CURRICULUM VITAE
Last Revised: June 3, 2014
1.
Name:
Douglas Charles Eaton
2.
Office Address:
Department of Physiology
Telephone: (404) 727-4533
Whitehead Biomedical Research Bldg. Fax:
(404) 727-0329
Room 648
Emory University Medical School
615 Michael Street
Atlanta, Georgia 30322
3.
E-mail Address:
deaton@emory.edu
4.
Citizenship:
5.
Current Titles and Affiliations:
Academic appointments:
Primary appointments:
Citizen of the United States
2008 - Present
Chairman, Department of Physiology, Emory University
Medical School, Atlanta, GA
2007 – 2008
Interim Chairman, Department of Physiology, Emory University
Medical School, Atlanta, GA
2005-Present
Director, Fellowships in Research and Science Teaching (FIRST)
program
2002-Present
Distinguished Professor, Department of Physiology, Emory University
Medical School, Atlanta, Georgia
1995 – Present
Director, Center for Cell and Molecular Signaling, Emory University
Medical School, Atlanta, GA
1987-2007
Deputy Chairman, Department of Physiology, Emory University
Medical School, Atlanta, Georgia
1986 - 2002
Professor, Department of Physiology, Emory University Medical
School, Atlanta, Georgia
Joint and secondary appointments:
1990-Present
Professor, Department of Pediatrics, Emory University Medical
School, Atlanta, Georgia
Clinical appointments: None
Other administrative appointments:
1996-1999
1995-Present
Director of Graduate Studies in Cell and Developmental Biology,
Emory University Graduate School of Arts and Sciences, Atlanta,
Georgia
Director and Investigator in the research center for Cell and Molecular
Signaling, Emory University Medical School, Atlanta, Georgia
Douglas C. Eaton, Ph.D.
6.
2
Previous Academic and Professional Appointments:
1988 - 1992
Director of Graduate Studies in Cell and Developmental Biology,
Emory University Graduate school of Arts and Sciences, Atlanta,
Georgia
1988
Acting Chairman, Department of Physiology, Emory University
Medical School, Atlanta, Georgia
1985 -1986
Director, Department of Physiology and Biophysics Graduate
Program, University of Texas Medical Branch, Galveston, Texas
1985 -1986
Professor, Department of Physiology and Biophysics University of
Texas Medical Branch Galveston, Texas
1978 -1985
Associate Professor, Department of Physiology and Biophysics,
University of Texas Medical Branch Galveston, Texas
1973 -1978
Assistant Professor, Department of Physiology and Biophysics,
University of Texas Medical Branch, Galveston, Texas
1973 -1988
Investigator, Marine Biological Laboratory, Woods Hole,
Massachusetts
1973 -1986
Adjunct Member, Marine Biomedical Institute, University of Texas
Medical Branch, Galveston, Texas
1972 -1973
Visiting Research Associate, Division of Biology, California Institute
of Technology, Pasadena, California
1971 – 1972
Postdoctoral training, Department of Physiology, University of
California at Los Angeles, Los Angeles, California (Susumu Hagiwara
and Jared Diamond)
7.
Previous Administrative Appointments:
8.
Licensures / Boards: None
9.
Specialty Boards:
10.
Education:
1967
11.
None
None
B.S.
Biology
California Institute of Technology,
Chemistry, Pasadena, California
1969
M.S.
Marine
Invertebrate
Physiology
Scripps Institute of Oceanography
University of California-San Diego
San Diego, California
1971
Ph.D.
Neuroscience
University of California-San Diego, San
Diego, California
Postgraduate Training:
Douglas C. Eaton, Ph.D.
1971 -1972
12.
Postdoctoral training, Department of Physiology, University of California
at Los Angeles, Los Angeles, California (S. Hagiwara and J. Diamond)
Military or Government Service:
1971 - 1972
1972 - 1973
1974 - 1984
13.
3
United States Marine Corps (LN2/LO2 Plant Operator)
USMC Reserve (Unit Admin)
USAF Reserve (Airborne Medical Technician)
Committee Memberships:
National and International:
National Science Foundation Neurobiology Advisory Panel, 1980-1983
National Institutes of Health Physiology Study Section; Ad-Hoc member, June, 1982;
February, 1984; Regular member, February 1, 1985 - June 30, 1988; Chairman, July
1, 1986 - June 30, 1988.
National Institutes of Digestive Diseases and Kidney Special Grants Study Section:
Regular member, July 1, 1989 - June 30, 1993; Chairman, July 1, 1991 - June 30,
1993.
National Institutes of Health General Medicine B Study Section: Regular Member, October
1, 1994 - June 30, 1998; Chairman, July 1, 1996 - June 30, 1998.
National Institutes of Standards and Technology review Board, 1985 - 1999.
National Institutes of General Medical Sciences: Large grants (GLUE) review panel, 1999,
2000
National Institutes of Digestive Diseases and Kidney: Invited by NIDDK staff to present a
“Grants Strategy” seminar at the American Society of Nephrology Meeting; October
27, 1994
American Physiology Society, Porter Physiology Development Committee, (promoting
development of minority faculty and students in the physiology sciences) 1990 -1993.
American Heart Association, Meeting Abstract Review Panel 1991-1993, 2000-2002.
American Society of Nephrology, Chairman of the program and Abstract Review Group
for Fluid and Electrolyte Physiology, 1995, 2004. Abstract reviewer: 1997, 1999,
2002, 2003.
American Heart Association Molecular Signaling I Review Panel: Regular Member, 19992003.
Councilor, American Physiological Society, 2000 – 2003.
American Physiological Society Epithelial Transport Group Steering Committee
American Society of Nephrology, National Program Committee, 2004-2005
68 Ad Hoc Review Panels and Site Visit Teams for NIDDK, NHLBI, NIGMS, NCRR,
and NCI. 1975-present
External Advisor, National Center for Biomimetic Nanotechnology, University of Illinois,
Urbana, 2006 - 2011
National Institutes of General Medical Sciences TWD-C (formerly MPRC-A) Study
Section: Regular Member, October 1, 2009 – September 30,2013.
American Physiological Society Daggs Award Committee 2010 -2015.
Douglas C. Eaton, Ph.D.
4
Regional and State:
Previous
National Kidney Foundation, Georgia Affiliate, Co- Chairman of the Medical Advisory
Committee and Chairman of the Research Committee, 1991-1996
Institutional:
Previous
Executive Committee for the Graduate Program in Cell and Developmental Biology
Medical Physiology Teaching Committee
Surgery Chair Search Committee
Chairman, Pharmacology Chair Search Committee
Faculty committee for Appointments, Promotions, and Tenure
Executive Committee, Division of Biological and Biomedical Sciences
Health Science Center Research Strategic Planning Committee
President’s University Priorities Committee
Medical School Research Advisory Committee
Chairman, Graduate School of Arts and Sciences Executive Committee
Director of Graduate Studies, Program in Cell and Developmental Biology
Director of Graduate Program in Physiological and Pharmacological Sciences
President’s Advisory Committee (2005 – 2008)
Vice President for Health Affairs Search Committee
Current
Clinical and Translational Science Award Application
Committee on Faculty Diversity and Retention (2010)
Cell Biology Chair Search Committee
14.
Consultantships: Scientific Advisory Board, Sucampo Pharmaceuticals, Bethesda, MD.
August 2007 to present.
Scientific Advisory Board, Takeda Pharmaceuticals, North America, Chicago, IL.
August 2006 to present.
15. Editorships and Editorial Boards:
Editorial Board, American Journal Physiology: Cell Physiology, 1984-1993
Associate Editor, American Journal Physiology: Cell Physiology, 1993-1996
Section Editor, Annual Review of Physiology, 1986-1989
Editorial Board, American Journal Physiology: Renal Physiology, 1998-2001
Editorial Board, American Journal Physiology: Renal Physiology, Fluid and Electrolytes
2007 - 2017
Associate Editor, American Journal of Physiology: Renal Physiology, 2001-2007
Associate Editor, Channels, 2007-2010
Associate Editor, Journal of Physiological Science, 2007-2011, 2013-2015
Editorial Board, Nanomedicine, 2005 – 2010
Editorial Board, Journal Biological Chemistry, 2003 – 2008
Editor, Frontiers in Physiology: Renal and Epithelial Physiology. 2009-present.
Douglas C. Eaton, Ph.D.
5
16.
Manuscript reviewer:
Am. J. Physiol.: Renal; Am. J. Physiol.: Cell; Am. J. Physiol.: Lung; Am. J. Physiol.: GI; J.
Gen. Physiol.; Biophys J.; J. Biol. Chem.; J. Cell Biology; Cell; Science; J. Anatomy; J.
Pharm. Exp. Therap., J. Theoretical Biol., Biochim. Biophys. Acta, Biochem. Pharm.,
NIPS, J. Physiology; Toxicology.
17.
Honors and Awards:
Participant in the 2nd Alpha Helix expedition to the Great Barrier Reef, 1972
Invited to chair sessions at Biophysical Society Meetings, 1975, 1976, 1978
President – Society of Neuroscience, Galveston Chapter, 1977 - 1979
Research Career Development Award from the National Institute of Arthritis and
Metabolic Diseases, 1978-1983
Alberta Heritage Foundation Fellow, 1982
Council Member, Society of General Physiologists, 1983 – 1985
Secretary, Society of General Physiologists, 1987 – 1990
President-Elect, President, Past President, Society of General Physiologists, 1991 – 1994
American Physiological Society Executive Committee, Cell Section, 1987 -1990
Secretary/Treasurer, Membrane Subgroup – Biophysical Society, 1988 -1991
Chairman, Membrane Subgroup – Biophysical Society 1992 and 1996
Chairman, Epithelial Transport Group, American Physiological Society, 1988-1992
American Physiological Society Executive Committee, Renal Section, 1996-1999
Councilor, American Physiological Society 1999-2003
Merit Award recipient from NIDDK 2001
American Physiological Society, Council Member 2000-2003
President-Elect, President, Past President, American Physiological Society, 2004-2007
Charter Member, American Academy of Nanomedicine 2005
Fellow of the American Association of Nanomedicine 2005
Fellow of the American Society of Nephrology 2003
Hugh Davson Distinguished Lecturer of the Cell and Molecular Section, American
Physiological Society, 2008
Bodil Schmitt-Neilson Distinguished Mentor and Scientist Award, American
Physiological Society, 2011
Robert W. Berliner Award for Excellence in Renal Physiology, American
Physiological Society, 2012
18.
Society Memberships:
Biophysical Society (elected) (Secretary/Treasurer, Membrane Subgroup, 1988-1991;
Chairman, Membrane Subgroup, 1992 and 1996)
Society of General Physiologists (elected) (Council Member, 1983-1985; Secretary, 19871990; President-Elect, President, Past President, 1991-1994)
Sigma Xi (elected)
Society for Neuroscience (charter member) (President- Society of Neuroscience, Galveston
Chapter, 1977-1979)
American Physiological Society (elected) (Chairman, Epithelial Transport Group, 19881992)
American Society of Cell Biology (elected)
Douglas C. Eaton, Ph.D.
6
American Society of Nephrology
American Society for Hypertension Research
American Thoracic Society
American Association for the Advancement of Science
American Society of Biochemistry and Molecular Biology
American Society of Nanomedicine (elected)
19.
Organization of National or International Conferences:
Administrative positions:
1986 - Organizer of symposium “Ion transport across epithelial tissues: new insight from single
channel measurements” at Federation of American Societies of Experimental Biology, St.
Louis meeting.
1986 - Co-organizer with L.J. Mandel of symposium “Cell calcium and the control of membrane
transport” at Society of General Physiologists 40th annual meeting, Woods Hole.
1987 - Organizer of symposium “membrane sorting and differentiation” at Membrane Subgroup
of the Biophysical Society, New Orleans meeting.
1991 - Co-organizer with B.J. Stanton of symposium “Ion channels in renal cells” federation of
American Societies of experimental Biology, Atlanta meeting.
1992 - Co-organizer with L.J. Mandel of Meeting “Molecular and cellular biology of membrane
transport,” American Physiological Society, Fall Meeting, Sarasota, Florida.
1992 - Organizer of symposium “Ion channels in epithelial cells,” Biophysical Society, Houston,
Texas.
1994 - Co-organizer with D.J. Benos, L.G. Palmer, B.C. Rossier, and D. Ausiello. Forefronts of
Nephrology “Epithelial Ion Channels” Arrolla, Switzerland.
1995 - Co-organizer with S.I. Helman of Symposium “Epithelial Sodium Transport: Issues and
Answers”, Federation of American Societies of Experimental Biology, Atlanta meeting.
1996 - Co-organizer with S.I. Helman of symposium “Epithelial Transport: Issues and Answers:
Part II”, Federation of American Societies of Experimental Biology, Washington
meeting.
1997 - Co-organizer with D.J. Benos, L.G. Palmer, B.C. Rossier, and B.Stanton of Meeting
“EnaC: a new superfamily of proteins”, American Physiological Society, Fall Meeting,
Park City, Utah.
2003 - Co-organizer with Daniella Rotin of Meeting “ENaC and Aldosterone,: American
Physiological Society, Summer Meeting, Vancouver, British Columbia.
2003 – Co-organizer with Sadis Matalon of Symposium “Regulation of ENaC in the Lung,”
American Physiological Society, San Diego Meeting.
2003 – Co-organizer with Sadis Matalon of Symposium “Interactions of Pathogens with Lung
Fluid Transport,” American Thoracic Society, Seattle Meeting
2006 – In Focus Symposia Experimental Biology Meeting, San Francisco, CA Four linked
symposia on new approaches to physiology (from nanomedicine to understanding of
membrane lipid signaling).
Douglas C. Eaton, Ph.D.
Sessions as chair:
20.
7
All of the above
Research focus:
Ion transport across excitable and epithelial cell membranes; cellular signal transduction; cellular
and molecular biology of membrane transport; nanosensor methods applied to clinical samples.
21.
Patents:
22.
Grant Support:
None
Active support:
Federally funded:
DHHS 5R37 DK-37963, Principal Investigator. “Regulation of ion transport in tight
epithelia.”, 09/01/02 - 08/31/14. Total 09/01/02 - 08/31/14: $2,425,305 for first five
years. 30% effort.
.DHHS 5K12GM000680. Director, “Institutional Research and Academic Career
Development: Fellowships in Research and Science Teaching (FIRST)” 09/01/00 –
07/31/15. $11,691,279 10% effort.
DHHS 1R01 HL63306 (L. Jain, P.I.) Co-Principal Investigator, “Regulation of Lung
Sodium Channels.” 05/1/01 - 06/31/06. Total 05/1/01 – 08/31/14. $1,457,000. 10%
effort.
DHHS 1T32 DK-07656. Program Co-Director (Director: Jeff Sands) “Research Training
in Nephrology.” 07/01/90 – 11/30/16 Total 07/01/90 – 11/30/16 $2,452,683
DHHS P30DK064399 Investigator. “Epithelial Pathobiology” A NIDDK Digestive
Disease Research Development Center Grant. PI Vince Yang M.D. 01/01/2002 –
12/31/2012. Provides 50% support for use of DDRDC core resources.
Contracts:
None
Other:
None
Previous support:
01/01/2002 – 12/31/2012. DHHS P30DK064399 Investigator. “Epithelial Pathobiology” A
NIDDK Digestive Disease Research Development Center Grant. PI Vince Yang
M.D. Provides 50% support for use of DDRDC core resources.
2002 – 2007
DHHS 1R01 HL-071621. Principal Investigator. “ENaC Assembly, trafficking,
and degradation in lung.”
1999-2010
DHHS 2P01 DK61521. Program Director. “Cellular Signaling and Kidney
Function.”
2003-2008
DHHS R01EB000508 Co-Principal Investigator (PI: Boris Mizaikoff, GATech
Douglas C. Eaton, Ph.D.
8
Chemistry). “Scanning Probes to Image Cellular Signaling Progress”
2006-2009
Parker B. Frances Fellowship Sponsor. “Regulation of Alveolar Fluid Balance” to
My Helms.
2006 – 2007
Takeda/Sucampo Pharmaceuticals. “Activation of Secretory Chloride Channels in
Epithelial Cells by SyntheticProstones”
1990 – 2005
DHHS 1T32 DK-07656, Program Co-Director, “Research Training in
Nephrology.”
1997 – 2005
NSF IBN 9603837, “Regulation of CNS Ion Channels by Lipid Signaling
Molecules.” Co-Investigator
1999- 2004
DHHS 1R01 DK56305, “Interaction of CFTR and Epithelia Na Channels.”
Principal Investigator
1998 – 2003
DHHS 1R01 DK54354, Renal Na+ Channels- Structure/Function Studies.” CoInvestigator with subcontract from U. Penn to Emory.
1996 – 2002 DHHS 1P01 DK-50268. “Cellular and Molecular Mechanisms of renal transport.”
Program Director
1974 - 1977
DHEW 1R01 NS-12008. “Ionic selectivity of a nerve cell Body.” Principle
Investigator. NS-12008 was a project which examined the selectivity and kinetic
characteristics of ion channels from nerve cells in gastropod neurons.
1975 - 1984
DHEW 1R01 NS-11963. “Effect of internal divalent cations on nerve cells.” Coprinciple Investigator. NS-11963 was a project to investigate the effect of internal
divalent cations and group-specific reagents on sodium and potassium channels in
squid giant axon.
1977 - 1986
DHHS 1R01 NS-13778. “Stochastic and Kinetic processes in membrane
function.” Project 1. Principle Investigator. Project 1 of NS-13778 investigate
the properties of channels in tight epithelial tissues using fluctuation methods and
single channel analysis.
1979 - 1984
DHEW 1K04 AM-00432. “Sodium transport mechanisms in mammalian urinary
bladder.” Principal Investigator. AM-00432 was a research career development
award to promote my investigation of ion channels in epithelial tissues.
1979 - 1995
DHHS 2R01 DK-38830 “Na+ Transport in Tight Epithelia.” Principal
Investigator. DK-38830 is a study of fluxes and intracelluar ion activities in tight
epithelia. It also proposes to isolate the gene(s) for the sodium channel of tight
epithelia by expression cloning using Xenopus oocytes as the expression vector.
(Formerly AM-20068).
1985 - 1986
DHHS 1S10 RR-02310. “A VAX-11/750 to support kinetic and stochastic
modeling.” Principal Investagator.RR02310 is a multiuser equipment grant to
support patch clamp analysis within the Department of Physiology, University of
Texas, Medical Branch.
1986 - 1987
DHHS 1R13 DK/GM- 37144. “Cell calcium and the control of membrane
Douglas C. Eaton, Ph.D.
9
transport.” Principal Investagator. DK/GM-37144 is a grant to support the 40th
annual meeting of the Society of General Physiologists for which I was the
organizer.
1987 - 2002
DHHS 1R01 DK-37963. “Regulation of Na+ Transport in tight Epithelia.”
Principal Investigator. DK-37963 is a proposal to examine single channel events
using patch clamp methods in A6 cells and rat cortical collecting tubule cells.
Regulation of individual sodium channel will be examined at a cellular level.
1989 -1994
DHHS 1P01 HL-27385. Project 3: “Genetic expression of the inward rectifier
channel protein in Xenopus oocytes.” Co-Investigator. HL27385 proposes to use
the Xenopus oocyte expression system as an assay for the inward rectifier channel
from cardiac tissue. It emphasizes molecular biological methods for the isolation
of the inward rectifier.
1990 -2000
DHHS 1T32 DK-07656. “Research Training in Academic Nephrology.” CoProgram Director. DK07656 is a training program for post-doctoral fellows who
intend to take up careers in academic nephrology.
1991 -1994
DHHS 1R01 DK-44017. “Regulation of Na and Cl channels in cystic fibrosis
cells.” Principal Investigator. DK-44017 is a proposal to examine the ion channel
regulatory defect associated with cystic fibrosis.
1996 – 2003
DHHS 1P01 DK-50268. “Cellular and Molecular Mechanisms of Renal
Transport.” Program Director. DK-50268 is a program to examine various
cellular and molecular aspects of signal transduction in renal cells (including
vascular smooth muscle and endothelial cells).
1997 -2002
DHHS 1P01 DK-50268. “Cellular and Molecular Mechanisms of Renal
Transport.” Program Director. DK-50268 is a program to examine various
cellular and molecular aspects of signal transduction in renal cells (including
vascular smooth muscle and endothelial cells).
1997 –1999
Cystic Fibrosis Foundation. “Regulation of Na and Cl channels in cystic fibrosis
cells.” Principal Investigator
1997 – 2000
NSF IBN 9603837. “Regulation of CNS Ion Channels by Lipid Signaling
Molecules.” Co-Investigator. This is a project to investigate the role of
arachidonic acid and other lipid metabolites in regulating potassium channels.
1998 - 2001
DHHS 1F32 DK-09729. “Aldosterone Activation of Na Channels.” This is a
post-doctoral fellowship of which I am sponsor to a fellow in my laboratory, Dr.
James Stockand, to investigate the cellular mechanisms by which aldosterone
increases sodium transport.
DHHS 1R01 DK-54354. “Renal Na+ Channels-Structure/Function Studies.” CoInvestigator with subcontract from U. Penn to Emory. This is a project to
investigate amino acid residues critical for the pore of the Na channel and the
residues responsible for the amiloride binding site. The role of my laboratory is to
provide expertise in single channel measurements.
DHHS 1R01 DK56305. “Interaction of CFTR and Epithelial Na Channels.”
Principal Investigator. CFTR and epithelial sodium channels mutually interact to
coordinate salt transport. This project investigates the mechanism.
1998 – 2003
1999 – 2004
Douglas C. Eaton, Ph.D.
1996 – 2003
1997 – 2005
2004 -2005
10
DHHS 1P01 DK50268. Program Director. “Cellular and Molecular Mechanisms
of Renal Transport.”
NSF IBN 9603837. Co-Investigator. “Regulation of CNS Ion Channels by Lipid
Signaling Molecules.”
DHHS 1 PN1EY016540. Principal Investgator. “Center for Development of
Biological Nanosensors.” A Center development grant to promote
GATech/Emory interaction in the area of nanomedicine.
23.
Clinical Service Contributions:
None
24.
Formal Teaching: Director of Graduate Studies, Program in Cell and Developmental Biology
Medical Student Teaching:
Medical Physiology Course (Cellular properties and transport; Renal syllabus and
lectures; and renal and gastrointestinal physiology) 1987-2009
Medical Physiology Teaching Conferences 1986-present
1991 Voted Best Teacher in Spring Medical Physiology Course
Medical Neuroscience Teaching Conferences 1987-2003, 2005, 2008
Healthy Human: Renal Physiology 2010 - present
Diseased Human: Renal Pathophysiology 2010 - present
Graduate Program:
BME 8121: Physiological Systems Course (Lecturer)
IBS711: Blood and Water
IBS512: Cell Physiology and Biophysics
IBS517: Systems Physiology
IBS559: Introduction to Laboratory Science (Course Director)
IBS580: Nutrition Science (Lecturer on Mineral and Fluid Balance)
IBS600: Blood and Water (Course Director)
IBS714: Membrane Biology
IBS715: Methods in Molecular Biology
IBS790: Graduate Seminar (Course Director)
Training programs:
Thesis advisor for 7 Ph.D. students
Thesis advisor for 1 M.D/PhD. student
Renal Fellowship Training Program (Preceptor for research training of 5 M.D. fellows)
Preceptor for research training of 37 Ph.D. post-doctoral fellows
BCBD Doctoral Training Program
Thesis Committee Member of 7 Emory graduate students (besides those above)
Thesis Committee Member of 2 Georgia Tech/Emory graduate student
Thesis Committee Member of 1 University of Alabama M.D/Ph.D. student
Mentoring Committee for 1 Department of Medicine Assistant Professor
Mentoring Committee for 1 Department of Pediatrics Fellow
Residency Program: None
Douglas C. Eaton, Ph.D.
11
Other categories:
Visiting Professor of Physiology and Biophysics, Harvard University Medical School,
1992. Invited to lecture on the properties of ion channels in the Graduate Cell Biology
Course.
Teaching Faculty for National Board of Medical Examinars Review Course. Miami,
Florida, 1993. Invited to lecture on renal, Acid-Base, and Electrolyte Physiology.
Emory University Graduate Nursing Program: Renal section Advanced Physiology
Course
Instructor for TATTO course (Teaching Tutorial for Graduate Students), 1998-2010.
Taught discussion, lecture, and microteaching (only representative of the Medical
School).
Participant in the 2nd Teaching Portfolio Development Workshop, 2000 (A one week
course to develop teaching mentoring skills and a teaching portfolio).
Selected as one of twenty Emory Faculty to teach in the Emory Annual Student Teaching
Workshop (preparing Teaching Assistants in teaching methods) 1995-2008.
25. Supervisory Teaching:
Predoc/
postdoc/
other
Time
Period
Ifshin, Mark S.
Pre
Lewis, Simon A.
Training
Current Position/
Institution
Degree
Institution
75-79
Ph.D.
U. Texas Med.
Branch
Director of Medical Computing,
Yale Univ
Post
74-78
Ph.D.
UCLA
Prof., U. Texas, Med. Branch
Wills, Nancy E.††
Post
75-78
Ph.D.
UCLA
Prof., U. Texas, Med. Branch
Niemtzow, Richard C.
Post
77-80
M.D.
U. de Lyon
U.S. Air Force Medical Corps
Horn, Richard
Post
78-80
Ph.D.
UCLA
Prof., Jefferson Med. College
Steele, Joy A.†
Pre
79-81
Ph.D.
U. Alberta
Assoc. Prof., U. Alberta
Silverthorn, Sadie U.†
Post
77-79
Ph.D.
U. So. Carolina
Senior Instructor, U. Texas, Austin
Clark, Mary A.† ††
Post
80
Ph.D.
U. Texas, Austin
Professor, Texas Weslyn Univ.
DePena, Charles**
Pre
81-82
M.D.
U. Texas Med.
Branch
Family Practice, Corpus Christi, TX
Stiernberg, Janet L.†
Post
84-85
Ph.D.
U. Texas Med.
Branch
Res. Assoc. Prof., U. Oklahoma
Hamilton, Kirk L.
Post
82-86
Ph.D.
Utah State
Assoc. Prof., University of Otago,
New Zealand
Frace, A. Michael
Pre
76-87
Ph.D.
U. Texas Med.
Branch
Sr. Researcher, Centers for Disease
Control
Name
Douglas C. Eaton, Ph.D.
12
Predoc/
postdoc/
other
Time
Period
Marunaka, Yoshinori
Post
Ling, Brian N.
Training
Current Position/
Institution
Degree
Institution
86-89
M.D./
Ph.D.
Kyoto Univ.
Assoc. Prof., Sick Children's
Hospital & U. Toronto
Post
87-89
M.D.
Emory Univ.
N/A
Kemendy, Alexandra†
Pre
85-91
Ph.D.
U. Texas Med.
Branch
Dean of Nursing, Colby-Sawyer
College
Ohara, Akito
Post
89-91
Ph.D.
Shiga Univ.
Assoc. Prof., Shiga U.
Duchatelle, Pascal
Post
89-92
Ph.D.
Univ. de Poitiers
Asst. Professor, Univ. Caens, France
Blank, Barbara*†
Pre
92
M.D.
Columbia Univ.
N/A
Schlanger, Lynn†
Post
92-93
M.D.
SUNY
Asst. Professor of Medicine, Emory
University
Matsunaga, Hiroshi
Post
91-93
M.D.
Tokyo Med. School
private practice
Pan, Jian-cui† ††
Post
91-93
Ph.D.
Fudan Univ.
same
Matsumoto, Paul S.
Pre
86-93
Ph.D.
Emory Univ.
Res. Assoc., U. Texas, Med. Branch
Kokko, Kenneth
Pre
89-93
M.D./
Ph.D.
Emory Univ.
N/A
Becchetti, Andrea
Post
92-95
Ph.D.
Univ. de Milan
Asst. Professor, Univ. Trieste, Italy
Gallego, Manolo**
Post
93-95
M.D.
Univ. Manilla
private practice
Worrell, Roger
Post
92-96
Ph.D.
U. Alabama,
Birmingham
Instructor, Dept. Physiology, Emory
University
Marrero, Mario**
Post
95-96
Ph.D.
U. New Mexico
Asst. Professor of Pharmacology,
Medical College of Georgia
Yue, Gang
Post
96-02
M.D./
Ph.D.
U. Alabama,
Birmingham
Senior Associate in Physiology,
Emory University
Stockand, James
Post
96-01
Ph.D.
U. Texas, Houston
N/A
Malik, Bela†
Post
97-
Ph.D.
U. Cinncinati
N/A
Meng, Xue-Jun
Post
98-02
M.D./
M.S
Tongji U., PRC
N/A
Waters, Rachel†
Post
98-
M.D.
U. Dunedin, NZ
N/A
Appleberry, Ollie
Kelly**†
Pre
97-02
Ph.D.
Emory Univ.
Asst.Professor, University of
Alabama, Birmingham
Miller, Lance
Post
99-01
Ph.D.
U. Utah
Instructor of Physiology
Helms, My†
Post
03-08
Ph.D.
Dartmouth
Asst.Prof. Pediatrics, Emory Univ.
Name
Douglas C. Eaton, Ph.D.
13
Time
Period
Name
Yu, Ling†
Predoc/
postdoc/
other
Post
Training
Current Position/
Institution
Degree
Institution
04-09
Ph.D.
Haifa Univ., Israel
Instructor, Emory Univ.
Bao, Hui-Fang†
Post
03-09
Ph.D.
Harbin Univ, China
Assistant Professor, Emory Univ.
Reifenberger, Matthew
Post
09-11
Ph.D.
Univ. Missouri
Associate at Hull Associates,
Boston, MA
Alli, Abdel**
Post
10-
Ph.D.
U. South Florida
In training, Emory Univ.
Guo, Laijing††
Post
10-11
M.D.
Harbin Univ., China
Asst.Prof. Medicine, BeijingUniv.
Hospital
Greenlee, Megan†
Post
11-
Ph.D.
University of Florida
In training, Emory Univ.
Stow, Lisa†
Post
11-12
Ph.D.
University of Florida
Research and Development,
Invitrogen Biotechnology, Inc.
Zhou, Yiquan†
Post
11-12
Ph.D.
Peking Union Med.
College, China
Marketing Specialist, Roche
Pharmaceuticals, Shanghai
Thai, Tiffany†
Post
12-
Ph.D.
Vanderbilt
University
In training, Emory Univ.
*
Summer students.
Minority Trainees
†
Female Trainees
††
Sabbatical period.
**
26.
Lectureships, Seminar Invitations, and Visiting Professorships (121 presentations since 1974):
1999 - University of Alabama, Birmingham, “Developmental expression of different types of
sodium channels in alveolar type II cells.”
1999 - University of Utah, “CFTR regulation of renal sodium channels: a role for purinergic
receptors.”
1999 - Medical College of Georgia, “CFTR regulation of renal sodium channels: a role for
purinergic receptors.”
1999 - Cystic Fibrosis Foundation Williamsburg Conference, “Direct interation of ENaC with
src tyrosine kinase and other membrane proteins.”
1999 - Case Western Reserve and The Rammelkamp Research Institute, “CFTR regulation of
renal sodium channels: a role for purinergic receptors.” And “Angiotensin II signaling
pathways in renal mesangial cells.”
1999 - Shizuoka, Japan. 1st International Conference on Control and Diseases of Sodium
Dependent Transport Proteins and Ion Channels. Plenary Lecture “Developmental
expression of different types sodium channels in alveolar type II cells.”
2000 - NATO Advanced Science Institute, Corfu, Greece, “Development expression of different
types of sodium channels in alveolar type II cells.”
2000 - The European Society for Comparative Physiology and Biochemistry, Liege, Belgium,
“Mixing and Matching of ENaC subunits produces channel diversity.”
2000 - ENaC 2000, Villars, Switzerland, “Developmental expression of different types of
Douglas C. Eaton, Ph.D.
14
sodium channels in alveolar type II cells.”
2001 - Northwestern University Medical School, “ENaC Diversity: Mixing and Matching
Subunits.”
2001 - University of Iowa, “Aldosterone Regulation of ENaC.”
2001 – Experimental Biology, Orlando, Florida. “Phospholipid and G Protein Modulation of
ENaC Open Probability” in Symposium “Structure and Gating of Epithelial Ion
Channels.”
2001 – Experimental Biology, Orlando, Florida. “Control of ENaC by Purinoceptors.”
2001 – Experimental Biology, Orlando, Florida. Cell and Molecular Section Keynote Address
“Egad, Not Another Channel or ENaC, ENaC Everywhere.”
2001 – University of Pittsburgh Medical School, “ENaC Diversity: Mixing and Matching
Subunits.”
2001 – Gordon Research Conference on Membrane Transport “Phospholipid and G Protein
Modulation of Epithelail Sodium Channels.”
2002 - University of Texas, Medical Branch, “ Aldosterone Regulation of ENaC.”
2002 - Tulane University “Aldosterone Regulation of ENaC.”
2002 - Gordon Research Conference on Membrane Transport Diseases “ ENaC and Acute Lung
Injury”
2003 - University of Texas, Health Science Center San Antonio “Aldosterone Regulation of
ENaC”
2003 - Experimental Biology, San Diego Meeting, “NO Regulation of ENaC”
2003 - American Thoracic Society, Seattle Meeting, “Influenza Virus Inhibits ENaC”
2003 – EnaC and Aldosterone: from Genomics to Physiology, Banff, Canada, “Aldosterone
regulation of ENaC.”
2004 - Experimental Biology, Washington Meeting, “Purinergic Agonists Alter ENaC Activity
by Two Different Mechanisms”
2004 - Medical College of Georgia, Dept. Physiology, “Regulation of ENaC by Inositol Lipids”
2004 - Syracuse University, Dept. Biology, Purinergic effects on Lung Fluid Balance.”
2004 - Purines Meeting, Chapel Hill, NC, “Purinegic Agonists Alter ENaC Activity by Two
Different Mechanisms.”
2005 - Biomedical Engineering/Institute for Bioengineering and Bioscience, Georgia Institute of
Technology, “Policy Forum: Thinking Outside the Lab.”
2005- University of North Carolina, Department of Pharmacology, “Purinergic Regulation of
ENaC.”
2005 - Pinhead Institute Science Conference, Telluride, Colorado. The Effects of Dopamine on
ENaC in the Lung.”
2005 – Telluride Town Hall Talk, Telluride, Colorado. The Salt of the Earth: The Evolution of
the Human Kidney or From Fish to Physiologist.”
2005 – Morehouse College, Department of Biology. “New Ideas About Lung Fluid Clearance or
Why Don’t We Drown Every Day?”
2005 – Southern Salt, Water, and Kidney Association. “Dopamine Regulation of ENaC by
EPAC.”
2006 - University of Georgia, Veterinary School, Athens, Georgia, “Transactivation of a Growth
Factor Receptors by Steroids.”
2007 - Emory University, “A new paradigm for lung fluid balance or why we don’t drown every
day”
Douglas C. Eaton, Ph.D.
15
2008 - University of Florida, “Transactvation of a Growth Factor Receptor by Steroids”
2008 - University of Florida, “A new paradigm for lung fluid balance or why we don’t drown
every day”
2008 - Medical University of South Carolina, “Transactivation of Growth Factor Receptors by
Steroids”
2008 - Experimental Biology 2008, San Diego, CA., “The Salt of the Earth or Strike While the
Ion is Hot” – Hugh Davson Distinguished Lectureship
2011 - Medical College of Georgia, ““ENaC Assembly and Trafficking”.
2011 - University of Florida, “ENaC Assembly and Trafficking”.
2011 - University of Florida, “Don’t Float the Mainstream: ENaC, Lipid Rafts”
2011 - West Coast Salt and Water Club, Morro Bay, California, “Ethanol, ROS, and regulation
of ENaC”
2011 - Keynote Speaker, Gulf Coast Physiological Society, “ENaC in Lipid Rafts: in Memory of
Dale Benos”
2011 - 1st Annual Dale J. Benos Lecturer, University of Alabama, “ENaC in Lipid Rafts: in
Memory of Dale Benos”
2011 - Keynote Speaker, Southwest Physiological Society, “Don’t Float the Mainstream: ENaC,
Lipid Rafts, and MARCKS Protein”
2012 - Wake Forest University Department of Medicine, “Ethanol, ROS, and regulation of
ENaC”
27. Invitations to National or International conferences:
1993 - Forefronts in Nephrology: Renal Ion Channels. “Regulation of the amiloride - blockable
sodium channel.” Arolla, Switzerland
1993 - University of Kent , Canterbury, England. The European Society for Comparitive
Physiology and Biochemistry, “G-protein regulation of the amiloride-blockable sodium
channels.”
1994 - University of Lausanne, Switzerland, “Regulation of amiloride-blockable sodium
channels.”
1994 - “Grants Strategy” Seminar, American Society of Nephrology Meeting, October 27, 1994
(Invited by NIDDK).
1996 - Cystic Fibrosis Foundation Williamsburg Conference, “Regulation of renalSodium
transport by ATP and CFTR.”
1998 - Cystic Fibrosis Foundation Williamsburg Conference, “CFTR- mediated release of
ATP.”
1999 - Cystic Fibrosis Foundation Williamsburg Conference, “Src-ENaCinteractions.”
1999 - Case Western Reserve and The Rammelkamp Research Institute, “CFTR regulation of
renal sodium channels: a role for purinergic receptors.” and “Angiotensin II signaling
pathways in renal mesangial cells.”
1999 - Shizuoka, Japan. 1st International Conference on Control and Diseases of Sodium
Dependent Transport Proteins and Ion Channels. Plenary Lecture “Developmental
expression of different types of sodium channels in alveolar type II cells.”
2000 - NATO Advanced Science Institute, Corfu, Greece, “Developmental expression of
different types of sodium channels in alveolar type II cells.”
2000 - The European Society for Comparative Physiology and Biochemistry, Liege, Belgium,
“Mixing and Matching of ENaC Subunits produces channel diversity”.
Douglas C. Eaton, Ph.D.
16
2000 - ENaC 2000, Villars, Switzerland, “Developmental expression of different types of
sodium channels in alveolar type II cells.”
2001 - University of Pittsburgh Medical School, “ENaC Diversity: Mixing and Matching
Subunits.”
2001 - Experimental Biology, Orlando, Florida. “Phospholipid and G Protein Modulation of
ENaC Open Probability” in Symposium “Structure and Gating of Epithelial Ion
Channels.”
2001 - Experimental Biology, Orlando, Florida. “Control of ENaC by Purinoreceptors”.
2001 - Experimental Biology, Orlando, Florida. Cell and Molecular Section Keynote Address
“Egad, Not Another Channel or ENaC, ENaC Everywhere.”
2001 - Gordon Research Conference on Membrane Transport “Phospholipid and G Protein
Modulation of Epithelial Sodium Channels”
2002 - Gordon Research Conference on Membrane Transport Proteins “Aldosterone Regulation
of Epithelial Sodium Channels”
2002 - University of Texas, Medical Branch “Aldosterone Regulation of ENaC”
2003 - University of Texas, Health Science Center San Antonio “Aldosterone Regulation of
ENaC”
2003 - Experimental Biology, San Diego Meeting, “NO Regulation of ENaC”
2003 - American Thoracic Society, Seattle Meeting, “Influenza Virus Inhibits ENaC”
2004 - Experimental Biology, Washington Meeting, Purinergic Agonists alter ENaC activity by
two different Mechanisms”
2004 - Medical College of Georgia, Department of Physiology, “Regulation of ENaC by Inositol
Lipids”
2004 - Syracuse University, Department of Biology, Purinergic effects an Lung Fluid Balance”
2004 - Purines Meeting, Chapel Hill NC, “Purinergic agonists alter ENaC activity by two
different Mechanisms”
2005 - Biomedical Engineering/Institute for Bioengineering and Bioscience, Georgia Institute of
Technology, “Policy forum: Thinking outside the Lab”
2005 - University of North Carolina, Department of Pharmacology, “Purinergic Regulation of
ENaC”
2005 - Pinhead Institute Science Conference, Telluride, Colorado. “The effects of Dopamine on
ENaC in the Lung”
2005 - Telluride Town Hall Talk, Telluride, Colorado. “The Salt of the Earth: The Evolution of
the Human Kidney or from Fish to Physiologist”
2005 - Southern Salt, Water, and Kidney Association. “Dopamine Regulation of ENaC by
EPAC”.
2006 – Telluride Science Research Conference, Telluride, Colorado. “Transactivation of the
IGF-1 Receptor by Aldosterone.”
2007 - Telluride Science Research Conference, Telluride, Colorado. ENaC in AT1 and AT2
cells in lung slices.”
2007 - ENaC & Aldosterone 2007, Zermatt, Switzerland, “Regulation of ENaC by basolateral
P2X receptors”
2008 - Experimental Biology 2008, San Diego, CA., “The Salt of Earth or Strike While the Ion
Is Hot”- Hugh Davson Distinguished Lectureship.
2008 - Telluride Science Research Conference, Telluride, Colorado. “ENaC trafficking in A6
cells”.
Douglas C. Eaton, Ph.D.
17
2009 - Satellite Conference on Transport in Lung Epithelium, IUPS, Kyoto, Japan, “Lung Fluid
Balance and EnaC”.
2009 - Epithelial Tansport, All Day Symposium,,IUPS, Kyoto, Japan, “Regulation of ENaC and
Lipid Rafts”.
2009 - Telluride Science Research Conference, Telluride, Colorado. “Sodium Transport in
Lung: or Why We Don’t Drown Every Day”.
2009 - CommBio, Christchurch, New Zealand. Plenary lecturer:“Sodium Transport in Lung: or
Why We Don’t Drown Every Day”.
2009 - New Zealand Salt and Water Society, Christchurch, New Zealand. Special Invited
Lecturer:“ENaC trafficking in A6 cells”.
2009 - Department of Physiology, Otago University, Dunedin, New Zealand. Special Invited
Lecturer:“ENaC trafficking in A6 cells”.
2010 - Telluride Science Research Conference, Telluride, Colorado. “ENaC Assembly and
Trafficking”.
2011 – Yoshi Kidokoro Memorial Symposium, Los Angeles, California. Invited Speaker,
“Sodium Transport in Lung: or Why We Don’t Drown Every Day”.
2011 - Plenary Lecturer, Great Wall Conference on Cardiology, Beijing, China, “ENaC in
Hypertension”
2012 – Visiting Professor, Kyoto Prefectural Medical School, Kyoto, Japan, “Ethanol, ROS, and
ENaC regulation”
2012 - Symposium Lecturer, Japanese Physiological Society, Matsumoto, Japan, “ENaC in Lipid
Rafts”
2014 – Symposium Lecturer, 2014 PanAmerican Congress, Iguassu Falls, Brazil,
“Channelopathies”
28.
Other Activities:
None
29.
Bibliography:
Published and accepted research articles in refereed journals:
1.
Eaton, D.C. Potassium accumulation near pacemaking cells of Aplysia. J. Physiol.
224:421; 1972.
2.
Hagiwara, S.; Eaton, D.C.; Stuart, A.E.; Rosenthal, N.P. Cation selectivity of squid axon
membrane. J. Memb. Biol. 9:373-384; 1972.
3.
Hagiwara, S.; Eaton, D.C.; Fukuda, J. Fluxes and selectivity of divalent cations in
barnacle muscle membrance. J. Gen. Physiol. 63:564-578; 1974.
4.
Kidokora, Y.; Grinnell, A.D.; Eaton, D.C. Effects of TTX on puffer and other related
fishes. J. Comp. Physiol. 89:59-72; 1974.
5.
Eaton, D.C.; Russell, J.M.; Brown, A.M. Ionic permeabilities of an Aplysia giant neuron.
J. Membr. Biol. 21:353-374; 1975.
6.
Lewis, S.A.; Eaton, D.C.; Diamond, J.M. The mechanism of Na+ transport by rabbit
urinary bladder. J. Memb. Biol. 28:41-70; 1976.
7.
Lewis, S.A.; Eaton, D.C.; Clausen, C.; Diamond, J.M. Nystatin as a probe for
Douglas C. Eaton, Ph.D.
18
investigating the electrical properties of tight epithelium. J. Gen. Physiol. 70:426; 1977.
8.
Russell, J.M.; Eaton, D.C.; Brodwick, M.S. Effect of nystatin on membrane conductance
and internal ion activities in Aplysia neurons. J. Memb. Biol. 37:137-156; 1977.
9.
Brown, A.M.; Brodwick, M.S.; Eaton, D.C. Intracellular Ca++ and extraretinal
photoreception in Aplysia giant neurons. J. Neurobiol. 8:1-18; 1977.
10. Eaton, D.C.; Oxford, G.S.; Brodwick, M.S.; Rudy, B. Removal of Na+ inactivation by
arginine specific reagents. Nature 271:473-476; 1978.
11. Brodwick, M.S.; Eaton, D.C. Sodium channel inactivation in squid axon is removed by
high internal pH or tyrosine specific reagents. Science 200:1494-1496; 1978.
12. Lewis, S.A.; Wills, N.K.; Eaton, D.C. Basolateral membrance potential of a tight
epithelium: Ionic diffusion and electrogenic pumps. J. Memb. Biol. 41:117-148; 1978.
13. Wills, N.K.; Lewis, S.A.; Eaton, D.C. Active and passive properties of rabbit descending
colon: A microelectrode and nystatin study. J. Memb. Biol. 45:81-108; 1979.
14. Wills, N.K.; Eaton, D.C.; Lewis, S.A.; Ifshin, M.S. The current-voltage relationship for a
tight epithelium. Biochim. Biophys. Acta 55:519-523; 1979.
15. Niemtzow, R.C.; Eaton, D.C.; Kunze, D.L.; Becker, S.N.; Wong, J.Y.; Olson, M.H.;
McBee, J.; Moulton, R.G.; Gauci, L.; Viallet, P.; Serrou, B.; Daniels, J.C. Correlation
between macrophage intracellular electrical potentials and malignant melanoma growth in
a murine model. Biomedicine 31:257-260; 1979.
16. Horn, R.; Brodwick, M.S.; Eaton, D.C. TEA blocks potassium current in squid axon.
Gen. Pharmac. 11:189-192; 1980.
17. Horn, R.; Brodwick, M.S.; Eaton, D.C. Effect of protein cross-linking reagents on
membrane currents of squid axon. Am. J. Physiol. 238:C127-C132; 1980.
18. Eaton, D.C.; Brodwick, M.S. Effects of internal Ba++ on K+ conductance of squid axon. J.
Gen. Physiol. 75:727-750; 1980.
19. Giorgi, C.; Kelly, P.J.; Eaton, D.C.; Guiot, G.; Derome, P. A study of the tridimensional
distribution of somatosensory evoked responses in human thalamus to aid the placement of
stimulating electrodes for the treatment of pain. Acta Neurochirurgica 30:279-287; 1980.
20. Eaton, D.C. Intracellular sodium ion activity and sodium transport in rabbit urinary
bladder. J. Physiol. 316:527-544; 1981.
21. Steele, J.A.; Poznansky, M.J.; Eaton, D.C.; Brodwick, M.S. Lipid vesicle-mediated
alterations of membrane cholesterol levels: Effects on Na+ and K+ currents in squid axon.
J. Membrane Biol. 63:191-198; 1981.
22. Eaton, D.C.; Frace, A.M.; Silverthorn, S.U. Active and passive Na+ fluxes Na+ fluxes
across the basolateral membrane of rabbit urinary bladder. J. Membrane Biol. 67:219-229;
1982.
23. Brodwick, M. S.; Eaton, D.C. Chemical modification of excitable membranes. Prog. Clin.
Biol. Res. 79: 51-72; 1982.
24. Silverthorn, S.U.; Eaton, D.C. Respiration and sodium transport in rabbit urinary bladder.
Douglas C. Eaton, Ph.D.
19
Biochim. Biophys. Acta 689:299-308; 1982.
25. LaBelle, E.F.; Eaton, D.C. Sulfhydryl reagents affect Na+ uptake into toad bladder
membrane vesicles. J. Membrane Biol. 71:39-45; 1983.
26. Clark, M.A.; Eaton, D.C. Effect of CO2 on neurons of the house cricket, Acheta
domestica. J. Neurobiol. 14:237-250; 1983.
27. LaBelle, E.F.; Eaton, D.C. Amiloride-inhibited Na+ uptake into toad bladder microsomes
is Na+-H+ exchange. Biochim. Biophys. Acta 733:194-197; 1983.
28. Ifshin, M.S.; Johnson, K.E.; Eaton, D.C. Acid pH and weak acids induce Na-Cl cotransport in the rabbit urinary bladder. J. Membrane Biol. 76:151-164; 1983.
29. Eaton, D.C.; Hamilton, K.L.; Johnson, K.E. Intracellular acidosis blocks the Na+ pump in
rabbit urinary bladder. Am. J. Physiol. (Renal) 16:F946-F955; 1984.
30. Hamilton, S.L.; Pratt, D.R.; Eaton, D.C. Arrangement of the subunits of the nicotinic
acetylcholine receptor of Torpedo californica as determined by alpha-neurotoxin crosslinking. Biochemistry. 24:2210-2219; 1985.
31. Wang, G.K.; Brodwick, M.S.; Eaton, D.C. Removal of sodium channel inactivation in
squid axon by the oxidant chloramine-T. J. Gen. Physiol. 86:289-302; 1985.
32. Hamilton, K.L.: Eaton, D.C. Single channel recordings from the amiloride-sensitive
epithelial Na+ channel. Am. J. Physiol. (cell) 249:C200-C207; 1985
33. Hamilton, K.L.; Eaton, D.C. Single channel recordings from two types of epithelial Na+
channels. J. Molecular Biochem. 6:149-171, 1986.
34. Frace, A.M.; Hall, S.; Brodwick, M.S.; Eaton, D.C. Effects of saxitoxin analogues and
ligand competition on sodium currents of squid axons. Am. J. Physiol. (Cell) 251:C159C166; 1986
35. Diaz Diaz, F.D.; LaBelle, E.F.; Eaton, D.C.; DuBose, T.D.,Jr. ATP-dependent proton
transport in human renal medulla. Am. J. Physiol (Renal) 251:F297-F302; 1986.
36. Eaton, D.C. Ion transport across epithelial tissues: insight from single channel
measurements. Federation Proc. 45:2707-2708; 1986
37. Hamilton, K.L.; Eaton, D.C. Regulation of single sodium channels in renal tissue.
Federation Proc. 45:2713-2717; 1986.
38. Nokta, M.; Eaton, D.C.; Steinsland, O.S.; Albrecht, T. Ca++ responses in Cytomegalovirusinfected fibroblast of human origin. Virology 157:259-267; 1987.
39. Wang, G.K.; Brodwick, M.S.; Eaton, D.C.; Strichartz, G.R. Inhibition of sodium currents
by local anaesthetics in chloramine-T treated squid axons. The role of channel activation.
J. Gen. Physiol. 89:645-667; 1987.
40. Ling, B. N.; Eaton, D.C. Effects of luminal sodium on single Na+ channels in A6
epithelia, a possible regulatory role for protein kinase C. Am. J. Physiol. (Renal)
25:F1094-F1103; 1989.
41. Hinton, C. F.; Eaton, D.C. Expression of amiloride-blockable Na+ Channels in Xenopus
oocytes. Am. J. Physiol. (Cell) 26:C825-C829; 1989.
Douglas C. Eaton, Ph.D.
20
42. Marunaka, Y.; Eaton, D.C. Chloride channels in the apical membrane of a distal nephron
cell line (A6). Am. J. Physiol. (Cell) 258:C352-C368; 1990.
43. Marunaka, Y.; Eaton, D.C. The effect of insulin and phosphatase on a Ca-dependent Cl
channel in a distal nephron cell line (A6). J. Gen. Physiol. 95:569-590; 1990.
44. Ling, B. N.; Kemendy, A. E.; Kokko, K.E.; Hinton, C. F.; Marunaka, Y.; Eaton, D.C.
Regulation of the amiloride-blockable sodium channel from epithelial tissue. J. Molecular
Cell. Biochem. 99:141-150, 1990.
45. Marunaka, Y.; Eaton, D.C. Effects of vasopressin and cAMP on single amilorideblockable sodium channels. Am. J. Physiol. (Cell) 260:C1071-C1084; 1991.
46. Ling, B. N.; Hinton, C. F.; Eaton, D.C. Potassium permeable channels in primary cultures
of rabbit cortical collecting tubule. Kidney Int. 40:441-452, 1991.
47. Eaton, D.C.; Ohara, A.; Ling, B. N.; Marunaka, Y.; Duchatelle, P.; Kemendy, A. E.;
Kokko, K. E.; Matsumoto, P.; Hinton, C. F. Cellular regulation of amiloride-blockable
sodium channels. Biomed. Res. 12(Supp. 2):31-36, 1991.
48. Ling, B. N.; Hinton, C. F.; Eaton, D.C. Amiloride-sensitive sodium channels in rabbit
cortical collecting tubule primary cultures. Am. J. Physiol. (Renal) 261:F933-F944; 1991.
49. Marunaka, Y.; Ohara, A.; Matsumoto, P.; Eaton, D.C. Cyclic-GMP-activated channel
activity in renal cells (A6). Biochim. Biophys. Acta 1070:152-156; 1991.
50. Hamilton, K. L.; Eaton, D.C. cAMP-induced potassium channel activity in the apical
membrane of cultures A6 kidney cells. Am. J. Physiol. (Renal) 261:F1055-1062; 1992.
51. Ling, B. N.; Webster, C. L.; Eaton, D.C. Eicosanoids modulate apical Ca2+-dependent K+
channels in cultured rabbit principal cells. Am. J. Physiol. (Renal) 263:F116-126; 1992.
52. Duchatelle, P.; Ohara, A.; Ling, B. N.; Kemendy, A. E.; Kokko, K.E.; Matsumoto, P. S.;
Eaton, D.C. Regulation of renal epithelial sodium channels. J. Molecular Cell. Biochem.
114:27-34, 1992.
53. Kemendy, A.E.; Eaton, D.C. Aldosterone alters the open probability of amilorideblockable sodium channels in A6 epithelia. Am. J. Physiol. (Cell) 262:C825-C837; 1992.
54. Frace, A. M.; Eaton, D.C. Chemical modification of amino groups on calcium activated K+
channels of GH3 cells. Am. J. Physiol. (Cell) 263:C1081-C1087; 1992.
55. Smith, T.F.; Sanchez-Legrand, F.; McKean, L.P.; Kutner, M.H.; Eaton, D.C. Role of
sodium in mediator release from human basophils. J. Allergy Clin. Immunol. 89:978-986;
1992.
56. Ling, B. N.; Kokko, K. E.; Eaton, D.C. Inhibition of apical Na+ channels in rabbit cortical
collecting tubules by basolateral prostaglandin E2 is modulated by protein kinase C. J.
Clin. Invest. 90:1328-1334; 1992.
57. Ohara, A.; Matsunaga, H.; Eaton, D.C. G-protein activation inhibits amiloride-blockable,
highly selective sodium channels in A6 cells. Am. J. Physiol. (Cell) 263:C352-C360;
1993.
58. Matsumoto, P. S.; Ohara, A.; Duchatelle, P.; Eaton, D.C. Tyrosine kinase regulates
epithelial sodium transport in A6 cells. Am. J. Physiol. (Cell) 264:C246-C250; 1993.
Douglas C. Eaton, Ph.D.
21
59. Worrell, R.T.; Caspar, K.A.; Eaton, D.C. cDNA libraries produced from the little skate,
Raja erinacea and the winter flounder, Pseudopleuronectes americanus epithelium.
M.D.I.B.L. Bulletin 32:137-138; 1993.
60. Ling, B. N.; Eaton, D. C. Cyclosporin A inhibits apical secretory K+ channels in rabbit
cortical collecting tubule principal cells. Kidney Int. 44: 974-984; 1993.
61. Ling, B. N.; Seal E. E.; Eaton, D. C. Regulation of mesangial cell ion channels by insulin
and angiotensin II: possible role in diabetic glomerular hyperfiltration. J. Clin. Invest. 92:
2141-2151, 1993
62. Ling, B. N.; Kokko K. E.; Eaton D. C. PGE2 activates clusters of apical Cl- channels in
principal cells via a cAMP-dependent pathway. J. Clin. Invest. 93:829-837, 1994.
63. Denson, D. D.; Duchatelle, P.; Eaton D. C. The effect of racemic ketamine on the large
conductance (BK) channel in GH3 cells. Brain Res. 638:61-68, 1994.
64. Matsunaga, H; Ling, BN; and Eaton DC. Ca2+-permeable channel associated with plateletderived growth factor receptor in mesangial cells. Am J Physiol (Cell). 267:C456-465,
1994.
65. Kumar, R.; Joyner, R. W.; Hartzell, H.C.; Ellingsen, D.; Rishi, F.; Eaton D. C.; Lu, C.;
Akita, T. Developmental changes in the G-proteins, cyclic nucleotides, and muscarinic
receptors in rabbit heart cells. J. Mol. Cell. Cardiol. 26:1537-1550, 1994
66. Denson, D.D. and Eaton D.C. Ketamine inhibition of large conductance Ca+2-activated
potassium channels is modulated by intracellular calcium. Am J Physiol (Cell). 267 :
C1452-1458, 1994.
67. Kokko, K.E.; Matsumoto, P.S.; Ling, B.N.; and Eaton, D.C. Effects of prostaglandin E2
on amiloride-blockable Na+ channels in a distal nephron cell line (A6). Am J Physiol
(Cell) 267:C1414-1425, 1994.
68. Eaton, D.C.; Becchetti, A.; Ma, H.; and Ling, B.N. Renal sodium channels: regulation and
single channel properties. Kidney Int. 48:941-949, 1995.
69. Ling, B.N.;Matsunaga, H.; Ma, H. and Eaton, D.C. Role of growth factors in mesangial
cell ion channel regulation. Kidney Int. 48:1158-1166, 1995.
70. Seal, E.E.; Eaton, D.C.; Gomez, L.M.; Ma, H.; Ling, B.N. Extracellular glucose reduces
the responsiveness of mesangial cell ion channels to angiotensin II. Am J Physiol (Fluid
and Electrolyte) 269:F389-F397, 1995.
71. Denson, D.D. ; Worrell, R.T.; and Eaton D.C. A possible role for phospholipase A2 in the
action of general anesthetics. Am J Physiol (Cell). 270 :C636-C644, 1996.
72. Ling, B.N.;Zuckerman, J.B.; Lin, C.-M.; Harte, B.J.; McNulty, K.A.; Smith, P.R.; Gomez,
L.; Worrell, R.T.; Eaton, D.C and Kleyman, T.R. Expression of the cystic fibrosis
phenotype in a renal amphibian epithelial cell line. J. Biol. Chem. 272:594-600, 1997.
73. Ismailov, I.I.; Kieber-Emmons, T.; Lin, C.-M.; Berdiev, B.K.; Shylonsky, V.G.; Patton,
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75. Venema, R.C., Ju, H., Venema, V.J., Schieffer, B., Harp, J.B., Ling, B.N., Eaton, D.C.,
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76. Marrero, M.B. Venema, V.J., Ju, H., Li, B., Li, J., Eaton, D.C., and Venema, R.C.
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77. Venema, V.J., Ju, H., Li, B., Sun, J., Eaton, D.C., Marrero, M.B., and Venema, R.C.
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78. Jain, L., Chen, X.-J., Brown, L.A., and Eaton, D.C. Nitric oxide inhibits lung sodium
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79. Rokaw, M. D.; Wang, J.-M.; Edinger, R.S.; Weisz, O.A.; Hui, D.; Middleton, P.;
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80. Marrero, M.B., V.J. Venema, H. Ju, D.C. Eaton, and R.C. Venema. Regulation of
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81. Venema, R.C., V.J. Venema, D.C. Eaton, and M.B. Marrero. Angiotensin II-induced
tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated
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82. Stockand, J.D., N.F. Al-Baldawi, O.K. Al-Khalili, R.T. Worrell, and D.C. Eaton. SAdenosyl-L-homocysteine hydrolase regulates aldosterone-induced Na+ transport. J Biol
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83. Denson, D.D., R.T. Worrell, P. Middleton, and D.C. Eaton. Ca2+ sensitivity of BK
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84. Jain L, Chen X.-J., Malik B., Al-Khalili O., Eaton D.C. Antisense oligonucleotides against
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85. Marunaka Y., Niisato N., O'Brodovich H., Eaton D.C. Regulation of an amiloride-sensitive
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86. Stockand, J.D., Spier, B.J., Worrell, R.T., Yue, G., Al-Baldawi, N., Eaton, D.C.
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88. Al-Baldawi, N.F., Stockand, J.D., Al-Khalili, O.K., Yue, G., Eaton, D.C. Aldosterone
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89. Becchetti,A., Kemendy,A.E., Stockand,J.D., Sariban-Sohraby,S., and Eaton,D.C.
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90. Stockand,J.D., Bao,H.F., Schenck,J., Malik,B., Middleton,P., Schlanger,L.E., and
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91. Stockand,J.D., Edinger, R.S., Eaton,D.C., Johnson, J.P. Toward understanding the role of
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92. Yue,G.; Edinger,R.S.; Bao,H.F.; Johnson,J.P.; Eaton,D.C. The effect of rapamycin on
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93. Denson, D.D.; Wang, X.; Worrell, R.T.; Eaton, D.C. Effects of fatty acids on BK
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94. Jain,L.; Chen, X.-J.; Ramosevac, S.; Brown, L.A.; Eaton, D.C. Expression of highly
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95. Denson, D.D.; Wang, X.; Worrell, R.T.; Al-Khalili, O.; Eaton, D.C. c-PLA 2 is required
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96. Worrell, R.T.; Bao,H.F; Denson, D.D.; Eaton, D.C. Contrasting effects of cPLA2 on
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97. Malik, B.; Schlanger, L.; Al-Khalili, O.; Bao, H.-F.; Yue, G.; Price, S.R.; Mitch, W.E.;
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98. Kleyman, T.R.; Zuckerman, J.B.; Middleton, P.; McNulty, K.; Hu, B.; Su, X.; An, B.;
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epithelial sodium channel. Am. J. Physiol. (Renal) 281:F213-21, 2001.
99. Stockand,J.D., Zeltwanger, S.; Bao, H.-F.; Becchetti,A.; Worrell, R.T.; Eaton,D.C. Sadenosyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of
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100. Eaton, D.C.; Malik, B.; Saxena, N.C.; Al-Khalili, O.; Yue, G. Mechanisms of
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101. Al-Khalili, O.; Duke, B.J.; Zeltwanger, S.; Eaton, D.C.; Spier, B.; Stockand, J.D. Cloning
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102. Yue, G.; Merlin, D.; Selsted, M.E.; Lencer, W.I.; Madara, J.L.; Eaton, D.C. Cryptdin 3
forms anion selective channels in the cytoplasmic membranes of human embryonic kidney
cells. Am. J. Physiol. Gastrointest. Liver Physiol. 282:G757-765, 2002.
103. Fink, A.S.; Wang, Y.; Mendez, T.; Worrell, R.T.; Eaton, D.C.; Nguyen, T.D.; Lee, S.P.
Angiotensin II evokes calcium-mediated signaling events in isolated do pancreatic
epithelial cells. Pancreas 25:290-295, 2002
104. Ma, H.-P.; Li, L.; Zhou, Z.H.; Eaton, D.C.; Warnock,D.G. ATP masks stretch activation
of epithelial sodium channels in A6 distal nephron cells. Am J. Physiol. (Renal) 282:F501F505, 2002.
105. Yue, G.; Malik, B.; Yue, G.; Eaton, D.C. Phosphatidylinositol 4,5-bisphosphate (PIP2)
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106. Amiri, F.; Shaw, S.; Wang. X.; Tang, J.; Waller, J.L.; Eaton, D.C.; Marrero, M.B.
Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high
glucose. Kidney Int. 61:1605-1616, 2002.
107. Chen,, X-J.; Eaton, D.C.; Jain, L. Beta-adrenergic regulation of amiloride-sensitive lung
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108. Matalon, S.; Lazrak, A.; Jain, L.; Eaton, D.C. Biophysical Properties of Na+ Channels in
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109. Becchetti, A.; Malik, B.; Yue, G.; Duchatelle, P.; Al-Khalili, O.; Kleyman, T.R.; Eaton,
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110. Wang, X.; Shaw, S.; Amiri, F.; Eaton, D.C.; Marrero, M.B. Inhibition of the Jak/STAT
signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin
synthesis in mesangial cells. Diabetes 51:3505-9, 2002
111. Bechara, R.I.; Brown, L.A.; Eaton, D.C.; Roman, J.; Guidot, D.M. Chronic ethanol
ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances
tumor necrosis factor-alpha- and angiotensin II-induced cytotoxicity via AT2 signaling in
rat alveolar epithelial cells. Alcohol Clin. Exp. Res. 27:1006-14, 2003
112. Kelly, O.; Lin, C.; Ramkumar, M.; Saxena, N.C.; Kleyman, T.R.; Eaton, D.C.
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113. Matalon, S.; Hardiman, K.M.; Jain, L.; Eaton, D.C.; Kotlikoff, M.; Eu, J.P.; Sun, J.;
Meissner, G.; Stamler, J.S. Regulation of ion channel structure and function by reactive
oxygen-nitrogen species. Am J Physiol Lung Cell Mol Physiol. 285:L1184-9, 2003
114. Hardiman, K.M.; McNicholas-Bevensee, C.M.; Fortenberry, J.; Myles, C.T.; Malik, B.;
Eaton, D.C.; Matalon, S. Regulation of amiloride-sensitive Na+ transport by basal nitric
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115. Byas-Smith, M.G.; Li, J.; Szlam, F., Eaton, D.C., Votaw, J.R., Denson, D.D. Isoflurane
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116. Chen, X.J., Seth, S., Yue, G., Kamat, P., Compans, R.W., Guidot, D., Brown, L.A., Eaton,
D.C., Jain, L. Influenza virus inhibits ENaC and lung fluid clearance. Am J Physiol Lung
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117. Ma, H.P., Al-khalili, O., Ramosevac, S., Saxena, S., Liang, Y.Y., Warnock, D.G., Eaton,
D.C. Steroids and exogenous gamma-ENaC subunit modulate cation channels formed by
alpha-ENaC in human B lymphocytes. J Biol Chem. 279:33206-12, 2004
118. Niisato, N., Eaton, D.C., Marunaka, Y. Involvement of cytosolic Cl- in osmoregulation of
αENaC gene expression. AM J Physiol Renal Physiol. 287:F932-9, 2004
119. Denson, D.D., Li, J., Wang, X., Eaton, D.C. Activation of BK-channels in GH3 cells by c-
PLA2-dependent G-protein signaling pathway. J Neurophysiol. 93:3146-56, 2005
120. Holtzclaw, J.D., Morris, L., Pyatt, R., Giver, C., Hoey, J., Gunn, R.B., Eaton, D.C.,
Haynes, J.K., Eisen, A. FIRST: A New Model for Developing Future Science Faculty. J.
College Science Teaching. 34:24-30, 2005
121. Malik, B., Yue, Q., Yue, G., Chen, XJ, Price, SR., Mitch, WE., Eaton, DC, Role of Ned4-2
and poly-ubiquitination in epithelial sodium channel degradation in untransfected renal A6
cells expressing endogenous ENaC subunits. Am J Physiol Renal Physiol. 289:F107-16,
2005
122. Helms, MN, Yu, L., Malik, B., Klienhenz, DJ, Hart, CM., Eaton, DC., Role of SGK1 in
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123. Eaton, DC, Chen, J., Ramosevac, S., Matalon, S., Jain, L, Regulation of Na+ channels in
lung alveolar type II epithelial cells. Proc Am Thorac Soc. 1:10-16, 2004
124. Helms, Mn., Liu, L., Liang, YY., Al-Khalili, O., Vandewalle, A., Saxena, S., Eaton, DC,
Ma, HP., Phosphatidyl-inositol-3,4,5-trisphophate (PIP3) mediates aldosterone stimulation
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125. Ma, HP, Eaton, DC. Acute Regulation of Epithelial Sodium Channel by Anionic
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126. Helms, MN., Chen, XJ., Ramosevac, S., Eaton, DC., Jain, L., Dopamine regulation of
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127. Joshi, PC., Applewhite, L., Ritzenthaler, JD., Roman, J., Fernandez, AL., Eaton, DC.,
Brown, LA., Guidot, DM. Chronic ethanol ingestion in rats decreases granulocytemacrophage colony-stimulating factor receptor expression and downstream signaling in the
alveolar macrophage. J Immunol. 175:6837-45, 2005
128. Banes-Berceli, Ak., Shaw, S., Ma, G., Brands, M., Eaton, DC, Stern, DM., Fulton, D.,
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129. Marrero, MB., Banes-Berceli AK., Stern, DM., Eaton, DC. Role of the JAK/STAT
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130. Jain, L., Eaton, DC. Alveolar fluid transport: a changing paradigm. Am J Physiol Lung
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131. Jain, L., Eaton, DC. Physiology of fetal lung fluid clearance and the effect of labor. Sem.
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132. Malik, B., Price, SR., Mitch, WE., Yue, Q., Eaton, DC. Regulation of epithelial sodium
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290:F1285-94, 2006
133. Helms, MN., Self, J., Bao, HF., Job, LC., Jain. L., Eaton, DC. Dopamine activates
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Am J Physiol. Lung Cell Mol Physiol. [Epub ahead of print], 2006
134. Johnson, MD., Bao, HF., Helms, MN., Chen, XJ., Tigue, Z., Jain, L., Dobbs, LG., Eaton,
DC. Functional ion channels in pulmonary alveolar type I cells support a role for type I
cells in lung ion transport. Proc Natl Acad Sci USA 103:4964-9, 2006
135. Joshi PV, Applewhite LD, Mitchell P, Fernainy K, Roman J, Eaton DC, Guidot DM. GMCSF receptor expression and signaling is decreased in lungs of ethanol-fed rats. Am J
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136. Cui XL, Ding Y, Alexander LD, Bao C, Al-Khalili OK, Simonson M, Eaton DC, Douglas
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and p38(SAPK). Free Radical Biol Med. 41:213-21, 2006
137. Denson DD, Liu L, Eaton DC. Co-localization of the alpha-subunit of BK-channel and cPLA2 in GH3 cells. Biochem Biophys Res Commun. 350:39-49, 2006
138. Holzman JL, Liu L, Duke BJ, Kemendy AE, Eaton DC. Transactivation of the IGF-1R by
aldosterone. Am J Physiol Renal Physiol. 292:F1219-28, 2007
139. Yu L, Bao HF, Self JL, Eaton, DC, Helms MN. Aldosterone –induced increases in
superoxide (O2) production counters nitric oxide inhibition of epithelial Na channel (ENaC)
activity in A6 cells. Am J Physiol Renal Physiol. 293:F1666-77, 2007
140. Bao HF, Zhang ZR, Liang YY, Ma JJ, Eaton DC, Ma HP. Ceramide Mediates Inhibition
of the Renal Epithelial Channel by Tumor Necrosis Factor α thyrough Protein Kinase C.
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141. Ma HP, Chou CF, Wei SP, Eaton DC. Regulation of the epithelial sodium channel by
phosphatidylinositides: experiments, implications, and speculations. Pflugers Arch.
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142. Gandhi SG, Rafii B, Harris MS, Garces A, Mahuran D, Chen XJ, Bao HF, Jain L, Eaton
DC, Otulakowski G, O’brodovich H. Effects of cardiogenic edema fluid on ion and fluid
transport in the adult lung. Am J Physiol Lung Cell Mol Physiol. 293:L651-9, 2007
143. Yu L, Eaton DC, Helms MN. Effect of divalent heavy metals on epithelial Na+ channels
in A6 cells. Am J Physiol Renal Physiol. 293:F236-44, 2007
144. Hemls MN, Jain L, Self JL, Eaton DC. Redox regulation of epithelial sodium channels
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145. Bao HF, Liu L, Self J, Duke BJ, Ueno R, Eaton DC. A Synthetic Prostone Activates
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146. Yu L, Helms MN, Yue Q, Eaton DC. Single-channel analysis of functional epithelial
sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells. Am J
Physiol Renal Physiol. 295:F1519-27, 2008.
147. Liu L, Duke BJ, Malik B, Yue Q, Eaton DC. Biphasic regulation of ENaC by TGF{alpha} and EGF in renal epithelial cells. Am J Physiol Renal Physiol.296:F1417-27, 2009.
148. Eaton DC, Helms MN, Koval M, Bao HF, Jain L. The contribution of epithelial sodium
channels to alveolar function in health and disease. Annu Rev Physiol. 71:403-23, 2009.
149. Huang H, Yang Y, Eaton DC, Sands JM, Chen G. The N-terminal 81-aa fragment is
critical for UT-A1 urea transporter bioactivity. J Epithel Biol Pharmacol. 3:34-39, 2010.
150. Eaton DC, Malik B, Bao HF, Yu L, Jain L. Regulation of epithelial sodium channel
trafficking by ubiquitination. Proc Am Thorac Soc. 7:54-64, 2010, Review.
151. Li J, Al-Khalili O, Ramosevac S, Eaton DC, Denson DD. Protein-protein interaction
between cPLA2 and splice variants of alpha-subunit of BK channels. Am J Physiol Cell
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152. Pech V, Pham TD, Hong S, Weinstein AM, Spencer KB, Duke BJ, Walp E, Kim YH,
Sutliff RL, Bao HF, Eaton DC, Wall, SMl. Pendrin modulates ENaC function by changing
luminal HCO3-. J Am Soc Nephrol 2010 Nov;21(11):1928-41. PMCID:PMC3014007
153. Kranz C, Eaton DC, Mizaikoff B. Analytical challenges in nanomedicine.
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154. Matalon S, Eaton DC. Dale J. Benos, Ph.D. (1950-2010). Am J Physiol Lung Cell Mol
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155. Zhuang J, Zhang X, Wang D, Li J, Zhou B, Shi Z, Gu D, Denson DD, Eaton DC, Cai H.
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Physiol Renal Physiol 2011 Aug;301(2):F410-F419. PMCID:PMC3154587
156. Thomas SV, Kathpalia PP, Rajagopal M, Charlton C, Zhang J, Eaton DC, Helms MN, Pao
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157. Wang LH, Wang N, Lu XY, Liu BC, Yanda MK, Song JZ, Dai HM, Sun YL, Bao HF,
Eaton DC, et al. Rituximab inhibits Kv1.3 channels in human B lymphoma cells via
activation of FcgammaRIIB receptors. Biochim.Biophys Acta 2012 Feb;1823(2):505-13
158. Eaton DC. Frontiers in renal and epithelial physiology - grand challenges. Front Physiol
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159. Bou Matar RN, Malik B, Wang XH, Martin CF, Eaton DC, Sands JM, Klein JD. Protein
abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed vs.
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160. Downs CA, Kriener LH, Yu L, Eaton DC, Jain L, Helms MN. beta-Adrenergic agonists
differentially regulate highly selective and nonselective epithelial sodium channels to
promote alveolar fluid clearance in vivo. Am.J.Physiol Lung Cell Mol.Physiol 2012 Jun
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161. Niisato N, Ohta M, Eaton DC, Marunaka Y. Hypotonic stress upregulates beta- and
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Renal Physiol 2012 Jul 15;303(2):F240-F252. PMCID:PMC3404587
162. Bao HF, Song JZ, Duke BJ, Ma HP, Denson DD, Eaton DC. Ethanol stimulates epithelial
sodium channels by elevating reactive oxygen species. Am.J.Physiol Cell Physiol 2012
Dec 1;303(11):C1129-C1138. PMCID:PMC3530770
163. Richards J, Greenlee MM, Jeffers LA, Cheng KY, Guo L, Eaton DC, Gumz ML.
Inhibition of alphaENaC expression and ENaC activity following blockade of the circadian
clock-regulatory kinases CK1delta/{varepsilon}. Am.J.Physiol Renal Physiol 2012
Oct;303(7):F918-F927. PMCID:PMC3469687
164. Alli AA, Bao HF, Alli AA, Aldrugh Y, Song JZ, Ma HP, Yu L, Al-Khalili O, Eaton DC.
Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS
protein. Am.J.Physiol Renal Physiol 2012 Sep 15;303(6):F800-F811.
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165. Alli AA, Song JZ, Al-Khalili O, Bao HF, Ma HP, Alli AA, Eaton DC. Cathepsin B is
secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel
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166. Yu L, Al-Khalili OK, Duke BJ, Stockand JD, Eaton DC, Bao HF. The inhibitory effect of
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167. Liu BC, Song X, Lu XY, Fang C, Wei SP, Alli AA, Eaton DC, Shen BZ, Li XQ, Ma HP.
Lovastatin attenuates effects of cyclosporine A on tight junctions and apoptosis in cultured
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168. Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC. WNK4
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169. Malviya SA, Kelly SD, Greenlee MM, Eaton DC, Duke BJ, Bourke CH, Neigh GN.
Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators
in a hippocampal cell model. Physiol Behav. 2013 Mar 26;
170. Liu BC, Song X, Lu XY, Li DT, Eaton DC, Shen BZ, Li XQ, Ma HP. High glucose
induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen
species. Biochim.Biophys.Acta 2013 Jun;1833(6):1434-42
171. Liu BC, Lu XY, Song X, Lei KY, Alli AA, Bao HF, Eaton DC, Ma HP. Scanning ion
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172. Guo LJ, Alli AA, Eaton DC, Bao HF. ENaC is regulated by natriuretic peptide receptor-
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173. Takemura Y, Helms MN, Eaton AF, Self J, Ramosevac S, Jain L, Bao HF, Eaton DC.
Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells.
Am.J.Physiol Lung Cell Mol.Physiol 2013 Mar 15;304(6):L428-L437
174. Greenlee MM, Mitzelfelt JD, Yu L, Yue Q, Duke BJ, Harrell CS, Neigh GN, Eaton DC.
Estradiol activates epithelial sodium channels in rat alveolar cells through the G proteincoupled estrogen receptor. Am.J.Physiol Lung Cell Mol.Physiol 2013 Dec;305(11):L878L889. PMCID:PMC3882529
175. Alli AA, Brewer EM, Montgomery DS, Ghant MS, Eaton DC, Brown LA, Helms MN.
Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction
in alveolar type 2 cells. Am.J.Physiol Lung Cell Mol.Physiol 2014 Jun 1;306(11):L1026L1035
176. Bao HF, Thai TL, Yue Q, Ma HP, Eaton AF, Cai H, Klein JD, Sands JM, Eaton DC. ENaC
activity is increased in isolated, split-open cortical collecting ducts from protein kinase
Calpha knockout mice. Am.J.Physiol Renal Physiol 2014 Feb 1;306(3):F309-F320.
PMCID:PMC3920049
177. Reifenberger MS, Yu L, Bao HF, Duke BJ, Liu BC, Ma HP, Alli AA, Eaton DC, Alli AA.
Cytochalasin E alters the cytoskeleton and decreases ENaC activity in Xenopus 2F3 cells.
Am.J.Physiol Renal Physiol 2014 May 14;
178. Song X, Liu BC, Lu XY, Yang LL, Zhai YJ, Eaton AF, Thai TL, Eaton DC, Ma HP, Shen
BZ. Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular
ROS and TRPC6 expression. Biochim.Biophys.Acta 2014 May;1843(5):894-901.
PMCID:PMC4015521
179. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R,
Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin
A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay
MA, Eaton DC, Lucas R. A Novel TNF-mediated Mechanism of Direct Epithelial Sodium
Channel Activation. Am J Respir Crit Care Med. 2014 Jul 16;PubMed PMID: 25029038.
[Epub ahead of print].
180. Eaton AF, Yue Q, Eaton DC, Bao HF. ENaC Activity and Expression is Decreased in the
Lungs of Protein Kinase C-α Knockout Mice. Am J Physiol Lung Cell Mol Physiol. 2014
Jul 11;PubMed PMID: 25015976. [Epub ahead of print].
181. Reifenberger MS, Yu L, Bao HF, Duke BJ, Liu BC, Ma HP, Alli AA, Eaton DC, Alli AA.
Cytochalasin E alters the cytoskeleton and decreases ENaC activity in Xenopus 2F3 cells.
Am J Physiol Renal Physiol. 2014 Jul 1;307(1):F86-95. PubMed PMID: 24829507;
PubMed Central PMCID: PMC4080154.
182. Alli AA, Brewer EM, Montgomery DS, Ghant MS, Eaton DC, Brown LA, Helms MN.
Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction
in alveolar type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L102635. PubMed PMID: 24682449.
Book Chapters:
1.
Lewis, S.A.; Wills, N.K.; Eaton, D.C. Membrane selectivity and ion activities of
mammalian tight epitelia. In: Current Topics in Membranes and Transport. Cellular
Mechanisms of Renal Tubular Ion Transport. F. Bronner; A. Kleinzeller, eds. Academic
Press, New York; 1980.
Douglas C. Eaton, Ph.D.
30
2.
Eaton, D.C. How are membrane properties of individual neurons related to information
processing in neural circuits. In: Information Processing in the Nervous System. H.A.
Pinsker; W.D. Willis, eds. Raven Press, New York; 1980.
3.
Niemtzow, R.C.; Frace, A.M.; Eaton, D.C.; Becker, S.N.; Robbins, C.H.; Perez-Polo, J.R.;
Daniels, J.C. Electrical potentials and related membrane properties of human murine
monoclear cells. In: Fundamental Mechanisms in Human Cancer Immulogy (chapter 5).
J.P. Saunders; J.C. Daniels; B. Serrou; C. Rosenfeld; C.B. Denney, eds. New York,
Elsevier North Holland; 1981.
4.
Brodwick, M.S.; Eaton, D.C. Chemical modifications of excitable membranes. In:
Proteins in the Nervous System: Structure and Function. B. Haber; J.R. Perez-Polo; J.D.
Coulter, eds. Alan R. Liss, Inc., New York; 1982.
5.
Eaton, D.C.; Russell, J.M. Renal Physiology. In: Medical Physiology. A.M. Brown;
D.W. Stubbs, eds. John Wiley & Sons, Inc., New York; 1983.
6.
Eaton, D.C.; Brodwick, M.S. Chemical modification of the Na+ channel: Specific amino
acid residues. In: The Physiology of excitable cells. W.R. Moody, A.D. Grinnell, eds.
Alan R. Liss, Inc., New York; 1983.
7.
Eaton, D.C. Electrical properties of Cells. In: Cells of the immune system. R.C.
Niemtzow, ed. CRC Press, Cleveland, Ohio; 1985.
8.
Eaton, D.C. Membrane properties of macrophage. In: Cells of the immune system. R.C.
Niemtzow, ed. CRC Press, Cleveland, Ohio; 1985.
9.
Eaton, D.C.; Hamilton, K.L. The amiloride-blockable sodium channel of epithelial tissue.
In: Ionic Channels. T. Narahashi, ed. Vol. 1, Plenum Press, New York. p251-282; 1988.
10.
Eaton, D.C. Polarity of Epithelial Cells. Annu. Rev. Physiol. 51:727-728; 1989.
11.
Eaton, D.C.; Marunaka, Y. Ion channel fluctuations: "noise" and single channel
measurements. In: Channels, Noise, and Impedance in Epithelia. S.I. Helman and W. Van
Driessche, eds., Academic Press, Orlando, Florida. p61-117; 1990.
12.
Eaton, D.C.; Marunaka, Y.; Ling, B. N. Channels in epithelia tissue. In Membrane
Transport in Biology. J. Schafer and G. Giebisch, eds., Vol. 5, Springer Verlag, New York.
p73-165; 1991
13.
Eaton, D.C.; Stockand, J.D.; Edinger, R.S.; Yue, G. ; Becchetti, A.; Al-Baldawi, N.;
Johnson, J.P.; Sariban-Sohraby, S. Mechanisms of aldosterone’s action on epithelial
sodium transport. In Control and Diseases of Sodium Dependent Transport Proteins and
Ion Channels. Y Suketa, E. Carafoli, M. Lazdunski, Y. Okada, and E.M. Wright, eds.,
Elsevier, Amsterdam. p9-15; 2000.
14.
Eaton, D.C., Jain, L. Signal transduction pathways in lung epithelial cells. In Etiology and
Treatment of Acute Lung Injury: From Bench to Bedside. S. Matalon, ed., IOS Press BV,
Amsterdam, Netherlands, pp. 129-137, 2002
15.
Eaton, D.C., Pooler, J.P. Vander’s Renal Physiology, 6th Ed., Lange Medical Books,
McGraw Hill, New York, New York, 2004
16.
Eaton, D. C., Jain, L. Ion Transport: Overview in Encyclopedia of Respiratory Medicine.
Douglas C. Eaton, Ph.D.
31
Elsevier Press, Oxford, UK 2006
17.
Eaton, D. C., Jain, L. Ion Transport: ENaC in Encyclopedia of Respiratory Medicine.
Elsevier Press, Oxford, UK 2006
18.
Eaton, D.C., Malik, B., Ma, H.-P. “Hypertension and Sodium Channel Turnover” in
Principles of Molecular Medicine, 2nd edition. Humana Press, Totowa, New Jersey 2008
Books edited and written:
1.
1987 - Cell Calcium and the Control of Membrane Transport. eds. Lazaro J. Mandel and
Douglas Eaton. Rockefeller Press, New York.
2.
1987 - Molecular Neuroscience; Expression of Neural Genes. eds. Fulton Wong, Douglas
C. Eaton, and William Willis. Alan R. Liss, New York
3.
1988 - Annual Review of Physiology, Volume 51. Special Topic: Epithelial polarity. ed.
Douglas C. Eaton.
4.
2004 – Vander’s Renal Physiology, 6th Ed., Douglas C. Eaton and John P. Pooler. Lange
Medical Books, McGraw Hill, New York, New York
5.
2008 – Vander’s Renal Physiology, 7th Ed., Douglas C. Eaton and John P. Pooler. Lange
Medical Books, McGraw Hill, New York, New York
6.
Eaton, D.C., Pooler, J.P. Renal Physiology in Medical Physiology:-A Systems Approach.,
editors: Hershel Raff and Michael Levitsky. McGraw Hill, New York, New York, 2009.
7.
2013 – Vander’s Renal Physiology, 8th Ed., Douglas C. Eaton and John P. Pooler. Lange
Medical Books, McGraw Hill, New York, New York
Book reviews: None
Manuals, videos, computer programs, and other teaching aids:
1.
Motion Picture: "The Nerve Impulse," Eaton, D.C. in collaboration with A. Clemente and
the Departments of Anatomy and Physiology, UCLA Medical School. Produced by
Encyclopedia Britannica Educational Corporation; 1972.
Other publications: THESIS Publication
1.
Eaton, D.C. Slow changes of membrane characteristics in Aplysia neurons as studied by
voltage clamp technique. Ph.D. Thesis (University of California, San Diego); 1971.
Abstracts:
1.
Eaton, D.C.; Brodwick, M.S. Effect of internal divalent cations in squid axon. Biophys. J.
15:41a;1975.
2.
Lewis, S.A.; Eaton, D.C.; Diamond, J.M. Location of a transport-related conductance
pathway in rabbit urinary bladder, a tight epithlium. Biophys. J. 15:232a; 1975.
3.
Eaton, D.C.; Brodwick, M.S. Inward rectification in Aplysia giant neuron. Biophys. J.
16:24al 1976.
4.
Lewis, S.A.; Eaton, D.C.; Clausen, C.; Diamond, J.M. Effect of nystatin on the electrical
properties of rabbit urinary bladder. Biophys. J. 17:21a; 1977.
Douglas C. Eaton, Ph.D.
32
5.
Russell, J.M.; Eaton, D.C.; Brodwick, M.S. Effects of nystatin on the Aplysia giant
neuron. Biophys. J. 16:75a; 1976.
6.
Clausen, C.; Lewis, S.A.; Diamond, J.M.; Eaton, D.C. AC impedance analysis in a tight
epithelium: Limitations of the method and initial results. Biophys. J. 17:21a; 1977.
7.
Horn, R.; Brodwick, M.S.; Eaton, D.C. Effect of protein crosslinking reagents on
membrane currents of squid axon. Biophys. J. 21:42a; 1978.
8.
Eaton, D.C.; Brodwick, M.S.; Ifshin, M.S. Inward rectification in Aplysia neurons.
Biophys. J. 21:83a; 1978.
9.
Eaton, D.C.; Brodwick, M.S. Barium block of potassium currents. Biophys. J. 21:164a;
1978.
10. Brodwick, M.S.; Eaton, D.C. Removal of Na+ inactivation by high pH and tyrosine
specific reagents. Biophys. J. 21:42a; 1978.
11. Lewis, S.A.; Wills, N.K.; Eaton, D.C. Electrical properties of the basolateral membrane of
the rabbit urinary bladder. Biophys. J. 21:151a; 1978.
12. Wills, N.K.; Lewis, S.A.; Eaton, D.C. Microelectrode; nystatin studies of rabbit
descending colon. Biophys. J. 21:151a; 1978.
13. Eaton, D.C.; Brodwick, M.S. Amino group reagents affect inactivation in squid axon.
Biophys. J. 25:305a; 1979.
14. Redmann, G.A.; Brodwick, M.S.; Eaton, D.C.; Steele, J.; Poznansky, M.J. Liposome
mediated lipid exchange effects on squid axon membrane currents. Biophys. J. 25:138a;
1979.
15. Steele, J.; Poznansky, M.J.; Redmann, G.A.; Brodwick, M.S.; Eaton, D.C. Cholesterol
movement and loading in perfused squid axon. Biophys. J. 25:138a; 1979.
16. Niemtzow, R.C.; Eaton, D.C.; Becker, S.N.; Olson, M.H.; Daniels, J.C. Correlation
between macrophage intracellular electrical potential and malignant melonoma growth in a
murine model. Clin. Res. 27:792a; 1979.
17. Silverthorn, S.U.; Eaton, D.C. Respiration and ion transport in rabbit urinary bladder.
Physiologist 22:115; 1979.
18. Ifshin, M.S.; Eaton, D.C. Effects of mucosal acid on rabbit urinary bladder. Physiologist
22:60; 1979.
19. Frace, A.M.; Hall, S.; Eaton, D.C.; Brodwick, M.S. Structure activity relationship of
saxitoxin analogs from Protogonyaulax. Biophys. J. 41:49a; 1983.
20. Hamilton, K.L.; Eaton, D.C. Anion flux across the basolaterol membrane of the rabbit
urinary bladder. Fed. Proc. 42:1353a; 1983.
21. Hamilton, K.L.; Eaton, D.C. Single channel recordings from the amiloride-sensitive
epithelial Na+ channel. lst Congress of the Comparitive Physiology and Biochemistry
Section of the International Union of Biological Sciences. Liege, Belgium; 1984.
22. Hamilton, K.L.; Eaton, D.C. Effects of amiloride on single-channel conductance events of
the epithelial Na+ channel. Workshop on Noise Analysis, Patch Clamp and Impedance
Douglas C. Eaton, Ph.D.
Analysis. Leuven, Belgium; 1984.
23. Hamilton, K.L.; Eaton, D.C. Single channel recording from the amiloride-sensitive
epithelial Na channel. Biophys. J. 47:262a; 1985.
24. Hamilton, K.L.; Eaton, D.C. Single channel recording from the amiloride-sensitive
epithelial Na channel. Fed. Proc. 44:646; 1985.
25. Frace, A. M.; Eaton, D.C. Chemical modification of amino groups on calcium activated
K+ channels of GH3 cells. Biophys. J. 51:55a; 1987.
26. Marunaka, Y.; Eaton, D.C. Effect of CDPC on single channel currents of the amiloridesensitive Na channel from cultured renal cells. Biophys. J. 53:522a; 1988.
27. Eaton, D.C.; Ling, B. N. The effect of cholera toxin, pertussis toxin, and gtp-gamma-s on
highly selective sodium channels in A6 cells. Kidney Int. 37: 373a, 1989.
28. Eaton, D.C.; Marunaka, Y. Comparison between the effects of amiloride and CDPC, an
amiloride analogue, on amiloride-sensitive sodium channels from cultured renal cells.
FASEB J. 2: A750; 1988.
29. Ling, B. N.; Eaton, D.C. Single sodium and potassium channel events in apical membrane
of rabbit cortical collecting tubule primary cultures. Kidney Int. 37: 377a, 1989.
30. Marunaka, Y.; Eaton, D.C. Different types of chloride channels in a distal nephron cell
line. Biophys. J. 55: 160a, 1989.
31. Marunaka, Y.; Eaton, D.C. The regulation of a chloride channel in a distal nephron cell
line. Biophys. J. 55: 160a, 1989.
32. Marunaka, Y.; Eaton, D.C. Different types of chloride channels in a distal nephron cell
line. FASEB J. 3: A862, 1989.
33. Kemendy, A. E.; Eaton, D.C. Aldosterone affects apical sodium channel density and open
probability in A6 epithelia. FASEB J. 3: A861, 1989.
34. Ling, B. N.; Eaton, D.C. Arachidonic acid modulates apical potassium channels in A6
cells. Clin. Res. 38: 468A, 1990.
35. Marunaka, Y.; Eaton, D.C. The regulation of a calcium-dependent chloride channel in
distal nephron cells by g-proteins. FASEB J. 4: A726, 1990.
36. Eaton, D.C.; Marunaka, Y. Effects of cyclic AMP and cholera toxin on an
amiloride-blockable sodium channel in renal cells. FASEB J. 4: A549; 1990.
37. Kemendy, A. E.; Eaton, D.C. Aldosterone-induced sodium transport in A6 epithelia is
blocked by 3 deazaadenosine, a methylation blocker. FASEB J. 4: A445, 1990.
38. Eaton, D. C.; Ling, B. N. Potassium channel regulation by arachidonic acid metabolites in
A6 cells. J ASN 1: 683, 1990
39. Marunaka, Y.; Eaton, D.C. Effect of osmolarity on an amiloride-blockable sodium channel
in a renal distal nephron cell line (A6). J. Gen. Physiol. 96: 41a; 1990.
40. Eaton, D.C.; Ohara, A. Regulation mechanisms of the epithelial sodium channel activity in
A6 cells. FASEB J. 5: A690; 1991.
Douglas C. Eaton, Ph.D.
41. Marunaka, Y.; Eaton, D.C. Effects of osmolarity on an amiloride-blockable sodium
channel in renal epithelium. FASEB J. 5: A690; 1991.
42. Kokko. K.; Ling, B.; Eaton, D. Modulation of apical sodium channel activity by
arachidonic acid metabolites in cultured A6 cells. FASEB J 5: A690, 1991
43. Ling, B. N.; Kokko, K. E.; Eaton, D. C. PGE2 activates apical Cl- channels in rabbit
cortical collecting tubule (RCCT) principal cells via cAMP-mediated pathway. J ASN 3:
813, 1992
44. Ling, B. N.; Kokko, K. E.; Matsumoto, P. S.; Eaton, D. C. Activation of a chloride
conductive pathway in a distal nephron cell line (A6) by PGE2, forskolin, and arginine
vasotocin (AVT). J ASN 3: 813, 1992
45. Matsunaga, H.; Ling, B. N.; Eaton, D. C. A calcium-permeable cation channel is activated
by PDGF in rat mesangial cells. J ASN 3: 814, 1992
46. Matsunaga, H.; Ling, B. N.; Eaton, D. C. A calcium-permeable cation channel is activated
by PDGF in rat mesangial cells. FASEB J 7: A352, 1993
47. Schlanger, L. E.; Eaton, D. C.; Ling, B. N. K+-sparing diuretic actions of trimethoprim:
inhibition of amiloride-sensitive, highly selective Na+ channels in A6 distal nephron cells.
FASEB J 7: A350, 1993
48. Schlanger, L. E.; Kleyman, T. R.; Eaton, D. C.; Ling, B. N. Apical trimethoprim blocks
amiloride-sensitive, Na+ channels in A6 distal nephron cells: K+-sparing diuretic actions. J
ASN 4: 879, 1993
49. Ling, B. N.; Kokko, K. E.; Eaton, D. C. Cyclic AMP promotes clustering of apical Clchannels in rabbit principal cells. J ASN 4: 872, 1993
50. Ling, B. N.; Eaton, D. C. Endothelin-1 inhibits apical Na+ and Cl- selective channels in
rabbit CCT principal cells. J ASN 4: 873, 1993
51. Schlanger, L. E.; Lin, C.; Kleyman, T. R.; Eaton, D. C.; Ling, B. N. Apical triamterene
blocks amiloride-sensitive, Na+ channels in A6 distal nephron cells. J ASN 4: 878, 1993
52. Matsunaga, H.; Ling, B. N.; Eaton, D. C. On the mechanism of activation of Ca2+permeable channels by PDGF in mesangial cells: involvement of GTP-binding protein and
tyrosine kinase. J ASN 4: 873, 1993
53. Denson DD, Eaton DC. The effect of racemic ketamine on the large conductance Ca+2activated potassium (BK) channels in GH3 cells. Neuroscience 19:707, 1993.
54. Ma, H.; Eaton, D. C.; Ling, B. N. Purinergic regulation of amiloride-sensitive, Na+
channels by apical adenosine in A6 cells. FASEB J 8:A223, 1994
55. Eaton, D.C.; Matsunaga, H.; Ling, B.N. PDGF-induced, Ca2+-permeable channels in
mesangial cells: activation involves a GTP-binding protein and tyrosine kinase. J Cell
Biochem 17:453, 1994
56. Denson, DD and Eaton DC. Ketamine inhibition of large conductance ca+2-activated
potassium channels is modulated by intracellular calcium. Anesthesiology 11:201, 1994.
57. Gallego, M.S., Eaton, D.C., and Ling, B.N. Endothelian-1 inhibits apical Na+ channels via
Douglas C. Eaton, Ph.D.
ET-B receptors in A6 cells. FASEB J 9:A64, 1995.
58. Schlanger, L.E., Eaton, D.C., and Ling, B.N. Luminal vasopressin regulates apical Na+
channels in A6 distal nephron cells. FASEB J 9:A64, 1995.
59. Worrell,R.T., Lin, C.-M., Kleyman,T.R., and Eaton, D.C. Cloning and expression of
xSCAD1, a member of the shortchain alcohol dehydrogenase family. FASEB J 9:A309,
1995.
60. Lin, C.-M., Worrell, R.T., Eaton, D.C., and Kleyman,T.R. Use of different
polyadenylation sites results in multiple mRNA species of xSCAD1. FASEB J 9:A309,
1995.
61. Middleton, P.M., Worrell,R.T., and Eaton, D.C. Antisense oligonucleotides of -, -, and
-xENaC decrease sodium channel density in the apical membrane of A6 cells. FASEB J
9:A388, 1995.
62. Ma, H., Matsunaga, H., Eaton, D.C., and Ling, B.N. G Protein activates PDGF-induced
Ca-permeable channels in mesangial cells. FASEB J 9:A390, 1995.
63. Gallego M.S., Eaton D.C., and Ling B.N. Endothelin-1 inhibits apical sodium channels
via ET-B receptors in distal nephron cells (A6). J. Invest. Med. 43: 262A, 1995
64. Kleyman T.R., Lin C., McNulty K., Gomez L.M., Worrell R.T., Eaton D.C., and Ling
B.N. Expression of the cystic fibrosis phenotype in a renal amphibian epithelial cell line
(A6). J. Am. Soc. Nephrol. 6: 342, 1995
65. Ma H., Matsunaga H., Li B., Marrero M.B., Eaton D.C., and Ling B.N. Activation of
platelet-derived growth factor (PDGF) receptor-operated Ca2+ channel via tyrosine kinase
and Ras in mesangial cells. FASEB J. 10: A139, 1996
66. Bao H.-F., Ma H., Sun J., Kleyman T.R., Eaton D.C., and Ling B.N. Inhibition of
amiloride-sensitive Na channels by luminal ATP in A6 distal nephron cells. FASEB J. 10:
A137, 1996
67. 89 additional for the years 1997 - 2013