Table S2. Genes down-regulated by PUFAs
Gene
Description
Name
YJL179W
bovine prefoldin subunit 1 homolog (putative)
YOR244W Acetyltransferase in the SAS gene family
YGL127C
SOH1 encodes a novel 14-kD protein with limited sequence similarity to RNA
polymerases. The Soh1 protein interacts with a DNA repair protein, Rad5p, in
a two-hybrid system assay.
YFR031C
YKR024C
YOR285W
YDR144C
YKL041W
YER056C
YLR011W
YDR019C
YPL045W
YDR456W
YMR004W
YCR054C
YBR034C
YPR025C
YDL100C
YGR098C
YOR076C
YNL244C
YML069W
YKL122C
YMR091C
YHR010W
YJL097W
Fold
Change
0,498
0,497
0,496
SMC chromosomal ATPase family member
putative RNA helicase
Protein of unknown function containing a rhodanese-like domain; localized to
the mitochondrial outer membrane; protein abundance increases in response
to DNA replication stress
aspartyl protease related to Yap3p
involved in secretion
purine-cytosine permease
FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone
detoxification; expression elevated at low temperature; sequesters the Cin5p
transcription factor in the cytoplasm in complex with the proteasome under
reducing conditions
glycine cleavage T protein (T subunit of glycine decarboxylase complex
Vacuolar sorting protein
Na+\/H+ exchanger
peripheral Golgi membrane protein
CTR86 shares a terminator region with THR4. CTR86 contains aGCN4
responsive site suggesting it may also be involved in amino acid biosynthesis.
0,496
0,496
0,496
nuclear protein arginine methyltransferase (mono- and asymmetrically
dimethylating enzyme)
novel cyclin gene\; encodes subunits of TFIIK, a subcomplex of transcription
factor TFIIH
0,492
Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling;
subunit of the GET complex, which is involved in Golgi to ER trafficking and
insertion of proteins into the ER membrane; has low-level ATPase activity;
protein abundance increases in response to DNA replication stress
involved in regulation of spindle pole body duplication
Coupling protein that mediates interactions between the Ski complex and the
cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets
nonstop mRNA for degradation; null mutants have superkiller phenotype (2,
3, 4, 5, 6 and see Summary Paragraph)
translation initiation factor 3 (eIF3)
binds DNA polymerase delta
component of signal recognition particle
involved in nuclear protein targeting
Ribosomal protein L27A
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in
elongation of very long-chain fatty acids; evolutionarily conserved, similar to
mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and
protein trafficking
0,491
0,496
0,496
0,495
0,495
0,494
0,494
0,493
0,493
0,492
0,492
0,491
0,490
0,490
0,490
0,490
0,490
0,490
0,490
YLR126C
YPL243W
YNL250W
YAL059W
YDR043C
YIL104C
YDR212W
YLR168C
YHR103W
YLL011W
YLR408C
YGL056C
YDL120W
YCR016W
YOR252W
YMR025W
YPR101W
YPL212C
YMR074C
YML017W
YKL076C
YML006C
YBL004W
YKL162C-A
Putative glutamine amidotransferase; has Aft1p-binding motif in the
promoter; may be involved in copper and iron homeostasis; YLR126C is not an
essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA
replication stress
component of signal recognition particle
Contains a purine-binding domain, two heptad repeats and a hydrophobic
tail.
putative transmembrane domain protein involved in cell wall biogenesis
transcriptional repressor which can bind to UAS-1 in the STA1 promoter and
which can interact with Ssn6p
0,489
Chaperone protein required for the assembly of box H/ACA snoRNPs and thus
for pre-rRNA processing, forms a complex with Naf1p and interacts with
H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p
cochaperones
chaperonin subunit alpha
possibly involved in intramitochondrial sorting
involved in bud growth
56 kDa nucleolar snRNP protein that shows homology to beta subunits of Gproteins and the splicing factor Prp4
0,488
Putative protein of unknown function; likely member of BLOC complex
involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion
protein localizes to the endosome; YLR408C is not an essential gene
similar to S. pombe sds23
mitochondrial protein that regulates mitochondrial iron accumulation
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
protein localizes to the nucleolus and nucleus; predicted to be involved in
ribosome biogenesis
Protein of unknown function that associates with ribosomes
Subunit of the Cop9 signalosome, which is required for deneddylation, or
removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in
adaptation to pheromone signaling; functional equivalent of canonical Csn6
subunit of the COP9 signalosome
Component of a protein complex associated with the splicing factor Prp19p.
intranuclear protein which exhibits a nucleotide-specific intron-dependent
tRNA pseudouridine synthase activity
0,486
Protein with homology to human PDCD5; PDCD5 is involved in programmed
cell death; N-terminal region forms a conserved triple-helix bundle structure;
overexpression promotes H2O2-induced apoptosis; YMR074C is not an
essential gene; protein abundance increases in response to DNA replication
stress
(putative) involved in mRNA splicing
Dubious open reading frame, unlikely to encode a protein; not conserved in
closely related Saccharomyces species; 69% of ORF overlaps the
uncharacterized ORF YKL075C
CAAX box containing protein
Component of the small-subunit (SSU) processome, which is involved in the
biogenesis of the 18S rRNA
Dubious open reading frame unlikely to encode a functional protein, based on
available experimental and comparative sequence data
0,482
0,489
0,488
0,488
0,488
0,488
0,488
0,487
0,486
0,485
0,485
0,485
0,485
0,483
0,483
0,482
0,482
0,481
0,481
0,481
0,481
YNL227C
YDL155W
YOR220W
YOR094W
YDR080W
YBR079C
YCL067C
YIL052C
YNL001W
YDR377W
YER184C
YDR503C
YJL031C
YGR057C
YIL127C
YIL138C
YDR373W
YPR108W
YER073W
YDR037W
YPR119W
YNL039W
YPR046W
YGL061C
YJL190C
YDL190C
YLR056W
YKL014C
YBL059C-A
YLR275W
YDR082W
YDR272W
YLR210W
YBR073W
Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late
step of ribosome biogenesis; associated with the cytosolic large ribosomal
subunit; contains a J-domain; mutation causes defects in fluid-phase
endocytosis
G(sub)2-specific B-type cyclin
Protein of unknown function; green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm; phosphorylated in response to alpha factor;
protein abundance increases in response to DNA replication stress
GTP-binding ADP-ribosylation factor
component of vacuolar membrane protein complex
translation initiation factor eIF3
Mating type protein alpha-2
Ribosomal protein L34B
Involved in protein translation
ATP synthase subunit f
Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white,
and prevents growth on glycerol or lactate as sole carbon source
Lipid phosphate phosphatase
Geranylgeranyltransferase Type II alpha subunit (PGGTase-II, alpha subunit)
involved in transport of nitrogen-regulated permeases
Putative protein of unknown function; identified in a screen for mutants with
decreased levels of rDNA transcription; green fluorescent protein (GFP)fusion protein localizes to the nucleolus; predicted to be involved in ribosome
biogenesi
Tropomyosin isoform 2
N-myristoylated calcium-binding protein that may have a role in intracellular
signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p;
member of the recoverin/frequenin branch of the EF-hand superfamily
Subunit of the regulatory particle of the proteasome
mitochondrial Aldehyde Dehydrogenase
lysyl-tRNA synthetase
G(sub)2-specific B-type cyclin
90 kd subunit of TFIIIB, also called TFIIIB90 or B'' or B''90 component
Involved in chromosome segregation
Death Upon Overexpression
Ribosomal protein S22A (S24A) (rp50) (YS22)
ubiquitin fusion degradation protein
C-5 sterol desaturase
Nucleolar protein required for the normal accumulation of 25S and 5.8S
rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be
involved in the biogenesis of the 60S ribosomal subunit
Similar to very hypothetical S. pombe protein
U1 snRNP protein of the Sm class
involved in telomere length regulation
Cytoplasmic glyoxylase-II
G(sub)2-specific B-type cyclin
Putative helicase similar to RAD54
0,480
0,480
0,479
0,479
0,478
0,478
0,478
0,478
0,478
0,478
0,478
0,478
0,476
0,476
0,476
0,476
0,476
0,476
0,475
0,475
0,475
0,475
0,474
0,474
0,473
0,473
0,472
0,472
0,470
0,469
0,469
0,469
0,468
0,468
YLR053C
YCL056C
Putative protein of unknown function
Peroxisomal integral membrane protein that regulates peroxisome
populations; interacts with Pex11p, Pex25p, and Pex27p to control both
constitutive peroxisome division and peroxisome morphology and abundance
during peroxisome proliferation
Putative protein of unknown function
RNA polymerase II subunit
The TyB Gag-Pol protein. Gag processing produces capsid proteins. Pol is
cleaved to produce protease, reverse transcriptase, and integrase activities.
0,468
0,467
YJR155W
YGR160W
Hypothetical aryl-alcohol dehydrogenase (AAD)
Dubious open reading frame unlikely to encode a functional protein, based on
available experimental and comparative sequence data
0,464
0,462
YNL002C
YGR246C
Q0140
YDR323C
Protein with similarity to ribosomal proteins including Rpl6p
RNA polymerase III transcription factor with homology to TFIIB
mitochondrial ribosomal protein encoded by mitochondrial genome.
cytosolic and peripheral membrane protein with three zinc fingers\; cysteine
rich regions of amino acids are essential for function
0,461
0,461
0,461
0,460
YOR078W
YMR085W
BUD site selection
Putative protein of unknown function; YMR085W and adjacent ORF
YMR084W are merged in related strains, and together are paralogous to
glutamine-fructose-6-phosphate amidotransferase GFA1
kinesin-like protein
Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA
and maturation of 18S rRNA; component of the SSU (small subunit)
processome involved in 40S ribosomal subunit biogenesis; copurifies with
Faf1p
18-kDa phosphotyrosine phosphatase of unknown function
Subunit of the NuA4 histone acetyltransferase complex, which acetylates the
N-terminal tails of histones H4 and H2A
Ubiquitin; becomes conjugated to proteins, marking them for selective
degradation via the ubiquitin-26S proteasome system; essential for the
cellular stress response; encoded as a polyubiquitin precursor comprised of 5
head-to-tail repeats; protein abundance increases in response to DNA
replication stress
Ribosomal protein L26B (L33B) (YL33)
Dubious open reading frame, unlikely to encode a protein; not conserved in
closely related Saccharomyces species; 98% of ORF overlaps the verified gene
YPT6; deletion causes a vacuolar protein sorting defect
Subunit of the regulatory particle of the proteasome
involved in silencing at telomeres, HML, and HMR
mitochondrial protein, prohibitin homolog\; homolog of mammalian BAP37
and S. cerevisiae Phb1p
0,460
0,460
Myristoylated subunit of ESCRTIII, the endosomal sorting complex required
for transport of transmembrane proteins into the multivesicular body
pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to
endosomal membranes
WD40 domain-containing protein involved in endosomal recycling; forms a
complex with Rrt2p that functions in the retromer-mediated pathway for
0,456
YHR054C
YGL070C
YGR161WB
YKL179C
YDR339C
YPR073C
YNL136W
YLL039C-R
YGR034W
YLR261C
YDL097C
YDR181C
YGR231C
YMR077C
YPL183C
0,466
0,465
0,464
0,459
0,459
0,459
0,458
0,458
0,457
0,457
0,456
0,456
0,456
0,456
YDL133W
YDR470C
YGR272C
YBR058C-A
YOR189W
YJL148W
YPR048W
YER050C
YPR105C
YKR031C
YOR294W
YOR327C
YHR170W
YKL173W
YLR367W
YOR305W
YLR441C
YBL003C
YER099C
YLR197W
YBL090W
YKL137W
recycling internalized cell-surface proteins; evidence it interacts with Trm7p
for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1
transposition; human ortholog is WDR6
Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates
its catalytic activity; capable of buffering the toxicity of C16:0 platelet
activating factor, a lipid that accumulates intraneuronally in Alzheimer's
patients
Outer membrane component of the mitochondrial fusion machinery; binds
directly to Fzo1p and Mgm1p and thus links these two GTPases during
mitochondrial fusion; involved in fusion of both the outer and inner
membranes; facilitates dimerization of Fzo1p during fusion; import into the
outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier
proteins but is not likely to function as a transmembrane transporter
Essential protein required for maturation of 18S rRNA; null mutant is sensitive
to hydroxyurea and is delayed in recovering from alpha-factor arrest; green
fluorescent protein (GFP)-fusion protein localizes to the nucleolus
involved in sphingolipid biosynthesis
Component of the INO80 chromatiin remodeling complex and target of the
Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin
remodeling to replication checkpoint responses
unshared RNA polymerase I subunit
Conserved NAPDH-dependent diflavin reductase; component of an early step
in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons
from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under
oxidative stress; Tah18p-dependent nitric oxide synthesis confers hightemperature stress tolerance
protein of the small subunit of the mitochondrial ribosome
Essential component of the conserved oligomeric Golgi complex (Cog1p
through Cog8p), a cytosolic tethering complex that functions in protein
trafficking to mediate fusion of transport vesicles to Golgi compartments
Phospholipase D
Regulator for ribosome synthesis
vesicle-associated membrane protein (synaptobrevin) homolog
cytoplasmic factor required for a late cytoplasmic assembly step of the 60S
subunit
U5 snRNP-specific protein related to EF-2
Ribosomal protein S22B (S24B) (rp50) (YS22)
Protein of unknown function; green fluorescent protein (GFP)-fusion protein
localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(Sglutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an
essential gene
Ribosomal protein S1A (rp10A)
Histone H2A (HTA1 and HTA2 code for nearly identical proteins)
ribose-phosphate pyrophosphokinase 2
homology to microtubule binding proteins and to X90565_5.cds
Component of the small subunit of mitochondrial ribosomes
Evolutionarily conserved copper-binding protein of the mitochondrial
intermembrane space, may be involved in delivering copper from the matrix
to the cytochrome c oxidase complex; contains a twin CX9C motif
0,455
0,455
0,453
0,452
0,451
0,451
0,450
0,450
0,450
0,450
0,449
0,449
0,449
0,449
0,448
0,447
0,445
0,445
0,444
0,444
0,443
0,443
YHR001WA
YER139C
8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex
0,443
CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of
Rpo21p; has a cysteine-rich motif required for function and conserved in
eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog,
RTR2, that arose from the whole genome duplication
high-temperature lethal
0,442
interacts with Nap1, which is involved in histone assembly
Cytosolic Aldehyde Dehydrogenase
Acireductone dioxygenease involved in the methionine salvage pathway;
ortholog of human MTCBP-1; transcribed as polycistronic mRNA with
YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage;
ADI1 mRNA is induced in heat shock conditions
YJR032W
peptidyl-prolyl cis\/trans isomerase
YLR392C
Protein of unknown function that contains 2 PY motifs and is ubiquinated by
Rsp5p; overexpression confers resistance to arsenite; green fluorescent
protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
YDR427W
Subunit of the regulatory particle of the proteasome
YPL222W
Putative protein of unknown function; proposed to be involved in responding
to environmental stresses; the authentic, non-tagged protein is detected in
highly purified mitochondria in high-throughput studies
YJL074C
SMC chromosomal ATPase family member
YBL063W
kinesin related protein
YLR103C
omosomal DNA replication initiation protein
YJL208C
mitochondrial nuclease
YKR023W
Putative protein of unknown function; the authentic, non-tagged protein is
detected in highly purified mitochondria in high-throughput studies
YOR148C
spliceosome-associated protein
YGR150C
Mitochondrial 15s rRNA-binding protein; required for intron removal of COB
and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs;
mutant is respiratory deficient and has defective plasma membrane electron
transport
YMR119W- Dubious open reading frame unlikely to encode a functional protein, based on
A
available experimental and comparative sequence data
YML108W Protein of unknown function; structure defines a new subfamily of the split
beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm and nucleus; YML108W is not an essential gene;
relative distribution to the nucleus increases upon DNA replication stress
YIL035C
alpha subunit of casein kinase II
YMR299C
Description
YMR154C
Cysteine protease similar to E. nidulans palB
YNR032Cubiquitin-like modifier
A
YHR184W
involved in meiosis, nuclear division and spore formation
YOL080C
RNA EXonuclease\; part of family of 3'-to5' exonucleases. See Moser et al.
1997 Nucleic acids Res. 25:5110-5118
0,440
0,440
0,438
YNR055C
0,426
YCR020WB
YDR162C
YPL061W
YMR009W
Putative ion transporter similar to the major facilitator superfamily of
transporters
0,441
0,437
0,437
0,437
0,436
0,436
0,435
0,434
0,434
0,434
0,433
0,433
0,433
0,432
0,430
0,429
0,428
0,428
0,428
0,428
YHR055C
YDR228C
YGL164C
copper-binding metallothionein
Component of pre-mRNA cleavage and polyadenylation factor I
RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis
of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in
higher eukaryotes
0,426
0,425
0,424
YDL121C
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
protein localizes to the endoplasmic reticulum; YDL121C is not an essential
protein
40S ribosomal protein S27A (rp61) (YS20)
Subunit of GID complex; involved in proteasome-dependent catabolite
inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms
dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a
degenerate RING finger motif needed for GID complex ubiquitin ligase activity
in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis;
required for survival upon exposure to K1 killer toxin
Sm-like protein
ATPase stabilizing factor
0,424
Mitochondrial intermembrane space protein of unknown function; imported
via the MIA import machinery; contains an unusual twin cysteine motif
(CX13C CX14C
7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex
Protein required for accurate chromosome segregation during meiosis;
involved in meiotic telomere clustering (bouquet formation) and telomere-led
rapid prophase movements (1, 2 and see Summary Paragraph)
Component of the BUB2-dependent spindle checkpoint pathway, interacts
with Bfa1p and functions upstream of Bub2p and Bfa1p
0,420
YKL156W
YIL097W
YJR022W
YDL130WA
YBL107C
YGR183C
YPL200W
YNL164C
YGR046W
YDR097C
YBR010W
YGR039W
Homolog of the human GTBP protein, forms a complex with Msh2p to repair
both single-base and insertion-deletion mispairs, redundant with Msh3p in
repair of insertion-deletion mispairs
0,422
0,422
0,422
0,421
0,419
0,418
0,416
0,416
0,415
Histone H3 (HHT1 and HHT2 code for identical proteins)
Mitochondrial protein required for cardiolipin biosynthesis; viability of null
mutant is strain-dependent; mRNA is targeted to the bud; mutant displays
defect in mitochondrial protein import, likely due to altered membrane lipid
composition
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data; partially overlaps the
Autonomously Replicating Sequence ARS722
Putative protein of unknown function; similar to the mouse IMPACT gene;
YDL177C is not an essential gene
0,415
0,414
YLR200W
Polypeptide 6 of a Yeast Non-native Actin Binding Complex, homolog of a
component of the bovine NABC complex
0,413
YOL149W
YBR148W
YKR035WA
YDR325W
Decapping protein involved in mRNA degradation
Spore-specific protein
Rad52p inhibitor
0,411
0,411
0,410
Yeast Condensin G
0,410
YNL224C
YDL177C
0,414
0,413
YDL170W
YDL225W
YGR187C
YMR130W
YGR103W
YOR370C
YLR144C
YHL007C
YPL070W
YLR164W
YER030W
YGR068C
YBR154C
YOR210W
YOL124C
YDR235W
YMR263W
YDR120C
YKL035W
YDL178W
YMR309C
YDR098C-R
YNL153C
YLR435W
YNL217W
YKL092C
zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain
type
Septin homolog
(putative) Hmg1\/2 protein
Putative protein of unknown function; YMR130W is not an essential gene
Component of several different pre-ribosomal particles; forms a complex with
Ytm1p and Erb1p that is required for maturation of the large ribosomal
subunit; required for exit from G0 and the initiation of cell proliferation (1, 3,
4, 5)
Rab geranylgeranyltransferase regulatory subunit
involved in cortical actin cytoskeleton assembly
serine\/threonine protein kinase
Cytoplasmic protein of unknown function containing a Vps9 domain;
computational analysis of large-scale protein-protein interaction data
suggests a possible role in transcriptional regulation
Mitochondrial inner membrane protein of unknown function; similar to
Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a
stoichiometric subunit of succinate dehydrogenase nor of the TIM22
translocase; expression induced by nitrogen limitation in a GLN3, GAT1dependent manner
Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of
the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null
mutant displays weak sensitivity to MMS and benomyl; contains a highly
conserved CHZ motif; protein abundance increases in response to DNA
replication stress
Protein proposed to regulate the endocytosis of plasma membrane proteins
by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane
25-kDa RNA polymerase subunit (common to polymerases I, II and III)
RNA polymerase II subunit
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex
(Trm11p-Trm112p), required for the methylation of the guanosine nucleotide
at position 10 (m2G10) in tRNAs; contains a THUMP domain and a
methyltransferase domain
U1 snRNP protein that shares 50\% sequence similarity with Prp39p U1
snRNP protein and has multiple copies of the crn-like TPR motif
0,409
Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is
involved in silencing at telomeres, rDNA, and silent mating-type loci; involved
in telomere maintenance
N2,N2-dimethylguanosine-specific tRNA methyltransferase
Uridinephosphoglucose pyrophosphorylase
D-Lactate Dehydrogenase (Cytochrome)
~100 kDa cytoplasmic protein
Retrotransposon TYA Gag and TYB Pol genes
bovine prefoldin subunit 4 homolog (putative)
Protein with a potential role in pre-rRNA processing
Putative protein of unknown function; weak sequence similarity to bis (5'nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole;
null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
GTPase-activating protein (GAP) for Rsr1p\/Bud1p
0,399
0,409
0,408
0,407
0,406
0,405
0,405
0,404
0,403
0,403
0,401
0,401
0,401
0,400
0,399
0,399
0,398
0,397
0,397
0,396
0,395
0,395
0,394
0,393
0,393
YMR256C
YCL054W
YDR324C
Q0110
YML091C
YFL062W
YDR316WA
YBL034C
YIL139C
YPR132W
YOR266W
YJL156C
YML062C
YMR081C
YMR319C
YMR052W
YER049W
YPL210C
YDR194C
YOL077WA
Q0182
YER002W
YKR026C
YDR068W
YOR274W
YEL003W
YDL208W
YMR212C
YHR060W
YOR147W
YMR070W
subunit VII of cytochrome c oxidase
Putative methyltransferase
Subunit of U3-containing 90S preribosome and Small Subunit (SSU)
processome complexes involved in production of 18S rRNA and assembly of
small ribosomal subunit; member of t-Utp subcomplex involved with
transcription of 35S rRNA transcript
mRNA maturase bI2
subunit of mitochondrial RNase P
similar to subtelomerically-encoded proteins
TyA gag protein. Gag processing produces capsid proteins.
0,392
0,392
0,392
component of the 17tic spindle
subunit of DNA polymerase-zeta (Pol-zeta), an enzyme whose sole function
appears to be translesion synthesis
0,388
0,388
Ribosomal protein S23B (S28B) (rp37) (YS14)
involved in pentamidine resistance protein
Serine protease of SPS plasma membrane amino acid sensor system (Ssy1pPtr3p-Ssy5p); contains an inhibitory domain that dissociates in response to
extracellular amino acids, freeing a catalytic domain to activate transcription
factor Stp1p
mitochondrial targeting protein
involved in mitochondrial RNA splicing
Low-affinity Fe(II) transport protein
involved in the cell cycle
Poly(rA)-binding protein involved in translation termination efficiency, mRNA
poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p
(eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2oxoglutarate
component of signal recognition particle
mitochondrial DEAD box RNA helicase
Subunit k homolog of ATP synthase
0,386
0,385
0,384
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit
biogenesis
34 KD alpha subunit of eIF2B
Protein of unknown function, green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm
transfer RNA isopentenyl transferase
bovine prefoldin subunit 2 homolog (putative)
HMG-like nuclear protein
PHO _E_ighty _F_ive _R_equiring
vacuolar H+-ATPase assembly protein
Mitochondrial inner membrane protein with similarity to Mdm31p, required
for normal mitochondrial morphology and inheritance; interacts genetically
with MMM1, MDM10, MDM12, and MDM34
2 Cys2-His2 zinc fingers at c-terminus, glutamine and asparagine rich
0,377
0,390
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0,388
0,384
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0,380
0,380
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0,378
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0,377
0,376
0,376
0,375
0,375
0,373
0,372
0,372
0,370
0,370
YOR304W
YML076C
YOL061W
YDL132W
YDL200C
YDR473C
YBL026W
YMR040W
YDR248C
YLL034C
YOR195W
YGR119C
YLR039C
YPR043W
YDR002W
YMR300C
YOR145C
YOL109W
YJL096W
YDR101C
YEL061C
YNL127W
YNL088W
YLR107W
YPL225W
YGL082W
ATPase component of a two subunit chromatin remodeling complex
Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid
response element to induce transcription of PDR12 and FUN34, encoding an
acid transporter and a putative ammonia transporter, respectively
Phosphoribosylpyrophosphate synthetase (ribose-phosphate
pyrophosphokinase)
0,369
0,368
involved in G1 cyclin degradation
6-O-methylguanine-DNA methylase
snRNP from U4\/U6 and U5 snRNPs
snRNA-associated protein of the Sm class
Protein of unknown function that may interact with ribosomes, based on copurification experiments; homolog of human BAP31 protein
Putative gluconokinase; sequence similarity to bacterial and human
gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the
cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0,368
0,367
0,365
0,365
0,365
Putative ATPase of the AAA family, required for export of pre-ribosomal large
subunits from the nucleus; distributed between the nucleolus, nucleoplasm,
and nuclear periphery depending on growth conditions
possible leucine zipper
Contains GLFG repeats in N-terminal half and heptad repeats in C-terminal
half
involved in transcription of ribosomal protein genes and ribosomal RNA
Ribosomal protein L43A
nuclear GTPase-activating protein for Ran
phosphoribosylpyrophosphate amidotransferase
Essential nucleolar protein required for pre-18S rRNA processing, interacts
with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is
involved in proteasome biogenesis; contains a KH domain
Overexpression causes resistance to Zeocin
mitochondrial ribosomal protein of the large subunit
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit
biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects
in absence of Rei1; associated with the ribosomal export complex
kinesin-related protein involved in establishment and maintenance of 17tic
spindle
Protein involved in recovery from cell cycle arrest in response to pheromone,
in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p,
and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2
topoisomerase II, Top2p localizes to axial cores in meiosis
RNA EXonuclease\; part of family of 3'-to5' exonucleases. See Moser et al.
1997 Nucleic acids Res. 25:5110-5118
0,364
Protein of unknown function; may interact with ribosomes, based on copurification experiments; green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm; protein abundance increases in response to DNA
replication stress
Putative protein of unknown function; predicted prenylation/proteolysis
target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein
localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0,351
0,368
0,365
0,364
0,363
0,362
0,361
0,361
0,359
0,359
0,359
0,357
0,354
0,354
0,353
0,352
0,352
0,351
YDR060W
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal
subunit biogenesis; involved in nuclear export of pre-ribosomes; required for
maintenance of dsRNA virus; homolog of human CAATT-binding protein
0,350
YBR162WA
YBR039W
YMR284W
YBR022W
involved in the secretory pathway
0,347
gamma subunit of mitochondrial ATP synthase
DNA binding protein
Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA
splicing metabolite; may have a role in regulation of tRNA splicing
Ubiquinol cytochrome-c reductase subunit 8 (11 kDa protein)
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
protein localizes to mitochondria; YLR283W is not an essential gene
Protein of unknown function; similar to Pbi2p; double null mutant lacking
Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance
increases in response to DNA replication stress
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data; null mutation is viable
transcription factor, member of Ada\/Gcn5 protein complex
Sm-like protein
transcription factor involved in karyogamy
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
localizes to the ER; null mutant displays increased levels of spontaneous
Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome
duplication
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
localizes to the ER; null mutant displays increased levels of spontaneous
Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome
duplication
Mitochondrial intermembrane space protein; mutation affects mitochondrial
distribution and morphology; contains twin cysteine-x9-cysteine motifs;
protein abundance increases in response to DNA replication stress
0,346
0,344
0,344
YJL166W
YLR283W
YHR138C
YOR050C
YPL254W
YNL147W
YCL055W
YOR044W
YOR055W
YKL053C-A
YNL175C
YDL157C
0,342
0,342
0,339
0,339
0,338
0,335
0,333
0,333
0,333
0,333
nucleolar protein
Putative protein of unknown function; the authentic, non-tagged protein is
detected in highly purified mitochondria in high-throughput studies
YGR008C
ATPase stabilizing factor
YKR071C
Description
YBR063C
Probable phosphopanthethein-binding protein
YDR322C-A subunit e of mitochondrial F1F0-ATPase
YMR311C
Regulates activity of protein phosphatase 1, Glc7p, which is involved in proper
chromosome segregation
0,333
0,332
YEL020W- mitochondrial inner membrane translocase
A
YMR158W- Dubious open reading frame unlikely to encode a protein, based on available
A
experimental and comparative sequence data; overlaps the verified gene
ATG16/YMR159C
YNL038W
Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol
(GlcNAc-PI), the first intermediate in the synthesis of
glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H
0,328
0,332
0,332
0,329
0,329
0,329
0,326
0,325
protein
YNR014W
YNL218W
YJL048C
YCR003W
YJR097W
YOR203W
YDL219W
YGL054C
YLR410WB
YBL046W
YDR087C
YIL063C
YKR100C
YMR107W
YER048WA
YOR254C
YDR051C
YDL147W
YDR532C
Putative protein of unknown function; expression is cell-cycle regulated,
Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W,
that arose from the whole genome duplication
Protein with DNA-dependent ATPase and ssDNA annealing activities; involved
in maintenance of genome; interacts functionally with DNA polymerase delta;
homolog of human Werner helicase interacting protein (WHIP); forms nuclear
foci upon DNA replication stress
UBX (ubiquitin regulatory X) domain-containing protein that interacts with
Cdc48p, transcription is repressed when cells are grown in media containing
inositol and choline
mitochondrial ribosomal protein MRPL32 (YmL32)
Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain;
involved in diphthamide biosynthesis; ortholog human Dph4
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data; overlaps 5' end of essential
DED1 gene required for translation initiation
D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect
nonsense suppression via alteration of the protein synthesis machinery;
ubiquitous among eukaryotes
14 KDa protein found on ER-derived vesicles
TyB Gag-Pol protein. Gag processing produces capsid proteins. Pol is cleaved
to produce protease, reverse transcriptase and integrase activities.
0,324
Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4
complex (along with catalytic subunit Pph3p and Psy2p) is required for
dephosphorylation of the histone variant H2AX, but not for
dephosphorylation of Rad53p, during recovery from the DNA damage
checkpoint; localization is cell-cycle dependent and regulated by Cdc28p
phosphorylation; required for cisplatin resistance; homolog of mammalian R2
involved in rRNA processing
nuclear protein, interacts with Gsp1p and Crm1p
Transmembrane protein with a role in cell wall polymer composition; localizes
on the inner surface of the plasma membrane at the bud and in the daughter
cell
Protein required for survival at high temperature during stationary phase; not
required for growth on nonfermentable carbon sources
Cysteine desulfurase (Nfs1p) activator; essential for the formation of the
persulfide intermediate at the desulfurase active site during pyridoxal
phosphate-dependent desulfuration of cysteine; required for mitochondrial
iron-sulfur cluster biosynthesi
ER protein translocation subcomplex subunit
Acid phosphatase involved in the non-vesicular transport of sterols in both
directions between the endoplasmic reticulum and plasma membrane;
deletion confers sensitivity to nickel
Subunit of the regulatory particle of the proteasome
Subunit of a kinetochore-microtubule binding complex with Spc105p that
bridges centromeric heterochromatin and kinetochore MAPs and motors, and
0,314
0,324
0,323
0,321
0,321
0,321
0,319
0,315
0,314
0,313
0,311
0,310
0,310
0,308
0,307
0,305
0,304
0,303
YHR157W
YBR290W
YDR363WA
YOR215C
YMR269W
YJL176C
YJL150W
YHR144C
YBL028C
YML019W
YLR262C-A
YHR121W
YOR075W
Q0275
YNL206C
YDR476C
Q0130
YBR244W
YMR230W
YCL066W
YKL099C
YPL059W
YMR158W
YDL243C
YGR182C
is also required for sister chromatid bi-orientation and kinetochore binding of
SAC components
mRNA is induced early in meiosis
copper transporter
unknown function, similar to S. pombe Dss1
0,303
0,303
0,302
Putative protein of unknown function; the authentic protein is detected in
highly purified mitochondria in high-throughput studies; null mutant displays
reduced frequency of mitochondrial genome loss
Nucleolar protein implicated in ribosome biogenesis; deletion extends
chronological lifespan
transcription factor
Dubious open reading frame unlikely to encode a functional protein, based on
available experimental and comparative sequence data
dCMP deaminase
Protein of unknown function that may interact with ribosomes; green
fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted
to be involved in ribosome biogenesis
Putative new 37kDa subunit of N-oligosaccharyltransferase complex
Protein of unknown that associates with ribosomes; null mutant exhibits
translation defects, altered polyribosome profiles, and resistance to the
translation inhibitor anisomcyin; protein abundance increases in response to
DNA replication stress
Protein of unknown function that may function in RNA processing; interacts
with Pbp1p and Pbp4p and associates with ribosomes; contains an RNAbinding LSM domain and an AD domain; GFP-fusion protein is induced by the
DNA-damaging agent MMS; relative distribution to the nucleus increases
upon DNA replication stress
0,301
endoplasmic reticulum t-SNARE, coprecipitates with Sec20p, Tip1p. and
Sec22p
Cytochrome-c oxidase subunit III, mitochondrially-coded
Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105,
disruption causes increase in Ty1 transposition. Isolated from the same
screen as the other named RTT genes.
0,295
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
protein localizes to the endoplasmic reticulum; YDR476C is not an essential
gene
F0-ATP synthase subunit 9 (ATPase-associated proteolipid)
Probable glutathione peroxidase (EC 1.11.1.9)
Ribosomal protein S10B
transcription factor involved in the regulation of alpha-specific genes
Subunit of U3-containing Small Subunit (SSU) processome complex involved
in production of 18S rRNA and assembly of small ribosomal subunit
Protein with glutaredoxin activity
Mitochondrial ribosomal protein of the small subunit
Hypothetical aryl-alcohol dehydrogenase
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data; partially overlaps the verified
0,291
0,301
0,300
0,299
0,299
0,299
0,297
0,296
0,296
0,295
0,293
0,291
0,289
0,287
0,286
0,286
0,285
0,285
0,285
0,284
YHL023C
YGL055W
YMR014W
YER105C
YDR088C
YMR003W
YHR012W
YJL168C
YNL085W
YNR034WA
YLR395C
YPL146C
YJL195C
YDR357C
YLR038C
YNL122C
YIL096C
YCL031C
YDR515W
YLR166C
YIR005W
YCR014C
YGL055WR
ORF TIM13/YGR181W
Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3
complex mediates downregulation of TORC1 activity upon amino acid
limitation; SEA complex is a coatomer-related complex that associates
dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required
for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p
phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed
meiotic DNA replication and double-strand break repair
delta-9-fatty acid desaturase
BUD site selection
Nucleoporin similar to Nup157p and to mammalian Nup155p
involved in mRNA splicing
Protein of unknown function; GFP-fusion protein localizes to the
mitochondria; null mutant is viable and displays reduced frequency of
mitochondrial genome loss
involved in vacuolar protein sorting
transcription factor containing a SET domain
retroviral protease signature protein
Putative protein of unknown function; expression is regulated by
Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the
whole genome duplication
Cytochrome-c oxidase chain VIII
Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome;
interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable
but growth is severely impaired
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data; partially overlaps the verified
gene YJL194W/CDC6
Protein of unknown function; likely member of BLOC complex involved in
endosomal cargo sorting; null mutant is sensitive to drug inducing secretion
of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to
the cytoplasm
subunit VIb of cytochrome c oxidase
Putative protein of unknown function; green fluorescent protein (GFP)-fusion
protein localizes to mitochondria; YNL122C is not an essential gene
Putative S-adenosylmethionine-dependent methyltransferase; associates
with precursors of the 60S ribosomal subunit; predicted to be involved in
ribosome biogenesis
involved in rRNA processing
RNA binding protein with La motif
100 kD component of the Exocyst complex\; required for exocytosis. The
Exocyst complex contains the gene products encoded by SEC3, SEC5, SEC6,
SEC8, SEC10, SEC15 and EXO70.
Component of the U2 snRNP, required for the first catalytic step of splicing
and for spliceosomal assembly; interacts with Rds3p and is required for
Mer1p-activated splicing
DNA polymerase IV
0,282
0,282
0,282
0,282
0,281
0,280
0,280
0,279
0,279
0,275
0,275
0,269
0,269
0,269
0,267
0,267
0,265
0,263
0,262
0,259
0,256
0,255
0,255
YBR211C
YKL089W
YMR132C
regulator of microtubule stability
centromere protein
Protein of unknown function, contains sequence that closely resembles a J
domain (typified by the E. coli DnaJ protein)
0,254
0,253
0,252
YDL005C
YDR261C
YLL009C
YER133W
YJL098W
YKL079W
YLR129W
YIL027C
Stoichiometric member of mediator complex
Exo-1,3-b-glucanase
cysteine-rich cytoplasmic protein
protein phosphatase type I
Sit4p-associated protein
kinesin heavy chain homolog
interacts with Dom3p
Member of a transmembrane complex required for efficient folding of
proteins in the ER; null mutant displays induction of the unfolded protein
response, and also shows K1 killer toxin resistance
DNA binding protein, homologous to mammalian RFX1-4 proteins
similar to beta-transducin superfamily
Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous
tails during double-strand break repair via single-strand annealing; green
fluorescent protein (GFP)-fusion protein localizes to the nucleus
adenylylsulfate kinase
Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of
histone H3 and is required in chromatin silencing at telomeres; contains a
Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans
and human DPY-30
Nucleolar protein, forms a complex with Noc4p that mediates maturation and
nuclear export of 40S ribosomal subunits; also present in the small subunit
processome complex, which is required for processing of pre-18S rRNA
ubiquitin like protein
Dubious open reading frame unlikely to encode a protein, based on available
experimental and comparative sequence data; partially overlaps the verified
ORF PEX14/YGL153W
TyB Gag-Pol protein. Gag processing produces capsid proteins. Pol is cleaved
to produce protease, reverse transcriptase and integrase activities.
0,249
0,248
0,248
0,246
0,244
0,243
0,242
0,241
coiled-coil protein involved in the spindle-assembly checkpoint
SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on
Arg-146; not an essential gene; predicted to be involved in rRNA processing
and ribosome biogenesis and in biopolymer catabolism
hypoxanthine guanine phosphoribosyltransferase
ubiquitin-like protein
SCEI -DNA endonuclease in mitochondrial 21S rRNA intron
Component of H\/ACA-box snoRNPs
0,227
0,227
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit
biogenesis; localizes to both nucleolus and cytoplasm
subunit II of cytochrome c oxidase
involved in mRNA decay
TFIIS-like small Pol III subunit C11
argininosuccinate lyase
0,221
YLR176C
YLR196W
YAL027W
YKL001C
YDR469W
YDL148C
YIL008W
YGL152C
YNL054WB
YGL086W
YOR021C
YDR399W
YDR139C
Q0160
YHR072WA
YNL110C
Q0250
YKL009W
YDR045C
YHR018C
0,241
0,238
0,237
0,233
0,232
0,232
0,232
0,229
0,229
0,227
0,226
0,223
0,223
0,220
0,218
0,217
0,216
YKL051W
YML009C
YDR468C
YML026C
YBL040C
YNL104C
YGR023W
YER159C
YGR090W
YJL138C
YLR051C
YMR188C
YDL140C
YDL166C
YMR124W
YJR152W
YDL058W
Q0075
YER112W
YHR037W
YDR168W
YGR168C
YLR456W
YPL265W
YBR067C
YBR048W
Q0297
YDR175C
YLR190W
Plasma membrane protein that may act together with or upstream of Stt4p to
generate normal levels of the essential phospholipid PI4P, at least partially
mediates proper localization of Stt4p to the plasma membrane
mitochondrial ribosomal protein MRPL39 (YmL39)
tSNARE that affects a Late Golgi compartment
Ribosomal protein S18B
encodes the HDEL receptor required for retention of ER proteins
alpha-isopropylmalate synthase (2-Isopropylmalate Synthase)
acts in concert with Mid2p to transduce cell wall stress signals
Transcriptional regulator which functions in modulating the activity of the
general transcription machinery in vivo
0,216
Component of the small-subunit processome; required for nuclear export of
tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their
delivery to Los1p for export; conserved from yeast to mammals
translation initiation factor eIF4A
Essential nucleolar protein involved in the early steps of 35S rRNA processing;
interacts with Faf1p; member of a transcriptionally co-regulated set of genes
called the RRB regulon
Mitochondrial ribosomal protein of the small subunit
RNA polymerase II large subunit
Essential NTPase required for small ribosome subunit synthesis, mediates
processing of the 20S pre-rRNA at site D in the cytoplasm but associates only
transiently with 43S preribosomes via Rps14p, may be the endonuclease for
site D
Protein of unknown function; GFP-fusion protein localizes to the cell
periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid
assay; YMR124W is not an essential gene; predicted to have a role in
organelle organization
allantoate permease
Integrin analogue gene
intron of mitochondrial COX1, aI5-beta
U6 snRNA associated protein
delta-1-pyrroline-5-carboxylate dehydrogenase
(putative) chaperone, involved in spindle pole body duplication and passage
through START
0,199
Putative protein of unknown function; YGR168C is not an essential gene
Putative pyridoxal 5'-phosphate synthase; null mutant displays increased
resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W
has a paralog, YPR172W, that arose from the whole genome duplication
dicarboxylic amino acid permease
cell wall mannoprotein
Ribosomal protein S11B (S18B) (rp41B) (YS12)
Dubious open reading frame of the mitochondrial genome; unlikely to encode
a protein, based on available experimental and comparative sequence data;
partially overlaps the verified gene RPM1
protein of the small subunit of the mitochondrial ribosome
Phosphorylated protein of the mitochondrial outer membrane, localizes only
to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial
0,168
0,168
0,213
0,212
0,211
0,208
0,206
0,206
0,199
0,197
0,194
0,193
0,189
0,188
0,185
0,181
0,173
0,173
0,170
0,169
0,168
0,165
0,163
0,161
0,151
0,149
0,140
Q0055
YDL134C
Q0070
YBR054W
YKL058W
YOR095C
YNL067W
Q0050
YJL189W
YKR065C
Q0080
YGR084C
YNL188W
YHR196W
YOR089C
YHR029C
YMR238W
YMR143W
YOR293W
YCL025C
YKL056C
YAL007C
YHR023W
Q0065
YDR450W
Q0045
YIL076W
YHR071W
distribution to buds; mRNA is targeted to the bud via the transport system
involving She2p
maturase aI2\; encodes intron-specific reverse transcriptase activity\;
putative endonuclease
0,138
serine-threonine protein phosphatase 2A
DNA endonuclease involved in intron homing
Homolog to HSP30 heat shock protein YRO1 (S. cerevisiae) 7
Transcription factor IIA, small chain
Ribose-5-phosphate ketol-isomerase
Ribosomal protein L9B (L8B) (rp24) (YL11)
maturase aI1\; intron-specific reverse transcriptase activity
Ribosomal protein L39 (L46) (YL40)
Constituent of the TIM23 complex; proposed alternatively to be a component
of the import motor (PAM complex) or to interact with and modulate the core
TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein
abundance increases in response to DNA replication stress
mitochondrially-encoded ATP synthase subunit 8
35 kDa mitochondrial ribosomal small subunit protein
Localizes to the spindle pole body
Nucleolar protein, component of the small subunit (SSU) processome
containing the U3 snoRNA that is involved in processing of pre-18S rRNA
small GTP-binding protein\; geranylgeranylated\; geranylgeranylation
required for membrane association\; also involved in endocytosis post vesicle
internalization
0,133
0,131
0,126
0,126
0,125
0,122
0,122
0,119
0,117
Thymidylate synthase (putative\; weak)
involved in pseudohyphal growth
Ribosomal protein S16A (rp61R)
Ribosomal protein S10A
Amino acid permease
Protein that associates with ribosomes; homolog of translationally controlled
tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the
cytoplasm and relocates to the mitochondrial outer surface upon oxidative
stress
p24 protein involved in membrane trafficking
Class II Myosin
I-SceII endonuclease activity is encoded by the aI4 intron
Ribosomal protein S18A
cytochrome-c oxidase subunit I
epsilon-COP coatomer subunit Sec28p
G1\/S cyclin (weak)
0,099
0,095
0,090
0,083
0,082
0,079
0,116
0,114
0,107
0,103
0,099
0,074
0,066
0,054
0,047
0,044
0,044
0,004