HEREDITY: INHERITANCE and TRENDS Unit Cover Page Topic Areas: DNA, Cell Reproduction and Specialization, Genetics Summary of Unit: The purpose of this unit is to assist students in formulating answers to the questions: “How are characteristics of one generation passed to the next? How can individuals of the same species and even siblings have different characteristics?” Additionally, students need to demonstrate understanding of: * the relationships of the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parent to offspring; * explain how DNA structure determines the proteins which carry out life functions through system of specialized cells; * use a model to illustrate the role of cellular division, and differentiation in producing and maintaining complex organisms; * make a defend a claim based on evidence that inheritable genetic variations may result from defined parameters, * apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population. Standards: DNA: NGSS HS-LS 1-1, HS-LS 1-4, HS-LS 3-1 Reproduction: NGSS HS-LS 1-2, HS-LS 1-4, HS-LS 3-2 Genetics: NGSS HS-LS 3-1, HS-LS 3-2, HS-LS 3-3 Literacy: RST.11-12.1 Cite specific textual evidence to support analysis of science and technical texts RST.11-12.9 synthesize information from a range of sources into a coherent understanding of a process, phenomenon, or concept, resolving conflicting information when possible. Resources: CellsAlive.com, DNAi.org, YouTube Videos (Bozeman, Crash Course), GeneticsAlive.com Key Words: Mitosis Cytokinesis Chromatid Centromere Centriole Spindle Cell Cycle Cloning Selective Breeding Nondisjunction Cyclins Stem Cells Trait Allele Hybrid Gene Gamete Sex-linked Hybridization Polyploidy Segregation Probability Punnet Square Homozygous Heterozygous Genotype Phenotype Pedigree Karyotype Mutations Homologous Diploid Haploid Meiosis Tetrad Crossing Over Incomplete Dominance Multiple Alleles Autosome Translation Transcription Co-Dominance Essential Questions: students will keep considering… How can I influence my chances of getting cancer? Why do some family members exhibit traits that are different from the rest of the family? How do genetic abnormalities affect an individual? How are traits inherited? Are they all inherited the same way? What traits did I inherit from my parents? Polygenic Dihybrid Nucleotide Transformation Chromatin Chromosome Codon Anticodon Knowledge: students will know…. All cells contain genetic information in the form of DNA molecules. Genes are regions in the DNA that contain instructions that code for the formation of proteins. (LS1.A) Each chromosome consists of a single very long DNA molecule, and each gene on the chromosome is a particular segment of the DNA. The instructions for forming species characteristics are carried in DNA. All cells in an organism have the same genetic content, but the genes expressed by the cell may be regulated in different ways. Not all DNA codes for a protein; some segments of DNA are involved in regulatory or structural functions and some have no, as yet known, function. (LS3.A) In sexual reproduction, chromosomes can sometimes swap sections in the process of meiosis, thereby creating new genetic combinations and thus more genetic variation. Although DNA replication is tightly regulated and remarkably accurate, errors do occur and result in mutations, which are also a source of genetic variation. Environmental factors can also cause mutations in genes, and viable mutations are inherited. (LS3.B) Environmental factors also affect expression of traits, and hence affect the probability of occurrences of traits in a population. Thus the variation and distribution of traits observed depends on both genetic and environmental factors. (LS3.B) In multicellular organisms individual cells grow and then divide via a process called mitosis, thereby allowing the organism to grow. The organism begins as a single cell (fertilized egg) that divides successively to produce many cells, with each parent cell passing identical genetic material (two variants of each chromosome pair) to both daughter cells. Cellular division and differentiation produce a maintain a complex organism, composed of systems of tissues and organs that work together to meet the needs of the whole organism (LS1.B) Misconceptions: All cells produce the same way. All offspring should resemble their parents. All siblings should have similar characteristics. Clones are exact copies of the original organism. The number of chromosomes does not indicate the complexity of an organism. Any two species can interbreed. Stem cells are only available through embryonic tissues.