Supplemental Digital Content 2. Characteristic of included studies Study Participants Design Source/Country Outcomes Summary Risk of Bias Albavera Hernandez 201024 Anjos 200925 Patients all Surveillance Pradera. Valle del ages study Cauca. Colombia Hospitalized Descriptive Hospital patients all study Universitário ages VZV incidence Low Use of resources High Varicella NA[1] Oswaldo. Recife. Pernambuco. Brazil Argentina, National Surveillance System 201026 All population Surveillance Ministry of Health. Study Participants Design Source/Country Outcomes Summary Risk of Bias Carvalho 200727 study Argentina incidence Ambulatory Cross Capela do Socorro. Varicella infants all sectional Sao Paulo. Brazil incidence Children < 15 Prospective Santisima Trinidad Varicella years old observational Children Hospital. incidence. Days hospitalized study Cordoba. Argentina of hospitalization Hospitalized Surveillance Ministry of Health. Mortality. patients all study Chile Admissions due Low ages Cevallos 200628 Low due to varicella Chile, Ministry of Health 200629 NA Study Participants Design Source/Country Outcomes Summary Risk of Bias ages Falaschi 200830 to varicella Children 0-14 Retrospective "Notti" Hospital. Admissions due years old descriptive to varicella. hospitalized study Mendoza. Argentina High Complications of varicella. Gallegos Ulloa 200731 All population Surveillance Ministry of Health. Varicella study Chile incidence. Mortality. Admissions due to varicella Low Study Participants Design Source/Country Outcomes Summary Risk of Bias Gentilcore 200632 Children < 4 Retrospective Noel Sbarra Varicella years old study Hospital. La Plata. incidence. Days hospitalized. Buenos Aires. of hospitalization. Hospital break Argentina Days of of varicella Gonzalez Ayala 200833 hospitalization Children < 4 Prospective “Sor Maria Admissions due years old observational Ludovica”Children to varicella. Hospital. La Plata. Complications of Buenos Aires. varicella. Use of Argentina Resources Day Care Centers. Use of resources. NA hospitalized Marcitelli 200634 High Ambulatory Descriptive High Study Participants Design Source/Country Outcomes Summary Risk of Bias children 6 cross Taubate. Sao Paulo. Complications of months-7 sectional Brazil varicella. years study Hospitalization attended at a rates day care center Perez Perez 200335 Patients Descriptive “Leon Cuervo Herpes zoster hospitalized longitudinal Rubio” Hospital. incidence. all ages study Pinar del Rio. Cuba Number of admissions due to herpes zoster NA Study Participants Design Source/Country Outcomes Summary Risk of Bias Pujadas 200836 All population Surveillance Uruguay study Quian 200537 Varicella Low incidence Children 0-14 Surveillance Montevideo. Hospitalizations years study Uruguay and ambulatory High visits due to varicella pre and post vaccination Quian 200838 Children 0-14 Surveillance Montevideo. Hospitalizations years study Uruguay and ambulatory visits due to High Study Participants Design Source/Country Outcomes Summary Risk of Bias varicella pre and post vaccination Quian 201039 Children 0-14 Descriptive Kinder garden and Number of cases years study schools. Villa of varicella. Tambores and Vaccination Piedra Sola. effectiveness High Paysandu and Tacuarembo. Uruguay Ramos Vico 200440 Children 0-6 Cross Day Care Centers. Mortality due to years sectional Sao Paulo. Brazil varicella Low Study Participants Design Source/Country Outcomes Summary Risk of Bias Saez Llorens 200241 Children 0-10 Retrospective Child Hospital. Admissions due years old study Panama City. to varicella. Panama Complications of hospitalized High varicella. Use of Resources Sao Paulo Secretary of Health 200542 Ambulatory Cross Sao Jose do Rio Varicella children 1-4 sectional Preto. Sao Paulo. incidence years old SIVIGILA Colombia 200743 All population Low Brazil Surveillance Surveillance Varicella study System in Public incidence Health. National NA Study Participants Design Source/Country Outcomes Summary Risk of Bias Institute of Health. Colombia SIVIGILA Colombia 200944 All population Surveillance Surveillance Varicella study System in Public incidence NA Health. National Institute of Health. Colombia Sociedad Chilena de Infectología 200145 Hospitalized Surveillance Committee of Use of resources. High patients all study Immunizations. Incidence. Chilean Society of Mortality ages Infectology. Chile Study Participants Design Source/Country Outcomes Summary Risk of Bias Valentim 200846 Ambulatory Decision- Brazil Hospitalizations and analysis due to varicella. hospitalized model Use of resources Moderate patients with varicella all ages Valero 200647 All population Surveillance Venezuela study Vujacich 200848 Varicella Low incidence Ambulatory Descriptive Center of Infectious Herpes zoster patients cross Studies (FUNCEI). incidence attended all sectional Buenos Aires. High Study Participants Design Source/Country Outcomes Summary Risk of Bias ages Mendoza Rodriguez 200749 Argentina Ambulatory Descriptive “Dr. Francisco Jose Herpes zoster patients cross Gomez Urcuyo” complications attended due sectional National Center of to herpes Dermatology. zoster all ages Managua. Nicaragua [1] NA: Not applicable References correspond to those of the main article High