Name: _____________________________________ Date: __________ Period: ______ Part 1: DNA Structure Go to http://www.biologycorner.com/APbiology/DNA/13-2_DNA_structure.html Draw a DNA molecule 4 base pairs long in the box below. Must show double ringed purines and single ringed pyrimidines. Also, draw and label the three parts of a nucleotide. DNA Nucleotide Part 2: DNA Replication Go to http://www.stolaf.edu/people/giannini/flashanimat/molgenetics/dna-rna2.swf Answer the following questions as you move through the animation of DNA replication. Before clicking 1. What class of proteins are the molecules with –ase endings? ______________ 2. Draw a portion of the DNA molecule on the screen. Click on the large arrow once. (total of one click) 3. Draw the portion of DNA that has “unzipped”. What enzyme was doing the “unzipping”? _________________________________ 1 More DNA Replication Click on the large arrow again (total of 2 clicks). 4. What begins to happen on one of the “unzipped” strands? ________________________________ ______________________________________________________________________________ 5. What enzyme is responsible for this? _________________________ Click several more times slowly and study what happens. 6. Can you hypothesize what function the enzymes could have in this process? (hint: what is the function of enzymes? ) ___________________________________________________________________. 7. Draw a diagram and create an explanation of each step of DNA replication (Include what you start and end with & what happens in between) Drawings Explanations Part 3: RNA Go to http://www.dnaftb.org/dnaftb/21/concept/index.html Read the text and answer the following questions 8. Where is RNA commonly found? ______________________________________. 9. Describe what is meant by the “central dogma” in biology. ________________________________ _______________________________________________________________________________ 10. Name the 3 types of RNA and the general roles they play in the making of protein. - ___________________________________________________________________ - ___________________________________________________________________ - ___________________________________________________________________ 2 Click on the animation button below. Step through the animation and compare and contrast the structure of RNA to DNA. Draw a double bubble diagram to compare and contrast. Draw a sketch of an RNA molecule (at least 6 nucleotides long using the all the appropriate nitrogen bases at least once). Part 4: Transcription (DNA RNA) Go to http://www.stolaf.edu/people/giannini/flashanimat/molgenetics/transcription.swf Answer the following question Before clicking 11. What molecule is displayed on the screen now? _____________ Click once 1 2. What type of molecule is the RNA polymerase? ______________________ Click again 13. What function does the RNA polymerase have? ______________________________________ 14. Where in the cell do you think this is taking place? _______________________ 15. What is the new red molecule called? __________. 16. Explain how the mRNA molecule forms. ________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ Click again 17. What nitrogen base replaces thymine on the RNA molecule? _______________. 3 Part 5: Translation (mRNA protein) Go to http://www.stolaf.edu/people/giannini/flashanimat/molgenetics/translation.swf Answer the following question Before clicking 18. What molecule is displayed on the screen now? _________. 19.Name one reason how you know. _________________________________________. Click once 20. Where in cell in this taking place? ___________________. Click again 21. What type of molecule is the tRNA (transfer RNA) bringing to the mRNA? __________________. 22. Draw and label the tRNA molecule. Click until the end watching the process of translation 23. As the tRNAs dock on the mRNA bringing amino acids with them what type of molecule is created? __________________________. Start the animation over 24. Write a summary of translation using words and a sketch 4