ciprofloxacine can be used for Rx. of :
a. syphilis (F)
b. UTI caused by multidrug resistance organisms (T)
c. soft tissue , bone , joints , intra abdominal infec. (T)
d. TB (T)
E.Legoneusis (T) .i
clarithromycin :
a- destroyed by stomach acidity
b- effective aganist atypical mycobacterial infec.
neomycine : a- used topically for bacterial eye infection
Adverse effects of tetracycline may include:
a)
dental caries.(F)
b)
thrombophlebtis.(T)
c)
bone marrow depression.(F)
d)
pseudomembranous colitis.(T)
Ciprofloxacin is used in all ,except:
a)
b)
c)
d)
Travellar's diarrhea
Staph infection
Osteomilitis.
UTI by pseudomonas
Regarding gentamycin:
a)
b)
c)
d)
More effective aginst G+
Has no effect on TB.
Has no effect on pseudomonas .
Not nephrotoxic .
Which one of the following tetracycline is better used
in renal failure :
a)
b)
c)
d)
Cloxacyclin
Doxycycline
Tetracycline
Minocyclin
In comparison of erythromycin ,ezithromycin has:
a)
b)
c)
d)
Broad spectrum T
More GIT tolerance
T
No inhibition of liver microsomal enzymes. T
Longer duration OF action
T
Ticracyclin :
a) Ineffective against steph aureus
b) Has narrow spectrum .
c) Effective against pseudomonas
T
F
T
One of the following antibiotics cannot be used in
pseudomonas aureginosa infections:
a)
b)
c)
d)
Piperacillin
Cefotaxime
Azithromycin
Gentamycin
Gentamycin is different from aztreonam in that
azteronam is
a) Used for gram +ve & -ve bacteria.F
b) Can be taken orally & parentrally F
c) Inhibit cell wall synthesis T
d) Has NO potential nephrotoxic effect T
Ciprofloxacin effectively used in:
a) Bacterial diarrhea.(T)
b) UTI in multidrug resistant bacteria.(T)
c) Gonorrhea.(T)
d) Anthrax.(T)
Gentamycin:
a)
b)
c)
d)
Cross BBB freely.(F)
Used for gram –ve bacilli.(T)
Nephrotoxic( T)
Used for UTI infections( T)
According to Minocyclin:
a.
b.
c.
d.
e.
It is preferred for renal insufficiency(F)
It has short half life
(F)
It is completely absorbed after oral administration( T)
Can treat acne ( T)
Can cross BBB (F)
According Azithromycin:
a.
b.
c.
d.
e.
Antacid decrease its bioavailability (F)
Has good effect on Chlamydia( T)
Cause less GI irritation (T)
Used as 2nd line for TB treatment ( T)
Is enzyme inhibitor ( F)
Ciprofloxacine :
Dose should be adjusted in renal insufficieny (T)
Causes cartlidge damage (T)
Used in treatment of UTI’s resistant to other drugs (T)
Works by inhibiting bacterial cell wall synthesis (F)
Doxycycline treats all of the following except :
- Gonorrhea
Erythromycin
 In low concentration ---- bacteriostatic
 In high concentration ---- bactericidal
Choose the correct sentence about tetracycline:
A. Broad spectrum.
B. Used in treatment of life threatening infection {X} as it
bacteriostatic not bactericidal.
C. Used with young child. {X} teeth discoloration
Most suitable tetracycline in renal impairment is:
doxycycline. The ONLY one
Premature neonate suffer from respiratory infection
and given antibiotic, After two days he have worse
destintion of abdomen, and blue to grayish appearance
, which antibiotic was he given?
cloramphenichol.
Chloramphenicol inhibits bacterial protein synthesis by
binding to ::
Answer: By binding to 50S subunit of the bacterial ribosome
Concurrent use of amino-glycoside should be avoided
with the following Antibiotics:
A- Ampicillin ( F)
B- Vancomycin (T) due to nephrotoxicity
Oral neomycin efficient in hepatic coma b/c :
It suppresses bacterial gut which synthesis ammonia ( hepatic coma b/c
of ammonia)
Antibiotics associated with enterocolitis
a)
b)
c)
d)
Ampicillin (T) broad spectrum
Chloramphenicol (T)
Vancomycin (F)
Clindamycin (F)
)Drug of choice to eradicate mengiococcal carrier
among tetracycline:
Minocyclines
Pt treated with oxatetracyclin complain of gastric
upset:
A- Give treat with milk (F)
B- Give it with meal (F)
C- Give it with antacids (F)
D- Non of the above ( T)
The answer: replace it with doxy - or Minocycline
among the reasons of bacterial resistance to
aminoglycosides :
A- mutation (T)
B- Efflux pump (T)
C- failure of antibiotics to penetrate cell wall (T)
D- b/c there is enzyme production that destroy the antibiotics (F) "
lactams ‫" يصير في‬
IMP: compare between erythromycin & his brothers
streptomycin, choose incorrect statement:
a- batiricidal
b-work by binding 50S ribosomal subunits
c-may cause ototoxicity
d-used in severe cases
-contraindicated treatment in pregnancy is
a- rifampicin
b- ethambutol
c-pyrazinamide
d-streptomycin
All of these drugs are citochrome p450 inhibitor
except:
a-erythromycin
b-clarithromycin
c- azithromycin
d-chloramphicol
tetracycline is not used in:
a-H pylori
b-nisseria meningitis * (=meningococcal)
c-brucellosis
d-bacterial diarrhea
which of these sentences does not match
the antibiotic with its side effect:
a-aminoglycoside_ototoxicity
b-ciprofloxacin_arrhythmia
c-polymyxin_nephrotoxicity
d-tetracyclin_bone marrow depression
which of these sentences is true:
a-UTI caused by pseudomonas treated by gentamycin
b-one of the fetal side effect of tetracycline is gray baby
syndrome
c-clarithromycin is more gastric upset and more
expensive than erythromycin.
d-chloramphenicol is one of the drug chose for
treatment of typhoid fever.
about aminoglycoside chose the incorrect :
a- in general they more active in alkaline medium.
b-amikacine is the proudest spectrum.
c- Respiratory distress is one of the serious side effects
of this group and there is no drug available to reverses
this effect.
d- Neomycin is not use in IV route.
- About tetracycline chose the incorrect:
a-oxytetracline is intermediately absorbed and acting.
b-absorption of doxycycline is impaired by divalent
cation
c- Minocycline use to eradicate mengiococcal carrier.
d-they are contraindicated for children under 8.
about chloramphenicol chose the correct :
a-cross placenta but not BBB
b-one of its side effect is psudomembrans colitis.
c-it inhibits protein syntheses by binding to 50S
ribosomal subunit irreversibly.
d-first drug chose for serious rickettsial infection.
-choose the correct:
a-ciprofloxacin is 1st line agent for legionallosis.
b-tobramycin is use against mycobacterium organism.
c-fluroqnilone is concentrated in kidney_ tear_ T
.lymphocyte
d-streptomycin use in severe brucellosis with
tetracycline.
-choose the incorrect:
a-absorption of fluroquinolone is impaired by antacid.
b-aminoglycoside cross the BBB in meningitis (=not
freely crossing)
c-erythromycin must be administered with enteric
coating to protect the GIT from its side effect.
d-clidamycin given orally or parenterally.
-about drug spectrum and activity chose
the incorrect:
a-aminoglycoside is more effective on gram( +) than
gram(-).
b-erythromycin is drug of chose of corynebacterial
infection.
c-clarithromycin spectrum as erythromycin but more
active against mycobacterium avium complex.
d-spectiomycin is 2ry treatment of gonorrhea.
Among the reasons of bacterial resistance to
aminoglycosides all true except:
A.
B.
C.
D.
mutation
Efflux pump
failure of antibiotics to penetrate cell wall
b/c there is enzyme production that destroy the antibiotics
which of fallowing durgs is use systemicly
A-streptomycin.
B-neomycin.
c-polymixins B.
d-bacitracin.
: