June 24, 2014 Patient noted green stool for a few days about 7 days ago. He takes green tea capsules, glucosamine, vitamin D, metamucil. He has had some heartburn at times. Medications: METFORMIN 500 mg twice daily DIFLUNISAL - 500 mg Tablet - one Tablet(s) by mouth daily as needed for arthritic pain FINASTERIDE 5 mg Tablet - one Tablet(s) by mouthdaily SIMVASTATIN - 20 mg Tablet - 1 Tablet(s) by mouth once a day TRIAMTERENE-HYDROCHLOROTHIAZID [DYAZIDE] - 37.5 mg-25 mg Capsule CHOLECALCIFEROL (VITAMIN D3) - (OTC) - 1,000 unit Capsule MULTIVITAMIN - (OTC) Glucosamin/chondroitin Over the counter antihistamines Flonase Irrigate nose with saline daily Astelastine nasal green tea capsules, glucosamine, vitamin D, metamucil Allergies: none Past medical history: -Sinus problems had deviated septum and sees Dr. who operated on him in 2012 with good effect. -Diabetes A1c 7.6 in 2011. A1C 6/24/2013 12.2 -Knee surgery left knee replaced -Hip replaced on right side -Symptomatic internal hemorrhoids -Banded x 4 -Colonoscopy 2001, 2007, 2012 small adenomas and tics history of polyps -prostate high PSA negative biopsy 2007 sees Dr. Eyre -CPAP machine for sleep apnea 9 mm -high cholesterol -high blood pressure -Sleep apnea on CPAP -pneumovax 6/24/2014 Family history: Mother: aneurysm on kidney died at age 90 Father: anemia died at age 87 Brother: thyroid cancer age 67. Brother: melenoma. Social history: no smoking, very little alcohol. Married 3 children. Sales executive. Review of systems: Patient denies chest pain, dyspnea, orthopnea, PND, leg edema, Lightheadedness, syncope, palpitations, ongoing sinus pain and ear pain, no chest pain and exercises, no shortness of breath, not depressed, sleeps okay, bowel movements and urination are good. Assessment of any Cognitive Impairment: Patient alert oriented with no cognitive impairment Depression Screening: Over the past 2 weeks, patient expresses normal interest/pleasure in activities. Over the past 2 weeks, the patient has not felt down, depressed or hopeless. Functional Ability: Patient exhibits a steady gait and has no trouble getting up and walking from a sitting position. Patient is self-reliant and able to do household chores. Patient can handle their own medications. Patient can handle their own money. Patient has no difficulty with hearing or site and feels safe in abode. Advance Care Planning was discussed and patient will consider code status and get back in touch with me. Physical examination: gentleman in no distress. Height 67 inches. Weight 244 pounds. Pulse 81. Oxygen saturation 98 percent. Blood pressure 118/76. Thyroid: normal. Lungs: clear. Heart: regular. No murmurs. Abdomen: soft and nontender. Extremities no edema. Skin: no suspicious nevi. Plan: We discussed the need to lose weight and we discussed in depth today a weekly intermittent fasting diet of 600 calories and he is going to try this. I scolded him that we need to really follow up on his diabetes and we will get blood test today and he's to call me in a week to go over them; he will come back in 2 months so we can see how everything's going with a diet and the need for change in medication. I told him the diabetes will accelerate heart disease and many other disease processes and so we need to get on top of his. Called 6/25/14: A1C 12.2 increase Metformin to 1000 twice daily and schedule appointment to consider victozia. Note Date: 06/25/14 June 26, 2014 Patient had a physical exam with me on 6/24/14 and have blood test. His hemoglobin A1 C came back at 12.2 and I called him today and asked him to come in immediately. Medications: METFORMIN 500 mg twice daily DIFLUNISAL - 500 mg Tablet - one Tablet(s) by mouth daily as needed for arthritic pain FINASTERIDE 5 mg Tablet - one Tablet(s) by mouthdaily SIMVASTATIN - 20 mg Tablet - 1 Tablet(s) by mouth once a day TRIAMTERENE-HYDROCHLOROTHIAZID [DYAZIDE] - 37.5 mg-25 mg Capsule CHOLECALCIFEROL (VITAMIN D3) - (OTC) - 1,000 unit Capsule MULTIVITAMIN - (OTC) Glucosamin/chondroitin Over the counter antihistamines Flonase Irrigate nose with saline daily Astelastine nasal green tea capsules, glucosamine, vitamin D, metamucil Allergies: none Past medical history: -Sinus problems had deviated septum and sees Dr. who operated on him in 2012 with good effect. -Diabetes A1c 7.6 in 2011. A1C 6/24/2013 12.2 -Knee surgery left knee replaced -Hip replaced on right side -Symptomatic internal hemorrhoids -Banded x 4 -Colonoscopy 2001, 2007, 2012 small adenomas and tics history of polyps -prostate high PSA negative biopsy 2007 sees Dr. Eyre -CPAP machine for sleep apnea 9 mm -high cholesterol -high blood pressure -Sleep apnea on CPAP -pneumovax 6/24/2014 -Shingles vaccine 6/25/14 Review of systems: Patient denies chest pain, dyspnea, orthopnea, PND, leg edema, Lightheadedness, syncope, palpitations, ongoing sinus pain and ear pain, no chest pain and exercises, no shortness of breath, not depressed, sleeps okay, bowel movements and urination are good. Physical examination: gentleman in no distress. I demonstrated injection of victozia in office and educated patient and he is able to inject drug. Plan: A1C 12.2 increase Metformin to 1000 twice daily and victozia started at 0.6 for one week and then 1.2 thereafter and warned about risk of pancreatitis and thyroid cancer. If tolerates victozia will switch Bydureon(exenatide microspheres). Will test sugars daily and will get urine protein/albumin ratio. July 17, 2014 Patient had a physical exam with me on 6/24/14 and have blood test. His hemoglobin A1 C came back at 12.2 and I called him today and saw him on the next day 6/25/14 and started him on victozia. On this medication he has noted less appetite. He also has no epigastric pain but more burping and some lower abdominal cramps. He doesn't have diarrhea. I had also increased his metformin to 1000 mg from 500 twice daily. Medications: Victoza 1.2 METFORMIN 1000 mg twice daily DIFLUNISAL - 500 mg Tablet - one Tablet(s) by mouth daily as needed for arthritic pain FINASTERIDE 5 mg Tablet - one Tablet(s) by mouthdaily SIMVASTATIN - 20 mg Tablet - 1 Tablet(s) by mouth once a day TRIAMTERENE-HYDROCHLOROTHIAZID [DYAZIDE] - 37.5 mg-25 mg Capsule CHOLECALCIFEROL (VITAMIN D3) - (OTC) - 1,000 unit Capsule MULTIVITAMIN - (OTC) Glucosamin/chondroitin Over the counter antihistamines Flonase Irrigate nose with saline daily Astelastine nasal green tea capsules, glucosamine, vitamin D, metamucil Allergies: none Past medical history: -Sinus problems had deviated septum and sees Dr. who operated on him in 2012 with good effect. -Diabetes A1c 7.6 in 2011. A1C 6/24/2013 12.2 -Knee surgery left knee replaced -Hip replaced on right side -Symptomatic internal hemorrhoids -Banded x 4 -Colonoscopy 2001, 2007, 2012 small adenomas and tics history of polyps -prostate high PSA negative biopsy 2007 sees Dr. -CPAP machine for sleep apnea 9 mm -high cholesterol -high blood pressure -Sleep apnea on CPAP -pneumovax 6/24/2014 -Shingles vaccine 6/25/14 Family history: Mother: aneurysm on kidney died at age 90 Father: anemia died at age 87 Brother: thyroid cancer age 67. Brother: melenoma. Social history: no smoking, very little alcohol. Married 3 children. Sales executive. Review of systems: Patient denies chest pain, dyspnea, orthopnea, PND, leg edema, Lightheadedness, syncope, palpitations, ongoing sinus pain and ear pain, no chest pain and exercises, no shortness of breath, not depressed, sleeps okay, bowel movements and urination are good. Physical examination: gentleman in no distress. He is frequently burping. He also has some nausea. Height 68 inches. Weight 234 pounds. This is a loss of weight of 10 pounds in 3 weeks. Blood-pressure 118/75. Pulse 88. Lungs clear. Heart regular. Abdomen is soft and nontender there is no epigastric tenderness or anything suggestive of pancreatitis. Assessment and plan: Patient's insurance company does not cover Victoza I had given him samples of this and he will now be transitioned to the once weekly Bydureon(exenatide microspheres). 2 mg every 7 days. He has had symptoms of increased burping and gas off and on for a year now worse and on increased metfromin. Plan will start Omeprazole 20 mg and plan upper endoscopy. Sudden onset of worsening diabetes and abdominal symptoms will get CT to exclude pancreatic problem. I am writing to report the results of your recent Pathology test: Gastrointestinal mucosal biopsies, four: 1. Gastroesophageal junction: - Squamous mucosa with a rare eosinophil, likely nonspecific. - Scant glandular gastric-type epithelium, within normal limits. - No intestinal metaplasia identified in this limited sample. 2. Gastric body: - Fundic mucosa, within normal limits. 3. Gastric antrum: - Antral mucosa with regeneration of gastric pits, consistent with a chemical-type gastropathy. 4. Duodenum: - Duodenal mucosa, within normal limits. All okay on biopsies. August 5, 2014 Thank you very much for referring Mr. to me. As you know, he was found to have type 2 diabetes about two years ago, but the chances are that he had it longer than that. He has two recent A1c levels of 12.2 and 10.5%. He has been trying several medications. He is taking Byetta 10 mg subcutaneously twice a day without any problems. On the other hand, he continues to have problems with metformin. He feels nauseated. He does not have any diarrhea. He does not have all his energy with this. I think that at this point we should stop the metformin and try some of the other oral agents. At one point, he did get a prescription to get a Bydureon, but he could not get it because it was out of stock at the pharmacy. He also is trying to take Victoza, but it was not covered by his insurance. He sleeps well at night. He gets up in the morning feeling somewhat nauseated. He is not exercising. He is not testing his blood sugars. He also has hyperlipidemia and he is taking simvastatin 20 mg a day, which is controlling his lipids quite well except for a mild increase in triglycerides. A recent CAT scan shows that he has significant fatty liver. His blood pressure is very well controlled with Dyazide and he takes that everyday. He also has gastroesophageal reflux for which he takes 20 mg of omeprazole. He had had problems with his knees and is taking glucosamine. He was found to have low levels of vitamin D and is taking 2000 units of vitamin D everyday. His review of systems is not very contributory. He has a dry mouth and nausea. He gets up at night to urinate, but not very often. He is also taking finasteride for an enlarged prostate. About seven years ago, he had several biopsies of the prostate taken by Dr. This was all normal and his PSA has significantly decreased by now with the finasteride. He feels hot most of the time. He gets up in the morning feeling fine. He has no problems relaxing. He has very little stress in his life at the present time. His usual weight is 236 pounds for his height of 5 feet 9 inches. Ideal weight for him would be about 200 pounds. He is not watching his diet that much at the present time. Past surgical history includes a left total knee replacement and right total hip replacement, both of them done at the Baptist. He does not drink alcohol and he does not smoke. He exercises by playing golf and going to the gym at least once a week under normal circumstances, but now with the nausea feeling he is unable to do. He works for 40 hours a week. His father died of cancer. Mother died of a blood clot. He has a brother who died of melanoma. He has two daughters and a son who are all healthy. On physical examination today, his weight is 237 pounds, blood pressure 130/80. Examination of the head; ear, nose, and throat is normal. He has no retinopathy. He has very mild lens opacities. Both ear canals are completely normal. Neck reveals normal carotid pulsations without any bruits. Thyroid glands palpated within the normal limits. Skin examination is normal except for minimal keratoses in the back of his chest. Spine is straight with no kyphosis. Muscle mass is normal for his age and sex. Lungs are clear to auscultation. Heart sounds are normal sinus rhythm with no murmurs. Abdomen is soft and nontender. Liver is barely palpable on the right upper quadrant. Upper extremities are completely normal. Lower extremities showed excellent pulses, absent ankle jerks, but normal knee jerks. He has mild decrease in vibratory sensation. Filament sensation is completely normal. With Mr. we need to get him to lose weight, at least 20 pounds, and also to normalize his blood sugars. These feeling of nausea and that he has is most likely due to metformin. He is one of these unfortunate persons who cannot tolerate these medications. We are going to stop it at the present time and he should slowly start feeling better in the next couple of days. I am going to start him on Onglyza once a day. We are going to add a little bit of glipizide in the form of 10 mg twice a day. He will continue on the Byetta for the time being. Later on, as he is losing more weight. We are going to try to cut down on the oral agents, particularly on the glipizide. We are going to give him a glucose meter for him to start checking his blood sugars initially twice a day. He is going to do it fasting in the morning and two hours after a meal. I will ask him to give me a call in about two weeks with the results of his blood sugars. As soon as he starts feeling better, we are going to ask him to start walking and playing more golf. We are also going to ask him to start going to the gym to help him with the weight loss. . Active Medication list as of 08/06/14: Medications - Prescription DIFLUNISAL - diflunisal 500 mg tablet. one Tablet(s) by mouth daily as needed for arthritic pain EXENATIDE [BYETTA] - Byetta 10 mcg/dose(250 mcg/mL)2.4 mL subcutaneous pen injector. one injection sq twice daily FINASTERIDE - finasteride 5 mg tablet. one Tablet(s) by mouth daily - (new list) FLUTICASONE - fluticasone 50 mcg/actuation nasal spray,suspension. one puff(s) nare once daily GLIPIZIDE - glipizide 10 mg tablet. one tablet(s) by mouth BID ac HYDROCORTISONE ACETATE [ANUCORT-HC] - Anucort-HC 25 mg suppository. 1 Suppository(s) rectally at bedtime Use three nights prior to you next appoinment and as needed for rectal bleeding HYDROCORTISONE-PRAMOXINE - hydrocortisone-pramoxine 2.5 %-1 % rectal cream. 1 Drop Topically twice a day as needed for itching Apply to perianal area for itching OMEPRAZOLE - omeprazole 20 mg capsule,delayed release. one capsule(s) by mouth daily ONDANSETRON - ondansetron 4 mg disintegrating tablet. one tablet,disintegrating(s) by mouth up to four times daily prn vomiting SAXAGLIPTIN [ONGLYZA] - Onglyza 5 mg tablet. one tablet(s) by mouth once a day SIMVASTATIN - simvastatin 20 mg tablet. 1 Tablet(s) by mouth once a day TRIAMTERENE-HYDROCHLOROTHIAZID [DYAZIDE] - Dyazide 37.5 mg-25 mg capsule. one Capsule(s) by mouth daily Medications - OTC CHOLECALCIFEROL (VITAMIN D3) - cholecalciferol (vitamin D3) 1,000 unit capsule. one Capsule(s) by mouth daily - (OTC) MULTIVITAMIN - multivitamin capsule. 1 Tablet(s) by mouth once a day - (OTC) HISTORY OF PRESENT ILLNESS: comes in today after his recent visit. He had had an episode of diarrhea with some nausea and vomiting last night, probably related to something that he ate. What is of concern to him is that his urine was very dark. He was concerned that there was something going on with his urine. PHYSICAL EXAMINATION: ABDOMEN: On physical examination, his abdomen was completely normal. VITAL SIGNS: Blood pressure was 120/70. His pulse was 72 per minute. His temperature was normal. ASSESSMENT AND PLAN: Up on analyzing the urine, it was completely normal. He then remembered having eating some beets the night before and we believe that that is the cause for the changes in the color of his urine. Note Date: 11/19/14 Medications - Prescription DIFLUNISAL - diflunisal 500 mg tablet. one Tablet(s) by mouth daily as needed for arthritic pain EXENATIDE [BYETTA] - Byetta 10 mcg/dose(250 mcg/mL)2.4 mL subcutaneous pen injector. one injection sq twice daily FINASTERIDE - finasteride 5 mg tablet. one Tablet(s) by mouth daily - (new list) FLUTICASONE - fluticasone 50 mcg/actuation nasal spray,suspension. one puff(s) nare once daily GLIPIZIDE - glipizide 10 mg tablet. one tablet(s) by mouth BID ac HYDROCORTISONE ACETATE [ANUCORT-HC] - Anucort-HC 25 mg suppository. 1 Suppository(s) rectally at bedtime Use three nights prior to you next appoinment and as needed for rectal bleeding HYDROCORTISONE-PRAMOXINE - hydrocortisone-pramoxine 2.5 %-1 % rectal cream. 1 Drop Topically twice a day as needed for itching Apply to perianal area for itching NYSTATIN-TRIAMCINOLONE - nystatin-triamcinolone 100,000 unit/gram-0.1 % topical ointment. apply locally twice a day OMEPRAZOLE - omeprazole 20 mg capsule,delayed release. one capsule(s) by mouth daily ONDANSETRON - ondansetron 4 mg disintegrating tablet. one tablet,disintegrating(s) by mouth up to four times daily prn vomiting SAXAGLIPTIN [ONGLYZA] - Onglyza 5 mg tablet. one tablet(s) by mouth once a day SIMVASTATIN - simvastatin 20 mg tablet. 1 Tablet(s) by mouth once a day TRIAMTERENE-HYDROCHLOROTHIAZID [DYAZIDE] - Dyazide 37.5 mg-25 mg capsule. one Capsule(s) by mouth daily Medications - OTC CHOLECALCIFEROL (VITAMIN D3) - cholecalciferol (vitamin D3) 1,000 unit capsule. one Capsule(s) by mouth daily - (OTC) MULTIVITAMIN - multivitamin capsule. 1 Tablet(s) by mouth once a day - (OTC) --------------- --------------- --------------- --------------HISTORY OF PRESENT ILLNESS: Mr. comes in because of the recent onset of constipation. In the past, he had problems with hemorrhoids that required treatment here at the medical center. He was doing very well for the last five or six months. For the last couple of weeks, he noticed that he has significant constipation. He has been taking Metamucil and stool softener every day. He also has some lower abdominal discomfort. He may go for two days without moving his bowels. Then, it will take him an hour to relieve himself. He is taking all his usual medications including Byetta 10 mg twice a day. His blood sugars are more or less controlled with occasional increases up to 116 mg/dl. He put on 9 pounds in weight. PHYSICAL EXAMINATION: GENERAL: Today, he has 2 to 3+ external hemorrhoids. He also has 1+ internal hemorrhoid. Rectum is completely empty. His prostate is slightly enlarged. Guaiac is negative. He had, had a colonoscopy recently. ASSESSMENT AND PLAN: I am going to give him an appointment to put outside around the hemorrhoid because that might be playing a role in his constipation. I will ask him to increase the stool softener to two a day and Metamucil also to twice a day. We will wait about two weeks and see if he gets better or not. .Procedure Tissue received Report Date date 11/08/2012 11/08/2012 Previous biopsies: 12-43038C 07-48174C 07-22531C 05-01871C (and more) Diagnosed by 11/12/2012 DR. I GI BX (2 JARS) NEEDLE PROSTATE BIOPSIES 12. COLON BX (1). PROSTATE BX'S. DIAGNOSIS: 1. Nasal sinus contents, right (A): Sino-nasal type mucosa with fibrosis, squamous metaplasia and chronic inflammation including eosinophils; bone fragments. 2. Nasal sinus contents, left (B): Sino-nasal type mucosa with fibrosis, squamous metaplasia and chronic inflammation including eosinophils; bone fragments. Clinical: Chronic sinusitis; turbinate hypertrophy. Gross: The specimen is received fresh in two parts, both labeled with the the medical record number. Part 1 is additionally labeled "right nasal sinus contents." It consists of multiple pink-tan fragments of tissue measuring 2.0 x 1.5 x 0.4 cm in aggregate. The specimen is placed in histo wrap and entirely submitted in cassette A. Part 2 is additionally labeled "left nasal sinus contents." It consists of multiple pink-tan fragments of tissue measuring 1.9 x 1.6 x 0.4 cm in aggregate. The specimen is placed in histo wrap and entirely submitted in cassette B.