Summer Assistantship Faculty Sponsor List Summer 2014 Below is a list of Brown faculty who have expressed an interest in working with medical students this summer. We urge you to contact them early in your application process to discuss potential collaborations. Please note that that you are not limited to faculty on this list – you may identify other faculty mentors independently. All applications and application materials must be submitted electronically as email attachments to Emily_Green@Brown.edu no later than noon on February 20, 2014 Samuel C. Dudley Jr., M.D., Ph.D. Director, Lifespan Cardiovascular Institute Ruth and Paul Levinger Chair in Medicine The Warren Alpert Medical School of Brown University 593 Eddy Street, APC 730 Providence, RI 02903 Telephone: (401) 444-5328 (Office) Fax: (401) 444-4652 Email Address: Samuel_dudley@brown.edu Project: Student might do a range of basic, translational, or human trials in heart science. The main focus of the laboratory is to develop new diagnostic tests and treatments for sudden cardiac death and a form of heart failure where the heart fails to relax, known as diastolic heart failure. The laboratory has 25 provisional or issued patents in the area and uses techniques including molecular biophysics, animal experiments, and human trials. The student could experience a complete benchbedside experience. The ideal student would be intelligent, assiduous, dependable, and have an interest in and a demonstrated aptitude for science. Funding would be available for students with strong qualifications. Eric Goldlust, MD, PhD, FACEP Asst Professor, Dept of Emergency Medicine (401) 261-8479 egoldlust@lifespan.org Project 1: ED Crowding Surveys: Student would analyze survey results from two national surveys of ED and hospital practices related to ED crowding. Subsequent analysis could inform future surveys. Helpful if student has some experience in data analysis using SPSS, R, or similar software. Should result in at least two articles for peer-reviewed publication. Project 2: Effects of an iPhone App on Patient Satisfaction and Empowerment: Student would survey patients on their satisfaction after ED visits, and analyze results to determine effects of an iPhone app. Student may also be able to assist in developing and leading interviews with ED patients as individuals or in groups regarding patient satisfaction, smartphone use, health literacy and health care needs of the ED population. Experience and/or interest in survey research, public health, and/or needs assessment a plus. Has potential for publication. I do not have funding at this time (but am applying for relevant grants). Also, I may have projects available for a student with experience in Discrete Event Simulation, to perform any of several projects with strong publication potential. Prior experience in this field a must; information on these projects available upon request. Thomas Roberts Associate Professor Department of Ecology and Evolutionary Biology Brown University Biomed Center 205 401-863-3608 Title and description: Determinants of muscle damage. The project will investigate the mechanical factors that determine damage and decrease in performance of skeletal muscles, using isolated muscle preparations. Student requirements: The student should have good quantitative and computer skills and be enthusiastic about musculoskeletal biology. Funding: I may be able to provide funding for a student. Eli Y. Adashi, MD, MS, CPE, FACOG Professor of Medical Science Former Dean of Medicine and Biological Sciences The Warren Alpert School of Medicine Brown University eli_adashi@brown.edu Potential Projects: 1. Assisted Suicide in the US: Past, Present, and Future. 2. The Caribbean Medical Education Enterprise: Challenges and Opportunities 3. Guns Violence: A Role for Medicine? 4. International Medical Graduates: Coming to America? 5. The Sunshine Act: Theory and Practice in Action 6. Fraud and Abuse in the American Health Care System: Incalculable and Incurable? No specific skills are required. No funding is available other than that which is secured (e.g. SRA) Name: Philip A. Gruppuso, MD Academic Department: Pediatrics (Endocrinology) Brown University Division of Pediatric Endocrinology Rhode Island Hospital 593 Eddy Street Providence, RI 02903 Phone: 401-444-5504 Title: Cell Signaling in Liver Development and Carcinogenesis Description: Several projects, all relating to signal transduction in liver, are available. Our laboratory uses animal models (rodents), liver cell lines and traditional biochemical approaches as well as genomic and proteomic methods. Qualifications: An interest in pursuing laboratory research. Prior experience is desirable but not required. Funding: This opportunity will qualify for T35 (BTR Program) funding. Summer Research Assistantships in Emergency Medicine: http://www.brown.edu/academics/medical/plme/current-students/enrichmentactivities/research-opportunities/summer-research-assistantship-emergenc Will Fairbrother, PhD. Associate Professor MCB Department Brown University 70 Ship Street, Room 404 LMM Building Providence, RI office 401 863-6215 lab 401 863-6329 fax 401 863-9653 skype ID will.fairbrother1 Title: Genome Sequencing in the Clinic Description: Whole genome sequencing (WGS) and exome sequencing are increasingly being used to identify causal alleles in genetic disease. A sequencing experiment is typically performed on trios (i.e. the patient and the unaffected parents) and typically return tens or hundreds of potential causal variants. For recessive disorders this will include two copies of the same loss-of-function alleles or, more commonly, a compound heterozygote: two different loss-of-function alleles. There could also be a de novo dominant variant. The problem comes in determining which of the hundreds variations could be causal. There are certain classes of mutations( e.g. nonsense mutations, frameshifts, deletions) where the variation will clearly affect the protein coding function of the gene. However recently we have shown that 1 in 3 variants affect the processing of the gene, specifically pre-mRNA splicing. Interestingly, certain antibiotics (e.g. aminoglycosides) function by binding RNA and can sometimes alter splicing events. These "off-target" interactions can manifest as side effects of drug treatment. Our lab has developed predictive methods of analyzing variation and also high throughput splicing assays. We use these assays to identify which disease alleles or clinically identified variants alter splicing. The high throughput splicing assay will also be used as a drug screening platform to see if any of these disorders can be reversed by antibiotic treatment. These research goals form the three projects available to incoming students: Projects - title, [qualifications] 1) Develop pipeline for predicting mutations in clinical sequencing projects that alter splicing [programming perl or python, UNIX navigation] 2) Using high throughput splicing assay to identify processing mutations [basic molecular biology lab skills] 3) Drug screen - identifying compound that reverses splicing defect [basic molecular biology lab skills, knowledge of basic pharmacology] Funding: There is a small chance lab funds will be available for this research. However students should assume they will need to apply in February to receive a $3,500 stipend from the medical school. Barbara S. Stonestreet, M.D. Professor of Pediatrics The Alpert Medical School of Brown University Staff Neonatologist Director, Neonatal-Perinatal Fellowship Program Department of Pediatrics Women & Infants Hospital of Rhode Island 101 Dudley Street Providence, RI 02905 Phone: (401) 274-1122, x 7429 Fax: (401) 453-7571 E-mail: bstonestreet@wihri.org Project: Brain injury in the fetal and neonatal brain. Students can work on a neonatal rodent project studying the effects of a new nuclear protein which uniquely becomes a cytokine when released from the nucleus, HMGB1. They can also study the effects of cytokines on brain injury in the fetal sheep brain. Student must have at least some neuroscience or biology background. Funding available Sharon Rounds, MD Professor of Medicine and of Pathology and Laboratory Medicine Vascular Research Laboratory Providence VA Medical Center 830 Chalkstone Ave Providence, RI 02908 401-457-3010 sharon_rounds@brown.edu Title of project: Effect of Acrolein on Lung Endothelial Permeability Description: Previous work from our laboratory has demonstrated that cigarette smoke increases lung vascular permeability and thereby may predispose to the devastating lung injury, acute respiratory distress syndrome (ARDS). We have also found that acrolein, a component of cigarette smoke alters endothelial cell permeability. The purpose of the proposed project is to determine if acrolein exerts this effect by altering function of mitochondria in lung endothelial cells. This project will entail use of cultured lung endothelial cells to measure morphology, number, and function of mitochondria exposed to cigarette smoke and/or acrolein. Ideal Student: The ideal student would be interested in lung disease, the pathophysiology of ARDS, and mechanisms of disease. The student should have completed biochemistry and histology. Undergraduate or other experience in working with cells and basic understanding of general chemistry (pH, buffers) would be ideal. Funding: Funding is available for supplies required for the project. Joseph Bliss MD, PhD Department of Pediatrics Women & Infants Hospital 101 Dudley St. Providence, RI 02905 401-274-1122 ext. 47484 jbliss@wihri.org Title: “Effect of Dietary Medium Chain Triglyceride Intake on Colonization of Preterm Infants with Candida”. This is a pilot clinical trial that will involve screening premature infants for colonization with the yeast, Candida. Colonized infants will then be enrolled and given a nutritional supplement to determine whether it is effective in reducing colonization. Colonization is a risk factor for invasive infection in these infants, so methods to reduce colonization have translational implications. The ideal student will have experience with microbiological methods and prior exposure to clinical research. Funding for a student is possible but not certain. Hannah Wei Wu, MD, PhD Assistant professor of Peadiatrics, Brown Univeristy Center for International Health Research, Rhode Island Hospital, 55 Claverick St, Rm 325, Providence, RI 02903 Tel: 401-444-7963 Email: Haiwei_wu@Brown.edu hwu@lifespan.org Recombinant proteins expression and purification of vaccine candidates for schistosoma japonicum Interested in public health problems in developing countries; with previous biology lab experience, easy-going personality, fast learner with strong academic record, pre-med student preferred Gideon Koren, MD Professor of Medicine and Director of the Cardiovascular Research Center Rhode Island Hospital and Brown University Coro West, 5th floor 1 Hoppin Street Providence, RI 02903 401-444-0392 Gideon_Koren@brown.edu Jean Daley, MD Assistant Professor of Surgery (Research) Brown University Middle House 303 Rhode Island Hospital 593 Eddy St. Providence, RI 02903 401-444-8212 jdaley@lfiespan.org Excellent summer opportunity for a student, especially for those interested in cardiology, cardiac surgery, emergency medicine, anesthesia, and/or intensive care medicine. Our laboratory is studying the origins of fatal heart rhythms that occur after myocardial infarction, using a model in New Zealand white rabbits. The student will be exposed a variety of research techniques including continuous ECG monitoring/analysis via implanted transmitter, embolization of coronary arteries under fluoroscopic guidance, echocardiography, programmed electrical stimulation of the heart to induce abnormal rhythms, drug therapy to prevent and treat acute arrhythmias, endotracheal intubation and anesthesia with continuous monitoring of ECG and arterial pressure, and optical mapping of abnormal rhythms in isolated hearts. The student will work as a member of a team to acquire and analyze data to determine mechanisms that underlie the proarrhythmic changes that occur after myocardial infarction. One of the ongoing projects examines the effects of aging on the vulnerability to arrhythmias after infarction; another project examines the effects of genetic vulnerability to arrhythmia (long QT syndrome) after infarction. Funding: The student will need to apply for a Summer Assistantship at Brown University. Interested students should contact Dr. Koren or Dr. Daley to discuss application for a Summer Assistantship. Elizabeth McQuaid, PhD, ABPP Director of Faculty Development, Bradley/Hasbro Children's Research Center, RI Hospital Director, Brown Clinical Psychology Training Consortium Associate Professor (Research), Department of Psychiatry and Human Behavior Alpert Medical School, Brown University Elizabeth_mcquaid@brown.edu (401)-444-7573 Needs Assessment and Intervention Development for Families affected by Pediatric Food Allergy Medical Student research interns will have the opportunity to work on several research and clinical initiatives related to Pediatric Food Allergy, including Food Allergy Virtual Environment Simulator (FAVEs) Project, involving design and testing of a Web-Based and Interactive Environments for Children with Food Allergies, and the Food Allergy School Transition (FAST) Project, developing an intervention to prepare families of chidren with food allergies to transition to kindergarten and the broader school environment. The Food Allergy Research Program is located at Rhode Island Hospital, in the Bradley-Hasbro Research Center. Our lab has several offices for research support staff, with dedicated desktop or laptop computers, full internet and phone access, and all the requisite office supplies and facilities. Working within the Food Allergy Research lab, the research intern will meet and interact with a large interdisciplinary team of pediatric food allergy researchers, including clinical psychologists, allergy specialists, child development and education experts, as well as other trainees in these areas. Interns will have to opportunity to assist with research participant recruitment and scheduling, orienting families to research protocols and conducting research visits, data entry, lab organization, and other tasks integral to research. Interns will also have opportunities to shadow a pediatric allergist in the Hasbro Food Allergy clinic. Opportunities are also available within the Childhood Asthma Research Program and Community Asthma Programs at RIH/Hasbro Children’s Hospital. The intern will meet with the primary faculty mentor, Dr. McQuaid, every week to develop an individual research project and to review progress with relevant literature review and data processing, and to synthesize this information within the context of the larger study. Interns will attend weekly lab meetings covering a variety of topics related to pediatric allergy. Dr. Jandasek will serve as a secondary mentor, providing day-today oversight of activities as well as training and supervision related to the processing and analysis of data. Emphasis will be placed on opportunities for preparing presentations for scientific conferences, and/or generating manuscripts for publication. At the end of the summer, the intern will be expected to have generated a “product” such as an abstract for conference submission, or manuscript to submit for publication. Concentration in psychology, biological sciences, or public health. Completion of research methods and introductory statistics course preferred. Strong organizational and time management skills, excellent attention to detail, a thorough working knowledge of MS Office applications, comfort and experience interacting with children and parents from a variety of cultural backgrounds. Rebecca Reece Department of Infectious Disease 1125 N. Main Street 401-350-6194 (pager) rreece@lifespan.org (best way to contact) Faculty: Dr. Aadia Rana and Dr. Tim Flanigan Quantitative Analysis of Barriers to Care among HIV patients in Kumasi Ghana: This will be a survey study conducted at the Komfo Anokye Teaching Hospital in Kumasi among both general and antenatal HIV clinics as to patients' perceived barriers to care: such as distance/transportation, cost, disclosure issues, lack of HIV knowledge, etc. It will be conducted with the help of a Ghanaian medical student who will serve as translator for the survey. We will have funding from external grants for this project. Rebecca Reece Department of Infectious Disease 1125 N. Main Street 401-350-6194 (pager) rreece@lifespan.org (best way to contact) Faculty: Dr. Aadia Rana and Dr. Tim Flanigan Retrospective Chart Review of 2004 HIV cohort in Kumasi Ghana: This will be a retrospective 10yr review of the first year that antiretrovirals were available to HIV infected patients at the HIV clinic at Komfo Anokye Teaching Hospital in Kumasi Ghana. Data will be abstracted looking at time to ARV initiation, treatment failure (ie drug regimen switch), retention to care or LTFU, mortality, etc. We are looking for 1-2 students to help with chart review for this summer, data will be entered into either Excel or Access so familiarity with either would be helpful. Students would need to apply for funding through the Summer Assistantship for this project. Elizabeth A. Lowenhaupt, MD, FAAP Department of Psychiatry and Human Behavior (Child and Adolescent Psychiatry Division Rhode Island Hospital, 593 Eddy St, POB-122, Providence, RI 02903 (401) 444-3762 elowenhaupt@lifespan.org "Juvenile Justice and Child Welfare Project" - A student could work either at the Rhode Island Training School ("RITS", our state's only juvenile correctional facility) or more broadly with the Department of Children, Youth, and Families (our state's child welfare agency) to develop a resource for mental health providers in the community regarding best practices for treatment for these vulnerable populations. The details of the project will vary depending on student interest and on current ongoing program development, of which there are several. There will be a clinical component with time spent getting to know the patients currently detained or incarcerated at the RITS, as well as the administrative, advocacy, and possibly academic (i.e. research) components as well. Students must be interested in working with adolescents and in participating in larger systems-wide advocacy projects - any experience with either would be welcome. In addition, students should ideally have participated in the Henrietta Leonard Medical Student Fellowship Program in Child and Adolescent Psychiatry to some degree during their first year of medical school. (I'm happy to provide more details about this program if requested) Unfortunately, I do not have any funding at this time (although in addition to the Brown SA application, there are a couple of other potential funding options through the Child Psychiatry national and regional organizations) Susan A. Rudders, MD Assistant Professor, Pediatrics The Warren Alpert Medical School at Brown University Pediatric Allergist/Immunologist Hasbro Children’s Hospital/Rhode Island Hospital 593 Eddy Street Providence, RI 02903 Phone: (401) 444 9879 Fax: (401) 444 2168 Email: srudders@lifespan.org Clinical predictors of inpatient interventions for food-induced anaphylaxis Food allergy is the leading cause of anaphylaxis in children. Approximately 10,000 U.S. children per year are hospitalized with a diagnosis of food allergy, tripling estimates from less than a decade ago. There is very little published data on the determinants of hospital admission or inpatient management of food-induced anaphylaxis (FIA). In order to address these important issues, we will perform a structured chart review of hospital admissions for FIA. A medical student working on the project will initially assist with the data abstraction process and data management. One the data has been collected; he/she will then have the opportunity to help with the data analysis and presentation of our findings with the opportunity to also conceptualize their own research question that could be addressed with this data. Medical students involved in this study will be trained to review the medical records. No specific previous experience is required but familiarity with medical terminology is preferred. Preferred candidates would also be interested in pediatrics and/or allergy/immunology, inquisitive, attentive to detail and independent. Students should apply for student assistantships (SA) for potential summer funding to participate in the project. Lei Wei PhD., MD Associate Professor Department of Orthopaedics Brown Medical School/RIH, Coro West/402H 1 Hoppin Street, Providence, RI 02903 phone: (401) 793 8384 fax: (401) 793 8360 e-mail: Lei_Wei@brown.edu Meniscus changes after pasot traumatic osteoarthritis. The project will study how meniscus changes will affect cartilage Students should apply for student assistantships (SA) for potential summer Belinda Borrelli, PhD Professor, Department of Psychiatry & Human Behavior Centers for Behavioral and Preventive Medicine Coro Building 167 Point Street, Suite 309 Belinda_Borrelli@Brown.edu Title of Project: Motivating Smokers with Physical Disabilities to Quit Smoking (NIH funded randomized controlled trial). Experiences can include: data entry, screening participants, recruiting participants into the study, structured interviews with participants, and assisting with general research tasks. Opportunities for assisting with conference presentations is possible. Qualifications: Familiarity with research; good social and communication skills; organization, attention to detail, and proficient use of Word and Excel. Funding: Unclear at this time. Megan L. Ranney MD MPH Department of Emergency Medicine megan_ranney@brown.edu / 401-444-2557 Project One: Title - Developing an advocacy curriculum regarding gun violence Description - I am chair of a national committee on Trauma & Injury Prevention, and have been asked to develop a more detailed educational initiative re: ways that physicians can deal with gun violence. The student would assist with collating literature and developing both online and in-person resources regarding gun violence. Possible projects could include creating presentations (e.g. Prezis, webinars); helping to disseminate screening tools; helping to collate lists of resources; liaising with local and national staff. Project Two: Title - "iDove -- A text-message-based depression prevention intervention for high risk teens" Description - I am in the midst of an NIH-funded grant to develop a text-message-based depression prevention intervention. The student would have the opportunity to get involved with the iterative refinement of the intervention. Roles would include recruiting high-risk teens in the ED, helping to arrange follow-up, participating in qualitative interviews, transcribing interviews, and altering the intervention based on the interviews. Qualificatons: A strong interest in and commitment to public health is the primary qualification. Additional necessary skills include attention to detail, good interpersonal skills, and the ability to deal with a variety of unpredictable situations (particularly for project 2). Desired but (not *necessary*) attributes include experience with medical literature searches, article authorship, qualitative analysis/user-centered-design, and/or advocacy. I will ask potential students to send me a resume/CV as well as a writing sample and two references. Funding: Not available for either project John Lafleur Department of Emergency Medicine Miriam Hospital 164 Summit Ave. 02906 401 639 2072; johnelafleur@gmail.com Quorum Quenching Enzymes in Pseudomonas UTI and Catheter-Associated UT Many bacteria employ chemical signalling to coordinate the expression of virulence and biofilm formation—this is a major problem in patients with urinary catheters. In the context of growing antibiotic resistance, findings ways to limit the expression of bacterial virulence/biofilm formation (rather than killing the bacteria outright) is an increasingly attractive idea. This project aims to assess the role of urinary catheters in modulating the gene expression of Pseudomonas clinical UTI isolates, and the role in preventing infection, if any, of a native anti-virulence enzyme known as paraoxonase which is normally released into human urine. Subject enrollment, sample collection, and lab processing of samples is being conducted at RIH. I would welcome a medical student to participate in this research over the summer. The student would be involved in all phases of the work including subject enrollment and sample collection (we do have a research assistant who does most of this), and working with the samples in the lab. This will involve molecular biology/microbiology techniques including culturing clinical UTI strains, learning how to perform and analyze gene expression studies on Pseudomonas aeruginosa, and performing western blots to measure paraoxonas1 in urine samples. The ideal student is very interested in these issues—this is the only absolute requirement. I do not have funding available; stipend for the summers work would need to be obtained through application for a ‘Summer Assistantship’ Name: Jeffrey Riese, MD and Brian Alverson, MD Department: Pediatrics Address: 593 Eddy Street, Rm 223 Multiphasic Bldg., Providence, RI 02903 Phone: 401-444-7396 Email: jriese@lifespan.org or balverson@lifespan.org Project Title: “High-flow nasal cannula use in patients hospitalized with bronchiolitis” Description: To study the use of high-flow nasal cannula (HFNC) in bronchiolitis and its impact on intensive care unit admission, need for endotracheal intubation, hospital length of stay, and hospital cost. In order to achieve this goal, we will perform an administrative database search and retrospective chart review over the time periods including before HFNC was introduced at Hasbro Chidren's Hospital, when HFNC was initiated in the Pediatric ICU and when HFNC was approved to be initiated and used on the general pediatric wards. Student prerequisites: No specific previous research experience required for this retrospective chart review. The ideal student will be enthusiastic, thoughtful, and one who is interested in learning more about inpatient care of children. Students considering a career in pediatrics are encouraged to apply. We will also provide some experience on the general wards and background education for the student as a way of clarifying the nature of the research question. Funding: We do not have funding support for this project, the student will need to apply for the Scholarship from Brown. Katherine M. Sharkey, MD, PhD Assistant Professor Departments of Medicine and Psychiatry & Human Behavior EP Bradley Hospital Sleep and Chronobiology Laboratory 300 Duncan Drive Providence, RI 02906 tel: 401-421-9440 fax: 401-453-3578 katherine_sharkey@brown.edu Title: Perinatal Sleep and Mood We have two projects related to perinatal sleep and depressive and anxiety disorders. The first is a prospective study of the effects of sleep and genetics on mood during the perinatal period. Participants are women with a history of a mood disorder (major depressive disorder or bipolar disorder) who are studied during pregnancy and in the postpartum period. Sleep is recorded for one week using wrist actigraphy at several time points during the perinatal period. Participants provide DNA samples for genotyping and saliva samples for circadian phase assessment with melatonin. The second study is a pilot clinical trial of a sleep and circadian rhythm intervention to improve sleep and mood in pregnant women with depression. The student would participate in visits with participants, recruiting participants, scoring sleep data. There are several projects that could emanate from this data set. Previous experience in sleep research or women's health would be ideal. Funding through the lab may be available but student should still apply for SA funding. Daphne Koinis Mitchell, Ph.D Associate Professor (Research), Dept of Psychiatry & Human Behavior, Brown Medical School Associate Professor of Pediatrics (Research), Brown Medical School Director, Community Asthma Program, Rhode Island Hospital, Providence RI dkoinismitchell@lifespan.org Project NAPS: Nocturnal Asthma and Performance in School. Principal Investigator: Daphne Koinis Mitchell, PhD, Associate professor (research), Dept of Psychiatry & Human Behavior, Brown Medical School. NAPS is a longitudinal, multimethod study examining asthma, sleep and school outcomes in inner city minority children between 79 years of age. An ancillary study, “Asthma and Physical Activity in Urban Children: Cultural and Contextual Factors” (Koinis Mitchell and Jelalian, PId) is also under way. Involvement will include assisting with research participant recruitment and scheduling, administering questionnaires to youth with asthma and their parents, piloting physical activity and exercise challenge protocols, study tracking setup and documentation, data entry, lab organization, and other tasks integral to research. Summer interns also will assist with asthma education activities at a local week-long summer camp for children with asthma. Opportunities to be involved in preparing a manuscript for publication may also be available. Strong organizational and time management skills, excellent attention to detail, a thorough working knowledge of MS Office applications, comfort and experience interacting with children and parents from a variety of cultural backgrounds. Spanish fluency is a plus, though it is not required. No funding is available. Elizabeth McQuaid, PhD Director of Faculty Development, Bradley/Hasbro Children's Research Center, RI Hospital Director, Brown Clinical Psychology Training Consortium Associate Professor (Research) Alpert Medical School, Brown University Project ARC: Asthma Management Across the High School Transition. Involvement in this study will include scheduling and assisting with research sessions, administering questionnaires to youth with asthma and their parents, data entry, lab organization, and other tasks integral to research. Summer interns also will assist with asthma education activities at a local week-long summer camp for children with asthma. Strong organizational and time management skills, excellent attention to detail, a thorough working knowledge of MS Office applications, comfort and experience interacting with children and parents from a variety of cultural backgrounds. Spanish fluency is a plus, though it is not required. No funding is available. Thomas O’Toole, MD, Professor of Medicine, Alpert Medical School Providence VA Medical Center 830 Chalkstone Avenue, T-34 Providence, RI 02908 p: (401) 273-7100 x6266 f: (401) 457-1482 e: thomas.o’toole@va.gov Title: Evaluating the needs of homeless Veterans. Description: The student will work with the research and medical teams to formulate data-driven responses to the needs of homeless Veterans. This will include an introduction to research processes as well as clinical exposures. The student will design project aimed towards describing or improving care for homeless and other vulnerable Veteran groups. The “ideal” student will be instrinically motivated to care for disadvantaged groups, sensitive to Veteran needs, and willing to be immersed in care models for special populations. It is helpful if the student has an open-minded goal for his/her summer opportunity or is willing to be mentored on research objectives/deliverables. Unfortunately, we are not able to provide funding. Birju Shah and Jim Padbury, M.D. Women and Infants’ Hospital of Rhode Island Department of Pediatrics/Neonatal-Perinatal Medicine Kilguss Research Institute, Research Office Suite # 203 200 Chestnut Street, Providence RI 02903 401-274-1122 x 48016 bshah@wihri.org Inter-alpha inhibitor protein as an early neonatal and Perinatal biomarker for systemic inflammatory response syndrome Our laboratory has shown previously that circulating levels of inter-alpha inhibitor protein (IAIP) in plasma decrease significantly during adult and neonatal sepsis as well as necrotizing enterocolitis. We have also demonstrated the beneficial effects of IAIP replacement therapy in experimental mice model of neonatal sepsis. In our current clinical translational project, we are investigating IAIP as a neonatal biomarker that can differentiate necrotizing enterocolitis from spontaneous intestinal perforation and matched controls and also as a Perinatal biomarker of chorioamnionitis. Therefore, we are collecting plasma or serum from residual blood samples from infants at Women and Infants’ Hospital. We are also collecting clinical data for these infants from electronic health care records. Desired qualifications: Basic computer skills (MS office), prior wet lab exposure would be beneficial but not necessary. Plans for mentoring: 1. Regular meetings and ongoing evaluation of the project 2. Analysis and discussion of results 3. Hands-on laboratory experience dealing with human samples 4. Participation in poster presentation and manuscript writing 5. Attendance at Friday research colloquium conferences 6. Presentation at laboratory meeting Maria D. Mileno, MD Associate Professor of Medicine Department of Medicine, Infectious Disease Director of Travel Medicine The Miriam Hospital 164 Summit Avenue Providence, RI 02906 401-793-4620 mmileno@lifespan.org I have developed a survey that would require a research assistant to ask travelers who seek pretravel advice whether they would consent to us calling them a few weeks after their trip to report on how things went. The student would stay in travel clinic during our office hours obtaining signed consent forms and organizing a call back schedule. They will also make some of the phone calls to the travelers to complete the 10 minute phone survey. We need to recruit about 400 individuals to have powerful data. I need someone who is organized, meticulous with data and follow through, personable and available. I promise they will enjoy talking to travelers! They will be included as authors on publications. I can provide funding. Scott Hewitt, MA, CPEHR Project Manager Brown Primary Care Transformation Initiative Teaching Associate Alpert Medical School of Brown University Phone: 401-729-2818 Fax: 401-729-2923 scott_hewitt@brown.edu The Brown Primary Care Transformation Initiative, based out of the Dept. of Family Medicine of Brown Univ. and Memorial Hospital of Rhode Island has opportunities for students this summer. We are looking for students interested in primary care and health care reform to provide assistance in collecting, curating, and analyzing quantitative and qualitative data on primary care practices that are implementing the Patient Centered Medical Home of model of care. Students will also assist Practice Transformation Facilitators and they directly engage practices to facilitate the implementation of the model. Ideally, candidates will be comfortable with Microsoft Office and interacting with physicians, medical staff, and patients in the practice setting. We anticipate being able to provide some funding. Pamela C. High, MD Professor of Pediatrics (Clinical) W Alpert Medical School of Brown University Director, Developmental-Behavioral Pediatrics Hasbro Children's/Rhode Island Hospital 593 Eddy Street Providence, RI 02903 phigh@lifespan.org Tel (401) 444-5440, Fax (401) 444-8488 I am working with Dr. Marsha VanVleet, director of the newborn nursery at Women and Infant and Dr. Luisa Cala Cala, a fellow in Developmental-Behavioral Pediatrics on a study that I think would be of great interest to a Spanish-English fluent student. We have created two educational interventions for new mothers and we will be testing them beginning in February and continuing through the summer. One intervention is a bilingual DVD, bilingual booklet and bilingual children’s book that promotes parent child interactions and focuses on reading with young children. The second is a bilingual video and booklet that teaching parents that many young infants can be fussy and supports them in learning to calm their babies and take care of their own needs. We will enroll 400 new mothers who are fluent in either Spanish or English and are insured through Medicaid into one of these two interventions. Each intervention group will serve as the control group for the other intervention. We will have follow-up telephone interview conducted when babies are 2-4 months and 5-6 months old. Interested students could assist in enrollment, interview parents in follow-up, enter data into a spread sheet, participate in data analysis and presentation and/or help prepare papers for publication. We do not currently have external funding for this project, so a talented and interested student would be a great addition to our team. Dr. Colleen Kelly Colleen_r_kelly@brown.edu The Miriam Hospital Women’s Medicine Collaborative 146 W River St Providence, RI 02904 Research assistant, 10 hours/week NIH-funded study of fecal transplant for recurrent C. difficile infection. It will be conducted over 1.5 years. Under the supervision of Dr. Colleen Kelly (PI) and Joyce McKenney (Research Manager), the research assistant will interview patients to gather information, make phone calls to research participants, book follow up visits for subjects, prepare and maintain study records, enter data into the study-database, prepare study materials, and transport specimens to the research laboratory. Qualified applicants will be able to work at least 3 days per week and have excellent organizational skills. Training in working with human research participants and protection of human subjects will be provided and is mandatory.