor of a. Cyclooxygenase, in return will form i. Prostaglandin b. Lypooxygenase, in return will from i. Leukotriene 2. This will then lead to reduction in a. Sneezing b. Rhinorrhea c. Nasal itching Side Effects 1. Rebound congestion a. If used more than few days 2. Tolerance 3. CNS stimulation Side Effects Hardly any, due to its topical admin 1. Dry of nasal mucosa 2. Burning sensation