The Cardiff University - Peking University Cancer Institute Summary Following Cardiff University's national award, recognising it as the UK's leading international research collaborator, the prize brought the Albert Hung Scholarship Programme and Cardiff’s ground-breaking collaborative medical research projects with China to the fore. In light of this national recognition, Cardiff University and Peking University have agreed that the time is right to develop their partnership further and establish a joint research institute. The new institute will consist of two designated research centres, one located at each university and will provide a true home and state-of-the-art facilities for its leading cancer specialists and elite students to collaborate more effectively and provide an environment in which to enhance the significant advances already achieved in the joint fight against cancer. To expedite matters and signal a clear commitment to this next phase in this exciting research partnership, Cardiff University has agreed to invest nearly £5 million over the next five years. Support is also being sought to continue to develop the scholarship opportunities for China’s elite students. The Universities Peking University is over a hundred years old and is China's leading university, frequently cited in the top 50 of the world's leading institutions. It is one of the top 5 Higher Education Institutions in Asia and its research, teaching and international activities are recognised worldwide for their excellence. Some of China’s leading cancer experts work at Peking’s University Hospital. With more than 1,000 beds and dedicated to the treatment of cancer, research, teaching and policy making, it is one of the largest facilities of its kind and is ranked No.1 in China for the treatment of the top 6 cancers 1 Cardiff University has two Nobel Prize winners, including its current President, Professor Sir Martin Evans, Nobel Laureate for Medicine in 2007 for his work in embryonic stem cells. Cardiff’s School of Medicine is the University’s largest school and is the only medical school in Wales providing full curriculum medical education and is one of the leading hubs in medical research in the UK recognised as a world leader in many medical specialties including cancer research. Cancer research at Cardiff University is carried out at the Schools of Medicine, Bioscience and Pharmacy and encompasses all the core specialties including: clinical trials; cancer metastasis; molecular diagnosis; imaging; cancer stem cells and anti-cancer compounds. Recently, the School of Medicine established the Institute of Cancer and Genetics to promote an integrated systemic approach to cancer research and clinical delivery. The School of Medicine also has one of the best operated cancer banks in the UK. The Cardiff University and Peking University Partnership Medical links between Cardiff and Peking have been ongoing for almost two decades, beginning with the visit of the first Peking Visiting Fellows in 1985, who have since become academic leaders in their specialist areas of cancer research. These important initial steps have, over time, led to a series of successful collaborative cancer projects further strengthening the universities joint commitment to work closer togeher. In 2007, to capture the rapid and significant medical progress made and to formally acknowledge the universities close partnership more formally, a Memorandum of Understanding (MoU) was signed in Peking by the Vice-Chancellor of Cardiff University, Dr David Grant and the Executive Vice-President of Peking University, Professor Yang Ke. 2 The first official visit by Cardiff University to Peking University Health Scientific Centre. The picture was taken shortly after the signing of the first MoU in April 2007. Since the signing of the MoU, exchanges and collaborations between the two institutions have accelerated on all fronts. To date, Cardiff has welcomed eight Peking Fellows to its specialist research facilities, who have undertaken vital research in lung cancer, breast oesophageal cancer, gastric cancer and colorectal cancer. It should also be acknowledged that all these Fellows were supported by the Albert Hung China Medical Scholarship Fund. Once the scholarship programmes were successfully completed, all the Fellows returned to Peking University to continue their careers, their research and share their knowledge with their colleagues. To date, they have jointly published 15 research papers and received 2 national grants and 2 local government grants to continue the research work originally developed at Cardiff. It should also be noted that three of the Fellows received their PhD doctorates in recognition of their novel research projects they conducted whilst at Cardiff University. High level academic exchanges between the universities continued to grow and have been complemented further by visiting lectures, research strategy meetings and seminars. It was the result of these discussions that Cardiff University welcomed a delegation from Peking University in January 2012. The delegation included the Director of Peking University cancer Hospital, the dean of Peking’s School of Oncology and the Director of Peking University Cancer Research Centre. It was during the visit, that a new MoU was signed and colleagues from both universities began to explore the idea of creating a joint research institution to advance the collaborative successes and to more effectively develop the joint medical research programmes in the areas of cancer treatment and diagnosis. 3 The signing ceremony of the renewed MoU, Jan 2012 The significant benefits that such an institute would create were clear and so both parties agreed that a new joint research facility should be established. The Institute It has been agreed that the new institute will be known as the: ‘Cardiff University - Peking University School of Oncology Joint Institute’ Dedicated space has been identified at both universities to accommodate the two centres and both single and joint studentship programmes at PhD, MD and Masters level will be created. In the future, it is also the intention to establish joint undergraduate opportunities that will provide students with the opportunity to study at both universities. 4 Proposed calendar of achievement Operation of the Joint Centres The Patron: It is suggested that a Patron is appointed to promote the work of the institute and provide a steer in fundraising activities. The Patron is also expected to have a strong interest in international, in particular Sino-UK relations. Governing body: The Institute will be governed by a Board and chaired by a Governor external to both universities. 5 Operations: The joint Institute will be managed by a management team, comprising a Director, Deputy Director(s), Chief Scientists, Chief Clinicians, and senior manager(s). The proposed governance, management, interaction of the joint venture. 6 Immediate research theme and projects The initial research projects and strategies will focus on the following research themes: Endocrine related cancers: namely breast cancer and prostate/urological cancer. Both centres have significant expertise in these fields and have been identified as a strength on which to build further. G-I cancers: Peking is the national centre for gastric cancer research in China and UK has recently launched its drive into colorectal cancer research. Cardiff and Peking have started its collaboration in gastric and colon cancer since 2011. This will also be a leading theme to develop. Lung cancer: Lung cancer is the major killer in both countries and has been on top agenda in cancer research and treatment in both countries. Cardiff and Peking have been collaborating in this area since 1999 with some exciting discoveries. Tumour banking:This is related to the first three lines but goes well beyond. Cardiff’s tumour bank and Peking tumour bank will collaborate by providing support to each other’s collection and to each other’s research. It is expected that specific projects under these themes will be drawn up soon with existing joint research projects, such as those listed below will be undertaken at the centres under the auspices of the new Cardiff University - Peking University School of Oncology Joint Institute. Tumour suppressors MTSS1, GDF9a and VEGI in human prostate and kidney cancers: the molecular, cellular and clinical implication. Partly funded by China Natural Science Foundation, the two universities have been collaborating since 2008. This study has entered the second phase: looking for small peptides and therapeutic implications. Cell death associated proteins, DAP and WISP in human gastric cancer. Started from 2010, the initial phase study is about to conclude with some fascinating results (manuscripts to be submitted in 2012). Prognostic value of iASPP and BMPs in human lung cancer. This is a lasting collaboration for the past decade. Again supported by the China Natural Science Foundation, Beijing Municipal Government and Peking University, this study continues to flourish. 7 Tumour banking: via collaboration, Cardiff has already conducted series studies on samples from Peking’s cancer bank, namely lung, oesophageal and gastric cancer. The prognostic implications of these banking materials and data will be explored. Joint applications for funding The two centres will apply to the funding bodies in the UK, EU and China, led by the respective theme leaders in the respective countries. It will also actively engage with industry, individuals and charitable organisations. Investment and scholarship support It has been agreed that, in order for the centres to achieve their ambitions and establish the Joint Institute at the earliest possible date, institutional investment is essential. This funding will provide the infrastructure and, critically, the Fellowships to allow the exchange of scholars and staff between the two centres. Investment in estate and key facilities are also vital. Scholarship support It is planned that the newly created Cardiff University - Peking University School of Oncology Joint Institute, will provide the impetus to expand the Albert Hung China Medical Scholarship Programme further and attract philanthropic support to provide China’s leading cancer research specialists with a unique international learning and research experience. During the first year of operation, both institutions are seeking scholarship investment of approximately £100,000 each per annum with an initial commitment of 5 years. 8