MINISTRY OF HEALTHCARE OF UKRAINE PIROGOV VINNYTSYA NATIONAL MEDICAL UNIVERSITY The Pharmaceutical Chemistry Department Analytical chemistry MODULE 2 Methodical guidelines for self-preparatory work of second-year students Vinnytsya 2013 «Approved» by Methodical council of Pirogov National Medical University of Vtinnytsya Minutes №2 from 20.11.2013 year Approved at the meeting of the Pharmaceutical Chemistry Department Re- Approved Minutes № 4 from 01.11.2013 year Head of the Pharmaceutical Chemistry Department _______________________ PhD Assistant Professor Yuschenko T.I. Minutes № 1 from 28.08.2014 year Head of the Pharmaceutical Chemistry Department Re- Approved ________________________ Minutes № ___ from 20____ year Head of the Pharmaceutical Chemistry Department _______________________ Authors Teachers of Pirogov Vinnytsya National Medical University (the pharmaceutical chemistry department): T.I. Yuschenko, A.E. Kosareva, L.V. Slobodyanyuk Рецензенти: - доцент кафедри хімії та хімічної технології Вінницького національного технічного університету, к.х.н., М.В.Євсєєва - доцент кафедри біологічної та загальної хімії Вінницького національного медичного університету імені М.І. Пирогова, к.х.н. О.В.Смірнова The Methodical guidelines created at the Pharmaceutical Chemistry Department of the Pirogov Vinnytsya National Medical University. The Methodical guidelines is made according to the requirements of the typical curriculum in analytical chemistry for the students of pharmaceutical higher schools and pharmaceutical departments of medical higher schools of the IIId – IVth accreditation levels (Specialization "Pharmacy ", "Clinical Pharmacy"). The given guidelines are intended for self-preparation and control of the mastering the level of knowledge of second-year students from module 2. Introduction The program of analytical chemistry is structured into 3 modules. It is consistent with the teaching standarts, the principles of Bologna process and improves students performance. Module 2 includes the study of theoretical foundations and mastering practical skills of chemical methods of quantitative analysis. Control mastering of knowledge of the modules is carried out after its the completion on the final lessons. These guidelines are intended for self-preparation of students to the practical lessons and final control of knowledge from module 2 "Quantitative Analysis". Test questions for the studens in – class and out – of class training are presented in the guidelines, which help to check the degree of learning of the theoretical material. At the end of the guidelines there is a list of recommended literature. The Methodical guidelines is made according to the requirements of the typical curriculum in analytical chemistry for the students of pharmaceutical higher schools and pharmaceutical departments of medical higher schools of the IIId – IVth accreditation levels (Specialization "Pharmacy ", "Clinical Pharmacy"). The given guidelines are intended for self-preparation and control of the mastering the level of knowledge of second-year students from module 2. The content of the test task The answer and substantiation 1. Gravimetric analysis 1.1. To determine calcium mass concentration in a medical preparation the gravimetric precipitation method was applied. Ammonium oxalate solution was used as a precipitator. The gravimetric form in this case is: A. Monohydrous calcium oxalate B. Anhydrous calcium oxalate C. Calcium carbonate D. Calcium oxide E. Calcium hydroxide 1.2. To determine Cu2+ mass concentration in a medical preparation the gravimetric precipitation method was applied. What matter can be used as a precipitator for this determination: A. NH4OH B. NaOH C. HCl D. H2SO4 E. HNO3 1.3. Choose the precipitation form which will coincide after a chemical formula with a gravimetrical form: A. BaSO4 B. CaC2O4 C. Fe(OH)3 D. Al(OH)3 E. Cr(OH)3 1.4. In In determining the moisture content of pharmaceuticals, the drug was heated to convert water into gas state. What method of analysis has been applied? A. Electrogravimetry B. Indirect Volatilization gravimetry C. Precipitation gravimetry D. Particulate gravimetry E. Precipitation titrimetry 1.5. To determine aluminum mass concentration in a medical preparation the gravimetric precipitation method was applied. Ammonium solution was used as a precipitator. The gravimetric form in this case is: A. Aluminum carbonate B. Ammonium carbonate C. Aluminum oxide D. Ammonium hydroxide E. Aluminum hydroxide 1.6. Which material should be selected as the precipitable form by gravimetric determination of sulphate ions: А. PbSO4, KSP = 1,6∙10 -8 B. CaSO4 , KSP = 2,5∙10-7 C. BaSO4, KSP = 1,1∙10-10 D. SrSO4, KSP = 3,2∙10-7 E. AgSO4, KSP = 1,6∙10-5 1.7. To determine sulfate ions mass concentration in a medical preparation the gravimetric precipitation method was applied. Barium chloride solution was used as a precipitator. Choose a solution for washing the precipitate of barium sulfate: A. Distilled water B. Diluted sulfuric acid solution C. Sodium sulfate solution D. Barium chloride E. Diluted nitric acid solution 1.8. To determine Cr3+ mass concentration in a medical preparation the gravimetric precipitation method was applied. What matter can be used as a precipitator for this determination: A. NaOH B. H2O2 C. NH4OH D. H2SO4 E. HCl 1.9. During gravimetric determination of mass fraction of sulfate ions in the magnesium sulphate preparation precipitation is performed by means of barium chloride solution. Precipitated barium sulfate should be rinsed with: A. Diluted solution of sulfate acid B. Distilled water C. Solution of barium chloride D. Solution of sodium sulfate E. Solution of hydrochloride acid 1.10. Gravimetric determination of carbonate ions in the contaminated sample CaCO3 conducted by: A. Electrogravimetry B. Direct volatilization gravimetry C. Precipitation gravimetry D. Particulate gravimetry E. Precipitation titrimetry 1.11. Specify the balance for the mass exact measuring: A. Hand balance B. Technochemical balance C. Technical balance D. Analytical balance E. Torsion balance 2. Titrimetric analysis 2.1. Select chemical vessels to measure the exact amount of titrant in titrimetric methods of analysis: A. Measuring cylinder B. Volumetric flask C. Burette D. Conical flask E. Pipette 2.2. Select the substance from which you can prepare a primary standard solution: A. NaOH B. K2Cr2O7 C. HCl D. KMnO4 E. CH3COOH 2.3. Specify the titration method, in which a standardized titrant solution is gradually added to the solution under study until a titration endpoint is reached: A. Direct titration B. Back titration C. Indirect titration D. Substitution titration E. Residue titration 3. Acid-base titration 3.1. What methods of acid-base titration can be used to determine the amount of acetic acid in the solution: A. Argentometry B. Acidimetry C. Alkalimetry D. Mercurometry E. Mercurimetry 3.2. A chemist in analytical laboratory needs to standardize solution of sodium hydroxide. What primary standard solution can be applied for this purpose? A. Chloride acid B. Nitric acid C. Oxalic acid D. Acetic acid E. Sodium tetraborate 3.3. Ammonia concentration in solution was determined by acid-base titration. Solution of sodium hydroxide was used as titrant. What standard solution can be used to standardize a solution of sodium hydroxide: A. Sodium tetraborate B. Acetic acid C. Silver nitrate D. Chloride acid E. Potassium carbonate 3.4. What pH indicator is used to determine the endpoint for the titration of acetic acid solution by NaOH solution: A. Titrated without indicator B. Phenolphthalein C. Methyl orange D. Both indicators E. Eosin 3.5. pH indicator is used to determine the endpoint in the acid-base titration. One of the methods for selecting the indicator - on the titration curve. Titration curve of the acid-base titration - a graphical dependence of: A. pH on the volume of analyzed solution B. Concentration of analyzed solution on the volume of added titrant C. pH on the volume of added titrant D. Concentration of analyzed solution on the concentration of titrant E. Concentration of titrant on the volume of analyzed solution 3.6. Which of the laws is the theoretical basis of titrimetric methods of analysis: A. Law of equivalent proportions B. Law of definite composition C. Law of conservation of mass D. Law of multiple proportions E. Nernst law 3.7. Select the secondary standard for standardization 0.1M potassium hydroxide solution: A. Chloride acid B. Sodium chloride C. Oxalic acid D. Sodium hydroxide E. Sodium tetraborate 3.8. What is the result of the titration is necessary to calculate the concentration of the analyzed solution in titrimetric methods of analysis: A. Concentration of the titrant, which reacted with analyzed substance B. The volume of titrant, which is expended for the reaction with the analyzed substance C. The mass of the reagent, which reacted with the analyzed substance D. The volume of analyzed solution, which reacted with titrant E. The mass of analyzed solution 3.9. Choose a couple of standard materials which can be used for standardization acid solutions: A. CaCO3, Na2B4O7 .10 H2O B. Na2CO3, NaCl C. H2C2O4 .2 H2O, Na2B4O7 .10 H2O D. Na2CO3, Na2B4O7 .10 H2O E. CaCO3, Na2CO3 3.10. Select the definition for the equivalence point in acid-base titration: Equivalence point is the point at which: A. You observe change of solution color B. Volume of the added titrant is equal to the volume of analyzed solution C. Number of titrant is strictly equivalent to the amount of titrated substance D. The time of the titration when the pH = 7 E. Occurrence of sediment 3.11. A chemist in an analytical laboratory needs to standardize a hydrochloric acid solution. What primary standard solution can be used for this purpose? A. Sodium hydroxide B. Oxalic acid C. Sodium tetraborate D. Acetic acid E. Sodium chloride 3.12. The drug contains sodium bicarbonate and sodium chloride. Suggest a method for quantitative determination of sodium bicarbonate: A. Argentometry B. Acid-base titration C. Complexometric titration D. Oxidation-Reduction titration E. Mercurimetry 3.13. Specify standard substances used for standardization of titrant solutions (NaOH, KOH) in the alkalimetric method: A. Oxalic and succinic acids B. Acetic and succinic acids C. Formic and acetic acids D. Sulphanilic and oxalic acids E. Sulphanilic and salicylic acids 3.14. What method of titrimetric analysis can be applied for the quantitative determination of sulphuric acid by means of the potassium hydroxide solution? A. Alkalimetry B. Acidimetry C. Oxidation-reduction D. Precipitation E. Complexation 3.15. Choose a pair of titrants for the qualitative determination of ammonia in a solution by the method of back titration: A. HCl, NaOH B. HCl, H2SO4 C. KOH, NaOH D. NaOH, KCl E. H2SO4, K2SO4 3.16. Specify the equivalence factor of Na2СО3 in quantitative determination according to the reaction Na2СО3 + HCl = NaCl+NaHCO 3: А. f=2 B. f=1/2 C. f=1/4 D. f=1 E. f=1/3 3.17. Specify the equivalence factor of H2SО4 in quantitative determination according to the reaction H2SО4 + 2NaOH = Na2SО4+2H2O: А. f=2 B. f=1/2 C. f=1/4 D. f=1 E. f=1/3 3.18. Choose a pair of titrants for the qualitative determination of ammonia in a solution by the method of back titration: A. HCl, NaOH B. HCl, H2SO4 C. KOH, NaOH D. NaOH, KCl E.H2SO4, K2SO4 4. Redox titration 4.1. The endpoint in the analysis of oxidizing and reducing agents by methods of the redox titration is determined: A.Without indicator B. Using redox indicators C. With specific indicator D. By instrumental methods E. By all these methods 4.2. Redox indicators are used to determine the endpoint in redox titration methods. The color of the redox indicator depends on: A. The degree of ionization of the substance B. Concentration of hydrogen ions C. Ionic strength of solution D. Redox potential of the system E. Concentration of hydroxide ions 4.3. Titration curve of the redox titration - a graphical dependence of: A. pH on the volume of analyzed solution B. Concentration of analyzed solution on the volume of added titrant C. pH on the volume of added titrant D. Concentration of analyzed solution on the concentration of titrant E. Redox potential of the system on the volume of added titrant 4.4. 0,1M solution of potassium permanganate is used as a titrant in permanganatometry. The solution is prepared like the secondary standard solution and standardized according to: A. Sodium chloride B. Potassium dichromate C. Sodium oxalate D. Sodium carbonate E. Calcium oxide 4.5. Which indicatorless method enables quantitative determination of iron (II) content? A. Permanganatometry B. Chelatometry C. Argentometry D. Iodometry E. Nitritometry 4.6. Choose a pair of substances that can be used for standardization of 0,1 M solution of KMnO4: A. Na2C2O4, CH3COOH B. K2CO3, CH3COOH C. CH3COOK, H2C2O4 D. KHC2O4, HCOOH E. Na2C2O4, H2C2O4 4.7. Permanganatometry can be can be used for determination of H2O2 in high-acidity medium. What acid can be used for production of such medium? A. HCl B. H2SO4 C. HNO3 D. CH3COOH E. H3PO4 4.8. What substance can be quantitatively determined by method of acid-base titration and oxidation-reduction titration? A. Sodium hydroxide B. Acetic acid C. Sodium sulphate D. Oxalate acid E. Ammonium chloride 4.9. In permanganatometric titration, a solution containing iron (II) ion is titrated with a solution of potassium permanganate. Equivalence factor of the potassium permanganate in the reaction equal to: A. 1/3 B. 1 C. 1/2 D. 1/5 E. 1/4 4.10. 0,1M solution of potassium permanganate is used as a titrant in permanganatometry for determination of reducing agents. The endpoint of permanganatometric titration is determined: A. Without indicator B. Using redox indicators C. With specific indicator D. By instrumental methods E. With external indicator 4.11. Select indicatorless method for quantitative determination of reducing agents (for example, sodium nitrite) content? A. Cerimetry B. Dichromatometry C. Permanganatometry D. Iodometry E. Nitritometry 4.12. In permanganatometric titration, a solution containing iron (II) ion is titrated with a solution of potassium permanganate. Equivalence factor of the iron (II) in the reaction equal to: A. 1/3 B. 1 C. 1/2 D. 1/5 E. 1/6 4.13. Reinhardt-Zimmerman solution (H2SO4 con. + H3PO4 + MnSO4) is used for iron in permanganatometry for iron (II) determination phosphoric acid should be added to: A. Create a highly acidic environment B. As an indicator C. For the masking of Fe(III) ions D. Create an alkaline environment E. As a catalyst 4.14. Reinhardt-Zimmerman solution (H2SO4 con. + H3PO4 + MnSO4) is used for iron in permanganatometry for iron (II) determination manganese sulfate is added to: A. Create a highly acidic environment B. As an indicator C. For the masking of Fe(III) ions D. Create an alkaline environment E. As a catalyst Iodometry 4.15. Concentration of potassium dichromate in a solution was determined by means of iodometry. Name a titrant of iodometric method for determination of strong oxidizer: A. Potassium iodide B. Sodium hydroxide C. Sodium thiosulfate D. Potassium permanganate E. Potassium bromate 4.16. Concentration of potassium dichromate in a solution was determined by means of iodometry. Name a titrant of iodometric method for determination of strong oxidizer: A. Potassium iodide B. Sodium hydroxide C. Sodium thiosulfate D. Potassium permanganate E. Potassium bromate 4.17. Iodometric determination of formaldehyde in formaline can be done by the back titration. Iodine surplus is titrated with the standard solution of: A. Sodium thiosulphate B. Sodium nitrate C. Sodium sulphate D. Sodium carbonate E. Sodium phosphate 4.18. Name the type of reaction that takes place during detection of ascorbic acid in a preparation by iodometric method: A. Neutralization B. Acylation C. Oxidation-reduction D. Precipitation E. Complexing 4.19. Specify the standardized solutions that can be used for direct and back titration of reducing agents in the iodimetric method: A. K2Cr2O7, I2 B. K2Cr2O7, Na2S2O3 C. I2, KI D. KMnO4, KI E. I2, Na2S2O3 4.20. Name a standard solution of iodimetric determination of reducing agents (direct titration)? A. Solution of KI B. Solution of KMnO4 C. Solution of Na2S2O3 D. Solution of K2Cr2O7 E. Solution of I2 4.21. Quantitative determination of iodide can be done by method of: A. Chelatometry B. Acid-base titration C. Oxidation-reduction titration D. Spectrophotometry E. Precipitating titration 4.22. Iodometric determination of formaldehyde in formaline can be done by the back titration. Iodine surplus is titrated with the standard solution of: A. Sodium thiosulphate B. Sodium nitrate C. Sodium sulphate D. Sodium carbonate E. Sodium phosphate 4.23. Standardized sodium thiosulfate solutions are used as titrant in iodometric titration. Equivalence factor of the sodium thiosulfate (Na2S2O3) equal to: A. 1/3 B. 1 C. 1/2 D. 1/5 E. 1/4 4.24. Choose a pair: standardized solution and additional reagent, that can be used for indirect titration of oxidizing agents in the iodometric method: A. K2Cr2O7, I2 B. Na2S2O3, KI C. I2, KI D. KMnO4, KI E. I2, Na2S2O3 4.25. In which method of redox titration starch (specific indicator) is used to detect the end point: А. Cerimetry B. Bromatometry C. Iodometry D. Nitritometry E. Permanganatometry 4.26. Potassium dichromate can be used for standardization of sodium thiosulfate solution. What titration method is used in this case: A.Back titration in an alkaline environment B.Direct titration in strongly acidic medium C.Back titration in acidic medium D.Indirect titration in acidic medium E. Direct titration in an alkaline environment Nitritometry 4.27. Specify the relevant indicators for fixation of the titration endpoint when using nitritometric method: A. Methylene orange B. Methylene blue C. Tropeolin 00 + methylene blue D. Starch solution E. Diphenylamine 4.28. Nitritometric determination of compounds containing primary aromatic amino group can be carried out under the following conditions: A. With observation of all the mentioned conditions B. At a temperature up to 10oC C. With adding of the crystalline KBr (catalyst) D. Chloric acid excess E. Slow titration 4.29. Nitritometric determination of primary aromatic amines in acidic medium results in generation of the following reaction product: A. Azide B. Nitrosoamine C. Nitrose arylenamine D. Nitrose antipyrine E. Diazonium salt 4.30. Name the method of redox titration in which both external and internal indicators are used to determine the end point: А. Cerimetry B. Bromometry C. Chelatometry D. Nitritometry E. Permanganatometry 4.31. Streptocide can be quantitatively determined by nitritometric titration. Equivalence factor of the streptocide equal to: A. 1/3 B. 1 C. 1/2 D. 1/5 E. 1/4 Bromatometry 4.32. It is required to determine the amount of sodium salicylate in a solution. What titrimetric method can be applied for the quantitative determination of aromatic compounds? A. Bromometry B. Mercurimetry C. Cerimetry D. Argentometry E. Chelatometry 4.33. Choose an appropriate indicator for fixation of titration end point in method of bromatometry: A. Tropeolin 00 B. Phenolphthalein C. Starch D. Methyl blue E. Methyl red 4.34. Select the method in which pH indicators are used to determine the end point: А. Cerimetry B. Bromatometry C. Iodometry D. Nitritometry E. Permanganatometry 4.35. What titrimetric method can be applied for the quantitative determination of phenol (carbolic acid)? A. Nitritometry B. Bromometry C. Chelatometry D. Argentometry E. Cerimetry 4.36. Streptocide can be quantitatively determined by bromatometric titration. What standard solution is used as titrant? A. Potassium permanganate solution B. Potassium iodide solution C. Potassium bromate solution D. Sodium nitrite solution E. Cerium (IV) sulphate solution 4.37. Streptocide can be quantitatively determined by bromatometric titration. Equivalence factor of the streptocide equal to: A. 1/6 B. 1 C. 1/2 D. 1/5 E. 1/4 Dichromatometry 4.38. Choose a reduction-oxidation method for the quantitative determination of iron (II) salts in a solution that contains hydrochloric acid: A. Dichromatometry B. Iodometry C. Permanganatometry D. Nitritometry E. Ascorbinometry 4.39. Content of potassium dichromate in a solution was determined by iodometric method. Name the titrant of iodometric method for oxidant determination: A. Potassium permanganate B. Sodium hydroxide C. Potassium iodide D. Sodium thiosulfate E Potassium bromate 4.40. Iron (II) ion was determined by dichromatometric titration. Equivalence factor of the potassium dichromate in the reaction equal to: A. 1/3 B. 1 C. 1/2 D. 1/6 E. 1/4 4.41 0,1M solution of potassium dichromatomate is used as a titrant in dichromatometry for determination of reducing agents. The endpoint of dichromatometric titration is determined: A. Without indicator B. Using redox indicators C. With specific indicator D. By instrumental methods E. With external indicator Cerimetry 4.42. A chemist in an analytical laboratory needs to standardize a cerium(IV) sulphate solution by iodometric titration. What primary standard solution can be used for this purpose? A. Potassium permanganate B. Sodium hydroxide C. Potassium iodide D. Sodium thiosulphate E. Potassium bromate 4.43. Ascorbic acid was determined by cerimetric titration. The endpoint was determined by a color change of the solution from red to blue. What indicator was used to determine the endpoint? A. Tropeolin 00 B. Phenolphthalein C. Ferroin D. Methyl red E. Starch 4.44. 0,1 M solution of cerium(IV) sulphate is used as a titrant in cerimetry for determination of reducing agents, for example iron (II) sulphate in drug. Equivalence factor of the cerium(IV) sulphate in the reaction equal to: A. 1/3 B. 1 C. 1/2 D. 1/6 E. 1/4 5. Precipitation titration 5.1. Thiocyanatometry is based upon using of secondary standard solution of potassium thiocyanate that should be standardized according to the following standard solution of: A. Silver nitrate B. Hydrochloric acid C. Sulfuric acid D. Iron (II) sulfate E. Copper (II) nitrate 5.2. Determination of sodium and potassium chlorides in pharmaceuticals can be done by means of: A. Argentometry, Mohr method B. Reduction-oxidation titration C. Alkalimetry D. Acidimetry E. Chelatometry 5.3. What standard solution (titrant) is used in Folgard's method of direct titration? A. Ammonium thiocyanate B.Sodium chloride C. Silver nitrate D. Potassium chromate E. Potassium dichromate 5.4. A composition under examination contains ions of Cl–, Br– and I– in equimolar quantities. The sequence of precipitate formation in course of argentometric titration will be determined by: A. Solubility product of the corresponding silver halogenides B. Value of oxidation-reduction potentials C. Way of titration - either back or direct D. Value of corresponding ion mobility E. Ionic strength of solution 5.5. What is the primary standard for standardization of Hg2(NO3)2 solution? A. Sodium chloride B. Sodium bromide C. Sosium sulphate D. Sodium hydroxide E. Sodium dichromate 5.6. Determination of sodium chloride by Folgard's method involves the following techniques: A. Back titration, argentometry B. Direct titration, argentometry C. Substitute titration D. Back titration, mercurimetry E. Direct titration, mercurimetry 6. Complexometric titration 6.1. Calcium chloride quantitative content can by measured by direct chelatometric titration method. Choose an indicator for the titration end point registering: A. Methyl red B. Starch C. Eosin D. Phenolphthalein E. Eriochrome black T 6.2. Chlorides presence in drinking water can be detected by mercurimetry method. One of the following solutions is used as titrant: A. Hg2(NO3)2 B. Hg(NO3)2 C. HgSO4 D. HgCl2 E. Hg2Cl2 6.3. Titrant of chelatometry method is trilon B solution that forms complex compounds with metal cations irrespective of their valence at a ratio of: A. 1 3 B. 1 2 C. 1 1 D. 2 1 E. 3 1 6.4. The drug contains calcium chloride. Suggest a method for quantitative determination of calcium: A. Precipitation titration B. Acid-base titration C. Chelatometry titration D. Oxidation-Reduction titration E. Mercurimetry titration 6.5. A chemist in an analytical laboratory needs to standardize an EDTA solution. What primary standard solution can be used for this purpose? A. Sodium chloride B. Zinc sulfate C. Chlorohydrogen acid D. Potassium sulfate E. Mercury (II) nitrate 6.6. Mercurometry method is used to determine the amount of halides in the solution. Select indicator to determine the endpoint for the mercurometric titration: A. Eriochrome black T B. Diphenylcarbazone C. Methyl orange D. Titrated without indicator E. Phenolphthalein 6.7. Chelatometry method is used for quantitative determination of: A. Halides B. Alkaline metals C. Alkaline heavy metals D. Alkaline earth and heavy metals E. Acids and bases 6.8. Mercury (II) nitrate solution is used as titrant to determine the amount of halides in the solution. What the primary standard substance can be used to standardize the mercury (II) nitrate solution: A. Chloride acid B. Sodium sulfate C. Sodium chloride D. Zinc sulfate E. Zinc chloride 6.9. Water Hardness can be determined by complexometric titration. Select conditions of determination: A. Ammonium buffer solution, eriochrome black T B. Ammonium buffer solution, diphenylcarbazone C. Acetic buffer solution, eriochrome black T D. Ammonium buffer solution, titrated without indicator E. Acetic buffer solution, diphenylcarbazone 6.10. In a complexometric titration, a solution containing the free metal ion is titrated with a solution of chelating agent until all of the metal ions are completely complexed. Equivalence factor of the metal in the complexometric titration method always equal to: A. 1/3 B. 1 C. 1/2 D. 2 E. 1/4 6.11. Mercurometry method is used to determine the amount of halides in the solution. What solution is used as titrant: A. Mercury (II) nitrate B. Mercury (I) nitrate C. Mercury (II) chloride D. Mercury (I) chloride E. Mercury (II) sulfate 6.12. Magnesium sulfate solution titrated using Eriochrome Black T to the end point. What analytical effect is observed at the point? A. Occurrence of sediment B. Restores proper color of indicator C. Colored solution becomes colorless D. Dissolution of sediment E. Colorless solution becomes colored 6.13. Mercurometry method is used for quantitative determination of: A. Heavy metals B. Alkaline metals C. Alkaline earth and heavy metals D. Halides E. Acids and bases 6.14. The drug contains aluminum nitrate. Suggest a method for quantitative determination of aluminum in the solution of the drug sample: A. Precipitation titration B. Acid-base titration C. Chelatometry titration D. Oxidation-Reduction titration E. Mercurimetry titration 6.15. Quantitative determination of calcium chloride is carried out by method of direct chelatometric titration. Choose an indicator for fixation of the titration endpoint: A. Eriochrome black T B. Phenolphthalein C. Methyl red D. Eosin E. Starch 6.16. Determination of medications containing cations of magnesium and calcium is done by trilonometric titration. What type of chemical reaction takes place in this case? A. Complexation B. Oxidation-reduction C. Electrophylic substitution D. Alkylation E. Precipitation 6.17. You are given 0,05 M solution of versene (chelating agent). What is standard substance for standardization of this solution? A. Metallic zinc B. Sodium tetraborate C. Sodium hydroxide D. Oxalic acid E. Potassium dichromate THE KEYS TO THE TESTS 1. Gravimetric analysis № of the test task 1.1 1.2 1.3 1.4 1.5 1.6 The correct answer D. B. A. B. C. C. № of the test task 1.7 1.8 1.9 1.10 1.11 The correct answer D. C. C. B. D. 2. Titrimetric analysis № of the test task 2.1 2.2 2.3 The correct answer C. B. A. The correct answer C. C. D. D. C. A. A. B. D. № of the test task 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3. Acid-base titration № of the test task 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 The correct answer C. C. B. A. A. A. D. B. A. 4. Redox titration № of the test task 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 The correct answer E. D E C. A. E. B. D. D. A. C. B. A. E. C. C. A. C. E. № of the test task 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 The correct answer E. C. A. B. B. C. D. C. A. E. D. B. A. E. B. B. C. E. A. № of the test task 4.39 4.40 4.41 4.42 4.43 4.44 5. Precipitation titration № of the test task 5.1 5.2 5.3 5.4 5.5 5.6 The correct answer A. A. A. A. A. A. 6. Complexometric titration № of the test task 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 The correct answer E. B. C. C. B. B D C. A. № of the test task 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 The correct answer C. A. B. D. C. A. A. A. The correct answer D. D. B. D. C. B. The list of the recommended literature 1. V.V. Bolotov, L.Yu. Klimenko, T.A. Kostina, S.V. Kolisnyk, K.V. Dynnik, T.V. Zhukova. ANALYTICAL CHEMISTRY COLLECTION OF LECTURES ON QUANTITATIVE ANALYSIS. The manual for students of higher schools. Edited by professor V.V.Bolotov . Kharkiv NUPh "Original" 2011 2. Harvey, David, 1956 – Modern analytical chemistry / David Harvey. — 1st ed.p. cm. 1. Chemistry, Analytic. I. Title.QD75.2.H374 2000, 543— dc21