Colin G. Rousseaux, BVSc, PhD, DABT, FRCPath, FIATP, FATS
ADDRESSES
Principal, Colin Rousseaux and Associates,
19 Klondike Rd.
Wakefield, QC, J0X 3G0
Canada
Department of Pathology and Laboratory Medicine,
Faculty of Medicine
University of Ottawa, 451 Smyth Road, Rm. 4155
Ottawa, ON K1H 8M5
Canada
Tel: (819) 459-2998
Fax:(819) 459-2960
email crousseaux@crxassociates.com
Tel: (613) 562-5422
Fax: (613) 562-5442
email rouseaux@uottawa.ca
Academic Affiliations
University of Ottawa: Adjunct Professor, Department of Pathology and Laboratory Medicine
University of Ottawa: Center for Research in Biopharmaceutical Sciences, Member
University of Ottawa: Digestive Diseases Research Group, Member
Université du Québec à Montréal: professeur associé, Faculté des sciences.
Personal Information
June 17, 1954
Date of birth:
Canadian
Australian
United Kingdom
Citizenship:
Secret Level II
Security Clearance (Canada)
EDUCATION
Degrees
PhD (1985)
University of Saskatchewan, Department of Veterinary Pathology, Western
College of Veterinary Medicine Thesis Title: The Teratological and
Reproductive effects of T-2 Trichothecene Mycotoxin.
BVSc-Hons (1977)
University of Melbourne, Faculty of Veterinary Science, Victoria,
Australia
Certification
2010
2009
2005
2004
2001
1999
1999
1994
Re-Certification Academy of Toxicologic Sciences (USA)
Re-Certification Diplomate of the American Board of Toxicology (USA)
Fellow of the Academy of Toxicologic Sciences (USA)
Re-Certification Diplomate of the American Board of Toxicology (USA)
Fellow of the International Academy of Toxicologic Pathologists (EU)
Re-Certification Diplomate of the American Board of Toxicology (USA)
Fellow of the Royal College of Pathologists, London, UK (EU)
Re-Certification Diplomate of the American Board of Toxicology (USA)
1
1991
1990
1981
1981
Member of the Royal College of Pathologists, London, UK (EU)
Diplomate of the American Board of Toxicology (USA)
Member of the Royal College of Veterinary Surgeons, London, England (EU)
National Examining Board Examination Accreditation, Canadian Veterinary
Medical Association, Canada (CAN)
Professional Affiliations
2010 2008 2003 1999 1990 1990 1989 1989 1989 1999 1988 1988 1986 1982 1981 1981 1981 1977 -
2006
2001
1997
1992
1982
2004
1998
1984
Judge and expert reviewer, EQUIPEX, Agence Nationale Recherché, Paris,
France
Member, Board of Scientific Advisors, Pathology Experts LLC, Hauptstrasse 90,
Binnigen, Basel, Switzerland
Member, Round Table of Toxicology Consultants
Member, Drug Information Association
Full Member, Society of Toxicology
Full Member, Teratology Society
Full Member, Society of Toxicologic Pathologists
Member of the Scientific Advisory Board CANTEST Ltd, Vancouver, Canada
Full Member, International Federation of Toxicologic Pathology
Fellow, International Academy of Toxicologic Pathology
Member, Canadian Federation of Biological Societies
Member, Society of Toxicology of Canada
Member, Canadian Association of Veterinary Pathologists
Member, Saskatchewan Veterinary Medical Association
Member, Alberta Veterinary Medical Association
Member, Canadian Veterinary Medical Association
Member, Royal College of Veterinary Surgeons
Member, Australian Veterinary Association
Awards
2006
2005
2003
2002
2001
2001
2001
2001
2001
Honors for Excellence as Past-President of the Society of Toxicologic Pathology
Meritorious Award for Excellence as President of the Society of Toxicologic
Pathology
Certificate of Appreciation, Health Products and Foods Branch, contributions to
the Continuing Education and Training Programme, Health Products and Foods
Branch, Health Canada
Certificate of Recognition, Health Products and Foods Branch, contributions to
the Continuing Education and Training Programme, Health Products and Foods
Branch, Health Canada
Certificate of Recognition, Society of Toxicologic Pathology, for Outstanding
Contributions as Councilor 1997-2001
Certificate of Recognition, Therapeutic Products Directorate, Health Products
and Foods Branch, Health Canada
Recognition award, Office of Regulatory and International Affairs, Health
Products and Foods Branch, Health Canada
Certificate of Appreciation, Health Products and Foods Branch, contributions to
the Continuing Education and Training Programme, Health Products and Foods
Branch, Health Canada
Award of Merit, Society of Toxicologic Pathologists
2
2000
2000
1999
1992
1990
1984-1985
1981-1982
1973-1977
Certificate of Appreciation, Health Products and Foods Branch, contributions to
the Continuing Education and Training Programme, Health Products and Foods
Branch, Health Canada
Scroll of Appreciation, Health Products and Foods Branch Campaign 2000
Interchange Canada Secondment to Therapeutic Products Programme
SmithKline Beecham Award for Research Excellence
Award of Merit from the Multiple Sclerosis Society of Canada
Graduate Scholarship, University of Saskatchewan
Exchange recipient Departments of Agriculture, Victoria, AUST and Alberta
CAN.
Commonwealth Tertiary Scholarship, University of Melbourne, Victoria,
Australia
Continuing Education
2010
2008
2010
2009
2009
2009
2008
2008
2008
2008
2008
2007
2007
2007
2007
2007
2006
2006
Neuropathology: Society of Toxicologic Pathology, 29th Annual Meeting, Chicago, IL.
June, 2010 (5 days)
NTP Satellite Symposium: Pathology Potpourri. Society of Toxicologic Pathology, 29th
Annual Meeting, Chicago, IL. June, 2010 (1 day)
Cancer: Society of Toxicologic Pathology, 29th Annual Meeting, Washington, DC. June,
2009 (5 days)
NTP Satellite Symposium: Pathology Potpourri. Society of Toxicologic Pathology, 28th
Annual Meeting, Washington, DC. June, 2009 (1 day)
Eighth Biennial Short Course on Toxicology and Pathology in Drug Discovery and
Development, University of Illinois. Champaign, IL, July 2007 (1 day).
Target Organ Toxicology and Pathology, University of Illinois. Champaign, IL, July
2007. (1.5 days)
Ehrlich II conference. Nuremberg, Germany, October, 2008 (3 days)
NTP Satellite Symposium: Pathology Potpourri. Society of Toxicologic Pathology, 27th
Annual Meeting, San Francisco, CA. June, 2008 (1 day)
Systems Pathology. Society of Toxicologic Pathology, 27th Annual Meeting, Vancouver,
BC. June, 2008 (5 days)
Management of Pesticide Resistance, Pest Management Regulatory Agency, Ottawa,
Ontario, February 19, 2008.
Pest Regulation Course, PMRA and Canadian Consumer Specialty Products Association,
Fairmont Chateau Laurier, Ottawa, Ontario, February 27-28, 2008.
Annual Faculty Development Day, Faculty of Medicine, University of Ottawa, Ottawa,
October 25, 2007.
International Congress of Toxicology, Montréal, March 15, 2007.
Toxen Symposium, Département de biologie, Faculté des sciences, Université du Québec
à Montréal, March 15, 2007.
Faculty Development Day, Faculty of Medicine, University of Ottawa, ON, February 20,
2007.
PBL Tutor training Workshop, Faculty of Medicine, University of Ottawa, ON, January
22 and 25, 2007. Roger Guindon Hall.
Registrant training on transparency Requirements for the New Pest Control Products
Act. June, 2006 (1 day)
Bacon and Egg Heads Meeting. West Block, Parliament Hill, Ottawa, ON, May, 2006
(1/4 days)
3
2006
Toxicologic pathology of the Respiratory System. Society of Toxicologic Pathology,
25th Annual Meeting, Vancouver, BC. June, 2006 (5 days)
2006 NTP Satellite Symposium: Pathology of the Urinary System. Society of Toxicologic
Pathology, 25th Annual Meeting, Vancouver, BC. June, 2006 (1 day)
2006 Application of the Human Relevance Framework to the Analysis of Rodent Tumor Data.
Society of Toxicologic Pathology CE #2, 25th Annual Meeting, Washington, DC. June,
2006 (1/2 day)
2006 Toxicologic Pathology of the Developing Central Nervous System CE #1. Society of
Toxicologic Pathology, 25th Annual Meeting, Vancouver, BC. June, 2006 (1/2 day)
2005 Pathology of the Immune System. National Toxicology Program Satellite Symposium.
Cardiovascular Toxicologic Pathology: Safety Assessment and Risk Management.
Society of Toxicologic Pathology, 24th Annual Meeting, Washington, DC. June, 2005 (1
day)
2005- Cardiovascular toxicologic pathology: Safety assessment and risk management. Society
of Toxicologic Pathology, 24th Annual Meeting, Washington, DC. June 19-23, 2005 (5
days). Attended few sessions between the duties as President and other committees.
2005 Immunostimulation – Issues and Risk Management. CE #1 Cardiovascular Toxicologic
Pathology: Safety Assessment and Risk Management. Society of Toxicologic Pathology,
24th Annual Meeting, Washington, DC. June, 2005 (1/2 day)
2005 Dietary Supplements: Everything You Wanted to Know but Were Afraid to Ask. CE #2
Cardiovascular Toxicologic Pathology: Safety Assessment and Risk Management.
Society of Toxicologic Pathology, 24th Annual Meeting, Washington, DC. June, 2005
(1/2 day)
2004 Conflict Resolution, Royal College of Medicine and the University of Ottawa, Ottawa,
November 2004 (2 days)
2004 Hepatotoxicity. Society of Toxicologic Pathology, 23rd Annual Meeting, Salt Lake City,
UT. June 13-17, 2004 (5 days). Attended a most sessions between the duties as
President-Elect and other committees.
2004 NTP Satellite Symposium: Hepatic Pathology. Society of Toxicologic Pathology, 23rd
Annual Meeting, Salt Lake City, UT (1 day). Participated in and interactively diagnostic
session (voting member). Most lesions were induced by toxicants.
2004 The American College of Veterinary Pathologists, 55th Annual Meeting, Orlando, FL,
November 2004 (4 days)
2004 Sixth Industrial Toxicologic Pathology Course, University of Illinois, Chicago, IL, July
2004 (3 days)
2004 Update on the Pathogenesis and Molecular Biology of Spinal Muscular Atrophy,
Canadian Parliamentary Library, Parliament Hill, Ottawa, March 11 (1.5 h)
2004 International Academy of Toxicologic Pathology: Contemporary Issues in Toxicologic
Pathology Joint, Kobe, Japan, February 15 (1 day)
2004 Armed Forces Institute of Pathology Registry of Toxicologic Pathology Slide
conferences (USA) Internet – with Foods Directorate Pathology Division (6 days)
2004 Joint International Meeting of the Japanese Society of Toxicologic Pathology and
International Federation of Societies of Toxicologic Pathology, Kobe, Japan, February
15-18 (4 days)
2003 Can Biotechnology prevent another Walkerton? The future for E. coli vaccines and the
Molecular biology and Pathogenesis of E. coli H0157, Canadian Parliamentary Library,
Parliament Hill, Ottawa, January 29 (1.5 h)
2003 National Toxicology Program: Peer-review. Savannah, GA June 14 (1 day)
4
2003
2003
2003
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2001
2001
2001
2001
2001
2001
2001
2001
2001
2001
2001
2001
2000
2000
2000
Armed Forces Institute of Pathology Registry of Toxicologic Pathology Slide
conferences (USA) Internet – with Foods Directorate Pathology Division (6 days)
The Human Genome: Implications for Toxicologic Pathology. 22nd Annual STP
Symposium, Savannah, GA June 15-19 (5 days)
Palliative Care Education Day. Ottawa, ON May 7 (1 day)
Industrial Toxicology and Pathology Course (5th) Chicago, IL, July 7-9 (2 days)
Non-Rodent Species in Toxicologic Pathology. 21st Annual STP Symposium, Denver,
CO June 2-6 (5 days)
Fifth Industrial Toxicologic Pathology Course, University of Illinois, Chicago, IL, July
2002 (3 days)
Techniques in Toxicologic Pathology, National Toxicology Program, Adams Mark
Hotel, Denver, CO June 1-5 (5 days)
Assessment and Management of Pharmaceuticals and Personal Care Products in the
Canadian Environment, Queen’s Landing, Niagara-on-the-Lake, ON February 24-27 (3
days).
Environmental Assessment Learning Event, Ottawa, ON February 18-19 (2 days).
Causality and Epidemiology: Using Epidemiology and Law to Establish Causation –
opposing paradigms, Ottawa, ON (1/2 day)
FACT: Foundation Course in Group Facilitation, Intersol, Ottawa, ON (4 days)
Course in Group Facilitation, Intersol Consulting Associates, Ottawa, ON (1 day)
Review of Time to Event Data in Preclinical, Clinical and Post Market Settings (C.
23.01.02) OCE, Ottawa, ON (1/2 day)
Prediction of in vivo Pharmacokinetics from in vitro ADME studies (C. 23.01.02) OCE,
Ottawa, ON (1/2 day),
Armed Forces Institute of Pathology Registry of Toxicologic Pathology Slide
conferences (USA) Internet – with Foods Directorate Pathology Division (6 days)
Armed Forces Institute of Pathology Slide conferences (USA) Internet – with Foods
Directorate Pathology Division (6 days)
Dialogue on Public Involvement, (B. 24.01.01) OCE, Ottawa, ON (1/2 day)
Cardiac Safety of Non-Cardiac Drugs (C. 23.01.02) OCE, Ottawa, ON (1/2 day)
Difficult conversations: How to discuss what matters most. The Harvard Negotiation
Project, VDD, Ottawa, ON (2 days)
Clinical Pharmacology, Drug Development and Regulation, Tufts Center for the Study of
Drug Development, Ottawa, ON (3 days)
American Armed Forces Institute of Pathology (RTPA) Monthly slide Conference
(Internet Based)
Clinical Trial Design and Issues: "Quality of Life" (C.6.01.03) OCE, Ottawa, ON (1 day)
Crown Liability and Protection (B: 12.01.03) OCE, Ottawa, ON (1 day)
Performance Measurement Training Series – Module 1: Developing Program Logic Models
(LCST0005) Learning Centre, Health Canada, Ottawa, ON (1 day)
Performance Measurement Training Series – Module 2: Identifying Key Performance Indicators
(LCST0006) Learning Centre, Health Canada, Ottawa, ON (1 day)
Administrative writing (LT9000) World Class Communications Consultants, Ottawa,
ON (1 day)
Pharmacokinetics (C: 07.01.01), OCE, Ottawa, ON, (1 day)
Armed Forces Institute of Pathology Slide conferences (USA) Internet (6 days)
Risk Management, University of Ottawa, Professional Training Service, (1.5 days)
Human Resource Productivity Management: The Human Element (B: 11.01) OCE,
Ottawa, ON, (1 day)
5
2000
Alignment 2000: Career Coaching Tools and Skills for Managers (CCPT) Learning
Centre, Health Canada, Ottawa, ON (1 day)
2000
Respect and Trust: Key to Optimal Performance for a Modern Public Service (LCDV0001)
Learning Centre, Health Canada, Ottawa, ON (1 day)
2000
2000
2000
An Overview of the Patent Process (B: 12.02), OCE, Ottawa, ON (1/2 day)
An Overview of Bioinformatics (C: 09.08) OCE, Ottawa, ON (1/2 day)
Review of Time-to-event Data in Pre-Clinical, Clinical and Post-Market Settings (C:
11.20) OCE, Ottawa, ON (1/2 day)
Intelligent Risk Management (LCBM9813) Rakos Associates, Ottawa, ON (1 day)
2000
2000
File Management for Better Information (LCBM0004) Learning Centre, Health Canada, Ottawa,
ON (1/2 day)
2000
2000
DNA Vaccines – Parts 3 (C: 09.05) OCE, Ottawa, ON (1/2 day)
Time management for increased productivity, (LCBM0001) Learning Centre, Health
Canada, Ottawa, ON (1/2 day)
Quality Fundamentals and Tool Workshop, Xerox, Ottawa, ON (3 days)
Toxicologic Pathology of the Reproductive and Endocrine Systems, Society of
Toxicologic Pathology 19th Annual Symposium, June, Phoenix AX (6 days).
Public Affairs Symposium, 40th Annual Meeting, Teratology Society, June, Palm Beach,
FL (1 day).
2000
2000
2000
2000
2000
2000
2000
Principled Negotiations. Sendralea Communications, Inc., Ottawa, ON (2 days).
Human Gene Transfer: Regulatory Aspects; TPP-CE, Ottawa, ON (1/2 day).
Critical Thinking: New Paradigm for Peak Performance. American Management Association,
Ottawa, ON (2 days)
Developing Public Policy in a Scientific Organization, Algonquin Management Centre, Ottawa,
ON (1 day)
Strange Bedfellows: Infection and Chronic Disease. Canadian Public Health Association, May,
Ottawa, ON (2 days)
Blood Proteins Expressed in Transgenic Plants, TPP-CE, Ottawa, ON. June (1/2 day).
Using Information Smartly, HC-CE, Ottawa, ON (1 day).
Sound Clinical Trail Practices in the Era of Gene Therapy; CBER, FDA and DIA (1/2 day).
Xenotransplantation: Critical Scientific and Regulatory Issues; TPP-CE, Ottawa, ON (1 day).
Leading with Knowledge for the 21st Century: Raising Corporate IQ; HC-CE, Ottawa, ON (1/2
day).
Standards and Standards-based Regulation, TPP-CE; Ottawa, ON (1/2 day).
Advanced Topics in Biotechnology. Human Gene Transfer Regulatory Aspects; TPP-CE, Ottawa,
ON (1/2 day).
Novel Vaccines Parts 1 and 2; TPP-CE, Ottawa, ON (1 day).
Exemptions under the Canadian Controlled Substances and Drugs Act; TPP-CE, Ottawa, ON (1/2
day).
Access to Unapproved Therapeutic Products; TPP-CE, Ottawa, ON (1/2 day).
2000
Receptor Mediated Signal Transduction; HC, Ottawa, ON (1/2 day).
2000
Detailed Analysis of Continuous and Categorical Outcome Data; University of Western Ontario,
ON (2 days).
Health Canada’s Cabinet Process; HC Policy Forum, Ottawa, ON (1/2 day).
Analytical Thinking and Problem Solving. Professional Training Service, University of Ottawa,
Ottawa, ON (1 day)
Assessment of Schedule C and D Drug Facilities (Biologics); TPP-CE, Ottawa, ON (2 days).
Dynamics of Effective Communication; Your Leadership Works, Inc. Ottawa, ON (1 day).
Ethics in Decision Making; HC-CE, Ottawa, ON (1 day).
Knowledge Management; Informatics, Ottawa, ON (1 day).
Human Gene Transfer; TPP-CE, Ottawa, ON (1/2 day).
Analysis of Survival Data; TPP-CE, Ottawa, ON (1/2 day).
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
6
2000
2000
2000
1999
1999
1999
1999
1999
1999
1999
1999
1999
1999
1999
1998
1998
1998
1998
1998
1998
1997
1997
1996
1995
1994
1994
1993
1993
1993
1992
1992
1992
An Overview of Pharmacogenomics, BIOTECanada
; Canadian Genetic Diseases
Network; GlaxoWellcome Inc and Therapeutic Products Programme, Ottawa, ON (1 day).
Learning for Leadership, HC-CE, Ottawa, ON (5 days).
Strategic Thinking and Analysis; Algonquin Management Centre, Ottawa, ON. (2 days)
Statistical Principles for Clinical Trials (ICH E9); University of Western Ontario ON (2
days).
Critical Reading of the Medical Literature; TPP, Ottawa, ON (1/2 day).
Analytical Method Validation, TPP; Ottawa, ON (1 day).
Establishment Licensing for Pharmaceuticals, Biologics and Radiopharmaceuticals, TPP,
Ottawa, ON.
Building Capability through Knowledge: Knowledge Capital and Knowledge
Management, Toronto, ON.
Myers-Briggs classification - management course, LC, Ottawa, ON
Toxicologic Pathology of the Nervous System, Society of Toxicologic Pathology, Washington,
DC.
Obtaining Unapproved Therapeutic Products, TPP-CE, Ottawa, ON (1/2 day).
Development of Electronic Submissions for Pesticide Registration (1 day)
ICH and the Canadian Drug Regulatory System, Drug Information Association,
Montreal, Quebec. (2 days)
Toxicologic Pathology of the Nervous System, Society of Toxicologic Pathology, June,
Washington, DC. (5 days)
CAI course for USEPA regulatory issues (2 days)
Responsible Regulatory Environment for Phase 1 Clinical Research in Canada, Ottawa,
ON (1.5 days)
Toxicologic Pathology and Biotechnological Products, Society of Toxicologic
Pathology, July, Vancouver, BC (5 days)
EnviroVet, University of Minnesota, Duluth, MN (3 days)
International Harmonization of Non-Clinical Toxicology Requirements: Regulation vs.
Practice, SOT Continuing Ed. #6, Seattle, WA (0.5 days)
Integration of Mechanistic, Pathologic, and Toxicokinetic Data in Safety Assessment,
SOT Continuing Ed. #11, Seattle, WA (0.5 days)
Incorporating Societal Values in Ecosystem Health Objectives; Addressing the
Challenge, AETA Annual Technical Review, Ottawa, ON (1 day)
Canadian Pharmaceutical Industry Conference, Toronto, ON (2 days)
Toxicologic pathology and Risk Assessment, Society of Toxicologic Pathology, June, St.
Louis, MI (5 days)
Toxicological Pathology of the Liver, Society of Toxicologic Pathology, June, San
Diego, CA (5 days)
EnviroVet, University of Minnesota, Duluth, MN (3 days)
Pharmacokinetics in Toxicologic Pathology, Society of Toxicologic Pathology,
Charleston, SC (5 days)
Insecticides: Mechanisms of Action, Metabolism and Toxicology in Vertebrates, SOT
Continuing Ed. #3, New Orleans, LA (0.5 days).
Mechanisms of Cell Death, SOT Continuing Ed. #10, New Orleans, LA (0.5 days)
Introduction to Toxicologic Pathology, University of Illinois, IL (2 days)
Developmental Toxicity: Cellular and Molecular Approaches, SOT Continuing Ed. #8,
Seattle, WA (0.5 days)
Case Studies in Risk Assessment: Emphasis on Exposure, SOT Continuing Ed. #2,
Seattle, WA (0.5 days)
Toxicologic Pathology of the Hemopoietic System, Phoenix, AZ (5 days)
7
1991
1991
1990
1990
1990
1990
1989
1988
1988
1988
1987
1987
1986
1985
1984
Female Reproductive Toxicology, SOT Continuing Ed. #4, Dallas, TX (0.5 days)
Risk Communication: Problems, Perceptions and Practice, SOT Continuing Ed. #12,
Dallas, TX (0.5 days)
Developmental Toxicity: Changing Factors in Embryonic Susceptibility, SOT Continuing Ed. #2, Miami Beach, FL (0.5 days)
Concepts in Cell Biology, SOT Continuing Ed. #11, Miami Beach, FL (0.5 days)
Concepts in Molecular Biology, AAP, Bethesda, MD (4 days)
Toxicologic Pathology of the Cardiovascular System, June, Ottawa, Ontario (5 days)
Statistics for Toxicologists, SOT Continuing Ed. #8, Atlanta, GA (0.5 days)
Peer Consultation to Increase Teaching Effectiveness (3 days)
Teaching with Cases, Saskatoon (2 days)
Pathology of the Intestine, American College of Veterinary Pathologists, Kansas City,
MO (4 days)
Immunopathology, American College of Veterinary Pathology, Monterey, CA (5 days)
General Principles in Toxicology and Toxicologic Pathology, Boston University School
of Medicine (5 days)
Toxicologic Pathology, American College of Veterinary Pathologists, New Orleans, LA
(5 days)
Reproduction and Teratology, American College of Veterinary Pathologists, Denver, CO
(5 days)
Teacher Effectiveness Training, Saskatoon, Saskatchewan (3 days)
WORK EXPERIENCE
Academic
Employment
20082007 2006 2004 2003 2003 1999 - 2003
1993 1993 - 1998
1991-1993
1985-1991
Scientific Advisory Board - Expert, Pathology Experts, Basel, Switzerland
Chairman, Board of Directors, Xenorex Malaria Research Institute, Kampala,
Uganda
President, Xenorex Research Group (Africa) Ltd.
Adjunct Professor, Department of Pathology and Experimental Medicine,
Faculty of Medicine, University of Ottawa, Ottawa, ON
Principal, Colin Rousseaux and Associates, Wakefield, QC
Chairman, Xenorex Research Group, Ottawa, ON
Visiting Professor, Department of Cellular and Molecular Medicine, Faculty of
Medicine, University of Ottawa, Ottawa, ON
Professeur associé, Département de biologie, Université du Québec à Montréal,
Montréal, Québec
Adjunct Professor, Faculty of Medicine, University of Alberta, Edmonton,
Alberta
Professor, Department of Veterinary Pathology, Western College of Veterinary
Medicine, University of Saskatchewan, Saskatoon, Saskatchewan
Associate Professor, Department of Veterinary Pathology, Western College of
Veterinary Medicine, University of Saskatchewan (Tenure July 1989)
Graduate Students Supervised
1990-1992
1990-1992
A. Kerviche, (Toxicology). The teratogenicity of abscisic acid and its analogues
B. Tornesi, (Reproduction). The effect of serum type and concentration on
mouse embryo and limb development in culture
8
1988-1992
1988-1991
1985-1987
L.G. MacNabb, (Toxicology), In vitro and in vivo evaluation of the teratogenic
effect of cadmium on the developing mouse limb
S.S. Semalulu, (Pathology), Trace elements and bovine abortion
J.W. Coates, (Pathology). A survey of malformed aborted bovine fetuses,
stillbirths and non-viable neonates for abnormal karyotypes
Graduate Student’s External Examiner
1993
W. Chen. Bioavailability in Environmental Risk. University of Alberta, Health Services
Administration and Community Medicine, College of Medicine
Teaching (University of Ottawa)
2009
2009
Pathological Basis of Disease Course (CMM 5001) Issues in toxicologic pathology.
Overview of the life cycle of health products from discovery to post market (HC OCE
CE C:15.09.01 January 6, 2009
2005
Overview of drug development (HC OCE CE course C: 5.01.01 February 1)
2005- Common Problems found in Histopathological Evaluation – lecture and lab. Universite
de Montreal a Quebec, November 16, 2005. (1/4 day)
2004 Overview of drug development (HC OCE CE course C: 5.01.01 June 1 and October 19)
2003Overview of drug development (HC OCE CE course C: 5.01.01)
2002-2003
Development and homeostasis (DH Block)
2002-2003
Pathophysiology of blood and body fluids (PHS4300)
2002-2003
Pathophysiology of the gastrointestinal system (PHS4300)
2002-2003
Pathophysiology of the hepatic and pancreatic systems (PHS4300)
2002-2003
Pathophysiology of the cardiovascular system (PHS4300)
2002-2003
Pathophysiology of the respiratory system (PHS4300)
2002-2003
Development and homeostasis (DH Block)
2002
Gastrointestinal diseases block (GIT Block)
2002
Guest moderator, American Armed Forces Institute of Pathology, RTPA, USA
2002
Biopharmaceuticals: Federal and international regulations (BPS4102)
2002
Overview of drug development (HC OCE CE course C: 5.01.01)
2001-2002
Development and homeostasis (DH Block)
2001-2002
Pathophysiology of blood and body fluids (PHS4300)
2001-2002
Pathophysiology of the gastrointestinal system (PHS4300)
2001-2002
Pathophysiology of the hepatic and pancreatic systems (PHS4300)
2001-2002
Pathophysiology of the cardiovascular system (PHS4300)
2001-2002
Pathophysiology of the respiratory system (PHS4300)
2001-2002
Pathophysiology of the gastrointestinal system (PHS4300)
2000-2001
Pathophysiology of the hepatic and pancreatic systems (PHS4300)
2000-2001
Pathophysiology of the cardiovascular system (PHS4300)
2000-2001
Pathophysiology of the respiratory system (PHS4300)
2000-2001
Mechanism of action of liver toxicity (OCE course C: 22.01.01)
2000-2001
Evaluation of Data from Suspected Cases of Liver Toxicity (OCE course C:
22.01.02)
2000-2001
Evaluation of liver structural and functional changes: Drug-induced or not?
(OCE course C: 23.01.01)
2000-2001
Overview of drug development (TPP CE course C: 5.01.01)
2000-2001
Testing Procedures: Conventional toxicity studies (TPP CE course C: 5.01.04)
Teaching (University of Saskatchewan)
9
1991-1992
1990-1991
1989-1990
1988-1989
1987-1988
1986-1987
1985-1986
1984-1985
1983-1984
1982-1983
Mammalian Necropsy; Surgical Pathology; Systemic Pathology; Necropsy
Rotation; General Toxicology I and II; Experimental Pathology
Mammalian Necropsy; Surgical Pathology; Systemic Pathology; Necropsy
Rotation; General Toxicology I and II; Applied Toxicology; Nutritional
Toxicology
Experimental Pathology; Mammalian Necropsy; Surgical Pathology; Systemic
Pathology; Necropsy Rotation; General Toxicology I and II
Mammalian Necropsy; Surgical Pathology; Systemic Pathology; Necropsy
Rotation; Nutritional Toxicology; General Toxicology I and II; Applied
Toxicology
Mammalian Necropsy; Surgical Pathology; Year III Pathology Clinics; Systemic
Pathology; Necropsy Rotation; Experimental Pathology; Vertebrate Toxicology
I and II
Mammalian Necropsy; Surgical Pathology; Systemic Pathology; Experimental
Pathology; Advanced Bovine Medicine; Vertebrate Toxicology I and II
Toxicologic Pathology; Mammalian Necropsy; Surgical Pathology; Necropsy
Rotation; Systemic Pathology; General Pathology
General Pathology
General Pathology and Necropsy
General Pathology; Systemic Pathology
Extension
Rousseaux, C.G. (2006). Getting involved in malaria control. University of Juba, Juba,
Southern Sudan
Rousseaux, C.G. (2006). Malaria and you; Radio 91.3 FM (Capitol), Kampala, Uganda
Rousseaux, C.G. (2005). Pathology for Non-Pathologists. American College of Toxicology,
USA
Rousseaux, C.G. (2004). Practical Examples regarding Clinical and Morphological Pathology
as it relates to the Assessment and Prediction of Risk Posed by New Chemical
Substances: New Chemical Substances, Healthy Environments and Consumer Safety,
Health Canada (1 day)
Rousseaux, C.G. (2004). Delivery of a Practical Course in Clinical and Morphological
Pathology as it relates to the Assessment and Prediction of Risk Posed by New Chemical
Substances: New Chemical Substances, Healthy Environments and Consumer Safety,
Health Canada (2 days)
Rousseaux, C.G. (1998). Pathology and the Regulatory Scientist: A course on the interpretation
of results of clinical, clinical pathology and altered morphology. Pest Management
Regulatory Agency, Health Canada (5 days).
Rousseaux, C.G. (1995). Chemicals and Toxicology: An Overview to Understanding Chemical
Risk. Canadian Pulp and Paper Association.
Rousseaux, C.G. (1995). Epidemiology: the Study of Patterns of Disease in Populations.
Canadian Pulp and Paper Association.
Rousseaux, C.G. (1995). Improving Wellness: Opportunities for Change. Canadian Pulp and
Paper Association.
Rousseaux, C.G. (1992). How Birth Defects Occur. University of Saskatchewan Extension
Program, Saskatoon, Saskatchewan, November 1992.
Rousseaux, C.G. (1992). The Trilogy of Specimen Submission. A 30 minute video written, and
co-directed with the Department of visual services explaining correct collection,
transport and disposal methods, using the principles of preservation of the specimen,
10
safety of self and others and compliance with the law. An initiative of the Occupational
Health and Safety Committee, University of Saskatchewan, Saskatoon, Saskatchewan.
Journal Review
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Toxicology and Applied Pharmacology
Fundamental and Applied Toxicology
Birth Defects Research Part B: Developmental and Reproductive Toxicology
Teratology
Toxicologic Pathology
Brain Research Bulletin
Canadian Veterinary Journal
Canadian Journal of Veterinary Research
Clinical Ecology
Toxicology in vitro
Organization for Economic Co-operation and Development
Reproductive Toxicology
Veterinary Pathology
Toxicology
Methods in Toxicology
BMC health Services Research
Pharmacy World & Science
Chemosphere
Grant Review
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Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Medical Research Council of Canada
Equine Health Research Fund
March of Dimes Research Foundation
Kinsmen Foundation
Health and Welfare Canada
Cato Institute
Fonds FCAR (Québec)
IRAP – RDA technical review (UBC)
Administration
University of Saskatchewan
1991-1992
1990-1991
1989-1991
1988-1993
1987-1991
1985-1991
1985-1987
1982-1985
Occupational Safety Committee
Animal Care Committee
Library Subcommittee, Academic Affairs Committee
Research Coordinator, Toxicology Group
Curriculum Planning Committee
Library Committee
Awards Committee
Committee for Grants, Graduate Studies and Research
Learned Societies
2011 - Chair, Working Group to Address Investment Strategies
2007 - 2009
Member, Fundraising Committee, Society of Toxicologic Pathology
11
2006 - 2010
2006 - 2009
Secretary, International Academy of Toxicologic Pathologists
Editorial Board, Toxicologic Pathology, Society of Toxicologic Pathology
Councilor, International Federation of Societies of Toxicologic Pathologists
2005 – 2006
Past president, Society of Toxicologic Pathology
2005 – 2006
Chair, Nominating Committee, Society of Toxicologic Pathology
2005 – 2006
Chair, Fundraising Committee, Society of Toxicologic Pathology
Member, Continuing Education Committee, Society of Toxicologic Pathology
2005 – 2009
Editorial Board, Toxicologic Pathology, Society of Toxicologic Pathology
2005 – 2006
Member, International Collaboration Task Force, Society of Toxicologic
Pathology
2005 – 2006
Councilor, International Federation of Societies of Toxicologic Pathologists
2004 - 2005
President, Society of Toxicologic Pathology
2004 - 2005
Member, Continuing Education Committee, Society of Toxicologic Pathology
2004 - 2005
Member, Symposium Committee, Society of Toxicologic Pathology
2004 - 2005
Ex officio, Journal Committee, Society of Toxicologic Pathology
2004 - 2005
Ex officio, STP – ACVP Collaboration Board of Directors, Society of
Toxicologic Pathology
2004 - 2005
Editorial Board, Toxicologic Pathology, Society of Toxicologic Pathology
2004 - 2005
Member, International Collaboration Task Force, Society of Toxicologic
Pathology
2004 - 2005
Councilor, International Federation of Societies of Toxicologic Pathologists
2004 Symposium co-chair (with M. Hirose National Institute of Health Sciences, Tokyo):
Carcinogenesis-current understanding of mechanisms and risk assessments:
Non-genotoxic carcinogenesis/low dose carcinogenic potential of genotoxic and
non-genotoxic carcinogens. Joint International Meeting of the Japanese Society
of Toxicologic Pathology and the International Federation of Societies of
Toxicologic Pathology
2003-2004
President-elect, Society of Toxicologic Pathology
Member, Continuing Education Committee, Society of Toxicologic Pathology
2003-2004
Chair, Strategic Planning, Society of Toxicologic Pathology
2003-2004
Member, Administrative Renewal, Society of Toxicologic Pathology
2003-2004
Editorial Board, Toxicologic Pathology, Society of Toxicologic Pathology
2003-2004
International Advisory Committee, Joint International Meeting of the Japanese
Society of Toxicologic Pathology and the International Federation of Societies
of Toxicologic Pathology
2003Member, Continuing Education Committee, Society of Toxicologic Pathology
Chair, Strategic Planning, Society of Toxicologic Pathology
Editorial Board, Toxicologic Pathology, Society of Toxicologic Pathology
Executive council liaison, Annual General Meeting Committee, Society of
Toxicologic Pathology
2002-2003
Editorial board, Toxicologic Pathology, Society of Toxicologic Pathology
Member, Continuing Education Committee, Society of Toxicologic Pathology
2002-2003
Strategic Planning Creation, Society of Toxicologic Pathology
2002-2003
Editorial Board, Toxicologic Pathology, Society of Toxicologic Pathology
2002
Chair, Cause of Death Task Force, Society of Toxicologic Pathology
2002
Strategic Planning for Executive Committee, Society of Toxicologic Pathology
2001Councilor International Federation of Societies of Toxicologic Pathology
2001
Journal and Publications Task Force- Society of Toxicologic Pathology
2000-2002
Peto Trend Test Task Force – Society of Toxicologic Pathology
12
2000
1999-2001
19991999-2002
1999-2000
1997-2001
1999-2000
1997
1996-1999
1996-1999
1995-1996
1995-1997
1994- 1998
1994- 1995
1993-1994
1992-1999
1991-1993
1988
Standard Tissue List Task Force – Society of Toxicologic Pathology
Professional Standards Committee – International Federation of Societies of
Toxicologic Pathology
Society of Toxicologic Pathologists - International Federation of Societies of
Toxicologic Pathologists Liaison
Member, Canadian Program Steering Committee, Drug Information Association
Chair, Strategic Planning Committee, Society of Toxicologic Pathologists
Executive Committee, Society of Toxicologic Pathologists
Educational Standards Committee, Society of Toxicologic Pathologists
Poster Chairperson, 16th International Symposium: Toxicologic Pathology of the
Kidney and Urinary Bladder, Society of Toxicologic Pathologists.
Member, Strategic Planning Committee, Society of Toxicological pathologists
Conference Organizing Committee, International Federation of the Societies of
Toxicologic Pathologists.
Conference Chairperson, 15th International Symposium: Toxicologic Pathology
and Risk Assessment, Society of Toxicologic Pathologists.
Conference Organizing Committee, Society of Toxicologic Pathologists
Education Fund Committee, Society of Toxicologic Pathologists
Conference Site Selection Committee, Society of Toxicologic Pathologists
Subcommittee on Kidney Dialysis: National Standards of Canada, CAN/CSAZ364.1.1-94 Extracorporeal Blood Circuit for Haemodialysers, Haemofilters
and Haemoconcentrators.
Ad Hoc Committee for Membership for the Society of Toxicology Canada
Centers of Excellence for Demyelinating Diseases Organizational Committee
President, Western Canadian Veterinary Diagnostic Pathologists
Government
2005 – 2006
2002
2001-2002
2001-2002
2001-2002
Legislative Renewal, Health Canada Consultant
Member, Acceptable Level of Risk Committee, VDD, HPFB, Health Canada
Chair, Advisory Committee on Guidelines, VDD, HPFB, Health Canada
Member, Science Issue Review Committee, VDD, HPFB, Health Canada
Member, Environmental Assessment Regulations under the Food and Drugs Act
Science Task Force (Health Canada)
2001-2002
Member, Branch Committee on Continuing Education and Training (Continuing
Education and Training Program, Health Products and Foods Branch)
2001- 2002
Member- Pre-market evaluation Working Group (Office of Regulatory and
International Affairs, HPFB, HC)
2001- 2002
Member, Dispute Resolution Working Group (Office of Regulatory and
International Affairs, HPFB, HC)
1999 Member, Risk Assessment of Hemp Oil in Cosmetics (Therapeutic Products Program,
HPB, HC)
Scientific and Medical
2006-Present
2006-Present
2005-2008
2004-2007
2003-Present
2003-Present
Chairman, Xenorex Malaria Research Institute, Kampala, Uganda
President, Xenorex Research Group (Africa) Ltd., Kampala, Uganda
Member, Scientific Advisory Board, Scienteur, Greenfield, Illinois, USA
Member, Scientific Advisory Board, CANTEST, Ltd., Vancouver, BC, Canada
Principal, Colin Rousseaux and Associates, Wakefield, QC
Chairman, Xenorex Research Group, Ottawa, ON
13
1995-1999
1994-1995
1992-1999
1990-1992
1984-1984
1982-1985
1981-1982
1979-1982
1978-1979
1977-1978
President, RSG ConsulTest Inc., Ottawa, Ontario
Executive Director of Research Services Group, Ottawa, Ontario
Principal and President GLOBALTOX INTERNATIONAL CONSULTANTS INC.,
Ottawa, Ontario
President, Global-Tox International Corp., Saskatoon, Saskatchewan
Professional Associate II, Veterinary Pathology, University of Saskatchewan
MSc. - Ph.D., University of Saskatchewan
Exchange Veterinary Pathologist, Provincial Diagnostic Laboratory, Lethbridge,
Alberta
Veterinary Pathologist, Benalla Regional Veterinary Laboratory, Victoria,
Australia
Veterinary Pathologist, Hamilton Regional Veterinary Laboratory, Victoria,
Australia
Locum, Mixed Practice in Gippsland, Victoria, Australia
Biomedical Practice
Pathology:
Pathology Working Groups, Pathology training programs, Peer Review,
Study Reading, Issue Definition and Resolution, Qualitative and
Quantitative Analysis, Statistical Evaluations, Mammalian and Aquatic
Pathology, Diagnostic and Research Pathology.
General Toxicology:
Program Development and Monitoring; Problem Definition and
Resolution; Qualitative and Quantitative Analysis; Statistical
Evaluations; Program Evaluation and Management; Critical Reviews;
Design and Interpretation of Acute, Subacute and Chronic Toxicity
Studies; Biovailability and Bioequivalency Studies; Teratology and
Reproduction Studies; Genotoxicity, Carcinogenesis and Bioassay
Studies; Legal Briefs; Pharmaco- and Toxicokinetics; and, DoseResponse Relationships for Pharmaceuticals, Agrochemicals, Foods, and
Chemicals.
Regulatory Toxicology: Pharmaceuticals: Program Assessment, IND, NDS and NDA
Preparation and review, Veterinary Drug Support, Expert Non-Clinical
Reports, Expert Panel Reviews, and Issue Resolution.
Agrochemicals: Comprehensive Data Summaries (OECD), Category A,
B, and C submissions, and Issue Definition and Resolution.
Foods: Nutraceutical and Vitamin Issue Resolution.
Chemicals: Effects Monitoring, Product Development and Registration,
and Issue Resolution.
Regulations:
Collaboration in the Creation of: Peer-review Policy for Veterinary
Drug Evaluations, Policies and Procedures for the Veterinary Drugs
Directorate, Environmental Assessment Regulations under the Food and
Drugs Act, Medical Marijuana Research Plan, Oral Contraceptive
Guidelines Modifications (TPP), Tier II Pre-Review for Antimicrobial
Products (TPP), IND Reviews (TPP), Cancer Issue Resolution and
Critical Review of Submissions (TPP), Creation of Data Requirements
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for Categories A and B Submissions of Pesticides (PMRA-OECD),
OECD neurotoxicity guidelines, International Joint Commission (USA
and Canada) on the Great Lakes - Endocrine disrupters and reproduction
(IJC), Biotech Pesticides (USEPA and AAFC), Modification of Toxicity
Identification Evaluation (USEPA).
Government Experience (Internal)
1974-1982
Department of Agriculture, Victoria, Australia
Duties: Manager Gross Veterinary Pathology, Pathologist, Field Studies,
Fire Emergency Animal Welfare Team, Foot and Mouth Disease
Emergency Management System.
1999-2001
Department of Health, Therapeutic Products Programme, Senior Scientist.
Duties: Critical reviews for: Hemolink™ blood replacement therapy,
phenylpropanolamine, bupropion (Zyban®) ear candles, and risk
assessment of THC in hemp products. Scientific advice: Bureau of
Pharmaceutical Assessment, Foods Directorate, Bureau of Licensed
Product Assessment, Environmental Health Directorate, Biologics and
Genetic Therapies Directorate and Pest Management Regulatory
Agency. Development of: method to review third party benefit-risk
assessments, change management strategy, benefit-risk assessment
methodologies, science and logic for risk assessment. Proposals: Good
Review Practices, Medical Marijuana Research Plan, and Benefit-Risk
IAS. Other Federal Institutions: Review of IRAP grants for NRC.
Teaching: Office of Continuing Education courses C: 5.01.01, C:
5.01.04, C: 22.01.01, C: 22.01.02, C: 23.01.01.
2001-2002
Department of Health, Veterinary Drugs Program (VDP), Senior Scientific
Advisor.
Duties: Critical reviews for: Carbadox® Environmental Assessment,
Toxicology of Clove Oil (Euginol and Methyleuginol), Meat Residues
Risk Assessments, Environmental Assessment of Veterinary Drugs, Risk
Assessment of Drug Residues in Horsemeat for human consumption.
Scientific input to regulatory policy: Environmental Assessment
Regulations interdepartmental task force, Health Canada Pre-market
review working group, Dispute resolution Working Group.
Development of Guidelines for: Carcinogenesis assessment,
Genotoxicity Assessment and Growth Promotants. Development of
Reviewers’ guides for Carcinogenic and Genotoxic assessment of
veterinary drugs. Data requirements for a new drug submission.
Collections: Collection of all relevant global regulations regarding
carcinogenesis, teratological, genotoxic, and general toxicity assessment
of veterinary drugs. Collection of materials for Environmental
Assessment, partitioning agents, growth promotion and antimicrobial
resistance issues. Proposals: Good Review Practices, Benefit-Risk
Assessment and submission data requirements, dispute resolution
methodology and acceptability of risk.
15
Community Activities
2005-2006
2004-2005
2000-2002
1995-1998
1994-1997
1993-1994
1991-1992
1991- 1992
1988-1993
1988-1992
1988
1988
1988
1987-1993
1987-1993
Science fair judge Jean d’Arc school Ottawa
Science fair judge Jean d’Arc school Ottawa
Science Fair Judge (National Research Council of Canada)
President, Ottawa Chamber Music Society
Canadian Ski Patrol (Mt. Ste. Marie) Gatineau Zone
Chair, Fundraising, National Capital Academy for Music
Kinsmen Foundation Granting Committee
Vice President/President, University of Saskatchewan Day Care Centre
National Board of Directors, Multiple Sclerosis Society of Canada
Neighborhood Watch
National Social Action Committee, Multiple Sclerosis Society of Canada
Programme Coordinator, Annual Conference for Individuals with MS,
Saskatoon, Saskatchewan
Committee for National Access and Awareness Week, Saskatoon
Board Member, Saskatoon Chapter, Multiple Sclerosis Society
Board Member, Provincial Board, Multiple Sclerosis Society, (President 1988 1990)
RESEARCH ACTIVITIES
Current
2008 - 2011
Hepatic toxicity nomenclature working group, INHAND multinational initiative,
National Institutes of Environmental Sciences (USA), Society of Toxicologic
Pathology (USA), European Society of Toxicological Pathology, International
Academy of Toxicologic Pathology, Raleigh NC – 2008.
2007- 2008
Applied for: A multifaceted malaria control. Global Fund through Ministry of
Health (Country Coordinating mechanism), Uganda (12,000,000 USD 20082011)
2006 Use and impact of herbal remedies on Plasmodium falciparum load ($5,000 seed money)
2005 - 2007
Investigation of the postnatal developmental effects of persistent organic
pollutants in mice (Health Canada $29,000)
2004 - 2006
Canadian Institutes of Health Research, Pathology of the SIR2 Transgenic
Mouse. (PI M. McBurney, Cancer Research Center, University of Ottawa)
2004 - 2009
Health Canada, Histomorphology of Glutamate Receptors in Human Post
Mortem Tissue. (PI O. Pulido and S. Gill)
2000 - 2001
Medical Research Council of Canada ($209,000: 2000-2001). Systematic
Reviews and Meta Analysis of Randomized Clinical Trials: Medical Use of
Marijuana (PI D. Moher)
1999 - 2005
Health Canada (G) Pathology of Tumor Necrosis Factor-induced disseminated
intravascular coagulation (PI H. Anisman, Carleton University)
Purpose: bench research for possible publication
Research Technique Experience
The following record is a list of research methods and study types that Colin Rousseaux has
practiced:
1. Gross, microscopic and ultrastuctural pathology and histopathology, including
standardized necropsy, tissue trimming, microtome operation and slide
preparation and staining for all tissues and organs – species evaluated include
16
2.
3.
4.
5.
6.
7.
8.
9.
10.
domestic animals, birds, fish and humans. I have limited experience in
immunocytochemistry. These techniques also include tissue special stains,
frozen sections and blood smears; and differential whole fetal staining (Alizarin
Red and Alcian Blue) and clearing;
Morphological dissection techniques such as the Wilson freehand technique for
embryonic structural evaluation, micro dissection of rodent fetuses,
microsurgical removal of embryonic limb bud tissue in mice;
Quantitative morphological evaluation of gross specimens (culture limbs) and
microscopic tissues (e.g., thyroid, lung and bone. Semi-quantitative scoring and
analysis has also been used;
Reproduction evaluation techniques in rodents and lagomorphs such as
synchronized breeding, determination of copulation (plug), evaluation of
implantation sites, viability assessments, evaluation of post natal development
markers, e.g., ear opening, hair etc;
Tissue and organ cultures including embryonic limbs, fibroblast and
hepatocellular cultures;
Microbiology methods including general aerobic and anaerobic culture, fungal
culture and special media culture for pathogens (e.g., salmonella). Quantitative
assessment of colony forming units (e.g., coliform counts), antibiotic sensitivity,
and enzyme analysis of cultured organisms for identification;
Genetic techniques include karyotyping and chromosomal banding, genetic
toxicity assessment using histidine reverse mutation (Salmonella typhimurium)
and sister chromatid exchange in Chinese hamster ovary cells. Some limited
experience in pedigree probabilistic assessment;
Cancer evaluation including evaluation of apoptosis, dysplasia, anaplasia and
neoplasia. Design and execution of rodent bioassays for carcinogenicity
determination;
Biochemistry including DNA, RNA and protein quantification, separation with
Sefadex gels, scintillation counting of radiolabelled material (tritium and Pb).
Standard clinical pathology hematology and clinical chemistry evaluation.
Tissue digestion and atomic absorption spectrophotometry of trace elements and
some experience with TLC, HPLC and GC with various detection methods.
I have personally done the following standardized studies:
 Ames Assay
 Sister chromatid exchange
 Karyotyping
 In vitro toxicity
 Pharmacokinetic and toxicokinetic studies using radioactive
isotopes and metabolism cages to determine absorption,
distribution, biotransformation and elimination (ADME)
 Acute, subacute, subchronic, chronic and lifetime exposure
toxicity studies
 A number of efficacy models (e.g., hypertensive rat model)
 Reproduction toxicity studies including Segment I, II and III
studies
 Carcinogenicity studies
 Special toxicology studies including neurotoxicity
INVITED LECTURES
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Rousseaux, C.G. (2009). How drugs are developed: from discovery to post market
developments. Toxicology and Pathology in Drug Discovery and Development Course,
University of Illinois. Champaign, IL, July 2009.
Rousseaux, C.G. (2008). The importance of a health research institute in achieving the goals of
the Ministry of Health and Social Services. Windhoek, Namibia, December 3, 2008
Rousseaux, C.G. (2008). Pathology as an important part of health research. Ministry of Health
and Social Services, Windhoek, Namibia, October 27, 2008
Rousseaux, C.G. (2008). Bacillus thuringiensis var. israelensis larvicidal control of Anopheles
sp. in the control efforts of malaria in Namibia, World Health Organization and UN,
Ministry of Health and Social Services, Windhoek, Namibia, February 5, 2008.
Rousseaux, C.G. (2008). Bacillus thuringiensis var. israelensis in the control of nuisance
mosquitoes in the municipality of Windhoek, Namibia, Windhoek City, Department of
Economic Development and Community Services, Windhoek, Namibia, February 11,
2008.
Rousseaux, C.G. (2008). Cannabis and the Cannabinoids: a forgotten magic bullet? Ehrlich II
conference. “Magic Bullets.” Nuremberg, Germany, October 3-5, 2008 (3 days).
Rousseaux, C.G. (2007). Cell injury and death: pathology for non-pathologists. International
Congress of Toxicology (ICTXI). Montréal, Canada, July 15, 2007
Rousseaux, C.G. (2007). Relevance of animal findings at the no observable effect level
(NOAEL) for human risk assessment. International Congress of Toxicology (ICTXI).
Montréal, Canada, July 16, 2007
Rousseaux, C.G. (2007). Toxicology of chemical mixtures: gaps and future directions. HECS,
Health Canada, March 23, 2007.
Rousseaux, C.G. (2007). How drugs are developed: from discovery to post market
developments. Seventh Industrial Toxicology and Pathology Short Course, University of
Illinois. Chicago, IL, July 2007.
Rousseaux, C.G. (2007). Product development plans for international regulatory agencies.
Seventh Industrial Toxicology and Pathology Short Course, University of Illinois.
Chicago, IL, July 2007.
Rousseaux, C.G. (2006). Using Bacillus thuringiensis var. israelensis as a larvicide in the
eradication of malaria, World Health Organization and USAID, Juba, Southern Sudan,
November 2006.
Rousseaux, C.G. (2006). Using Bacillus thuringiensis var. israelensis as part of a multifaceted
malaria eradication project, Ministry of Health, Juba, Southern Sudan, November 2006.
Rousseaux, C.G. (2006). The use of a multifaceted approach to malaria eradication, Ministry of
Health, Kampala, Uganda, November 2006.
Rousseaux, C.G. (2006). The determination of the efficacy of Bacillus thuringiensis var.
israelensis as a larvicide in Uganda, Uganda, Virus Research Institute, Entebbe, Uganda,
October 2006.
Rousseaux, C.G. (2006). Using Bacillus thuringiensis var. israelensis as part of a
comprehensive malaria reduction programme, Ministry of Health, Kampala, Uganda,
October 2006.
Rousseaux, C.G. (2006). Problem areas in pathology as they affect the veterinary practitioner.
Faculty of Veterinary Science, Makerere University, Kampala, Uganda, October 2006.
Rousseaux, C.G. (2006). Toxicologic Pathology and the Veterinarian. Faculty of Veterinary
Science, Makerere University, Kampala, Uganda, February 2006.
Rousseaux, C.G. (2006). Alternative methods to Anopheline Mosquito Control for Malaria in
Eastern Africa, Ministry of Health, Uganda, Kampala, Uganda, February 2006.
18
Rousseaux, C.G. (2005) The use of Histopathology in Establishing a Disease Baseline for the
Red River and Lake Winnipeg Basin. Ministry of the Environment, Manitoba, June
2005.
Rousseaux, C.G. (2005). Translating Toxicologic Pathology findings of the Gastrointestinal
Tract for Regulatory Interpretation. The United States Food and Drug Administration,
May 2005.
Rousseaux, C.G. (2005). Pathology of the Gastrointestinal System: Lesions and Disease. The
American College of Toxicology, Chicago, IL May 2005.
Rousseaux, C.G. (2004). Strategies to address the lack of highly qualified personnel: Is
increased examination a way to solve this problem? The American College of
Veterinary Pathologists, Orlando, FL, November 2004.
Rousseaux, C.G. (2004). Building a Development Plan for International Regulatory Agencies.
Sixth Industrial Toxicology and Pathology Short Course, Chicago, IL, July 2004.
Rousseaux, C.G. (2004). Dealing with International Regulatory Agencies. Sixth Industrial
Toxicology and Pathology Short Course, Chicago, IL, July 2004.
Rousseaux, C.G. (2004). Problem Solving Regulatory Issues. Sixth Industrial Toxicology and
Pathology Short Course, Chicago, IL, July 2004.
Rousseaux, C.G. (2004). Overview of the Life Cycle of health Products from Discovery to PostMarket, Office of Continuing Education, Health Canada, February, June and October,
2004.
Rousseaux, C.G. (2004). Trouble Shooting in Toxicopathology: Applications and Methodology
10th International Congress of Toxicology, Tampere, Finland, July 11-15
Rousseaux, C.G. (2004). How Drugs are developed: From Discovery to Post Market. Novartis
Research, Basil, Switzerland, July 2004.
Rousseaux, C.G. (2004) Regulatory Issues regarding Hepatoxicity. 23rd Annual Society of
Toxicologic Pathology Meeting, Salt Lake City, UT, June 2004.
Rousseaux, C.G. and McBurney, M.W. (2004). Gene Silencing: Gene Inactivation in
Mammalian Stem Cells. Joint International Meeting of the Japanese Society of
Toxicologic Pathology and the International Federation of Societies of Toxicologic
Pathology, Kobe, Japan, February 2004.
Rousseaux, C.G. (2004). Beyond the Genome: Nature and nurture. Joint International Meeting
of the Japanese Society of Toxicologic Pathology and the International Federation of
Societies of Toxicologic Pathology, Kobe, Japan, February 2004.
Rousseaux, C.G. (2003). A Novel Approach to Direct-to-Consumer Advertising, Health
Canada, Ottawa, ON, June 2003.
Rousseaux, C.G. (2003). A Novel Approach to Direct-to-Consumer Advertising, Drug
Information Association, Ottawa, ON, November 2003.
Rousseaux, C.G. (2003) Medicinal Marijuana: Background and Present Status in Canada. Tenth
Palliative Care Educational Day, NCR Congress Centre, Ottawa, ON, May 2003.
Rousseaux, C.G. (2002) Risk Assessment including a Social Construct. Fifth Industrial
Toxicologic Pathology Course, University of Illinois, Chicago, IL, July 2002.
Rousseaux, C.G. (2002) Cause of Death: How sure are we and how do we report it? 21st Annual
Society of Toxicologic Pathology Meeting, Denver, CO, June 2002.
Rousseaux, C.G. (2002) Bioethics in biotechnology. Samuel Genest Grade 12, Ottawa, Ontario,
March 2002.
Rousseaux, C.G. (2002) Environmental Assessment: Veterinary Drugs. Environmental
“Learning Event,” Ottawa, ON, February 2002.
Rousseaux, C.G. (2001). Nausea and Vomiting: Pathophysiology. Ottawa Institute of Palliative
Care, Ottawa, ON, January 2001
19
Rousseaux, C.G. (2001) Clearing the Smoke: The Benefits and Risks or Zyban for Smoking
Cessation? Bureau of Licensed Product Assessment, Ottawa, ON, January 2001
Rousseaux, C.G. (2000) Regulatory Issues concerning the Safety and Efficacy of Herbal
Remedies and Alternative Medicines, Teratology Society, Palm Beach, FL, June, 2000
Rousseaux, C.G. (2000) Clearing the Smoke: What do we really know about Medicinal
Marijuana? Ottawa Institute of Palliative Care, Ottawa, ON, June 2000
Rousseaux, C.G. (1998) Veterinary medicine and environmental risk management. EnviroVet,
University of Minnesota, Duluth, MN, July 1998
Rousseaux, C.G. (1998) Toxicologic pathology: What is it? CAVP, July, 1998
Rousseaux, C.G. and Smith, G. (1998) The use of clinical and morphologic pathology for
human health assessment of pesticides in Canada. Pest Management Regulatory Agency,
Ottawa, Ontario, Canada, February 1998.
Rousseaux, C.G. (1996) Toxicologic Pathology and Risk Assessment. 15th Annual Society of
Toxicologic Pathologists Meeting, St. Louis, MO, June 1996.
Rousseaux, C.G. (1996) So What about Pathology? How does the Regulatory Toxicologist
evaluate Pathology Data? Pest Management Regulatory Agency, Ottawa, Ontario,
Canada, November 1996.
Rousseaux, C.G. (1995) Reproductive Ecology. International Joint Commission for the Great
Lakes, Racine WI, January 1995.
Rousseaux, C.G. (1994) Toxicologic Pathology and Environmental Risk Management.
EnviroVet 1993, University of Minnesota, Duluth, MN, July 1994.
Rousseaux, C.G. (1994) Toxic Response Characteristics. Sponsor's Seminar Series, sponsored
by the Eco-Research Chair in Environmental Risk Management. Continuing Education
Centre, University of Alberta, Edmonton, Alberta, March 1994.
Rousseaux, C.G. (1994) Measurement of Toxicologic Adverse Effects. Sponsor's course,
sponsored by the Eco-Research Chair in Environmental Risk Management. Continuing
Education Centre, University of Alberta, Edmonton, Alberta, March 1994.
Rousseaux, C.G. (1994) Toxicity Data Quality Issues. Sponsor's course, sponsored by the EcoResearch Chair in Environmental Risk Management. Continuing Education Centre,
University of Alberta, Edmonton, Alberta, March 1994.
Rousseaux, C.G. (1994) Risk Assessment and Epidemiology. Sponsor's course, sponsored by
the Eco-Research Chair in Environmental Risk Management. Continuing Education
Centre, University of Alberta, Edmonton, Alberta, March 1994.
Rousseaux, C.G. (1993) Toxic or Non-Toxic? A question of balance of Real and Perceived
Risks. First in the Risk Management Seminar Series. Sponsored by the Eco-Research
Chair in Environmental Risk Management. Mackenzie Health Sciences Centre,
University of Alberta, Edmonton, Alberta, December 1993.
Rousseaux, C.G. (1993) Living functions and toxic effects. 1993 Summit on Environmental
Risk, Council for Yukon Indians, Whitehorse, Yukon, August 1993.
Rousseaux, C.G. (1993) Dose dependence in toxicology. 1993 Summit on Environmental Risk,
Council for Yukon Indians, Whitehorse, Yukon, August 1993.
Rousseaux, C.G. (1993) Toxicology studies. 1993 Summit on Environmental Risk, Council for
Yukon Indians, Whitehorse, Yukon, August 1993.
Rousseaux, C.G. (1993) Environmental health risks - principals. 1993 Summit on Environmental Risk, Council for Yukon Indians, Whitehorse, Yukon, August 1993.
Rousseaux, C.G. (1993) Environmental health risks - food contaminants. 1993 Summit on
Environmental Risk, Council for Yukon Indians, Whitehorse, Yukon, August 1993.
Rousseaux, C.G. (1993) The role of Toxicologic Pathology in assessing environmental health.
EnviroVet 1993, University of Minnesota, Duluth, MN, July 1993.
20
Rousseaux, C.G. (1993) La pathologie: un instrument pour établir des modèles à base
biologique de dose-réponse dans l'évaluation du risque environnemental, Université de
Montréal, Montréal, Québec, mars 1993.
Rousseaux, C.G. (1993) Modèles de tératogènes, L'université du Québec à Montréal, Montréal,
Québec, février 1993.
Rousseaux, C.G. (1993) Prenatal exposure: Is the Fetus at Risk in our Industrial Society? Abst
p. 86-87. Eleventh Annual International Symposium on Man and His Environment in
Health and Disease, Dallas, TX. February 1993.
Rousseaux, C.G. (1993) Vitamin A: A Two-Edged Sword for the Fetus. . Abst p. 84-85. Ninth
Annual International Symposium on Man and His Environment in Health and Disease,
Dallas, TX, February 1993.
Rousseaux, C.G. (1992) Toxicologic Pathology: Generating Data that Counts. Drug Research
Bureau, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, January
1992.
Rousseaux, C.G. (1991) Interaction of all-trans retinoic acid and dexamethasone on the
developing CD-1 mouse fetus: In vivo and in vitro effects, NIEHS, Raleigh, NC, May
1991.
Rousseaux, C.G. (1991) The Interaction of Vitamin A and Dexamethasone on Post Natal
Behavioral Development. Abst p. 49. Ninth Annual International Symposium on Man
and His Environment in Health and Disease. Dallas, TX, February 1991.
Rousseaux, C.G. (1991) Evaluation of Subclinical Toxic Insults: Research Strategies. Abst p.
50. Ninth Annual International Symposium on Man and His Environment in Health and
Disease. Dallas, TX, February 1991.
Rousseaux, C.G. (1990) The Importance of Morphology in Toxicology. University of Waterloo,
Department of Biology, Waterloo, Ontario, November 1990.
Rousseaux, C.G. (1990) The Impact of Xenobiotics on the Fetus: Research Findings using
Multiple Test Systems. University of Windsor, Department of Biology, Windsor,
Ontario, November 1990.
Rousseaux, C.G. (1990) Research Strategies for Subclinical Toxicological Evaluation of
Environmental Illness. Ontario Ministry of Health Advisory Committee on Environmental Hypersensitivity Workshop, Alton, Ontario, September 1990.
Rousseaux, C.G. (1990) Limitations of Toxicologic Pathology. University of Western Ontario,
Department of Pharmacology and Toxicology, London, Ontario, June 1990.
Rousseaux, C.G. (1990) Toxicology and the veterinarian. Melbourne University, School of
Veterinary Science, Parkville, Victoria, Australia, May 1990.
Rousseaux, C.G. (1990) Cell adhesion molecules: how form and function are related. Abst p.
56. Eighth Annual International Symposium on Man and His Environment in Health and
Disease, Dallas, TX, February 1990.
Rousseaux, C.G. (1990) Chemical exposure through skin contact: Dermatotoxicology. Abst p.
57. Eighth Annual International Symposium on Man and His Environment in Health and
Disease, Dallas, TX, February 1990.
Rousseaux, C.G. (1990) Nutritional aspects of trace element interactions. Seventh. Abst p. 47.
Annual International Symposium on Man and His Environment in Health and Disease,
Dallas, TX, February 1989.
Rousseaux, C.G., Olkowski, A., Chauvet, A., Gooneratne, R. and Christensen, D.A. (1989)
Sulphate- related neurological disease in sheep. Abst p. 48. Seventh Annual
International Symposium on Man and His Environment in Health and Disease, Dallas,
TX, February 1989.
21
Rousseaux, C.G. (1989) Trace element interactions. Ann. Mtg. Sask. Vet. Med. Assoc.,
Saskatoon, Saskatchewan, January 1989.
Rousseaux, C.G. (1988) Modulation of T-2 toxicity in CD-1 mice. "Trichothecenes, Blue-Green
Algal and Marine Toxins", FASEB Summer Conference, Copper Mountain, CO, July
1988.
Rousseaux, C.G. (1988) Comparison of autolysis with lesions that follow T-2 toxin administration. "Trichothecenes, Blue-Green Algal and Marine Toxins", FASEB Summer
Conference, Copper Mountain, CO, July 1988.
Rousseaux, C.G. (1988) Fetal toxicologic pathology. Environmental Health Group, Dallas, TX,
July 1988.
Rousseaux, C.G. (1988) Covert operations: the problem of incriminating mycotoxins in disease.
Sixth Annual International Symposium on Man and His Environment in Health and
Disease. Dallas, TX, February 1988.
Rousseaux, C.G. (1988) Is it safe? The challenge of carcinogen risk assessment. University of
Illinois, Urbana, IL, February 1988.
Rousseaux, C.G. (1988) Fundamental research in biomedical sciences. University of Illinois,
Urbana, IL, February 1988.
Rousseaux, C.G. (1987) Indoor air quality, a problem during work and play. Abst. p. 37. Ann.
Acad. Env. Med. 22nd Annual Meeting, Nashville, TN, October 1987.
Rousseaux, C.G. (1987) Proving your point: descriptive versus inferential statistics in clinical
trials. Abst. p. 39. Ann. Acad. Env. Med. 22nd Annual Meeting, Nashville, TN, October
1987.
Rousseaux, C.G. (1987) Veterinary toxicological problem solving: a multidisciplinary
approach. Ontario Veterinary College, University of Guelph, Guelph, Ontario, February
1987.
Rousseaux, C.G. (1987) A practical approach to determining etiology of fetal anomalies. Ann.
Mtg. Sask. Vet. Med. Assoc., Saskatoon, Saskatchewan, January 1987.
Rousseaux, C.G. (1986) How subclinical toxic insults may produce aberrant immunological
responses. Abst. p. 6. 20th Advanced Seminar - 21st Annual Meeting American
Academy of Environmental Medicine. Clearwater, FL, October 1986.
Rousseaux, C.G. (1986) The immune system and how it relates to other body systems. Abst. p.
31. 20th Advanced Seminar - 21st Annual Meeting American Academy of Environmental Medicine. Clearwater, FL, October 1986.
Rousseaux, C.G. (1986) Environmental fungi and their effect on the immune system. Abst. p.
64. 20th Advanced Seminar - 21st Annual Meeting American Academy of
Environmental Medicine. Clearwater, FL, October 1986.
Rousseaux, C.G. (1986) Trichothecene mycotoxins: A dilemma for pathologist, teacher and
researcher. Department of Veterinary Pathology, Colorado State University, Fort
Collins, CO, September 1986.
Rousseaux, C.G. (1986) Trichothecene mycotoxins: Masters of disguise and often accused of
being agents in search of a disease. FASEB, "Trichothecenes," Copper Mountain, CO,
July 1986.
Rousseaux, C.G. (1985) Abnormal development: An overview. O.S. Longman Bldg.,
Edmonton, Alberta, December 1985.
Rousseaux, C.G., Klavano, G.G., Johnson, E.S., Snitka, T.K., and Harries, W.N. (1985)
"Shaker" Calf Syndrome, a newly recognized inherited neurodegenerative disorder of
horned Hereford calves. Canadian Veterinary Medical Association, Calgary, Alberta,
July 1983.
22
PUBLICATIONS and PRESENTATIONS
Scientific Publications (Peer-reviewed)
Thoolen, R., Maronpot, R.R, Harada, T., Nyska, A., Rousseaux, C.G., Nolte, T., Malarkey, D.,
Kaufmann, W., Küttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M., Brix, A.,
Singh, B., Belpoggi, F., and Ward, J.M (2010). Hepatobiliary Lesion Nomenclature and
Diagnostic Criteria for Lesions in Rats and Mice (INHAND). Toxicol. Pathol. 38
(Suppl): 1009-1010
Ochoa, R., and Rousseaux, C.G. (2009). The role of the toxicologic pathologist in risk
management. Toxicol Pathol. 37: 705-707; 2008
Sequeira J, Boily G, Bazinet S, Saliba S, He X, Jardine K, Kennedy C, Staines W, Rousseaux
C.G., Mueller R, McBurney MW (2008). sirt1-null mice develop an autoimmune-like
condition. Exp Cell Res. 314: 3069-3074; 2008
Chu, I., Valli, V.E., Rousseaux, C.G. (2006) Combined Effects of 2,3,7,8-tetrachlorodibenzo-pdioxin and Polychlorinated Biphenyl Congeners In Rats. Toxicol. Environ. Health. (In
Press)
Rousseaux, C.G. (2005) Critical review Human Health and Ecological Tier Testing Schemes for
Genetically Engineered Microorganisms used in TSCA Applications. Environmental
Protection Agency, USA.
Rousseaux, C.G. (2005) Troubleshooting in Toxicologic Pathology. Toxicol. Appl. Pharmacol.
207: 214-224.
Rousseaux, C.G. and Schachter, H. (2003) Regulatory Issues Concerning the Safety, Efficacy
and Quality of Herbal Remedies. Birth Def. Res. (Part B): 68: 505-510.
Christafori, P, Colman, K, DeBruyne, E., Fouillet, X., Germann, P-G, Haschek, W.M., Karbe, E.,
Issacs, K., Kennedy, S., Konishi, Y., Rousseaux, C.G., Sjogren, I., Skydsgaard, M.,
Tryphonas, L. (2003) Report of the IFSTP Professional Standards Subcommittee
(PSSC). Toxicol. Pathol. 31: 562-565.
Rousseaux, C.G. (1997) Toxicologic Pathology and Risk Assessment. Toxicol. Pathol. 25: 22
Shury, T., Rousseaux, C.G., Keiner, J., and Politis, M. (1994) Interactive Effects of Cadmium
and Retinoic Acid on Mouse Limb Bud Development In Vitro. Bull. Environ. Contam.
Toxicol. 53, 570-576.
Rousseaux, C.G. (1994) Congenital Defects as a cause of perinatal mortality of beef calves.
Vet. Clinics of North America: Food Animal Practice. 10, 35-51.
Rousseaux, C.G., Politis, M.J., and Keiner, J. (1993) The effects of selenium methionine and
sodium selenite on the development of murine limbs in culture. Environ. Toxicol. Chem.
12, 1283-1290.
Tornesi, B., Palasz, A.T., DelCampo, M.R., Rousseaux, C.G., Archer, F.J, and Mapletoft, R.
(1993) In vitro culture of preimplantation mouse embryos and day 12 limb-buds: Effects
of serum and albumin. Reproductive Toxicol. 7, 583-601.
Rousseaux, C.G., and MacNabb, L.G. (1992) Oral administration of D-Penicillamine causes
neonatal mortality without morphologic defects in CD-1 mice. J. Appl. Toxicol. 12, 3538.
Olkowski, A.A., Gooneratne, S.R., Rousseaux, C.G., and Christensen, D.A. (1992) The role of
thiamine status in sulphur-induced polioencephalomalacia. Res. Vet. Sci. 52, 78-85.
Yagminas, A.G., Little, P.B., Rousseaux, C.G., and Villeneuve, D.C. (1992) Neuropathologic
findings in young male rats in a subchronic oral toxicity study using triethyl lead. Fund.
Appl. Toxicol. 19, 380-387.
23
Rousseaux, C.G., Thompson, B.E., and Zintel, B. (1992) The effect of water source on the
growth and development of CD-1 mouse limb buds in submerged culture. Toxicol.
Methods. 2, 177-187.
Kotak, B.G. Kenefick, S.L., Fritz, D.L., Rousseaux, C.G., Prepas, E.E., and Hrudey, S.E. (1992)
Occurrence and toxicological evaluation of cyanobacterial toxins in Alberta surface
waters. Water. Res. 27, 495-506.
Kim, J.S., Hamilton, D.L., Blakley, B.R., and Rousseaux, C.G. (1992) The effects of thiamin on
lead metabolism: Organ distribution of lead 203. Can. J. Vet. Res. 56, 256-259.
Blakley, B.R., and Rousseaux, C.G. (1991) The effect of invermectin on the immune response.
Am. J. Vet. Res. 52, 593-595.
Kim, J.S., Hamilton, D.L., Blakley, B.R., and Rousseaux. C.G. (1991) The effects of thiamin on
the tissue distribution of lead: Whole body retention of lead 203. Toxicol. Lett. 56, 4352.
Rousseaux, C.G., Olkowski, A.A., Chauvet, A., Gooneratne, S.R., and Christenson, D.A. (1991)
Ovine polioencephalomalacia associated with dietary sulphur intake. J. Vet. Med. 38,
229-239.
Olkowski, A.A., Rousseaux, C.G., and Christensen, D.A. (1991) The association of sulphatewater and blood thiamine concentration in cattle: a field study. Can. J. Anim. Sci. 71,
825-832.
Blakley, B.R., Gagnon, J.M., and Rousseaux, C.G. (1991) The effect of 2, 4, -D on chemicaland viral-induced tumor formation in mice. Am. J. Vet. Res. 52, 593-595.
Olkowski, A.A., Gooneratne, S.R., Crichlow, E.G., Rousseaux, C.G., and Christensen, D.A.
(1990) Effects of high dietary sulphur on brain functions using evoked potentials
technique. Can. J. Vet. Res. 54, 113-118.
Rousseaux, C.G., Townsend, H.G., Philips, O.A., and Dimmock, J.R. (1990) Toxicologic
studies on a novel antineoplastic bis-Mannich base, derived from a conjugated styryl
ketone. Fund. Appl. Toxicol. 14, 318-326.
Kim, J.S., Crichlow, E.C., Blakley, B.R., and Rousseaux, C.G. (1990) The effects of thiamin on
the neurophysiological alterations induced by lead. Vet. Human. Toxicol. 32, 101-105.
Kim, J.S., Blakley, B.R., and Rousseaux, C.G. (1990) The effects of thiamin on the tissue
distribution of lead. J. Appl. Toxicol. 10, 93-97.
Rousseaux, C.G. (1990) An inexpensive temporary incubator conversion for submerged organ
culture. Vet. Human Toxicol. 32, 459.
Rousseaux, C.G., Schiefer, H.B., Hancock, D.S., and Olfert, E.D. (1990) Differentiation of
lesions caused by mycotoxin T-2 from autolytic morphologic change in CD-1 mice. J.
Comp. Pathol. 103, 379-385.
Geor, R.J., Petrie, L., Papich, M.G., and Rousseaux, C.G. (1989) The protective effects of
sucralfate and ranitidine in foals experimentally intoxicated with phenylbutazone. Can.
J. Vet. Res. 53, 231-238.
Heath, S.E., Naylor, J.M., Guedo, B.L., Petrie, L., Rousseaux, C.G., and Radostits, O.M. (1989)
The effects of feeding milk to diarrheic calves supplemented with oral electrolytes. Can.
J. Vet. Res. 53, 477-485.
Willis, S.E., Jackson, M.L., Meric, S.M., and Rousseaux, C.G. (1989) Whole blood platelet
aggregation in dogs with liver disease. Can. J. Vet. Res. 50, 1893-1897.
Coates, J.W., Schmutz, S.M., and Rousseaux, C.G. (1988) A survey of malformed aborted
bovine fetuses, stillbirths and nonviable neonates for abnormal karyotypes. Can. J. Vet.
Res. 52, 258-263.
24
Schiefer, H.B., Rousseaux, C.G., Hancock, D.S., and Blakley, B.R. (1987) A study of the
carcinogenic and immunosuppressive effects of low-level, long-term oral exposure to T2 toxin in CD-1 mice. Food Chem. Toxicol. 25, 593-601.
Rousseaux, C.G., and Schiefer, H.B. (1987) Maternal toxicity, embryo-lethality and abnormal
fetal development in CD-1 mice following one oral dose of T-2 toxin. J. Appl. Toxicol.
7, 281-288.
Blakley, B.R., Hancock, D.S., and Rousseaux, C.G. (1987) Embryotoxic and immunotoxic
effects of prenatal T-2 toxin exposure in mice. Can. J. Vet. Res. 51, 399-403.
Mechor, G.D., Rousseaux, C.G., Petrie, L., Babiuk, L.A., and Radostits, O.M. (1987) The
protective effect of colostral antibody against fatal neonatal bovine herpes virus infection
(BHV). Can. J. Vet. Res. 51, 452-459.
Rousseaux, C.G., Schiefer, H.B., and Hancock, D.S. (1986) Reproductive and teratological
effects of continuous low level dietary T-2 Toxin in CD-1 mice for two generations. J.
Appl. Toxicol. 6, 179-184.
Rousseaux, C.G., Klavano, G.G., Johnson, E.S., Snitka, T.K., and Harries, W.N. (1985)
"Shaker" Calf Syndrome, a newly recognized inherited neurodegenerative disorder of
horned Hereford calves. Vet. Pathol. 22, 104-111.
Rousseaux, C.G. (1985) Automated differential staining for cartilage and bone in whole mount
preparations of vertebrates. Stain Technol. 60(5), 295-297.
Rousseaux, C.G., Nicholson, S., and Schiefer, H.B. (1984) Fatal hemorrhage in pregnant CD-1
mice following one oral dose of T-2 toxin. Can. J. Comp. Med. 49, 95-98.
Nichol, A.W., Elsbury, S., and Rousseaux, C.G. (1981) Porphyrin accumulation in sheep
bones associated with 1,2,4-trichlorobenzene. Bull. Environ. Contam. Toxicol. 27, 7278.
Rousseaux, C.G., Gill, I., and Payne-Crostin, A. (1981) Spontaneous hip fractures in pigs
associated with calcium deficiency. Aust. Vet. J. 57, 508-510.
Full Papers Published in Conference Proceedings (Peer-reviewed)
Rousseaux, C.G. (1985) The potential chronic effects of highly toxic chemicals. International
Symposium on Highly Toxic Chemicals: Detection and Protection Methods, Toxicology
Research Centre, Saskatoon, Sask., September 1985, pp. 48-54.
Schiefer, H.B., and Rousseaux, C.G. (1984) Lethal hemorrhages in pregnant mice following
one oral dose of T-2 toxin. The proceedings, First World Congress, New Compounds in
Biological and Chemical Warfare: Toxicological Evaluation. Ghent, Belgium, May
1984. Edited by A. Heyndrickx, pp. 252-253.
Case Reports (Peer-reviewed)
Rousseaux, C.G., Doige, C.E, and Tuddenham, T. (1989) Epidural lymphosarcoma with
myelomalacia in a seven-year-old Arabian gelding. Can. Vet. J. 30, 751-753.
Schmutz, S.M., Coates, J., and Rousseaux, C.G. (1987) Chromosomal trisomy in an anomalous
bovine fetus. Can. Vet. J. 28, 61-62.
Rousseaux, C.G. (1987) Ultrastructure of canine gastronoma. J. Comp. Pathol. 97, 605-607.
Coates, J.W., Rousseaux, C.G., and Schmutz, S.M. (1987) Multiple defects in an aborted
bovine fetus associated with chromosome 27 trisomy. NZ Vet. J. 35, 173-174.
Semalulu, S.S., and Rousseaux, C.G. (1989) Suspected oriental mustard seed (Brasica juncea)
poisoning in cattle. Can. Vet. J. 30, 595-596.
Rousseaux, C.G., Smith, R.A., and Nicholson, S. (1986) Acute Pinesol toxicity in a domestic
cat. Vet. Hum. Toxicol. 28, 316-317.
25
Hylton, W.E., and Rousseaux, C.G. (1985) Intestinal obstruction associated with
omphaloarteritis in a calf. J. Am. Vet. Med. Assoc. 186, 1099.
Rousseaux, C.G., and Wenger, B.S. (1985) Are pesticides involved in arthrogryposis? Can.
Vet. J. 26, 257-258.
Shahar, R., Rousseaux, C.G., and Steiss, J. (1985) Peripheral polyneuropathy in a dog with a
functional beta-islet cell tumour and widespread metastases. J. Am. Vet. Med. Assoc.
187, 175-177.
Rousseaux, C.G. (1984) Hepatocellular carcinoma in a goat. Aust. Vet. J. 61, 193.
Rousseaux, C.G., Futcher, K.G., Naylor, J.M., and Clark, E.G. (1984) Cauda equina neuritis, a
chronic idiopathic polyneuritis in two horses. Can. Vet. J. 25, 214-218.
Rousseaux, C.G., and Wenkoff, M. (1984) Accidental intracarotid artery injection of
chloramphenicol in a cow. J. Am. Vet. Med. Assoc. 184, 1287-1288.
Rousseaux, C.G., Klavano, G.G., Johnson, E.S., Snitka, T.K., and Harries, W.N. (1983) A
newly recognized inherited neurodegenerative disorder of horned Hereford calves. Can.
Vet. J. 24, 296-297.
Rousseaux, C.G., Audette, R.J., and Ellefson, G. (1982) Methyl alcohol toxicity in cattle. Can.
Vet. J. 23, 252.
Rousseaux, C.G., and Dalziel, J.B. (1981). Aspergillus pneumonia in an ostrich (Struthio
camelus). Aust. Vet. J. 57, 151.
Harrison, M.A., Nicholls, T.J., and Rousseaux, C.G. (1980) Lindane toxicity in lambs. Aust.
Vet. J. 56, 42.
Rousseaux, C.G. (1979) Pink bones in sheep carcasses. Aust. Vet. J. 55, 253.
Presentations at Meetings and Abstracts
Rousseaux, M.W.C., Marcogliese, P.C., Haque, M.E., Joselin, A., Irrcher, I., Aleyasin, H.,
Rousseaux, C.G., Slack, R.S., Shen, J., Mak, T.W., and Park, D.S. (2010). Study of the
Pink DJ double knockout mouse. Neuropathology: STP Annual General Meeting,
Chicago, IL June 20-24, 2010.
Rousseaux, C.G. (2007). Towards malaria eradication: A multifaceted multimodal approach. 5th
European Congress on Tropical Medicine and International Health, Amsterdam,
Netherlands, May 24 – 28, 2007.
Marrif, H.I, Bowers, W.J., Nakai, J.S., Chu, I., Mueller, R., Rousseaux, C.G., Gill, S., Wade, M.,
Moir, D., Pulido, O. (2006). Developmental Neuropathology: Effects of In Utero and
Lactational Exposure to a Mixture of Persistent Organic Pollutants (POPs), Based on
Maternal Blood Profiles in Canadian Arctic Populations, Society of Toxicologic
Pathology Annual Meeting, Vancouver, June, 2006
Pulido, O., Veinot, J., Mueller, R., Kavanagh, M., Rousseaux, C.G., Gill, S. (2005) Toxicologic
Pathology of Glutamate Receptors (GluRs) – An opportunity for pharmaceutical
development. Part I – Human Heart. Cardiovascular Toxicologic Pathology: Safety
Assessment and Risk Management, STP Annual General Meeting, Washington, DC
June, 2005.
Gill, S., Veinot, J., Mueller, R., Kavanagh, M., Rousseaux, C.G., Pulido, O. (2005) Toxicologic
Pathology of Glutamate Receptors (GluRs) – An opportunity for pharmaceutical
development. Part II – Inflammation and Lymphoid Oragans. Cardiovascular
Toxicologic Pathology: Safety Assessment and Risk Management, STP Annual General
Meeting, Washington, DC June, 2005.
Pulido, O., Veinot, J., Mueller, R., Kavanagh, M., Rousseaux, C.G., Gill, S. (2004) Human heart
glutamate receptors (GluRs) - possible effector sites: An opportunity for drug discovery.
Joint International Meeting of the Japanese Society of Toxicologic Pathology and the
26
International Federation of Societies of Toxicologic Pathology, Kobe, Japan, February
2004.
Rousseaux, C.G. (2004). The Society of Toxicologic Pathology’s position on the need for sub
specialization in the veterinary Pathology. The American College of Veterinary
Pathologists, 55th Annual Meeting, Orlando, FL, November 2004.
Rousseaux, C.G. (2004). Troubleshooting in Toxicopathology. International Congress of
Toxicology, Tempere, Finland, June, 2004.
Witteman, J, Birkholz, D.A., Goudey, S.E., Rousseaux, C.G. and J. Zelikoff (1998) Aquatic
toxicity associated with Kimberlite #1: Environmental effects of diamond mining.
Aquatic Toxicology Workshop, Quebec City, October 1998
Goudey, S.E., Birkholz, D.A., Witteman, J, Rousseaux, C.G. and J. Zelikoff (1998) Aquatic
toxicity associated with Kimberlite #2: Innovative procedures to determine aquatic
toxicity associated with diamond mining. Aquatic Toxicology Workshop, Quebec City,
October 1998.
Birkholz, D.A., Witteman, J, Goudey, S.E., Rousseaux, C.G. and J. Zelikoff (1998) Aquatic
toxicity associated with Kimberlite #3: Metals, effects, and chemical analysis. Aquatic
Toxicology Workshop, Quebec City, October 1998.
Rousseaux, C.G., Birkholz, D.A., Witteman, J, Goudey, S.E. and J. Zelikoff (1998) Aquatic
toxicity associated with Kimberlite #4: Histopathology of exposed fish. Aquatic
Toxicology Workshop, Quebec City, October 1998.
Birkholz, D.A., Witteman, J, Goudey, S.E., Rousseaux, C.G. and J. Zelikoff (1998) Aquatic
toxicity associated with Kimberlite #5: Immunological competence. Aquatic
Toxicology Workshop, Quebec City, October 1998.
Birkholz, D.A., Witteman, J, Goudey, S.E., Rousseaux, C.G. and J. Zelikoff (1998) Aquatic
toxicity associated with Kimberlite #6: Biomarkers and chemical analysis. Aquatic
Toxicology Workshop, Quebec City, October 1998.
Francois, D., McAfee, B, Mulye, H, McDonell, R., Nicholson, I., Sebastien, R., Tolson, N, and
Rousseaux, C.G. (1996) New Canadian requirements for pesticides. SETAC,
Washington, DC, November 1996.
Taylor, J., Nicholson, I., Curwin, B., and Rousseaux, C.G. (1996) New Canadian pesticide “UseSite Categories.” SETAC, Washington, DC, November 1996.
Rousseaux, C.G., Branchaud, A., and P.A. Spear (1995) Evaluation of liver histopathology in
the St. Lawrence lake sturgeon (Acipenser fulvescens) collected from their spawning site.
Canadian Society of Zoologists, Rimouski, May 1995.
Rousseaux, C.G., Buttar, H.S., and Moffatt, J.H. (1995) Comparative toxicity of femciclovir
and ganciclovir in mice: Histological changes in the testicular tissue. 14th Ann. Ottawa
Reproductive Biology Workshop, Ottawa, ON, June 1995.
Rousseaux, C.G. (1995) Introduction to the Role of Pathology in Aquatic Toxicology. Aquatic
Toxicology Workshop, St. Andrews, N.B. 1995.
Desjardins, S., Cauchy, M.J., and Rousseaux, C.G. (1995) Metoprolol and Captopril Treatment
on Pathological Finds at Death in Running Cardiomyopathic Hamsters. J. Mol. Cell
Cardiol. 27: A171, 1995.
Desjardins, S., Cauchy, M.J., Kozliner, E., Rousseaux, C.G., Carigan, G., Carrier, K., and
McGilveray, I.J. (1994) Metoprolol effects in the running cardiomyopathic hamster.
XIIth International Congress of Pharmacology, Montréal, Quebec, July 1994.
Moffet, J., Rousseaux, C.G., and Hayes, P.A. (1994) Reconceptialization of risk management
involving public perception and technical risk assessment. SETAC, Denver, CO,
November 1994.
27
Rousseaux, C.G., Moffet, J., and Hayes, P.A. (1994) The importance of combining science and
social science values in risk management. SETAC, 15th Ann. Mtg. Denver, CO,
November 1994.
Rousseaux, C.G. (1994) Biomarkers Aquatic Toxicology Workshop. Sarnia, Ontario, October
1994.
Tones, P.I., and Rousseaux, C.G. (1992) Application of fish behavior and pathology to toxicity
identification evaluation procedures. SETAC 13th Ann. Mtg. Cincinnati, OH, November
1992.
Rousseaux, C.G., Branchaud, A., and Spear, P.A. (1993) Evaluation of liver histopathology in
St. Lawrence lake sturgeon (Acipenser fulvescens) collected from two spawning sites.
SETAC 14th Ann. Mtg. Huston, TX, November 1993.
Politis, M.J., Keiner, J., and Rousseaux, C.G. (1992) The effect of selenium methionine and
sodium selenite on murine limb development in culture. Society of Toxicology, 31st
Annual General Meeting, Seattle, WA, February 1992, Toxicologist. 12, 1, Abst #1299.
Kerviche, A., Rousseaux, C.G., and Gusta, L.V. (1992) An investigation of the teratogenicity of
the plant hormone abscisic acid (ABA) and analogue of ABA using a chick embryo in
vitro test. Society of Toxicology, 31st Annual General Meeting, Seattle, WA, February
1992, Toxicologist. 12, 1, Abst #1295.
Tornesi, B., Palasz, A.T., Liqin, T., Del Campo, M.R., Rousseaux, C.G., and Mapletoft, R.J.
(1992) The effect of concentration of different sera on mouse embryos and limb buds in
culture. Abst. #310. International Embryo Transfer Meeting, Theriogenology, Denver,
CO, January 1992.
Tornesi, B., Palasz, A.T., Liqin, T., Del Campo, M.R., Rousseaux, C.G., and Mapletoft, R.J.
(1992) The effects of concentration and source of sera on mouse embryos and limbs in
culture. Abst # 19. Can. West. Soc. Reprod. Biol., Edmonton, Alberta, February 1992.
Rousseaux, C.G. and Kulyk, W.M. (1992) The effect of Staurosporine on the growth and
development of cultured CD-1 mouse limbs. Abst #26. Society of Toxicologic
Pathologists. Eleventh International Symposium, Phoenix, AZ, May 1992.
Rousseaux, C.G., Politis, M.J., Hrudy, S. and Keiner, J. (1992) The effect of microcystin-LR on
growth and development of cultured CD-1 mouse limbs. Abst # 306. VI International
Congress of Toxicology, Rome Italy, July 1992.
Tornesi, B., Palasz, A., Rousseaux, C.G., and Mapletoft, R.J. (1991) The effect of concentration
of albumin in different sera on mouse embryo culture. Abst. p. 19. Canada West Society
for Reproductive Biology, Saskatoon, Saskatchewan, February 1991.
Olkowski, A.A., Rousseaux, C.G., and Christensen, D.A. (1991) Association of sulfate-water
and blood thiamine concentration in cattle: a field study. Livestock research and
demonstration update, University of Saskatchewan, Saskatoon, Saskatchewan, February
1991.
Rousseaux, C.G. (1991) Postnatal effects of all-trans retinoic acid and dexamethasone in the
CD-1 mouse. Abst. #652. Canadian Federation of Biological Sciences, Kingston,
Ontario, June 1991.
MacNabb, L.G., and Rousseaux, C.G. (1991) Cadmium-induced limb reduction in CD-1 mice
investigated with a submerged limb bud culture technique. Society of Toxicology, 30th
Annual General Meeting, Dallas, TX, February 1991, Toxicologist. 11, 1, Abst #1148.
Thompson, G., and Rousseaux, C.G. (1991) The effect of water source on the development of
murine limbs in submerged culture. Society of Toxicology, 30th Annual General
Meeting, Dallas, TX, February 1991, Toxicologist. 11, 1, Abst #1149.
28
Semalulu, S.S., and Rousseaux, C.G. (1991) The role of trace elements in bovine abortion.
Society of Toxicology, 30th Annual General Meeting, Dallas, TX, February 1991,
Toxicologist. 11, 1, Abst #1352.
Kerviche, A., and Rousseaux, C.G. (1991) Comparative embryotoxicity of retinoic acid,
abscisic acid and its analogue PBI-11. Society of Toxicology, 30th Annual General
Meeting, Dallas, TX, February 1991, Toxicologist. 11, 1, Abst #1138.
Rousseaux, C.G. (1991) Dexamethasone potentiates the teratogenic action of all-trans retinoic
acid in CD1 mice. Society of Toxicology, 30th Annual General Meeting, Dallas, TX,
February 1991, Toxicologist. 11, 1, Abst #1139.
Semalulu, S.S., Salisbury, C.D.C., MacNeil, J.D., and Rousseaux, C.G. (1991) Lesions
associated with trace element aberrations in bovine fetuses. Society of Toxicologic
Pathologists, Tenth International Symposium, Monterey, CA, June 1991.
MacNabb, L.G., and Rousseaux, C.G. (1991) Oral administration of D-Penicillamine causes
neonatal mortality without morphologic defects in CD-1 mice. Annual Meeting of the
Teratology Society, Boca Raton, FL. Teratology. 43, P134.
Tornesi, B., Palasz, A.T., Liqin, T., Del Campo, M.R., Rousseaux, C.G., and Mapletoft, R.J.
(1991) Culture of mouse limb buds with various sera at concentrations based on albumin
content. International Meeting on Reproductive Technologies. The Hague, The
Netherlands, Proceedings, p. 1351, January 1991.
Tornesi, B., Palasz, A.T., Liqin, T., Del Campo, M.R., Rousseaux, C.G., and Mapletoft, R.J.
(1991) The effect of concentration of albumin in different sera and source of sera on
mouse embryos and limbs in culture. Abst # 29. Can. West. Soc. Reprod. Biol.,
Saskatoon, Saskatchewan, February 1991.
Rousseaux, C.G., and Venables, D. (1990) A Rapid Inexpensive Incubator Conversion for
Submerged Organ Culture. Society of Toxicology, 29th. Ann. Mtg. Miami Beach, FL.
Toxicologist. 10, 1, Abst #1311.
Rousseaux, C.G. (1990) Freund’s adjuvant-induced disseminated granulomas in sheep. Society
of Toxicologic Pathologists, IX International Symposium, Ottawa, Ontario, June 1990.
Rousseaux, C.G., Townsend, H.G., Phillips, O.A., and Dimmock, J.R. (1989) Toxicologic
studies on a novel antineoplastic mannich base. Society of Toxicology 28th. Ann. Mtg.,
Atlanta, GA. Toxicologist, 9, 1, Abst #502.
Kim, J.S., Rousseaux, C.G., and Blakley, B.R. (1989) The effects of thiamine on tissue
distribution of lead. Abst #352. Canadian Federation of Biological Sciences, Calgary,
Alberta, June 1989.
Olkowski, A.A., Rousseaux, C.G., Chauvet, A., Gooneratne, S.R., and Christensen, D.A. (1989)
Is polioencephalomalacia in sheep related to dietary sulphur? International Conference
on H2S Toxicity, Banff, Alberta, June 1989.
Olkowski, A.A., Rousseaux, C.G., Chauvet, A., Gooneratne, S.R., and Christensen, D.A. (1988)
Polioencephalomalacia in sheep: Association with high dietary sulphur. 38th Annual
Meeting American College Veterinary Pathologists, Kansas City, MI, November 1988.
Petrie, L., Geor, R.J., Papich, M.G., and Rousseaux, C.G. (1988) The effect of Sucralfate and
Ranitidine in foals with phenylbutazone induced gastric ulceration. Association of
Veterinary Teachers and Research Workers, Scarborough, UK, March 1988.
Willis, S.E.W., Meric, S., Jackson, M., and Rousseaux, C.G. (1988) The evaluation of platelet
aggregation in dogs with liver disease. Am. College of Vet. Internal Medicine,
Washington, DC, May 1988.
Geor, R.J., Petrie, L., Papich, M.G., and Rousseaux, C.G. (1988) Protective role of Sucralfate
and Ranitidine in foals intoxicated with phenylbutazone. Am. College of Vet. Internal
Medicine, Washington, DC, May 1988.
29
Rousseaux, C.G. (1988) The importance of trace elements in animal health. Sask Vet. Med.
Assoc. Winter meeting, February 1988.
Rousseaux, C.G. (1988) Health vs. wealth: The principles of toxicologic risk assessment.
Abst. p. 61. Ann. Acad. Env. Med. 23rd Annual Meeting, Incline Village, NV, October
1988.
Rousseaux, C.G. (1988) The failure of risk assessment procedures to protect all individuals
from ill health. Abst. p. 63. Ann. Acad. Env. Med. 23rd Annual Meeting, Incline
Village, NV, October 1988.
Mechor, G.D., Rousseaux, C.G., Radostits, O.M., Petrie, L., and Babiuk, L.A. (1987) The
protective effect of bovine Herpes virus-1 (BHV-1) colostral antibody against fatal
neonatal BHV-1 infection. World Vet. Cong., Montreal, Quebec, August 1987.
Rousseaux, C.G., Hamilton, D.L., Hancock, D.S., and Schiefer, H.B. (1987) Comparison of
pathologic changes with 59Fe uptake following oral administration of T-2 toxin to CD-1
mice. Abst. p. 129. 38th Annual Meeting Amer. College Vet. Path. Monterey, CA,
November 1987.
Rousseaux, C.G., Schiefer, H.B., Hancock, D.S., and Blakley, B.R. (1986) Carcinogenic and
immune function effects of long-term dietary T-2 toxin in CD-1 mice. FASEB,
"Trichothecenes," Copper Mountain, CO, July 1986.
Rousseaux, C.G., and Schiefer, H.B. (1986) The effect of long-term low-dose dietary and single
oral high dose of T-2 toxin on reproduction and fetal development of CD-1 mice.
FASEB, "Trichothecenes," Copper Mountain, CO, July 1986.
Rousseaux, C.G., Mechor, G.D., Petrie, L., Babiuk, L.A., and Radostits, O.M. (1986) The
protective effect of bovine herpes virus-1 (BHV-1) colostral antibody against fatal
neonatal BHV-1 infection. Abst. . 37. 37th Annual Meeting American College
Veterinary Pathologists, New Orleans, LA, December 1, 1986.
Coates, J.W., Rousseaux, C.G., and Schmutz, S.M. (1986) Multiple birth defects in a calf
associated with chromosomal trisomy. Abst. p. 3. Canadian Veterinary Medical
Association, Charlottetown, PEI, July 1986.
Schiefer, H.B., Rousseaux, C.G., Hancock, D.S., and Blakley, B.R. (1986) Long-term toxicity
of mycotoxin T-2 in CD-1 mice. Toxicol. Lett. 31 (Suppl.), S203.
Blakley, B.R., Hancock, D.S., Rousseaux, C.G., and Blakley, P.M. (1986) Prenatal exposure to
T-2 toxin and the immune system. Teratology. 33, 75C.
Coates, J.W., Rousseaux, C.G., and Schmutz, S.M. (1986) A survey of morphologically
abnormal bovine fetuses for abnormal karyotypes. Abst. p. 164. 37th Annual General
Meeting American College of Veterinary Pathologists, New Orleans, LA, December 1,
1986.
Rousseaux, C.G., and Schiefer, H.B. (1985) The effect of one oral high dose of T-2 toxin given
on different days of gestation on murine development. Abst. p. 10. Canada West
Society for Reproductive Biology, Saskatoon, Saskatchewan, February 1985.
Rousseaux, C.G. (1985) Automated differential staining for cartilage and bone in mammalian
fetuses. Abst. p. 228. Amer. Coll. of Vet. Path. Ann. Mtg., Denver, CO, December 1985.
Hamilton, D.L., Hancock, D.S., Rousseaux, C.G., and Schiefer, H.B. (1985) Effect of
intragastric T-2 toxin on 59 Fe uptake in the mouse. Abst. #91. Sixty-sixth Ann. Mtg.
Conf. of Research Workers in Animal Disease, Chicago, IL, November 1985.
Schiefer, H.B., Hancock, D.S., and Rousseaux, C.G. (1985) Role of solvents in trichothecene
toxicosis. Gordon Research Conference on Mycotoxins, Colby-Sawyer College, New
London, NH, June 1985.
30
Rousseaux, C.G., and Schiefer, H.B. (1984) Determination of the long-term reproductive and
teratogenic effects of low-level dietary T-2 toxin. Abst. p. 8. Canada West Society for
Reproductive Biology, Saskatoon, Saskatchewan, February 1984.
Rousseaux, C.G. (1984) Murine placental hemorrhage as a result of T-2 mycotoxin
administration. Abst. #PA-110. Canadian Federation Biological Societies, Saskatoon,
Saskatchewan, June 1984.
Rousseaux, C.G., and Schiefer, H.B. (1984) Comparison of the long-term effects of low dose
dietary and one oral high dose of T-2 toxin on murine reproduction and fetal
development. Abst. #254. Conf. Research Workers in Animal Disease, Chicago, IL,
November 1984.
Rousseaux, C.G., and Klavano, G.G. (1982) "Shaker" Calf Syndrome. Abst. p. 36. Canadian
Western Society for Reproductive Biology, Saskatoon, Saskatchewan, February 1982.
Jericho, K.W.F., and Rousseaux, C.G. (1982) Abortion and infections respiratory disease in a
group of cattle. Canadian Veterinary Medical Association, Quebec City, Quebec, July
1982.
Johnson, E.S., Rousseaux, C.G, Klavano, G.G, and Snitka, T.K. (1982) "Shaker" Calf
Syndrome: A newly recognized multiple systems neurofilamentous neuraxonal
degeneration. Conference of Neuropathologists, Toronto, Ontario, September 1982.
Rousseaux, C.G., and Schiefer, H.B. (1983) Determination of the teratogenic potential of
dietary T-2 toxin. Abst. #177. Conf. Research Workers in Animal Diseases, Chicago,
IL, November 1983.
Books (Peer reviewed)
Haschek, W.M., Rousseaux, C.G. and Wallig M. (2012) Haschek and Rousseaux’s Handbook
of Toxicologic Pathology. Third Edition. Volumes I, II and III, Elsevier, San Diego (in
progress.
Haschek, W.M., Rousseaux, C.G., and Wallig M. (2010) Fundamentals of Toxicologic
Pathology. Second Edition. Academic Press, San Diego. pp. 691.
Haschek, W.M., Rousseaux, C.G. and Wallig M. (2002) Handbook of Toxicologic Pathology.
Second Edition. Volumes I, and II, Academic Press, San Diego.
Haschek, W.M., and Rousseaux, C.G. (1998) Fundamentals of Toxicologic Pathology.
Academic Press, San Diego.
Hrudey, S.E., Chen, W., and Rousseaux, C.G. (1995) Bioavailability in Environmental Human
Health Risk Assessment. Lewis Publishers, Boca Raton, FA.
Haschek, W.M., and Rousseaux, C.G. (1991) Handbook of Toxicologic Pathology. Academic
Press, San Diego pp. 1081.
Book Chapters (Peer reviewed)
Rousseaux, C.G., (2010) Nomenclature: Terminology for Morphological Alterations. In
Fundamentals of Toxicologic Pathology, second edition (W.M. Haschek, C.G.
Rousseaux and M.A. Wallig, Eds.), Elsevier, San Diego. 67 – 80.
Rousseaux, C.G., (2010) Bones and Joints. In Fundamentals of Toxicologic Pathology, second
edition (W.M. Haschek, C.G. Rousseaux and M.A. Wallig, Eds.), Elsevier, San Diego.
441 - 450.
Rousseaux, C.G., (2010) Clinical Pathology. In Fundamentals of Toxicologic Pathology, second
edition (W.M. Haschek, C.G. Rousseaux and M.A. Wallig, Eds.), Elsevier, San Diego.
43 – 66.
31
Rousseaux, C.G., (2010) Developmental Pathology. In Fundamentals of Toxicologic Pathology,
second edition (W.M. Haschek, C.G. Rousseaux and M.A. Wallig, Eds.), Elsevier, San
Diego. 633 – 672.
Rousseaux, C.G., (2010) Nervous System. In Fundamentals of Toxicologic Pathology, second
edition (W.M. Haschek, C.G. Rousseaux and M.A. Wallig, Eds.), Elsevier, San Diego.
377 – 410.
Rousseaux, C.G., (2010) Endocrine System. In Fundamentals of Toxicologic Pathology, second
edition (W.M. Haschek, C.G. Rousseaux and M.A. Wallig, Eds.), Elsevier, San Diego.
513 – 552.
Hood, R., Rousseaux, C.G., and Blakley, P.M. (2002) Embryo and fetus. In Handbook of
Toxicologic Pathology (W.M. Haschek, C.G. Rousseaux and M.A. Wallig, Eds.), Vol. II
pp 895-937. Academic Press, San Diego.
Rousseaux, C.G., Haschek, W.M. and, Wallig, M.A. (2002) General Toxicologic Pathology: An
Introduction. In Handbook of Toxicologic Pathology (W.M. Haschek, C.G. Rousseaux
and M.A. Wallig, Eds.), Vol. I. pp 3-14. Academic Press, San Diego.
Gad, S.C., and Rousseaux, C.G. (2002) Use and Misuse of Statistics as an aid in Study
Interpretation. In Handbook of Toxicologic Pathology (W.M. Haschek, C.G. Rousseaux
and M.A. Wallig, Eds.), Vol. I. pp 327-418. Academic Press, San Diego.
Rousseaux, C.G., Wallig, M.A., and Haschek, W.M. (2002) Organ specific Toxicologic
Pathology: An Introduction. In Handbook of Toxicologic Pathology (W.M. Haschek,
C.G. Rousseaux and M.A. Wallig, Eds.), Vol. II pp 1-2. Academic Press, San Diego.
Panter, K.E., and Rousseaux, C.G. (1995) Overview of reproductive toxicity. In Clinical and
Diagnostic Veterinary Toxicology: A System Affected Approach. 4th Ed. (W.B. Buck,
V.R. Beasley, T.L. Carson, D.C. Dorman, G.D. Osweiler and G.A. Van Gelder, Eds.) (In
Press).
Villeneuve, D.C., Chu, I.H., and Rousseaux, C.G. (1994) Toxicological studies on mixtures of
chemical contaminants in the Great Lakes. In Toxicology of Chemical Mixtures: From
Real Life Examples to Mechanisms of Toxicological Interactions. (R. Yang, Ed.).
Academic Press, San Diego.
Rousseaux, C.G., and Blakley, P.M. (1991) The fetus. In Handbook of Toxicologic Pathology.
(W.M. Haschek and C.G. Rousseaux, Eds.), pp. 938-983. Academic Press, San Diego.
Ruben, Z., and Rousseaux, C.G. (1991) The limitations of toxicologic pathology. In Handbook
of Toxicologic Pathology. (W.M. Haschek and C.G. Rousseaux, Eds.), pp. 131-142.
Academic Press, San Diego.
Review Articles (Peer-reviewed)
Rousseaux, C.G., (2008) A review of Glutamate receptors I: Current understanding of their
biology. Japan, J Toxicol Pathol. 21: 21-51, 2008
Rousseaux, C.G., (2008) A review of Glutamate receptors II: Pathophysiology and pathology.
Japan, J Toxicol Pathol. 21: 133-173, 2008
Foster, W.G., and Rousseaux, C.G. (1995) The reproductive toxicology of Great Lakes
contaminants. Environmental Health Perspective.
Chu, I, Villeneuve, D.C., and Rousseaux, C.G. (1994) Toxicology of coal liquefaction products:
an overview. J. Appl. Toxicol. 14, 241-256.
Rousseaux, C.G. (1994) Congenital defects as a cause of perinatal mortality of beef calves. Vet.
Clinics North Amer. 10: 35-51.
Rousseaux, C.G. (1989) A practitioner's guide to defining the etiology of developmental
anomalies in livestock. Compend. Cont. Ed. 11, 1515-1521.
32
Rousseaux, C.G., and Dua, A.K. (1989) Pharmacology of HI-6, an H-series oxime. Can. J.
Physiol. Pharmacol. 67, 1183-1189.
Rousseaux, C.G. (1988) Trichothecene mycotoxins: real or imaginary toxins? Comments on
Toxicol. 2, 37-49.
Rousseaux, C.G. (1989) The hazards of fungi to man. Clin. Ecol. 6, 11-15.
Rousseaux, C.G. (1987) The use of animal models for predicting the potential chronic effects
of highly toxic chemicals. J. Haz. Materials. 14, 283-292.
Rousseaux, C.G. (1987) Developmental anomalies in farm animals. I. Theoretical
considerations. Can. Vet. J. 28, 23-29.
Rousseaux, C.G., and Ribble, C.S. (1987) Developmental anomalies in farm animals. II.
Defining etiology. Can. Vet. J. 28, 30-40.
Rousseaux, C.G. (1987) Immunologic responses that may follow exposure to chemicals. Clin.
Ecol. 5, 33-37.
Course Manuals
Rousseaux, C.G. (2009) Handbook: Overview of the life cycle of health products. Biologist
development program (BIDP), January 6, 2009 pp. 1-160
Rousseaux, C.G. (2006) Overview of Malaria Control: Presentation and practical examples. Pp.
1-10.
Rousseaux, C.G. (2002) Student Handbook: Overview of Biopharmaceuticals: the Product Life
Cycle. Pp. 1-91.
Rousseaux, C.G. (2002) Student Handbook: Body Fluids, Blood, Electrolytes, Cardiac,
Gastrointestinal, Hepatic, Pancreatic and Pulmonary Pathophysiology. Pp. 1-125.
Rousseaux, C.G. (2001) Student Handbook: Overview of Drug Development. Pp. 1-257.
Rousseaux, C.G. (2001) Student Handbook: Testing Procedures – Conventional Toxicity
Studies pp. 1-378.
Rousseaux, C.G. (2001) Student Handbook: Mechanisms of Action of Liver Toxicity pp. 1-68.
Rousseaux, C.G. (2001) Student Handbook: Evaluation of Liver Structural and Functional
Changes: Drug-related or Not? Pp. 1-68.
Rousseaux, C.G. and Smith, G. (1998) Student Handbook: Guide to using morphological
pathology for human health risk assessment of pesticides, pp. 1-334.
Rousseaux, C.G. (1989) Proving your point: The elements of research in the biomedical
sciences, University of Saskatchewan, pp. 1-60.
Rousseaux, C.G. (1988) Experimental Pathology, University of Saskatchewan, pp. 1-250,
revised 1989 pp. 1-109.
Rousseaux, C.G. (1987) A practical approach to determine the etiology of fetal anomalies.
Continuing Veterinary Education, Western College of Veterinary Medicine, University
of Saskatchewan, pp. 1-50.
Non-Peer-reviewed Publications
Kiirya, H. and Rousseaux, C.G. (2006) Malaria: Organic spray passes the test. New Vision
Newspaper, 13 December, Uganda.
Muyita, S., Natabaalo, G. and Rousseaux, C.G. (2006) Malaria: Government studies a biological
drug for malaria. Monitor, 11 December, Uganda.
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. Am. J. Vet.
Res. 66: 1111 – 1112.
33
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. Can. Vet. J.
46: 1 – 2.
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. J. Am. Vet.
Med. Assoc. 226: 1964 – 1965.
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. J. Vet. Med.
Ed. 32: 383.
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. Toxicol.
Pathol. 33: 621 – 622.
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. Vet. Clin. Path.
34: 179 – 180.
Harris, R.H. and Rousseaux, C.G. (2005). Closing the Supply vs. Demand Gap for Veterinary
Pathologists: A Multifaceted problem in need of a Multifaceted Solution. Vet. Pathol.
42: 403 – 404.
Barnes, D.G. and Rousseaux, C.G. (2005) Toxicity: Not a dirty word. Biotechnology Focus, 14
– 16, July.
Rousseaux, C.G. (2004) From the President. The Scope, 20 (2), 1, 4.
Rousseaux, C.G. and Tuomari, D. (2000) The Scientific and Regulatory Policy Committee. The
Scope, 16 (3), 5.
Rousseaux, C.G. (2000) Cause of Death and the Peto Trend Test. The Scope, 16 (3), 10.
Keenan, C.M. and Rousseaux, C.G. (2000) Into the Millennium. The Scope, 16 (1), 1.
Rousseaux, C.G. (1999) Pest Management Regulatory Agency --- Canada. The Scope, 14 (3), 8.
Rousseaux, C.G. (1996) Development of Biotechnological Products. Biotech Directory.
Rousseaux, C.G. (1989) Assessing Risk. Global Climatic Change Series. Extension and
Community Relations, pp. 191-195.
Rousseaux, C.G. (1989) Magnetic Resonance Imaging. MS Saskatchewan News. 2, 4.
Rousseaux, C.G. (1989) Planning to survive. MS Saskatchewan News. 3, 6.
Nicholson, S., and Rousseaux, C.G. (1988) Pets for a pre-school. Pre-school Information
Registry and Service Inc., Newsletter 3, 7.
Book Reviews
Rousseaux, C.G. (2000) Cannabis and Cognitive Functioning. By N. Solowij. Can. J.
Psychiatry 45: 82-83.
Rousseaux, C.G. (1992) Endocrine Toxicology. Editors: C.K. Atterwill and J.D. Flack. Can.
J. Biochem.
Rousseaux, C.G. (1991) Reproductive Pathology of Domestic Animals, by K. McEntee, Can.
Vet. J. 32, 426.
Technical Reports
Rousseaux, C.G. (2011) Review and edit symbiosis and biological control, Institute Armand
Frappier, Laval, QC
Rousseaux, C.G. (2011) Critical review of toxicology data and legal opinion, Winston and
Strawn, Chicago, USA
Rousseaux, C.G. (2011) Dry cow teat sealant, Ancare Scientific, New Zealand
34
Rousseaux, C.G. (2010) Preparation of a business plan for a generic drug manufacturing facility
in the prairies, client confidential, Canada
Rousseaux, C.G. (2010) Evaluation of extractables from the next generation proprietary dry
powder inhaler, client confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of leachables from the next generation proprietary dry
powder inhaler, client confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of the toxicity and morphology caused by inhaling acetic
acid, client confidential, NJ, USA
Rousseaux, C.G. (2010) Evaluation of the health risks of inhaled tetrahydrofuran, client
confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of the health risks of inhaled n-C16 – C40 alkanes, client
confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of the health risks of inhaled n-dodecane, client
confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of the health risks of inhaled n-tetradecane, client
confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of the health risks of inhaled acetaldehyde, client
confidential, California, USA
Rousseaux, C.G. (2010) Evaluation of plastic colorants, client confidential, California, USA
Rousseaux, C.G. (2009) Evaluation of metals in a therapeutic powder from a dry powder
inhaler, client confidential, California, USA
Rousseaux, C.G. (2009) Registration of a generic glufosinate pesticide, client confidential,
Canada
Rousseaux, C.G. (2009) Evaluation of benzene concentrations and cancer risk, client
confidential, California, USA
Rousseaux, C.G. (2009) Regulatory (pathology interpretation) support, client confidential, acne
preparation, Montreal, Canada and Research Triangle Park, USA
Rousseaux, C.G. (2009) Evaluation of extractables and leachables from a proprietary inhaler,
client confidential, California, USA
Rousseaux, C.G. (2007) Detailed development plan for a anticancer drug, client confidential,
Montreal, Canada
Rousseaux, C.G. (2008) Pharmacokinetics and PB-PK assessment of an inhaled insulin
preparation, client confidential, California, USA
Rousseaux, C.G. and Schachter, H.M. (2008) Transport of Dangerous Goods regulations and
registration, client confidential, New Jersey, USA
Rousseaux, C.G. (2008) Registration of an Agrochemical product, client confidential, USEPA –
Physical Chemistry, USA
Rousseaux, C.G. (2008) Registration of XENOBAC (Bti larvicide), Law Enforcement,
Department of Agriculture, Ministry of Agriculture, Water and Forestry, Republic of
Namibia.
Rousseaux, C.G. (2008) The Pest Management Regulatory Agency reading room – what it is an
how to use it, client confidential, Saskatoon, Saskatchewan.
Rousseaux, C.G. (2008) Registration of a generic form of the Pesticide Clethodim, client
confidential, St. Michaels, Barbados
Rousseaux, C.G. (2008) Registration of a generic form of the Pesticide Clethodim, client
confidential, St. Michaels, Barbados
Rousseaux, C.G. (2007) Registration of a generic form of the Pesticide Dicamba, client
confidential, St. Michaels, Barbados
35
Rousseaux, C.G. (2007) Evaluation of monensin for safety, efficacy, and quality, client
confidential, St. Michaels, Barbados
Rousseaux, C.G. (2007) Evaluation of livestock vaccines for safety, efficacy, quality and
potency, client confidential, St. Michaels, Barbados
Rousseaux, C.G. (2007) Critical evaluation of the Tg.AC mouse model as a regulatory
predictive tool for evaluation of dermal carcinogenicity, Stiefel Canada Inc., Montréal,
Canada
Rousseaux, C.G. (2007) Non-parametric analysis of pulmonary carcinogenesis data and
interpretation, client confidential, California, USA
Rousseaux, C.G. (2007) Critical assessment of the role of sigma receptors (1R and 2R) in the
toxicity of a novel tyrosine kinase inhibitor, client confidential, California, USA
Rousseaux, C.G. (2007) Development of a knowledge engineering white paper for the
preparation, creation and submission of materials to the Pest Management Regulatory
Agency for registration of a generic pesticide, Farmers of North America, Saskatoon,
SK, Canada
Rousseaux, C.G. (2007) Critique of the proposed “Protection of Proprietary Interests in
Pesticide Data in Canada [PPIP]” (PRO2006-3, December 2006) under the new Pest
Control product Act (in force; 2006) to replace the current “Product Specific
Registration [PSR]” (T-1-249, July 1987) requirements for the protection of proprietary
interests in data submitted to the Pest management Regulatory Agency, client
confidential, St. Michaels, Barbados.
Rousseaux, C.G. (2007) Evaluation of livestock vitamins for safety, efficacy, and quality, client
confidential, St. Michaels, Barbados
Rousseaux, C.G. (2007) Evaluation of livestock vaccines for safety, efficacy, quality and
potency, client confidential, St. Michaels, Barbados
Rousseaux, C.G. (2007) An approach to determining information and data gaps related to the
risk assessment of chemical mixtures, Health Canada, Ottawa, ON, Canada
Rousseaux, C.G. (2007) Critique of the proposed “Protection of Proprietary Interests in
Pesticide Data in Canada,” Pest Management Regulatory Agency, Health Canada,
Ottawa, ON Canada
Rousseaux, C.G. (2007) Registration of AQUABAC™ (Bti larvicide), National Drug Authority,
Kampala, Uganda
Rousseaux, C.G. (2007) The significance of dose and time response of PCNA staining following
inhalation of proprietary inhaled insulin formulation, client confidential, California, USA
Rousseaux, C.G. (2007) Registration of a generic form of Neomycin soluble, St. Michaels,
Barbados
Rousseaux, C.G. (2007) Registration of a generic form of Neomycin powder, client confidential,
St. Michaels, Barbados
Rousseaux, C.G. (2007) Registration of a generic form of Tetracycline powder, client
confidential, St. Michaels, Barbados
Rousseaux, C.G. (2006) Intra-lymphatic administration of a peptide precipitant – potential
adverse health effects, client confidential, California, USA
Rousseaux, C.G. (2006) Registration of a generic form of Ivermectin, client confidential, St.
Michaels, Barbados
Rousseaux, C.G. (2006) Registration of a generic form of the Pesticide Glyphosate, client
confidential, St. Michaels, Barbados
Rousseaux, C.G. (2006) Registration of a Disinfectant, Client and Compound Confidential,
Toronto, Canada
Rousseaux, C.G. (2005) Histopathology of Sturgeon from riviere de la prairie, Montreal, QC.
36
Rousseaux, C.G. (2006) Critique of a natural health product survey from Sweden.
Rousseaux, C.G. (2006) Evaluation of the Proprietary Issue Surrounding a generic form of the
Pesticide Glyphosate, Saskatoon, SK, Canada
Rousseaux, C.G. (2006) Differences in carcinogenic responses of the Han Wistar and SD rats
(Client and compounds are confidential).
Rousseaux, C.G. (2006) Pathology Working Group – Evaluation of Papillomas in TgAC
Transgenic Mice, Spencerville, OH, USA
Rousseaux, C.G. (2006) Issue Assessment and Work plan for a Response to the Food and Drug
Administration, Carcinogenesis Assessment Committee, Newark, NJ, USA.
Rousseaux, C.G. (2006) Needs and Issue Assessment for a Category A submission for a Novel
Biological Pesticide, Quebec City, QC, Canada
Rousseaux, C.G. (2006) Histopathology of tissues from rats treated with PBDE Bureau of
Chemical Safety, Toxicology Research Division, Food Directorate and Systemic
Toxicology & Pharmacokinetics Section, Environmental and Occupational Toxicology
Division, Health Canada
Rousseaux, C.G. (2006) Histopathology of tissues from rats treated with Dioxin and
polychlorinated biphenyls. Bureau of Chemical Safety, Toxicology Research Division,
Food Directorate and Systemic Toxicology & Pharmacokinetics Section, Environmental
and Occupational Toxicology Division, Health Canada
Rousseaux, C.G. (2006) Pathological and Toxicological Effects of Gestational and Lactational
Exposure to a Mixture of Persistent Organochlorine in Rats Bureau of Chemical Safety,
Toxicology Research Division, Environmental and Occupational Toxicology Division,
Health Canada
Rousseaux, C.G. (2005) Issue Assessment and Strategy concerning an issue with an Excipient in
a Testosterone Cream. Client and product Confidential, EMEA, Europe.
Rousseaux, C.G. (2005) Histopathology of Brains from Rats Treated with Different
Environmental Contaminants. Bureau of Chemical Safety, Toxicology Research
Division, Food Directorate and Systemic Toxicology & Pharmacokinetics Section,
Environmental and Occupational Toxicology Division, Health Canada
Rousseaux, C.G. (2005) Scientific Working Group regarding Potential Harmful Effects of
Outflow from Devil’s Lake ND, USA into the Red River MB, Canada; Winnipeg, MB.
Rousseaux, C.G. (2005) Potential Fish Pathogens and Probable Harmful Effects of Outflow
from Devil’s Lake ND, USA into the Red River MB, Canada; Winnipeg, MB.
Rousseaux, C.G. (2005) Histopathology of Sturgeon taken from pristine and polluted
environments. Université du Quebec à Montreal, Departémant de Biologie, Montreal,
QC
Rousseaux, C.G. (2005) Developmental Plan for a Biological Adjuvant, Ottawa, ON
Rousseaux, C.G. (2005) Evaluation of the Health Effects Arising from Exposure to Bacillus
thuringiensis Spores found in some Mattresses, Montreal, QC.
Rousseaux, C.G. (2005) Report and Semi-quantitative Analysis of Myelin Disposition in young
rats Treated with an Undisclosed Mixture of Environmental Chemicals. HPFB, Health
Canada, Ottawa
Rousseaux, C.G. (2005) Environmental Scan of International Biotechnology Stewardship
Activities, Office of Biotechnology and Science, HPFB, Health Canada, Ottawa
Rousseaux, C.G. (2005) Report and Analysis of Brain development in Young (PND 11 and 21)
rats Treated with a Mixture of Persistent Organic Pollutants. HECS, Health Canada,
Ottawa
Rousseaux, C.G. (2005) Contract slide reading for a Contract Research Organization (clients
and CRO cannot be disclosed).
37
Rousseaux, C.G. (2005) Critical review of a New Drug Submission with an Indication for
Prevention of Skin Damage following Therapeutic Radiation, Biologics and Genetic
Therapies Directorate, Health Canada
Rousseaux, C.G. (2005) Critical review of a New Drug Submission with an Indication for
Diagnosis of Delayed Type Contact Dermatitis, Biologics and Genetic Therapies
Directorate, Health Canada
Rousseaux, C.G., (2005) Critical review and Advice on Pesticides and Foods, CFSAN, Food
and Drug Administration, Maryland, USA.
Rousseaux, C.G. (2005) Evaluation of Brains from Rats Treated with Isoflavones for Multiple
Generations: Hematoxylin and Eosin Plus Luxol Fast Blue – Cresyl Violate Stained
Sections. Foods Directorate, HPFB, Health Canada, Ottawa
Rousseaux, C.G. (2004) Legal advice concerning an unintentional pesticide exposure (all
materials confidential)
Rousseaux, C.G. (2004) Activities and Reports as part of the Scientific Advisory Board for
CanTEST Inc.
Rousseaux, C.G. (2004) Report to the Scientific Advisory Board (medical devices and client
confidential)
Rousseaux, C.G. (2004) Preparation of a Master Product/Master Copy Registration for
Microbiological Pesticide Submissions (compounds and client confidential)
Rousseaux, C.G. (2004) Preparation of a Category A Microbiological Pesticide Submission
(compound and client confidential).
Rousseaux, C.G. (2004) Development Plan for a Therapeutic Vaccine for Neoplastic Disease
(compound and client confidential).
Rousseaux, C.G. (2004) Development plan for a New Drug, based on metabolites of a vitamin
(compound and client confidential).
Rousseaux, C.G. (2004) Critical review of a New Drug Submission with an indication for
acromegaly, Biologics and Genetic Therapies Directorate, Health Canada.
Rousseaux, C.G. (2004) Pathology Working Group: Evaluation of specific lesions in a 2,4-D
study, EPL Inc.
Rousseaux, C.G. (2004) Critical review of a New Drug Submission with an indication for
psoriasis, Biologics and Genetic Therapies Directorate, Health Canada.
Rousseaux, C.G. (2004) Critical review of a New Drug Submission with an indication for the
treatment of viral hepatitis, Biologics and Genetic Therapies Directorate, Health Canada.
Rousseaux, C.G. (2004) Guide to using Clinical and Morphologic Pathology for Human Health
Assessment of New Chemicals, Healthy Environment and Consumer Safety, Health
Canada.
Rousseaux, C.G. (2004) Guideline: Approach and Procedures for Reviewing Publications and
Third Party Data, Water Quality, Healthy Environment and Consumer Safety, Health
Canada
Rousseaux, C.G. (2003) Advice Regarding the Carcinogenicity of the Sulphate Conjugate of
DU 127090, Client confidential
Rousseaux, C.G. (2003) Critical review of the New Drug Submission with an indication for
osteoporosis, Biologics and Genetic Therapies Directorate, Health Canada.
Rousseaux, C.G. (2003) Critical review of the New Drug Submission with an indication for
osteporosis, Biologics and Genetic Therapies Directorate, Health Canada.
Rousseaux, C.G. (2003) Health product commodities risk assessment: Options analysis for the
Environmental Assessment Regulations under the Canadian Food and Drugs Act, Office
of Regulatory and International Affairs, Health Products and Foods Branch, Health
Canada
38
Rousseaux, C.G. (2003) Environmental Assessment Regulations under the Canadian Food and
Drugs Act, review of best practices and current Canadian and international activities
regarding best practices. Office of Regulatory and International Affairs, Health Products
and Foods Branch, Health Canada
Rousseaux, C.G. (2003) Proposed methodology based on current Health Canada risk assessment
and decision-making frameworks to determine the acceptability of Direct-to-Consumer
Advertising of Drugs regulated under the Canadian Food and Drugs Act, Director
Generals Office, Health Products and Foods Branch, Health Canada
Rousseaux, C.G. (2003) Guideline: Drinking water guidelines for trichloroethylene, Bureau of
water quality and health, Safe Environments Programme, Healthy Environment and
Consumer Safety branch, Health Canada.
Rousseaux, C.G. (2003) Forensic assessment and critical review of internal and external
documents relevant to direct-to-consumer advertising and marketing of therapeutics,
Office of Regulatory and International Affairs, Health Products and Foods Branch,
Health Canada.
Rousseaux, C.G. (2002) Past Policies and Standard Operating Procedures for Veterinary Drug
Review, Veterinary Drugs Directorate, Health Canada.
Rousseaux, C.G. (2002) Data Requirements for New Drug Submissions, Veterinary Drugs
Directorate, Health Canada.
Rousseaux, C.G. (2002) The Environmental Hazard Assessment of Biphenyl, Environment
Canada
Rousseaux, C.G. (2002) Critical Review of the Genotoxicity and Carcinogenicity of Carbadox,
Veterinary Drugs Directorate, Health Canada.
Rousseaux, C.G. (2002) Review of Toxicity Data and Evaluation of the Carcinogenicity of
Euginol and Methyl Euginol, Veterinary Drugs Directorate, Health Canada.
Rousseaux, C.G. (2002) Analysis, Assessment and the Acceptability of Risk, Veterinary Drugs
Directorate, Health Canada.
Rousseaux, C.G. (2002) Triage of Disputes: Alternative Dispute Resolution, Office of
Regulatory and International Affairs, Health Canada.
Rousseaux, C.G. (2001) Synopsis of Global Third Party Review Methods, Bureau of Veterinary
Drugs, Veterinary Drugs Program, Health Canada.
Rousseaux, C.G. (2001) Guideline: Guidance concerning the design, analysis and
interpretation of chronic rodent carcinogenicity studies in support of a Veterinary New
Drug Submission, Bureau of Veterinary Drugs, Veterinary Drugs Program, Health
Canada.
Rousseaux, C.G. (2001) Guideline: Guidance concerning the design, analysis and
interpretation of genotoxicity studies in support of a Veterinary New Drug Submission,
Bureau of Veterinary Drugs, Veterinary Drugs Program, Health Canada.
Rousseaux, C.G. (2001) Review Methodology for the Assessment of Benefit-Risk Posed by an
Approved Veterinary Drug, Veterinary Drugs Directorate, Health Canada.
Rousseaux, C.G. (2001) Defining Added Value given by Critical Review of Branch
Submissions. Office of Regulatory and International Affairs, Health Canada.
Rousseaux, C.G. (2001) Critical Review of Environmental Assessment of Carbadox in Swine
Production, Veterinary Drugs Directorate, Health Canada.
Rousseaux, C.G. (2001) Critical Review of Non-clinical Studies for Hemolink® New Drug
Submission, Biologic and Genetic Products Directorate, Health Canada.
Rousseaux, C.G. (2000) Proposed Change Management Strategy, Therapeutic Products
Directorate, Health Canada.
39
Rousseaux, C.G. and Li, K.Y.R. (2000) Review of the Safety Issues Pertaining to
Phenylpropanolamine, Bureau of Licensed Product Assessment, Health Canada.
Rousseaux, C.G. (2000) Critical Data Review of the Safety and Efficacy of Ear Candles, Office
of Science, Therapeutic Product Programme, Health Canada.
Rousseaux, C.G. (2000) Review of the Benefit-Risk Assessment for the Approved Therapeutic
Product Zyban® Bupropion Hydrochloride, Bureau of Licensed Product Assessment,
Health Canada.
Rousseaux, C.G. (1999) Critical Review of the Risk Assessment of THC in Industrial Hemp
Products, Environmental Health Directorate, Health Canada.
Rousseaux, C.G. (1999) A Plan for the Development and Implementation of Good Review
Practices within the Therapeutic Product Programme, Health Canada.
Rousseaux, C.G. (1999) Science, Logic and Judgement: Risk Management Policy Forum, Health
Protection Branch, Health Canada.
Rousseaux, C.G. (1999) Development Plan for a New Therapeutic Product for the Treatment of
Multiple Sclerosis, University of Alberta, compound confidential.
Rousseaux, C.G. (1999) Evaluation of Bacterial Insecticides, Client and compound confidential.
Rousseaux, C.G. (1999) Creation of a Drug Development Plan for a Barrier Cream to Protect
Individual from Intoxication by Nerve Gas Agents, Department of National Defense,
compound confidential.
Rousseaux, C.G. (1999) Histopathologic Evaluation of Burbot and Pike from Warbamun Lake
in December 1998, Golder Associates Ltd.
Rousseaux, C.G. (1999) Environmental Effects Monitoring Cycle Two Grande Prairie,
Weyerhaeuser.
Rousseaux, C.G. (1999-1997) Evaluation and Registration of Category A Submission Pesticides,
Clients and compounds confidential.
Rousseaux, C.G. (1999-1996) Evaluation and Registration of Category B Submission Pesticides,
Clients and compounds confidential.
Rousseaux, C.G. (1999-1993) Evaluations of the Toxicity of Product Components to Generate
Surrogate Safety Data, Clients and compounds confidential.
Rousseaux, C.G. (1999-1996) Risk Assessment of Bacterial Contamination of a Food Products,
Clients and foods confidential.
Johnston, G., Low, D. Rousseaux, C.G. and Louie, T. (1999) Expert Panel Review of a
Fluoroquinolone Antibiotic, Client and compound confidential.
Rousseaux, C.G. (1999-1993) Toxicity Evaluation of Product Contaminants, Clients and
compounds confidential.
Rousseaux, C.G. (1998) Evaluation of Toxic and Allergic Reactions caused by Contamination
of a natural Health Product, Client and compound confidential.
Rousseaux, C.G. (1998) Assessment of Gender and Gonadal Maturity, Golder Associates,
compound confidential.
Rousseaux, C.G. and Hobden J (1998) Pre-Clinical Evaluation and Clinical Evaluation Report
of a Nasal Steroid, Client confidential.
Rousseaux, C.G. (1998) Marketing Opportunities with respect to Endocrine Disruption, Client
and compound confidential.
Rousseaux, C.G. (1998) Issue Identification and Evaluation of a Mosquito Repellent, Client and
compound confidential.
Rousseaux, C.G. (1998) Evaluation of the Toxicity of a Compound for Preventing Soil Erosion,
Client and compound confidential.
Smith, G. and Rousseaux, C.G. (1998) Evaluation of No Hormonal Effect Levels in Pork
following Treatment with a Veterinary Drug, Client and compound confidential.
40
Rousseaux, C.G. (1998) Evaluation of Hepatic Vacuoles as an Adverse Effect for use in Risk
Assessment, Client and compound confidential.
Rousseaux, C.G. (1998) Reactivation of Drug Identification Numbers, Client and compound
confidential.
Rousseaux, C.G. (1998) Evaluation of the Toxicology of Disinfectants for Import into Canada,
Client and compound confidential.
Rousseaux, C.G. (1998) Potential Toxicity of Copper Sulphate Sheep Dip to Other Species,
Client confidential.
Rousseaux, C.G. (1998) Dose-response Study: Histopathology of Teleosts Exposed to
Kimberlite Mine Tailings, Client and compounds confidential.
Smith, G. and Rousseaux, C.G. (1998) Preparation of BLA Submission Regarding a Novel
Biopharmaceutical for the FDA, Client and compound confidential.
Rousseaux, C.G. (1998-1993) Therapeutic Product Registrations, Clients and compounds
confidential.
Rousseaux, C.G. and Smith, G. (1998) Hematological Evaluation of Squirrel and Cynomologus
Monkeys in an Animal Colony, Client and compound confidential.
Rousseaux, C.G. (1998) Evaluation of Hazardous Chemical Synthesis Plant for GMP
compliance and Bystander Toxicity Issues, Client and compound confidential.
Rousseaux, C.G. (1998) Pathology Working Group for the Evaluation of Carcinogenicity of
Electromagnetic Frequencies, US National Institute of Health.
Rousseaux, C.G. (1998) Evaluation of Hepatic Vacuoles as an Adverse Effect for use in Risk
Assessment, Client and compound confidential.
Rousseaux, C.G. and Smith, G. (1998) Guide to using Clinical and Morphologic Pathology for
Human Health Assessment of Pesticides, Pest Management Regulatory Agency.
Rousseaux, C.G. (1998) Definition of Minor Use Alterations, Data Requirements and Data
Codes for Category B Pesticide Submissions, Pest Management Regulatory Agency.
Rousseaux, C.G. (1997) Critical Review of Peer-Reviewed Literature concerning Bone Quality
issues and Salmon Calcitonin, Client and compound confidential.
Rousseaux, C.G. (1997) Expert Opinion on the Microbial Contamination of a Number of Lots of
an Antibiotic Nasal Spray during Manufacture, Client and compound confidential.
Rousseaux, C.G. (1997) Good Laboratory Practices Handbook, National Research Council,
Canada.
Rousseaux, C.G. and Smith G. (1997) Expert Panel Review Regarding a New Antibiotic, Client
and compound confidential.
Rousseaux, C.G. (1997) Warbamun Lake Fish Study: Histopathologic Evaluation of Gas
Bubble Disease in Warbamun lake, Alberta Utilities.
Rousseaux, C.G. (1997) Pulp Mill Fall 1997 Environmental Health Effects Monitoring: Teleost
Histopathology.
Rousseaux, C.G. (1997) Preclinical Expert Report for the Evaluation and Iron Chelating Agent,
Client and compound confidential.
Rousseaux, C.G. (1997) Pathology Peer Review of Rats Exposed to a Novel Biopharmaceutical
Agent, Client and compound confidential.
Rousseaux, C.G. (1997) Technical Evaluation of Histopathology as an Environmental
Monitoring Tool, Aquatic Evaluation of Toxic Effects, CanMET, Natural Resources
Canada.
Rousseaux, C.G. (1997) Evaluation of an Organophosphate Antidote for Registration as a Drug,
Department of National Defense, Compound confidential.
Rousseaux, C.G. (1997) Expert Evaluation and Pre-Clinical Report for a Novel Anti-asthmatic
Therapeutic Product, Client and compound confidential.
41
Rousseaux, C.G. (1997) Rainbow Trout Histopathology following Exposure to Effluent, Beak
Consultants Ltd, compound confidential.
Rousseaux, C.G. (1997) Development Plan for Two Novel Biotechnological Therapeutic
Products, Client and compounds confidential.
Rousseaux, C.G. (1997) Peer Review of the Pathology Findings in three Subchronic Studies,
Client and compound confidential.
Davignon, J., Rousseaux, C.G., and Larochelle, P. (1996) Expert Panel Review of a Lipid
Lowering Agent, Client and compound confidential.
Rousseaux, C.G. (1996) Histopathology of Rainbow Trout Exposed to Laboratory Water, 0.01,
0.1. 1.0 and 10% TID, Client confidential.
Rousseaux, C.G. (1996) Identification of Parasites in Lake Trout, Arctic Grayling and Cisco
Fish Samples from Lac de Gras and Lac du Sauvage, Golder Associates Ltd.
Rousseaux, C.G. (1996) Histopathology of the Nasal Cavity of Rats Treated with Test Article T3102 Intranasally, Client and compound confidential.
Rousseaux, C.G. (1996) Pathology Working Group: Lesions in the Nasal Cavity of Rats, EPL
Inc.
Rousseaux, C.G. (1996) Expert Opinion concerning the Finding of Lymphoblastic Leukemia in
a Dog during the Development of a Drug.
Rousseaux, C.G. (1996) Diavik Mine Baseline Study: Histopathologic Evaluation of Collected
Fish Samples, Golder Associates Ltd.
Rousseaux, C.G. (1996) Definition of Use Site Categories, Data Requirements and Data Codes
for Category “A” Pesticide Submissions, Pest Management Regulatory Agency.
Rousseaux, C.G. (1996-1993) Safety and Efficacy Evaluations, Bureau of Non-Prescription
Drugs, Health Canada.
Rousseaux, C.G. (1995) Histopathologic Evaluation of Fathead Minnow Fry Exposed to Mine
Tailings, Client and compound confidential.
Rousseaux, C.G. and Prior M.G. (1995) Review of Hydrogen Fluoride Toxicity, Environment
Canada.
Rousseaux, C.G. and Foster, W.G. (1995) Reproductive Ecology, International Joint
Commission for the Great Lakes.
Rousseaux, C.G. (1995) Histopathology of Rainbow Trout Exposed to Athabasca River Water,
10% TID and Napthenic Acid, Client confidential.
Mullen, J. and Rousseaux, C.G. (1995) Evaluation of the Environmental Hazards Program
Workshop on Indicators of Program Impact, Health Canada.
Rousseaux, C.G. (1994) The Correlation of Histopathologic Findings with Antemortem
Magnetic Resonance Images of Cadmium-Treated Rats, Health Canada.
Rousseaux, C.G. (1994) Testicular Pathology of 1,26 PCB-treated Rats, Health Canada.
Rousseaux, C.G. (1994) Pathological Changes seen in Cardiomyopathic Hamsters, Client and
compound confidential.
Rousseaux, C.G. (1993) Pulp Mill Effluent Exposure Study: Histopathology of Fathead
Minnows, Pulp and Paper Research Institute of Canada.
Rousseaux, C.G. (1993) Alberta Pacific Forest Industries Baseline Study: Histopathology of
Mountain Whitefish, Long nose Suckers, Walleye, Goldeye and Burbot.
Rousseaux, C.G. (1993) Ultrastructural Evaluation of the Cochlea from Exposed Guinea Pigs
following Exposure to Amikacin, Bureau of Drug Research, Health and Welfare Canada.
Rousseaux, C.G. (1993) Histopathologic Evaluation of Fry Exposed to Secondary Treatment
Effluent form a Pulp Mill, Weyerhaeuser Canada Ltd.
Rousseaux, C.G. (1993) Pathology of Femciclovir-treated Mice, BDR, Health Canada.
42
(Reports before 1993 and those that have a confidentiality agreement, which does not
allow citation, have not been included)
43