Supplementary Table 1: ISAAC questionnaire comparing the respiratory health of
CTM v healthy children
ISAAC questionnaire
Has your child ever had wheezing or whistling in the chest at any time in the past?
Has your child ever had asthma?
Does your child cough with a cold?
Does your child have a cough even without having a cold?
Has your child ever had Pneumonia?
Once:
More than once:
CTM n/N (%)
7/10 (70%)
4/10 (40%)
3/10 (30%)
1/10 (10%)
0/10 (0%)
1/10 (10%)
10/10 (100%)
Has your child ever had Whooping cough?
Once:
More than once:
Has your child ever had Bronchiolitis?
Once:
More than once:
Has your child ever had Croup?
Once:
More than once:
0/10 (0%)
3/10 (30%)
0/10 (0%)
3/10 (30%)
3/10 (30%)
1/10 (10%)
2/10 (20%)
Has your child ever had a problem with sneezing, or a runny or blocked nose when he/she DID NOT have a cold or flu?
In the past 12 months had any of the following medications to manage cough, wheeze or asthma?
Salbutamol, Ventolin, Asmol:
Flixotide, Seretide, Pulmicort:
Oral Steroids:
Has your child ever had eczema?
4/10 (40%)
4/10 (40%)
2/10 (20%)
1/10 (10%)
4/10 (40%)
Interview
Does your child have a doctors diagnosis of 4/10 (40%) asthma? answered yes to question (n)
Total number of children in group (N)
Healthy n/N (%)
4/17 (24%)
0/17 (0%)
15/17 (88%)
4/17 (24%)
0/17 (0%)
1/17 (6%)
0/17 (0%)
1/17 (6%)
1/17 (6%)
0/10 (0%)
1/17 (6%)
4/17 (24%)
1/17 (6%)
3/17 (18%)
5/17 (29%)
4/17 (24%)
1/17 (6%)
3/17 (18%)
4/17 (24%)
0/17 (0%)
P value
0.04
0.01
0.52
1.00
0.41
0.54
1.00
0.41
0.01
0.37
N/A
0.37
1.00
N/A
1.00
0.13
N/A
0.13
1.00
1.00
1.00
0.68

Supplementary table 2: Details on the lung function of the healthy cohort of children
Age/sex Height
5.4/F
5.1/F
4.5/M
4.2/F
5.0/M
5.1/M
5.0/M
5.2/F
4.7/F
5.2/F
4.7/F
4.4/F
4.0/F
5.3/F
4.6/F
4.8/M
4.3/F
Z score
-1.1
1.7
-0.8
0.5
0.2
1.0
0.3
1.2
0.8
1.1
0.1
1.7
1.1
0.5
0.6
1.0
-0.1
LCI FEV
7.5 pred
8.7 86
8.0 103
6.9 118
7.2 77
7.4 128
7.1 118
6.5 116
7.9 99
7.2 109
8.2 87
6.8 127
7.3 122
6.6 146
7.0 115
7.7 N/A
7.1 101
1
% b
FVC % pred
119
97
129
83
119
115
141
100
N/A
109
92
92
127
73
131
118
110
R5Hz Z score
0.45
0.08
-1.02
0.73
0.77
0.59
-1.55
-0.65
0.59
1.62
-0.86
1.87
0.87
2.80
-0.39
1.03
1.70
X5Hz score
-0.59
-0.04
0.30
0.12
-0.15
0.17
-0.09
1.16
-1.22
0.3
0.39
-0.15
-1.43
-2.22
0.04
0.99
0.62