Comparison of Laparoscopic and Open Revision Roux-en-Y Gastric Bypass. Yasmine Assadipour, Khashayar Vaziri Jeremy L Holzmacher, Richard Amdur, P Lin Background Revision Roux-en-Y gastric bypass (RRYGB) is performed in patients who have undergone bariatric surgery, but experienced recidivism or complications which have failed medical management. Traditionally, revisions have been approached in an open fashion given the risk of anastomotic leak and other morbidities, which has been reported in the literature to be as high as 20%. The purpose of this study is to compare outcomes of patients who have undergone laparoscopic and open RRYGB. Methods A retrospective review of clinical data from all patients who had undergone RRYGB at a single institution was performed. The data on pre-operative co-morbidities, operative variables, and post-operative outcomes were collected and analyzed using t-test and chi square with Yates’ correction. Results Ninety-six RRYGB were performed of which 17 were laparoscopic. There was no significant difference in preoperative comorbidities of gender, age, BMI, diabetes, hypertension, or sleep apnea. Average follow up was 20.3 months. There was a significantly lower blood loss in the laparoscopic group. The laparoscopic group had a shorter operative time, and had higher % excess weight loss, although this was not significant. There was no significant difference in ICU days or length of stay. Similarly, there was no significant difference in morbidity between laparoscopic and open RRYGB (Table 1). The anastomotic leak rate for open revisions was 2.5%. There were no leaks in the laparoscopic revision group. Conclusion Revision RYGB can be performed safely with a lower incidence of anastomotic leak than originally reported. A laparoscopic approach can be performed safely with significantly less blood loss and a trend towards a shorter operative time and greater excess weight loss when compared to open revisions. Long term comparable weight loss was achieved without an effect on morbidity or mortality. Future larger studies may be able to demonstrate shorter operative times and superior weight loss of laparoscopic revisional bariatric surgery. Table 1: Outcomes OR Time (minutes) Estimated Blood Loss OPEN (n=79) 206.0 +/- 61.67 n=69 171.49 +/- 148.52 n=78 LAPAROSCOPIC (n=17) 170.8 +/- 60.23 n=10 56.82 +/- 100.35 n=17 p 0.095 0.004 ICU stay Length of Stay % EWL (12 months) Mortality Bleeding MI Leak Wound Infection DVT Pneumonia 0.81 +/- 1.16 n=78 5.56 +/- 3.1 n=78 45.05 +/- 17.36 n=27 0 1 1 2 3 1 0 0.93 +/- 1.49 n=15 4.69 +/- 1.92 n=16 62.39 +/- 10.23 n=2 0 0 0 0 1 0 0 0.884 0.284 0.179 0 0.641 0.641 0.507 .696 .641 0