Summer Assistantship Faculty Sponsor List Summer 2016 Below is a list of Brown faculty who have expressed an interest in working with medical students this summer. We urge you to contact them early in your application process to discuss potential collaborations. Please note that that you are not limited to faculty on this list – you may identify other faculty mentors independently. Faculty were asked if they would be able to provide funding for student work outside of the Summer Assistantship process. Their answers are included below. Barbara S. Stonestreet, MD Professor, Department of Pediatrics 101 Dudley Street, Providence, RI (401) 274-1122, x 47429 bstonestreet@wihri.org (1). Neuroprotective strategies in neonatal brain injury. Brief Description: Hypoxia-ischemia (HI) is the leading cause of neurodevelopmental morbidities in preterm and full term infants. The only therapeutic strategy to treat HI encephalopathy (HIE) is hypothermia for full term infants, which is only partially protective, and treatment does not exist for HI exposed preterm infants except for supportive care. Based upon the Stroke Therapy Academic Industry Roundtable (STAIR) criteria, sufficient dose-response and therapeutic time windows, adequate histological and behavioral outcomes, and understanding mechanism(s) of action for neuroprotectants are necessary for preclinical drug development to facilitate translation of neuroprotective strategies from animals to humans. The basis of this proposal is the identification of novel immunomodulatory proteins, Inter-alpha Inhibitor Proteins (IAIPs) that are currently in development as effective therapeutic agents in systemic inflammation/shock syndromes. Results should yield novel preclinical information to accelerate IAIPs use as neuroprotective agents to treat HI-related brain injury in human premature and full term infants. (2). Neuroprotective strategies in the fetus and neonate. Brief Description: Students can be involved in work with rodents that includes surgery, behavioral studies, and histopathological evaluation of important anti-inflammatory neuroprotective studies in neonatal hypoxic ischemic rats. Other exciting work includes translational studies in fetal sheep again to develop therapies to protect the premature brain from injury. Qualifications: some biology and neuroscience background Funding: None Eli Y. Adashi, MD, MS, CPE, FACOG Professor of Medical Science eli_adashi Multiple health policy projects. No funding available. Sun Ho Ahn, MD, FSIR Assistant Professor of Radiology Alpert Medical School of Brown University Director IR Fellowship Associate Editor MHRI sun_ho_ahn@brown.edu Mike (Mai) He, MD, PhD Assistant Professor, Department of Pathology & Laboratory Medicine 101 Dudley Street, Providence, RI (401) 274 – 1122 x 41310 mai_he@brown.edu; mhe@wihri.org Title: D-dimer Levels during Pregnancy Description: Pregnancy is associated with increased risk of deep-venous thrombosis. The natural course of D-dimer levels during and after pregnancy has not been well studied so there are no established normal reference ranges for the antepartum and postpartum periods. This is a prospective study using residual blood sample combined with chart review. Qualification/previous experience: None needed. Funding: Yes. Again, we may need two and able to fund two. Dr. James Padbury Department of Pediatrics 401 2741122,x147405 james_padbury@brown.edu Description: Preterm delivery and preeclampsia are the leading causes of maternal and newborn morbidity and mortality. We are employing a Pathway Analysis based approach whereby we are curating the medical literature, public databases and archives of expression and genetic data for genes with demonstrated relationship to preterm labor and preeclampsia. We have built a robust, web-based, semantic data mining tool to curate published literature on preterm birth and preeclampsia. The curators review each article, identify the genes clearly associated with preterm delivery or preeclampsia, assign the correct Human Genome Database unique gene ID number for each relevant gene in the article, review the citations in the article for additional publications that may not have been captured in the database query, provide annotations on the individual articles and, lastly, extract SNPs in the genomic region and SNPs in the 10 kb of sequence in the upstream 5’ region of the gene and 5 kb of sequence downstream of the genomic region using the UCSC genome browser and dbSNP. This is a robust educational experience. Bioinformatics is an important new discipline that is allowing researchers interested in clinical and translational projects to manipulate large data sets and large amounts of information. This is a very contemporary approach and an invaluable skill set. This will further be valuable as a scientific experience with extensive exposure to genetics, cell and molecular biology. Students develop substantial expertise in genetics, genomics, understanding of gene structure, understanding the sources of genetic variation between individuals and participation in the publication process. Joseph Bliss, MD, PhD Associate Professor of Pediatrics 101 Dudley St., Providence, RI (401) 274-1122 x 47484 jbliss@wihri.org Title: Effect of Dietary Medium Chain Triglyceride Intake on Colonization of Preterm Infants with Candida Description: A pilot clinical trial in which premature infants who are colonized with the yeast, Candida, are randomly assigned to receive a nutritional supplement to determine whether it reduces their colonization. Candida can cause serious invasive infections in premature infants who are colonized. Qualifications: Prior experience with human subject research and/or clinical trials is a plus, but not required. Funding: None available. Wael Asaad MD, PhD Assistant Professor of Neurosurgery and Neuroscience wael_asaad@brown.edu Project Title: Human Neuromodulation Research Project Description: Our lab studies human subjects in the setting of neuromodulation to better understand the basic manifestations and mechanisms of neurological diseases as well as normal brain function, and to understand the mechanisms of neuromodulation (deep brain stimulation) and devise ways to improve upon it. Qualifications: Strong interest in neuroscience; coding in Matlab or Python a plus (for data analysis and experimental task design). Funding: Students in our lab would be eligible to apply for a Doris Duke Fellowship for an entire year, but we currently have no mechanism just for summer funding. Jun Feng, MD, PhD Assistant Professor of Surgery Director of Cardiothoracic Surgery Research Lab. 1 Hoppin Street, Providence RI 02903 (401) 793-8065 jfeng@lifespan.org Title: Diabetic Regulation of SK/IK Channels and Endothelial Function Description: My current research interests focus on the role of potassium channels in coronary microcirculation and endothelial function in both animals and humans. My current project is focusing on the effects of diabetic regulation of calcium-activated potassium channels and human coronary endothelial function. My strong background in cardiovascular physiology, pharmacology, microvascular physiology, cell biology and bio-informatics combined with my specific training and expertise make me well suited for the key research areas for this application. Qualification: Medical Students with or without Lab experiences Funding: None. Jerrold Rosenberg, MD Clinical Assistant Professor of Orthopaedics jerrold_rosenberg@brown.edu Description: Our project would be measuring functional improvement in patients undergoing rehabilitation. Qualifications: No specific qualifications. A student interested in PM&R would be preferred but not required. Funding: None. Phyllis A. Dennery, M.D. Sylvia Kay Hassenfeld Professor of Pediatrics Chair, Department of Pediatrics Warren Alpert Medical School of Brown University Pediatrician-in-Chief, Rhode Island Hospital Medical Director, Hasbro Children’s Hospital 593 Eddy Street Providence, Rhode Island 02903 401-444-5648 - phone 401-444-6378 - fax David Egilman MD, MPH President GHETS Clinical Professor of Family Medicine Alpert School of Medicine at Brown University 8 North Main Street Attleboro, Massachusetts 02703 Cell 508-472-2809 Office 508-225–5091 Ext 11 degilman@egilman.com Project description: This person will be responsible for providing critical support in family medicine program development in Southeast Asia, Africa, and Latin America. They will provide logistical and programmatic support to our partners at various medical institutions for a variety of projects including curricula development projects, faculty exchange and training projects, as well as projects seeking to improve primary care. It is a great opportunity for a student seeking hands on experience in global health. Qualifications: An ideal candidate will possess strong interpersonal skills, and be extremely organized and detail-orientated. The ideal candidate will also possess prior experiences in cross-cultural settings, field experience in a developing country, foreign language skills, and a background or demonstrated interest in public health, development, media, or social justice. Funding: None available. Beatrice E. Lechner, MD Neonatologist, Department of Pediatrics Women & Infants Hospital of Rhode Island 101 Dudley Street, Providence, RI 02905 Assistant Professor of Pediatrics The Warren Alpert Medical School of Brown University | 401-274-1122, ext. 47438 2 possible projects: 1. Defining the role of proteoglycans in preterm birth. In this project, a cell culture scratch test model will be used to assess the role of various proteoglycans in the maintenance of intact fetal membranes throughout pregnancy, including rescuing the phenotype. Some experience in basic research methods, ideally cell culture, is helpful. 2. A survey based analysis of the communication gap between healthcare providers and parents of sick newborns in the neonatal intensive care unit. In this study, a survey will be developed and administered to healthcare providers as well as parents. Some experience in qualitative research methods is helpful. Funding: none available Lindsay M. Orchowski, Ph.D. Department of Psychiatry and Human Behavior Alpert Medical School of Brown University Staff Psychologist, Rhode Island Hospital 146 West River Street, Suite 11B, Providence RI 02904 Lindsay_Orchowski@brown.edu (p) 401-444-7021; (f): 401-444-7109 Description: Dr. Orchowski serves as the Deputy Title IX Coordinator for the Medical School, and is the PI of 2 CDC funded evaluations of sexual assault programming for middle and high school students, and the PI of a Department of Defense funded evaluation of sexual assault prevention for men in the military. Medical students would have the opportunity to contribute to study tasks on one of the projects of their choosing, may opt to work with Dr. Orchowski on developing a publication relating to sexual violence from existing project data, or develop a review of the literature addressing violence prevention. Qualifications: No prior research experience is necessary. Individuals who are motivated to learn about sexual violence prevention and evaluation research would be a good fit for our research team. Funding: None available. Mark J. Fagan MD Department of Medicine 593 Eddy St. Providence, RI 02903 401-444-8472 mfagan@lifespan.org Title: Using Morbidity and Mortality Conference to Teach Third year Medical Students about Patient Safety and Diagnostic Error Brief Description: The purpose of this project is to design, implement, and evaluate a tool for students to use when attending Morbidity and Mortality conference during the internal medicine clerkship. The tool would prompt students to identify and classify patient safety issues that occurred in the case and propose remedies to address the identified safety issues. The student’s role would be to conduct a literature review, design and pilot test the tool, submit the project for IRB approval, and create a plan for implementation and evaluation of the tool in the internal medicine clerkship. Qualifications: Ideally, the student would have some experience with survey design and the IRB submission process. Funding: None available. Roland C. Merchant, MD, MPH, ScD Associate Professor Emergency Medicine and Epidemiology Alpert Medical School of Brown University Rhode Island Hospital (O): (401) 444-5109 (F): (401) 444-4307 Researchers from the Departments of Emergency Medicine and Psychiatry and Human Behavior are seeking a highly motivated medical student for an interesting study on an emergency medicine-based intervention to decrease risk of sexually transmitted infections. The research involves direct contact with adult emergency department patients at Rhode Island Hospital during summer 2016. The medical student chosen for the study will recruit adult emergency department patients to watch a video about sexually transmitted infections and complete a survey. The study particularly aims to recruit racial/ethnic minority patients into the study. The intent of the study is to determine the efficacy of this type of intervention in the emergency medicine setting. The ideal candidate for the position will be someone who can work independently, is comfortable with approaching patients and recruiting them to the study, is interested in the topic under study, and has an interest in racial/ethnic minority health promotion. Elizabeth Goldberg, MD 593 Eddy Street Claverick 209 Providence, RI 02903 401-444-7975 egoldberg1@lifespan.org Title: The Centers for Medicare and Medicaid Physician Quality Measures and Hypertension Screening of At Risk Individuals in the Emergency Department Qualifications: Applicants should be interested in health services research or cardiovascular risk prevention strategies. Competency in excel and statistical data analysis is preferred, but not necessary. Attention to detail and excellent communication skills will be important. The RA will assist the PI with analyzing CDC data on elevated blood pressure visits in the ED setting and will help design tables that show change over time of hypertension by age, gender, and other demographic variables. Description: The principal investigator will meet weekly to discuss study progress, concerns, and address research questions. The student is welcome to shadow the PI during adult emergency medicine shifts and will have the opportunity to assist with recruiting adult emergency department patients in another ongoing hypertension study. Students will receive career mentorship about physician scientist and academic faculty tracks. Funding: None available. Mary M. Flynn, PhD, RD, LDN Biomed – Brown University Department of Medicine, The Miriam Hospital 164 Summit Ave Providence, RI 02906 401.793.4707 Mary_Flynn@brown.edu Title: Food is Medicine Description: The student(s) would be involved in the Food is Medicine program I have started at Lifespan Community Health Institute. The program involves delivering a 6-week cooking program of plant-based, olive oil recipes to low-income patients. There will be at least 2 cooking programs underway the summer of 2016. One involves patients from clinics at RIH and TMH who have type 2 diabetes. The other cooking program will involve overweight/ obese 10-15 year olds that are referred from the Pediatric Endocrinology clinics at Hasbro. The student(s) will be involved in data entry and basic statistical analysis for both programs, under my guidance (mentor). Desired previous experience: some work with low-income populations would be preferred; work experience that involved working with people; basic cooking skills Academic qualifications: completion of a at least one college level nutrition course preferred; completion of CITI training or willingness to do so for anyone taking this assistantship. Funding: None available. Neha P. Raukar, MD, MS FACEP CAQ Primary Care Sports Medicine Assistant Professor Director, Division of Sports Medicine Department of Emergency Medicine Consulting Physician, Brown University Athletics Warren Alpert School of Medicine nraukar@lifespan.org Title: Does awareness lead to change? Description: Regarding mentoring, the team (including the student), will meet weekly. These meeting will focus on feedback and guidance on research activities (which include patient recruitment, consent, and administration of the intervention; patient follow ups; basic data analysis; literature reviews and abstract and manuscript development) and discussion about career interests and plans; weekly progress reports; focused readings on the topic. The SRA student will be mentored in the interpretation of clinical data, and the pursuit of research questions with important, practical clinical and public health implications. The SRA student will benefit from weekly journal clubs presented by SRA program PIs which furnish insights to communication and interoperation of research findings in clinical and scientific communities. Students will have the opportunity to gain clinical perspective by electing to observe clinical Emergency Medicine and spending time alongside residents/attendings at a level I trauma center. Qualifications: Write well; Have some background in research; Are goal oriented and can get tasks done; Are organized; Have outstanding attention to detail and ability to multi-task; Self-motivated; Have strong interpersonal skills and can quickly develop rapport; Have familiarity with citation software (e.g., EndNote) Funding: None available. Elizabeth Lowenhaupt Departments of Psychiatry and Human Behavior (Division of Child & Adolescent Psychiatry) and Pediatrics (Division of Adolescent Medicine) elowenhaupt@lifespan.org, 401-444-3743 RIH, 593 Eddy Street, POB-122, Providence 02903. Title: Rhode Island Training School - Juvenile Correctional Treatment Services. Description: A student working with me would identify a specific project relating to either medical or psychiatric treatment of adolescent currently incarcerated at the Rhode Island Training School (RITS). The experience would include the development of a new program or service at the Training School, analysis of available data relating to medical and psychiatric factors of incarcerated youth in RI, and/or clinical observation in the medical and psychiatric clinic as well as some individual and group therapy interventions at the RITS. The student should talk with me prior to applying for summer funding so that we could identify a more specific interest and topic for the project. Funding: none available; although students could apply to the American Academy of Child & Adolescent Psychiatry for possible additional funding.