SYNTHESIS and EVALUATION of SOME NEW PYRIDINE BEARING
HYDRAZONE DERIVATIVES as POTENTIAL ANTIBACTERIAL AGENTS
Betül Kaya1, Yusuf Özkay1, Zafer Asım Kaplancıklı1, Fatih Demirci2, Juan Buen3
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470 Eskişehir, Turkey
2
Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, Eskişehir, Türkiye
3
Infection and Cancer Group, School of Medicine, University of Antioquia, Medellín, Colombia
(betulkaya@anadolu.edu.tr)
1
In recent years, in terms of spreading worlwide rapidly and developing resistance to antimicrobial
agents, bacterial infections become a major health problem [1]. That’s why the discovery of new
antimicrobial agents which suppress only the evalution of pathogens without harming host cells and
the challenge with multidrug-resistance has becme a huge interest in medicinal chemistry [2].
Hydrazone derivatives have been found to exhibit antimicrobial activity [3,4]. One of the most
common antibacterial drugs nifuroxazide, possesses a hydrazone moiety in its moleculer structure and
used as an intestinal antiseptic [2]. There are many studies confirmed that pyridines have also been
found to show antibacterial activity in many studies [5,6]. Izoniazid, that used in the treatment of
tuberculosis, have both hydrazide and pyridine moieties, which proves that these structures play a
very significant role in antibacterial activity [7]. Combination of two active moieties lead to a rise in
biological activity.
Based on the advantages of hydrazone and pyridine moieties, we have synthesised a new series of
hydrazone derivatives and tested their antibacterial activity. The structures of the obtained compounds
have been evaluated using FT-IR, 1H-NMR, 13C-NMR, MS spectral data and elemental analyses
results. Variable and modest activity were determined against the investigated species of bacteria and
fungi.
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