Synthesis of Some 2-(2-Benzylidenehydrazinyl)-6,7-Dimethoxyquinazolin-4-Amine Derivatives and Their Antimicrobial and Cytotoxic Activity Evaluation G. Turan-Zitouni1, Z.A. Kaplancıklı1, L. Yurttaş1, Z. Cantürk2, H. Gencer2, M. Baysal3 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey Department of Microbiologie, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey 2 3 Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey Corresponding author e-mail: [email protected] The synthesis of nine new quinazoline derivatives and subsequent evaluation of their anticancer activity were aims of present work. The intermediate product 2-hydrazinyl-6,7dimethoxyquinazolin-4-amine  was refluxed with different aromatic aldehydes in ethanol to yield 2-(2-benzylidenehydrazinyl)-6,7-dimethoxyquinazolin-4-amine derivatives. The structures of the compounds were elucidated by NMR, MS spectral data and elemental analyses. The prepared compounds were investigated for their potential antimicrobial [2,3] and cytotoxic activities . R :- H, -CH3, -OCH3, -Cl, -OH, -NO2, -CN, -CH(CH3)2, -N(CH3)2 Scheme 1. Synthetic route of the compounds (2a – 2i) References  J.A. Jhonson, H.J. Thomas, H.J. Schaeffer, J Am Chem Soc. 80, 1958, 699-702.  CLSI . Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically Approved Standard, CLSI Document M7-A7 . 7 th Ed. ISBN 1-56238 . 2006, 587 – 589.  L. Yurttaş , Y. Özkay, H. Karaca et al.,. Lett Drug Des Discov. 10, 2013 486 – 491.  M.V. Berridge, P.M. Herst, A.S.Tan, Biotechnol. Annu. 11, 2005,127-152.