Synthesis of Some 2-(2-Benzylidenehydrazinyl)

Synthesis of Some 2-(2-Benzylidenehydrazinyl)-6,7-Dimethoxyquinazolin-4-Amine
Derivatives and Their Antimicrobial and Cytotoxic Activity Evaluation
G. Turan-Zitouni1, Z.A. Kaplancıklı1, L. Yurttaş1, Z. Cantürk2, H. Gencer2, M. Baysal3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University,
Eskişehir, Turkey
Department of Microbiologie, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University,
Eskisehir, Turkey
Corresponding author e-mail: [email protected]
The synthesis of nine new quinazoline derivatives and subsequent evaluation of their anticancer
activity were aims of present work. The intermediate product 2-hydrazinyl-6,7dimethoxyquinazolin-4-amine [1] was refluxed with different aromatic aldehydes in ethanol to
yield 2-(2-benzylidenehydrazinyl)-6,7-dimethoxyquinazolin-4-amine derivatives. The structures
of the compounds were elucidated by NMR, MS spectral data and elemental analyses. The
prepared compounds were investigated for their potential antimicrobial [2,3] and cytotoxic
activities [4].
R :- H, -CH3, -OCH3, -Cl, -OH, -NO2, -CN, -CH(CH3)2, -N(CH3)2
Scheme 1. Synthetic route of the compounds (2a – 2i)
[1] J.A. Jhonson, H.J. Thomas, H.J. Schaeffer, J Am Chem Soc. 80, 1958, 699-702.
[2] CLSI . Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow
Aerobically Approved Standard, CLSI Document M7-A7 . 7 th Ed. ISBN 1-56238 . 2006, 587 –
[3] L. Yurttaş , Y. Özkay, H. Karaca et al.,. Lett Drug Des Discov. 10, 2013 486 – 491.
[4] M.V. Berridge, P.M. Herst, A.S.Tan, Biotechnol. Annu. 11, 2005,127-152.