Highly express in gastric cancer
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Supplementary Table-1. The main cancer associated lncRNAs LncRNA Species Expression Biological Significance Refer- name 7SK/RN7SK ence Human Highly express in Controls RNAP II activity and gastric cancer serves as scaffold [14] for protein-protein interactions A130040M12Rik Mouse /VL30 Highly express in Forms a PSF-RNA complex to melanoma regulates [15] proto-oncogene transcription, cell proliferation, and tumorigenesis ANRIL/ Human CDKN2B-AS Highly express in Negatively regulates expression of [16, 17] prostate cancer, tumor-suppressor genes CDKN2A acute, and lymphoblasttic remodeling CDKN2B via chromatin leukemia, glioma and melanoma BOK-AS1/ Human BOKAS BCAR4 Highly express in Inhibits Bok-induced apoptosis [18, 19] leiomyosarcoma Human Highly express in Promotes metastasis by activating breast cancer [20] the expression of a cell-migration pathway BCYRN1/BC200 Human Highly express in Improves expressions of the key breast, cervix, metastasis-supporting oesophagus, [21] proteins lung MMP9 and MMP13 and ovary cancer cells CCAT1 Human Highly express in Promotes cancer cell proliferation [22, 23] colorectal and and gastric cancer cells long-range chromatin interactions migration; at the MYC locus 1 regulates CCND1/BCL1 Human Highly express in Induces TLS allosteric change; breast cancer [13] inhibits CBP and p300 activity; regulates cyclin D1 gene expression of TIGA1 expression EPB41L4A-AS1/ Human TIGA1 GAPLINC Highly express in Ectopic lung cancer Human [24] inhibits tumor cell proliferation Highly express in Regulates CD44-dependent cell gastric cancer [25] invasiveness and associates with poor prognosis GAS5/SNHG2 Human Down-regulatedin Functions as a tumor suppressor; breast cancer promotes apoptosis and controls [26] cell cycle GHET1 Human Highly express Promotes gastric carcinoma cell in gastric cancer [27] proliferation by increasing c-Myc mRNA stability H19/ASM Human Highly express in Functions as an oncogene; [28] bladder, lung, controls IGF2 expression in cis liver, breast, ovary, prostate and colorectal cancer cells HIF1A-AS1 and Human Highly express in Regulates cell proliferation and 2 renal and kidney apoptosis [29] cancer cells HNF1A-AS1 Human Highly express in Regulates and [30] Highly express in Interacts with PRC2 and regulates [31] lung proliferation and metastasis oesophageal adenocarcinoma cells HOTAIR/HOXA Human 2 S HULC breast cancer Human chromatin state Highly express in Regulates cell proliferation, [32] liver and gastric apoptosis and tumor metastasis cancer cells KCNQ1OT1/LIT Human 1 Highly express in Functions ovarian as and interacts colorectal cancers an oncogene; with [29] histone methyltransferase G9a and PRC2, leading to gene silencing KRAS1P Human Highly express in Function as a proto-oncogene prostate, [33] and hepatocellular cancer cells LncRNA-LALR1 Human Highly express in Promotes cell cycle progression hepatocellular and and liver carcinoma accelerates [34] hepatocyte proliferation during regeneration by liver activating Wnt/β-catenin signaling. LincRNA-p21/ Human Trp53cor1 Down-regulated in Functions as a direct [13, 35, colorectal and lung transcriptional target of p53 and to 36] cancer cells mediate p53-dependent apoptosis; regulates mRNA translation and protein stability Loc554202 Human Highly express in Regulates breast cancer LSINCT5 Human proliferation and [37] migration in breast cancer cells. Highly express in Affects cell proliferation. [38] breast and ovarian cancer cells MALAT1/HCN Human Highly express in Regulates breast cancer, metastasis associated genes and hepatocellular, regulates cell motility 3 the expression of [39, 40] pancreatic and gastric cancer cells MALAT2 Human Highly express in Regulates cell metastasis [41] gastric cancer MEG3/GTL2 Human Down-regulated in Functions as a tumor suppressor; [42] bladder, stimulate p53-mediated gastric, lung, transactivation and suppress tumor glioma, growth in the absence of p53 hepatocellular and prostate cancer cells MIAT/RNCR2/G Human OMAFU Highly express in Functions as an oncogene; binds [19] colon, kidney, lung to splicing factors such as SF1 and breast cancer cells MINA/ROX/MDI Human G Highly express in Regulates chromatin H3K9me3 [19] gastric carcinoma, and influences the heterochromatin esophageal structure squamous cell carcinoma, and lung cancer cells MIR17HG/MIH Human G1 Highly express in Controls Human Down-regulated in Regulates Human Human p16INK4Aexpression to Down-regulated in Acts in response to DNA damage [45] to limit apoptosis Highly express in Regulates BRCA2 and controls prostate [44] modulate senescence NSCLC tissues PCAT1 [43] angiogenesis. prostate cancer PANDAR survival, breast, gastric and proliferation, differentiation, and lung cancer cells MIR31HG cell tumor homologous recombination 4 [46] tissues PCGEM1 Human Highly express in Regulates cell proliferation and prostate cancer apoptosis; promotes [47] colony formation PINC Mouse Highly express in Associates with PRC2; regulates breast cancer cell survival and cell [48] cycle progression in breast cancer PTENP1 Human Highly express in Suppresses the oncogenic hepatocellular PI3K/AKT pathway, inhibits cell carcinoma proliferation, [49] migration/invasion as well as induces autophagy and apoptosis PVT1 Human Highly express in Controls levels of MYC through lung cancer [50, 51] regulation of MYC protein stability RRP1B Human No available A information tumor progression and [52] metastasis susceptibility candidate gene, it is potentially a dynamic modulator of transcription and chromatin structure SRA1 Human Highly express in Co-activator of steroid receptors [53] breast and prostate and other transcription factors; cancer cells SUMO1P3 Human associates with metastasis Highly express in Controls gastric cancer TARID Human cell differentiation, metastasis and invasion Down-regulated in TARID directs demethylation and head and [54] [55] neck, activates the tumor suppressor lung and ovarian TCF21 via GADD45A cancer cells TERRA Mouse Down-regulated in Facilitates 5 telomeric [56] breast and prostate heterochromatin cancer cells inhibits formation telomerase by and direct binding TUSC8 Human Down-regulated in Promotes cervical cancer cell proliferation [57] through upregulation of c-Myc in cervical cancer UCA1 Human Highly express in Regulates cell growth and [58] Highly express in Regulates p53 mRNA stability and [59] bladder and gastric promotes invasion cancer cells WRAP53 Human osteosarcoma, lung, colon impacts transcription of p53 target and genes breast cancer cells XIST or SXI1 Human XIST expression is Triggers chromatin instability and lost breast, in [19] female promotes caner development ovarian, and cervical cancer cells YIYA Human Highly express in Regulates cell cycle progression at [60] liver, esophageal, the G1/S transition ovary and breast cancer cells ZNFX1-AS1 Human Down-regulated in A putative tumor suppressor; breast, liver, lung, regulates mammary development kidney cancer cells 6 [61]
