268 | P a g e Meiosis Unit Cover Page (see guidelines on page 21) 269 | P a g e Meiosis Unit Front Page At the end of this unit, I will: Know the difference between sexual and asexual reproduction. Understand the difference between haploid and diploid cells. Understand the steps involved in meiosis with regard to gametes and chromosome number. Interpret a karyotype, being able to identify gender or potential disorder from the karyotype. Roots, Prefixes and Suffixes I will be able to understand when I see them in words are: Homo-, chromo-, hap-, di-, karyo -logous, -some The terms I can completely define are: Gene, homologous chromosome, gamete, haploid, fertilization, diploid, meiosis, crossing over, karyotype, telomere, nondisjunction The assignments I will have completed by the end of this unit are: Meiosis Unit Cover Page (page 269) Reproduction Notes (page 271, 273) Understanding Haploid & Diploid (page 272) Pictomicrograph of Chromosomes (page 274) Chromosomes and Karyotypes (page 275 ) Using Karyotypes to Predict Genetic Disorders (pages 276-277) Patient Histories: Karyotyping Activity (pages 277-279) Meiosis Layered Foldable (page 281) Meiosis Overview (page 282) Meiosis Notes (pages 283-289) Meiosis Songs (pages 290-291) Meiosis Pipe Cleaner Play (pages 292-295) Meiosis Unit Review (pages 300-304) Meiosis Unit Student Concept Cards (page 305) Meiosis Unit Student Concept Map (page 306) Parent/Significant Adult Review Page (pages 307-308) Meiosis Unit Back Page (309) 270 | P a g e Reproduction Notes A form of reproduction that: What is asexual reproduction? is _____ - _______________ (only ____________ parent is needed) produces ___________ ____________clones of the parent ( __________ _________ of the original) Characteristics: ________________________ What are some characteristics of asexual reproduction? ________________________ Allows _________ spread of an organism (ex. ________________ growth) Since the offspring are identical, there is no mechanism for introducing What are some specific examples of asexual reproduction? Why do organisms have sex? ____________ . Prokaryotes undergo _______________ ___________________ Hydra reproduce by _____________________ Planaria reproduce by ________________________________ Several plants reproduce through _____________________ reproduction. Most of these organisms can reproduce _______________ as well. Sexual reproduction increases ____________________ by producing new _____________________ combinations. Genetic diversity allow ____________________ to _________________ to ever- changing environments 271 | P a g e Meiosis and Reproduction Warm-up Humans have 46 chromosomes in all of their body cells. The first cell of the organism is made by joining egg and sperm. 1. How many chromosomes do you think are in a human egg or sperm cell? Explain. _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 2. Do you think that cell division by mitosis (duplication of cells) can produce egg or sperm? Explain. _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ Understanding Haploid and Diploid If N=2, 2N would look like: = A chromosome = A chromosome There are 2 different types of chromosomes in this cell. 2N means that this cell is diploid (or there are two copies of each chromosome). How many total chromosomes are present in this cell? _________ 1. Draw the chromosomes in a diploid cell of an organism where N=3. 2. How many combinations of haploid (eggs or sperm) cells are possible if N=2? Draw the possible combinations. 3. How many combinations of haploid cells are possible if N=3? Draw the possible combinations. 272 | P a g e Reproduction Notes ________________ for fertilization usually come from separate parents Sexual Reproduction What is the difference between oogenesis and spermatogenesis? What does it mean to have a haploid vs. a diploid set of chromosomes? – Female produces an ________ (____genesis) – Male produces ____________ (__________ genesis) Both gametes are ____________, with a ________ set of ____________________________. The new individual is called a __________________, with ______ sets of chromosomes (___________________). What is dividing zygote called? Once the zygote begins to divide, it is called an _________________. Consists of ____________________ and ____________________________ Meiosis: Formation of _______ ___________ reproductive cells (gametes) from a single ____________ cell of the parent. What does sexual reproduction consist of? – In humans, meiosis only occurs in the _____________ – Spermatogenesis: In the ______________(in males) – Oogenesis: In the _______________ (in females) ______________________: _______________________ of ___________ gametes from two different parents to produce a ____________ individual Chromosomes vary from species to species. Prokaryotes generally have only one major chromosome, consisting of a single circle of DNA Turkeys have 82 Giant redwoods have 22 A tropical fish has the same number of chromosomes as humans, which is 46 273 | P a g e Photomicrograph of Chromosomes What is the name for the way these chromosomes are organized? _______________________________________ Circle the sex chromosomes in the following image. What is the gender of this person? ______________ Is the following karyotype normal or abnormal? Why? What is the gender of this person? ___________________________________ 274 | P a g e Chromosomes and Karyotypes Human Chromosome Characteristics: How do you calculate the haploid number from the diploid number of an individual? ___________ set for humans: 2n = ______ chromosomes n = 23 chromosomes (haploid set) Two types of chromosomes: What are the two types of chromosomes? • ___________________ (chromosomes 1 – 22) • _______ Chromosomes (chromosome ____) Autosomes: • ________________ chromosomes (w/ ________________ pairs) What is the difference in characteristics between an autosome and sex chromosomes? • Humans have _____ pairs Sex chromosomes: • Humans have ____ pair • ___________-sex chromosomes are ____________________ (__ __) • ________-sex chromosomes are ____- _____________________ (__ __) Scientists can organize chromosomes in a cell into a ________________ What can karyotypes tell us? In a karyotype, chromosomes are arranged in order of__________, _____________ _______________, and ___________________ position. 275 | P a g e USING KARYOTYPES TO PREDICT GENETIC DISORDERS Use the following website to help you fill in the blanks and answer the following questions. http://learn.genetics.utah.edu/content/begin/traits/predictdisorder/ 1. A normal human karyotype has ______ chromosomes: _____ pairs of autosomes and ____ sex chromosomes. Cells don’t always end up with these chromosomal numbers, though. The following text outlines what happens when cells end up with too much or too little genetic information. 2. Too many or too few chromosomes: a. To understand how our cells might end up with too many or too few chromosomes, we need to know how the cells normally get _____ chromosomes. b. First we need to understand meiosis. Meiosis is the cell division process that produces egg and sperm cells (___________), which normally have ______ chromosomes each. c. If eggs and sperm only have one set of _____________________, then how do we end up with 46 chromosomes? During ______________________, when the egg and sperm fuse, the resulting _________________ has two copies of each chromosome needed for proper development, for a total of ________. 3. How can cells end up with too many or too few chromosomes? a. Sometimes chromosomes are incorrectly distributed into the egg or sperm cells during _______________. When this happens, one cell may get __________ copies of a particular chromosome, while another cell gets none. b. What happens if a sperm or egg cell with an abnormal number of chromosomes participates in fertilization? It depends on how many chromosomes the gamete has. For example, if a ___________ with an extra chromosome fertilizes an egg with a normal chromosome number, the resulting zygote will have _____ copies of one chromosome. This is called _______________. c. If a sperm that is missing a ___________________ fertilizes an egg, then the resulting zygote will have only one copy of that chromosome. This is called ________________________ d. People who are born with an abnormal number of chromosomes often have genetic disorders because their cells contain too much or too little genetic information. Scientists can predict genetic disorders by looking for extra or missing chromosomes in a ___________________. 276 | P a g e USING KARYOTYPES TO PREDICT GENETIC DISORDERS 4. Missing pieces of chromosomes a. In some cases, genetic material is missing from a chromosome. Such chromosomes are said to have __________________. b. Deletions large enough to be seen in a karyotype result in the loss of many _____________. In humans, these are less common than deletions that remove small portions of a chromosome. c. A _________________________ is a chromosome rearrangement in which part of a chromosome breaks off and then reattaches to a different chromosome. QUIZ: Use the options listed below and your knowledge to answer the following questions. Some options will be used more than once. Normal female Turner Syndrome Normal male Klinefelter Syndrome Down Syndrome 1. _______________________ 5. _______________________ 2. _______________________ 6. _______________________ 3. _______________________ 7. _______________________ 4. _______________________ 8. _______________________ 277 | P a g e Patient Histories: Karyotyping Activity Introduction This exercise is a simulation of human karyotyping using digital images of chromosomes from actual human genetic studies. You will be arranging chromosomes into a completed karyotype, and interpreting your findings just as if you were working in a genetic analysis program at a hospital or clinic. Karyotype analyses are performed over 400,000 times per year in the U.S. and Canada. Imagine that you were performing these analyses for real people, and that your conclusions would drastically affect their lives. G Banding During mitosis, the 23 pairs of human chromosomes condense and are visible with a light microscope. A karyotype analysis usually involves blocking cells in mitosis and staining the condensed chromosomes with Giemsa dye. The dye stains regions of chromosomes that are rich in the base pairs Adenine (A) and Thymine (T) producing a dark band. A common misconception is that bands represent single genes, but in fact the thinnest bands contain over a million base pairs and potentially hundreds of genes. For example, the size of one small band is about equal to the entire genetic information for one bacterium. The analysis involves comparing chromosomes for their length, the placement of centromeres (areas where the two chromatids are joined), and the location and sizes of G-bands. 278 | P a g e Patient Histories: Karyotyping Activity Your assignment: This exercise is designed as an introduction to genetic studies on humans. Karyotyping is one of many techniques that allow us to look for several thousand possible genetic diseases in humans. You will evaluate 3 patients' case histories, complete their karyotypes, and diagnose any missing or extra chromosomes. The assignment will be completed online, while the questions must be answered on the following page. Use the following website to help these patients diagnose their disorders from karyotypes and answer the following questions. http://www.biology.arizona.edu/human_bio/activities/karyotyping/karyotyping2.html Patient Histories: Patient A Patient A is the nearly-full-term fetus of a forty year old female. Chromosomes were obtained from fetal epithelial cells acquired through amniocentesis. Complete Patient A's Karyotype (this will have to be done online). Patient B Patient B is a 28 year old male who is trying to identify a cause for his infertility. Chromosomes were obtained from nucleated cells in the patient's blood. Complete Patient B's Karyotype. Patient C Patient C died shortly after birth, with a multitude of anomalies, including polydactyly (more than five fingers on a hand) and a cleft lip. Chromosomes were obtained from a tissue sample. Complete Patient C's Karyotype. 279 | P a g e Patient Histories: Karyotyping Activity Making a diagnosis: The next step is to either diagnose or rule out a chromosomal abnormality. In a patient with a normal number of chromosomes, each pair will have only two chromosomes. Having an extra or missing chromosome usually renders a fetus inviable (meaning that it will not live). In cases where the fetus makes it to term, there are unique clinical features depending on which chromosome is affected. Listed below are some syndromes caused by an abnormal number of chromosomes. Diagnosis Chromosomal Abnormality Normal # of chromosomes Patient's problems are due to something other than an abnormal number of chromosomes. Klinefelter's Syndrome One or more extra sex chromosomes (i.e., XXY) Down's Syndrome Trisomy 21, extra chromosome 21 Trisomy 13 Syndrome Extra chromosome 13 1. What observations can you make regarding patient A’s karyotype? _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 2. What diagnosis would you give patient A? Explain your answer. _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 3. What observations can you make regarding patient B’s karyotype? _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 4. What diagnosis would you give patient B? Explain your answer. _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 5. What observations can you make regarding patient C’s karyotype? _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 6. What diagnosis would you give patient C? Explain your answer. _________________________________________________________________________________________________________ _________________________________________________________________________________________________________ 280 | P a g e Meiosis Layered Foldable 281 | P a g e Meiosis Overview Follow your teacher’s powerpoint presentation, and draw the overview of meiosis, using two different colors. 282 | P a g e Meiosis Notes Meiosis begins after interphase, when the __ __ __replicates. Meiosis is often called ____________________/____________________ Reduction: Process takes a ________________ cell with two sets of chromosomes and reduces it to a _________________ cell with one set of chromosomes. When does meiosis start? What is meiosis often called and why? Division The cytoplasmic division of one cell into _______ cells. This takes 2 rounds of division. Meiosis can be broken up into two phases of division: and . Meiosis I Prophase I Prophase I is much like the prophase of mitosis: 1. Nuclear membrane _________________________ 2. ________________ form 3. Chromatin ________________ into __________________. However, unlike mitosis, where the chromosomes of a homologous pair are randomly scattered within the nucleus, in prophase I of meiosis: 1. Homologous chromosomes group with other homologous chromosomes to form a “_________________” 2. A “_________________” occurs at the point where the chromosomes ___________ ___________, _______________, and ______________ ________________ of the chromosome 283 | P a g e Check for Understanding: Phases of Meiosis Name of Phase Description 1. Homologous chromosomes pair up and form tetrad 2. Spindle fibers move homologous chromosomes to opposite sides 3. Nuclear membrane reforms, cytoplasm divides, 4 daughter cells formed 4. Chromosomes line up along equator, not in homologous pairs 5. Crossing-over occurs 6. Sister chromatids separate 7. Homologous chromosomes line up alone equator 8. Cytoplasm divides, 2 daughter cells are formed On each of the images, label the phase of meiosis. 284 | P a g e Meiosis Notes Metaphase I Metaphase I 1. _____________________ chromosomes _________ ____ at the _______________ _______________ . 2. Microtubules (_______________) attach to the kinetochore of _____________________ Anaphase I Anaphase I 1. Homologous chromosomes ____________________. 2. _____________________________________________________________________ _______________________________________________ Telophase I Telophase I/Cytokinesis 1. _____ daughter _________ are formed with each one containing only _____ chromosome of the _________________ __________. 2. The daughter cells are now ___________________. 285 | P a g e Meiosis Application: Label the micrographs of lily anthers undergoing meiosis. 1. A cell with a diploid number (2N) of 20 undergoes meiosis. This will produce ________ daughter cells, each with a haploid number of ____________ chromosomes. 2. Crossing over occurs during this phase: _______________________ 3. True or False: The only difference in mitosis and meiosis is that meiosis happens in order to create sex cells. 4. At the end of meiosis I, ________ daughter cells are created. These daughter cells are [diploid | haploid]. (Pick one) 5. Meiosis occurs in what type of cells: ____________________________ 6. Circle the homologous chromosomes. 286 | P a g e Meiosis Notes Meiosis II Prophase II Prophase II 1. DNA does __________ ________________________. 2. Prophase II is just like ______________ prophase. Metaphase II Metaphase II 1. All of the chromosomes line up at the ____________________ plate. Anaphase II Anaphase II 1. __________________ divide 2. _______________ ____________________ migrate separately to each pole. 287 | P a g e Mitosis vs. Meiosis 288 | P a g e Meiosis Notes Telophase II/Cytokinesis Telophase II/Cytokinesis 1. Chromosomes revert to _________________. 2. ____________ ____________. 3. Cytoplasm _______________. 4. Four ______________ daughter cells are obtained Mitosis vs. Meiosis 289 | P a g e Meiosis Song to the Tune of “Are You Sleeping” Use your fingers to “act out” meiosis to this song. Your teacher will direct you. I’m from my mommy I’m from my daddy Replicate Replicate At prophase we cross over Then shuffle, shuffle, shuffle Separate Separate 290 | P a g e Meiosis Square Dance Lyrics Now coil up, coil up, coil up tight With a fiber stuck to your centromere If we’re to do meiosis right You’re pulled into the center here Interphase one is almost done On the central plate for metaphase two Marks the start of prophase one Just like before it’s déjà vu Face your partners and do them bow At Interphase one you duplicate Do-se-do crossover now So now that you can separate Allemande left with your left hand The fibers tugging this is it Promenade around the land Time for your chromatids to split Now grab your partner’s chromatid Anaphase, anaphase, anaphase two Crossing arms you’ll be glad you did This time you wave goodbye to you The nuclear membrane breaks down here At telophase two half the teams on hand Attach your fiber to you centromere You’re feeling sad you’re a single strand The fibers pull the dance is done Now this is just your normal state Hold on tight its metaphase one With some luck you’ll procreate Couples move to the central plate So rest a while and unwind too It’s anaphase one so you separate As the nuclear membrane surrounds you Now wave goodbye to reach your goal Now meiosis is complete Each partner move to the other pole Four nuclei from ones the treat Telophase one is mighty sad The cytoplasm will divide You’re all alone lost what you had Four gametes form with you inside Together we’ll no longer be And if we zoom out you will find These parts of you will be dear to me Many more of the same kind Prophase, prophase, prophase two And if you’re wondering what’s the use The spindles coming after you It’s all so we can reproduce… reproduce 291 | P a g e Meiosis Pipe Cleaner Play Act 1: Scene I – Interphase Act 1: Scene 2 – Prophase I Act 1: Scene 4 –After Cytokinesis of Meiosis I Act 2: Scenes 3 and 4 – After Cytokinesis of Meiosis II 292 | P a g e Meiosis Pipe Cleaner Play Introduction: A fruit fly’s testes are going through meiosis. What combination of alleles will be passed on in each of his gametes? Act 1: Scene 1 - Interphase The fruit fly has 6 chromosomes. The genotype of your fruit fly is GgBbrr. Remove these chromosomes from your bag to start the play. -Chromosome 1: with allele G (for Gray eyes) -Chromosome 2: with allele g (for green eyes) -Chromosome 3: with allele B (for black, solid body) -Chromosome 4: with allele b (for striped body) -Chromosome 5: with allele r (for shriveled wings) -Chromosome 6: with allele r (for shriveled wings) Draw the arrangement of your chromosomes during the S-phase of interphase. Show duplicated DNA connected at the centromere. Make sure to mark the alleles. Act 1: Scene 2 - Prophase I Homologous chromosomes pair up (not line up) Cross-over occurs on at least 2 homologous pair with at least 2 alleles. (Switch beads) Draw the new genetic combinations of your chromosomes at this phase after cross-over. Act 1: Scene 3- Metaphase I Random line-up of homologous pairs. Act 1: Scene 4 – Anaphase I ,Telophase I, and Cytokinesis Homologous pairs separate Nuclei reform in two separate cells. Draw the chromosomes and alleles that exist in each of the two cells. Act 2: Scene 1 and 2 – Prophase II and Metaphase II Nuclei disappear Chromosomes line up at equator. Act 2: Scene 3 and 4 – Anapahse II ,Telophase II, and Cytokinesis Sister chromatids split to opposite poles Nuclei reform in 4 separate cells (4 haploid gametes are created) Draw the allele combination present in each of the haploid gametes. 293 | P a g e Meiosis Pipe Cleaner Play Act 3: Fertilization Choose one of the four gametes created and write down its Genotype here ____________. Have it fertilize another gamete with the genotype Gbr. What is the new offsprings full genotype? _________________ Draw the new fly offspring in the space below. Use color and make sure it matches the genotype. 294 | P a g e Meiosis Pipe Cleaner Play Act 3: Fertilization Your fly meets a female fly, and they like each other and want to have baby flies. Choose one of your four gametes to be the “sperm” Draw what kind of fly would be created if your fly’s sperm fertilized an egg in the other fly with the allele combination Gbr. Encore! Return all pipe-cleaners into the original bag! 295 | P a g e 296 | P a g e 297 | P a g e 298 | P a g e 299 | P a g e Meiosis Unit Review 1. What term is used to describe “body” cells containing the normal number of chromosomes? _______________________ 2. What term is used to describe cells containing half the number of chromosomes? _________________ 3. Mitosis produces (circle one) diploid / haploid cells. 4. Meiosis produces (circle one) diploid / haploid cells. 5. Define the difference between diploid and haploid. 6. How many pairs of chromosomes do human body cells have? _______ pairs. 7. Which pair of chromosomes designates the organism’s gender? Chromosome # _____ 8. What is the difference between oogenesis and spermatogenesis? Chromosome Numbers of Some Common Organisms Organism Body cell (2n) Gamete (n) Human 46 _______ Garden Pea _______ 7 Fruit Fly 8 _______ Tomato _______ 12 Dog 78 _______ Chimpanzee _______ 24 Leopard Frog 26 _______ Corn _______ 10 Apple _______ 17 Indian Fern 1260 _______ 300 | P a g e Meiosis Unit Review Meiosis I (Prophase I, Metaphase I, Anaphase I, Telophase I) During prophase I, the _______________________ coil up and the _____________ fibers form. Then each pair of homologous chromosomes come together to form a four-part structure called a ____________ (tetra = what number?____). A tetrad consists of two homologous chromosomes, each made up of two sister chromatids. These 4 chromatids in a ____________ are held very close and tightly together. In fact, they are so close that the arms of non-sister chromatids can wind and twist around each other, and exchange genetic information (genes, DNA). This is called _______________ ____________. Crossing over results in new combinations of alleles. The Phases of MEIOSIS Before meiosis begins: Interphase Before meiosis begins, what must happen to the cell’s DNA/chromosomes? ____________________________________ Meiosis occurs in sexual reproduction when 1 diploid germ cell produces 4 haploid cells that can mature to become ____________________ (sperm or ova). Prophase I Like prophase of mitosis: 1. The ______________ ______________ disappears. 2. ___________________ move to the opposite poles and the _______________ ___________ form between the centrioles. 3. __________________ condenses into sister _________________. Unlike prophase of mitosis: 1. Pairs of homologous chromosomes form _________. 2. _________________ _________ may occur. 301 | P a g e Meiosis Unit Review Metaphase I 1. Spindle fibers attach to _________________. 2. Tetrads line up at the ___________________ plate. Anaphase I 1. Tetrads, which consist of two ___________________ ________________, separate. Telophase I / Cytokinesis I 1. _______________ __________________ reappears. 2. _______________ ______________ disappears. 3. ___________________, the division of the cytoplasm and the organelles begins and ends forming two cells. Meiosis II (Prophase II, Metaphase II, Anaphase II, Telophase II) The purpose of meiosis II is to separate _______________ ___________________ of each chromosome into separate cells. 302 | P a g e Meiosis Unit Review Prophase II 1. _______________ _______________ disappears. 2. _______________ _____________ form. 3. __________________ condenses into sister _________________. Metaphase II 1. Sister chromatids attach to the ________________ ________________. 2. Sister chromatids line up at the ________________. Anaphase II 1. Sister chromatids separate into _____________________. 2. Chromosomes move to the opposite ___________. Telophase II 1. ______________ _________________ reforms. 2. 4 ______________ are formed. 303 | P a g e Meiosis Unit Review Comparing Mitosis and Meiosis: Determine whether the following characteristics apply to mitosis, meiosis, or both by putting a check in the appropriate column(s) Characteristic No pairing of homologous chromosomes Two Divisions Four daughter cells Produced Associated with growth and asexual reproduction Associated with sexual reproduction One Division Two daughter cells are produced Involves duplication of chromosomes during interphase prior to division Chromosome number is maintained Chromosome number is halved Crossing over occurs Tetrads form Daughter cells are identical to parent cell Daughter cells only have half the genetic information as the parents Produces gametes Chiasmata or synapsis occurs in prophase Independent assortment of tetrads along metaphase plate Sister Chromatids separate Homologous Chromosomes separate Genetic diversity is introduced Cloning 304 | P a g e Mitosis Meiosis Meiosis Unit Student Concept Cards 305 | P a g e Meiosis Unit Student Concept Map 306 | P a g e Parent/Significant Adult Review Page Student Portion Unit Summary (write a summary of the past unit using 5-7 sentences): Explain your favorite assignment in this unit: Adult Portion Dear Parent/ Significant Adult: This Interactive Notebook represents your student’s learning to date and should contain the work your student has completed. Please take some time to look at the unit your student just completed, read his/ her reflection and respond to the following Please write down 3 facts that your student has shared with you that they learned during this unit: What assignment was the most effective at helping your student learn the content of this unit: Parent/ Significant Adult Signature: 307 | P a g e Intentionally Left Blank 308 | P a g e Meiosis Foldable Directions: You will be using two templates to create two 6-tab foldables. For each template, cut along the solid lines and fold along the dashed lines. Assemble the three pieces into a foldable similar to the one on page 18 of your interactive notebook. The 12 tabs should be labeled or filled as follows: Meiosis Drawing of a cell in telophase I. Drawing of a cell in interphase Drawing of a cell in late prophase II. Drawing of a cell in early prophase I. Drawing of cell in metaphase II. Drawing of a cell in late prophase I. Drawing of cell in anaphase II. Drawing of cell in metaphase I. Drawing of a cell in telophase II. Drawing of a cell in anaphase I. Drawing of the final products of meiosis Requirements: Shows Process – drawings must start with a cell that starts with diploid number (2N = 6) to create four haploid gametes (N = 3) as the end product. Correct number of chromosomes must be shown throughout the process. Chromosomal Size or Centromere Considerations – differentiate the chromosomes using varying sizes or varying centromere positions. The homologous pairs should be of the same size with the same centromere position. Colorful – must include four or more colors throughout the foldable. Differentiate your homologous pairs with at least two different colors. Neat – consider sketching in pencil, then trace in ink and color. Informative – underneath each of the 12 tabs, include all important identifying characteristics of that stage of meiosis. Storage – Create a “pocket” on page 281 to store your layered foldable. Optional: you can place your foldable in a clear page protector in front of page 281. 309 | P a g e Meiosis Unit Back Page The California State Standards I have come to use and understand are: (Please check all that you do feel you used and understood this unit) Meiosis is an early step in sexual reproduction in which the pairs of chromosomes separate and segregate randomly during cell division to produce gametes containing one chromosome of each type. Only certain cells in a multicellular organism undergo meiosis. New combinations of alleles may be generated in a zygote through the fusion of male and female gametes. Why approximately half of an individual’s DNA sequence comes from each parent. The role of chromosomes in determining an individual’s sex. The genetic basis for Mendel’s laws of segregation and independent assortment. 310 | P a g e