Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Publications juni 2015 Medical dissertations 1. Husted H. Fast-track hip and knee arthroplasty: clinical and organizational aspects. Medical doctoral thesis. Copenhagen University. Defended September 28, 2012. (Acta Orthop; Supp.346, 83; 1-38). 2. Krenk L. Postoperative cognitive decline after fast-track hip and knee arthroplasty. PhD thesis Copenhagen University. Defended September 28, 2012. 3. Lunn TH. High-dose glucocorticoid to improve postoperative recovery in total hip and knee arthroplasty. PhD thesis Copenhagen University. Defended April 18, 2013. 4. Jakobsen TL. Progressive strength training commenced early after fast-track total knee arthroplasty. Feasibility and effect. PhD thesis Copenhagen University. Defended December 4, 2013. 5. Jans Ø, Orthostatic intolerance during early mobilization after major surgery. PhD thesis Copenhagen University. Defended January 23, 2014. 6. Andersen LØ. Local infiltration analgesia in fast-track hip and knee replacement. Medical doctoral thesis. Re-submitted Copenhagen University 2014. 7. Lindberg-Larsen M. Early morbidity after bilateral and revision hip and knee arthroplasty in Denmark. PhD thesis Copenhagen University. Defended March 12, 2015. 8. Bjerregaard LS. PhD to be submitted in 2015. 9. Jans Ø. Medical doctoral thesis to be submitted in 2015. 1 10. Jørgensen CC. Medical doctoral thesis to be submitted end 2015 11. Lange J. Perspectives on treatment and outcome of chronic periprosthetic hip joint infection. PhD thesis submitted Århus University Hospital April 2015. 2 Publications in peer-reviewed journals 1. Husted H, Andersen KV, Soballe K. Reconvalescence and sick leave following total knee and hip arthroplasty. Ugeskr Laeger 2009; 171:2892-2896. 2. Holm B, Kristensen MT, Myhrmann L, Husted H, Andersen LO, Kristensen B, Kehlet H.The role of pain for early rehabilitation in fast track total knee arthroplasty. Disabil Rehabil 2010; 32:300-306. 3. Andersen LØ, Husted H, Kristensen BB, Otte KS, Gaarn-Larsen L, Kehlet H. Analgesic efficacy of subcutaneous local anesthetic wound infiltration in bilateral knee arthroplasty: a randomised, placebo-controlled, double-blind trial. Acta Anaesthesiol Scand 2010; 54:543-548. 4. Andersen LØ, Kristensen BB, Madsen J.L, Otte KS, Husted H, Kehlet H. Wound spread of radiolabeled saline with multi- versus few-hole catheters. Reg Anesth Pain Med 2010; 35:200-202. 5. Kehlet H, Soballe K. Fast track hip and knee replacement - what are the issues? Acta Orthop 2010; 81:271-272. 6. Husted H, Otte KS, Kristensen BB, Ørsnes T, Wong C, Kehlet H. Low risk of thromboembolic complications after fast-track hip and knee arthroplasty. Acta Orthop 2010; 81:599-605. 7. Husted H, Solgaard S, Hansen TB, Søballe K, Kehlet H. Care principles at four fasttrack arthroplasty departments in Denmark. Dan Med Bull 2010; 57:A4166. 8. Andersen LØ, Gaarn-Larsen L, Kristensen BB, Husted H, Otte KS, Kehlet, H. Analgesic efficacy of local anaesthetic wound administration in knee arthroplasty. Volume vs. concentration. Anaesthesia 2010; 65:984-990. 9. Andersen LØ. Husted H, Kristensen BB, Otte KS, Gaarn-Larsen, Kehlet H. Analgesic efficacy of intracapsular vs. intra-articular local anaesthesia for knee arthroplasty. Anaesthesia 2010; 65:904-912. 10. Andersen KV, Bak M, Christensen BV, Harazuk J, Pedersen NA, Søballe K. A randomized controlled trial comparing local infiltration analgesia with epidural infusion for total knee arthroplasty. Acta Orthop 2010; 81:606-610. 11. Husted H, Otte KS, Kristensen BB, Ørsnes T, Kehlet H. Readmissions after fast-track hip and knee arthroplasty. Arch Orthop Trauma Surg 2010; 130:1185-1191. 3 12. Holm B, Kristensen MT, Bencke J, Husted H, Kehlet H, Bandholm T. Loss of kneeextension strength is related to knee swelling after total knee arthroplasty. Arch Phys Med Rehabil 2010; 91:1770-1776. 13. Krenk L, Rasmussen LS, Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol Scand 2010; 54:951-956 14. Larsen K, Hansen TB, Soeballe K, Kehlet H. Patient-reported outcome after fast-track hip arthroplasty: a prospective cohort study. Health Qual Life Outcomes 2010; 8:144. 15. Jans Ø, Kehlet H, Hussain Z, Johansson P. Transfusion practice in hip arthroplasty – a nationwide study. Vox Sanguinis 2011; 100:374-380. 16. Lunn TH, Kristensen BB, Andersen LØ, Husted H, Otte KS, Gaarn-Larsen L, Kehlet H. Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomised, placebo-controlled trial. Br J Anaesth 2011; 106:2308. 17. Husted H, Troelsen A, Otte KS, Kristensen BB, Holm G, Kehlet H. Fast-track surgery for bilateral total knee replacement. J Bone Joint Surg Br 2011; 93-B: 351-356. 18. Holm B, Kristensen MT, Husted H, Kehlet H, Bandholm T. Thigh and knee circumference, knee-extension strength, and functional performance after fast-track total hip arthroplasty. Phys Med & Rehabil 2011; 3: 117-24. 19. Jans Ø, Kehlet H, Johansson PI, Blood transfusion in major orthopaedic surgery. Ugeskr Læger 2011; 173: 815-817. 20. Krenk L, Rasmussen LS. Postoperative delirium and postoperative cognitive dysfunction in the elderly – what are the differences? Minerva Anestesiologica 2011; 77:74249. 21. Lunn TH, Husted H, Solgaard S, Kristensen BB, Otte KS, Kjersgaard AG, GaarnLarsen L, Kehlet H. Intraoperative local infiltration analgesia for early analgesia after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial. Reg Anesth Pain Med 2011; 36:424-29. 22. Otte K, Husted H, Ørsnes T, Kehlet H. Bilateral simultaneous total hip arthroplasty in a fast track setting. Hip International 2011; 21:336-339. 4 23. Andersen LØ, Otte KS, Husted H, Gaarn-Larsen L, Kristensen B, Kehlet H. Highvolume infiltration analgesia in bilateral hip arthroplasty. A randomized, double-blind placebo-controlled trial. Acta Orthop 2011; 82:423-426. 24. Kehlet H, Andersen LØ. Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice. Acta Anaesthesiol Scand 2011; 55:778784. 25. Husted H, Troelsen A, Kehlet H. Undocumented regimes after total hip and knee arthroplasty can deteriorate the results. Ugeskr Laeger 2011; 173:1802-1805. 26. Husted H, Otte KS, Kristensen BB, Kehlet H. Fast-track revision knee arthroplasty. A feasibility study. Acta Orthop 2011; 82:438-40. 27. Husted H, Lunn TH, Troelsen A, Gaarn-Larsen L, Kristensen BB, Kehlet H. Why still in hospital after fast-track hip and knee arthroplasty? Acta Orthop 2011; 82:679-684. 28. Husted H, Munk Jensen C, Solgaard S, Kehlet H. Reduced length of stay following hip and knee arthroplasty in Denmark 2000-2009: from research to implementation. Acta Ortop Trauma Surg 2012; 132:101-104. 29. Munk S, Dalgaard J, Bjerggaard K, Andersen I, Hansen TB, Kehlet H. Early recovery after fast-track Oxford unicompartmental knee arthroplasty. 35 patients with minimal invasive surgery. Acta Orthop 2012; 83:41-45. 30. Jakobsen TL, Husted H, Kehlet H, Bandholm T. Progressive strength training (10 RM) commenced immediately after fast-track total knee arthroplasty: is it feasible? Disabil Rehabil 2012; 34:1034-40. 31. Jans Ø, Bundgaard-Nielsen M, Solgaard S, Johansson PI, Kehlet H Orthostatic intolerance during early mobilization after fast-track hip arthroplasty. Br J Anaesth 2012:108:436-43. 32. Holm B, Husted H, Kehlet H, Bandholm T. Effect of knee joint icing on knee extension strength and knee pain early after total knee arthroplasty: a randomized cross-over study. Clin Rehabil 2012; 26:716-723. 33. Krenk L, Rasmussen LS, Bæk-Hansen T, Bogø S, Soeballe K, Kehlet H. Delirium after fast-track hip and knee arthroplasty. Br J Anaesth 2012; 108:607-11. 34. Kjærsgaard-Andersen P, Kehlet H. Should deep venous thrombosis prophylaxis be used in fast-track hip and knee replacement? Acta Orthop 2012; 83:105-106. 5 35. Lange J, Troelsen A, Thomsen RW, Soeballe K. Chronic infections in hip arthroplasties: comparing risk of reinfection following one-stage and two-stage revision: a systematic review and meta-analysis. Clin Epidemiol 2012; 4:57-73. 36. Larsen K, Hansen TB, Søballe K, Kehlet H. Patient-reported outcome after fast-track knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2012; 20:1128-1135. 37. Bandholm T, Kehlet H. Physiotherapy exercise after fast-track total hip and knee arthroplasty: time for reconsideration? Arch Phys Med Rehabil 2012; 93:1 292-4. 38. Lunn TH, Kristensen BB, Gaarn-Larsen L, Husted H, Kehlet H. Post-anaesthesia care unit stay after total hip and knee arthroplasty under spinal anaesthesia. Acta Anaesthesiol Scand 2012; 56:1139-45. 39. Jans Ø, Kehlet H, Johansson PI. Transfusion-related mortality after primary hip arthroplasty – an analysis of mechanisms and confounders. Vox Sang 2012; 103:301308. 40. Krenk L, Rasmussen LS, Siersma VD, Kehlet H. Short-term practice effects and variability in cognitive testing in a healthy elderly population. Exp Gerontol 2012; 47:432436. 41. Jakobsen TL, Kehlet H, Bandholm T. Reliability of the 6-min walk test after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2013;21:2625-2628. 42. Krenk L, Rasmussen, LS, Kehlet H. Delirium in the fast-track surgery setting. Best Pract Res Clin Anaesthesiol 2012; 26:345-53. 43. Lunn TH, Kristensen BB, Gaarn-Larsen L, Kehlet H. Possible effects of mobilisation on acute post-operative pain and nociceptive function after total knee arthroplasty. Acta Anaesthesiol Scand 2012; 56:1234-1240. 44. Krenk L, Jennum P, Kehlet H. Sleep disturbances after fast-track hip and knee arthroplasty. Br J Anaesth 2012; 109:769-75. 45. Kristensen MT, Jakobsen TL, Nielsen JW, Jørgensen LM, Nienhuis RJ, Jønsson LR. Cumulated ambulation score to evaluate mobility is feasible in geriatric patients and in patients with hip fracture. Dan Med J 2012; 59:A4464. 46. Munk S, Jensen NJF, Andersen I, Kehlet, H, Hansen TB. Effect of compression therapy on knee swelling and pain after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2013; 21:388-392. 6 47. Lunn TH, Andersen LØ, Kristensen BB, Husted H, Gaarn-Larsen L, Bandholm T, Ladelund S, Kehlet H. Effect of high-dose preoperative methylprednisolone on recovery after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial. Br J Anaesth 2013; 110:66-73. 48. Aalund PK, Larsen K, Hansen TB, Bandholm T. Normalized knee-extension strength or leg-press power after fast-track total knee arthroplasty: which measure is most closely associated to performance-based and self-reported function? Arch Phys Med Rehabil 2013; 94:384-90. 49. Skovgaard C, Holm B, Troelsen A, Lunn TH, Gaarn-Larsen, Kehlet H, Husted H. No effect of fibrin sealant on drain output or functional recovery following simultaneous bilateral total knee arthroplasty. Acta Orthop 2013;84:153-158. 50. Madsen M, Larsen K, Hansen TB. Late group-based rehabilitation has no advantages compared with supervised home-exercises after total knee arthroplasty. Dan Med J 2013; 60:A4607. 51. Jørgensen CC, Kehlet H. Role of patient characteristics for fast-track hip and knee arthroplasty. Br J Anaesth 2013; 110:972-980. 52. Jørgensen CC, Kehlet H. Outcomes in smokers and alcohol users after fast-track hipand knee arthroplasty. Acta Anaesthesiol Scand 2013; 57:631-638. 53. Holm B, Thorborg K, Husted H, Kehlet H, Bandholm T. Surgery-induced changes and early recovery of hip muscle strength, leg-press power and function after fast-track total hip arthroplasty. PLOS ONE 2013; 8:e62109. 54. Kehlet H. Fast-track hip and knee arthroplasty. Lancet 2013. 381:1600-1602. 55. Harsten A, Kehlet H, Toksvig-Larsen S. Recovery after total intravenous general anaesthesia vs. spinal anaesthesia for total knee arthroplasty; a randomized controlled trial. Br J Anaesth 2013; 111:391-399. 56. Andersen KV, Nikolajsen L, Haraldsted V, Odgaaard A, Soeballe K. Local infiltration analgesia for total knee arthroplasty: should ketorolac be added? Br J Anaesth 2013; 111:242-248. 57. Krenk L, Jennum P, Kehlet H. Activity, sleep and cognition after fast-track hip or knee arthroplasty. J Arthroplasty 2013; 28:1265-1269 7 58. Lunn TL, Kehlet H. Perioperative glucocorticoids in hip and knee surgery – benefit vs. harm? A systematic review of randomized controlled trials. Acta Anaesthesiol Scand. 2013; 57:823-834.. 59. , Lunn TH, Gaarn-Larsen L, Kehlet H. Prediction of postoperative pain by preoperative pain response to heat stimulation in total knee arthroplasty. Pain 2013; 154:1878-1885 60. Pape B, Thiessen PS, Jakobsen F, Hansen TB. Interprofessional collaboration may pay off: introducing a collaborative approach in an orthopaedic ward. J Interprof Care 2013; 27:496-500. 61. Lindberg-Larsen M, Jørgensen CC, Husted H, Kehlet, H. Simultaneous and staged bilateral total hip arthroplasty. A Danish nationwide study. Arch Orthop Trauma Surg 2013;133:1601-1605 62. Kehlet H, Thienpont E. Fast-track knee arthroplasty - status and future challenges. The Knee 2013; S29-S33 63. Jørgensen CC, Foss NB. Age as a surgical risk factor. Ugeskr Læger 2013;41;24022405 64. Jørgensen CC, Kehlet H. Fall-related readmissions after fast-track total hip and knee arthroplasty, cause of concern or consequence of success? Clin Interv Aging 2013;8:1569-1577 65. Jørgensen CC, Jacobsen M, Soeballe K, Hansen TB, Husted H, KjærsgaardAndersen P, Hansen L, Laursen M, Kehlet H Thromboprophylaxis only during hospitalisation in fast-track hip and knee arthroplasty, a prospective cohort study. BMJ Open 2013;3:e003965 66. Jans Ø, Jørgensen CC, Kehlet H, Johansson P. Role of preoperative anemia for transfusion and readmisson in fast-track hip- and knee arthroplasty Transfusion 2014;54:717-726. 67. Bjerregaard LS, Bagi P, Kehlet H. Postoperative urinary retention (POUR) in fast-track total hip- and knee arthroplasty. A challenge for orthopedic surgeons. Acta Orthop 2014:85:8-10. 8 68. Krenk L, Jennum P, Kehlet H. Postoperative sleep disturbances after Zolpidem treatment in fast-track hip and knee replacement. J Clin Sleep Med 2014; 10:321-326. 69. Andersen LØ, Kehlet H, Analgesic efficacy of local infiltration analgesia in hip and knee arthroplasty: a systematic review. Br J Anaesth 2014;3:360-374. 70. Lindberg-Larsen M, Jørgensen CC, Husted H, Kehlet H. Early morbidity after simultaneous and staged bilateral total knee arthroplasty. KSSTA Journal 2015;3:831-837. 71. Bandholm T, Thorborg K, Lunn TH, Kehlet H, Jakobsen TL. Knee pain during strength training shortly following fast-track total knee arthroplasty: a cross-sectional study. PLOS ONE 2014;9:e91107 72. Kehlet H, Jørgensen CC. Patient safety in fast-track total hip and knee replacement. In: Bentley G, ed. European Instructional Lectures. EFORT 14. Springer Berlin Heidelberg. DOI 10.1007/978-3-642-54030. 73. Krenk L, Kehlet H, Hansen TB, Solgaard S, Søballe K, Rasmussen L. Cognitive dysfunction after fast-track hip and knee replacement. Anesth Analg 2014; 118:10341040. 74. Holm B, Bandholm T, Lunn TH, Husted H, Aalund P, Hansen TB, Kehlet H. Role of preoperative pain, muscle function and activity level on discharge readiness after fasttrack hip and knee arthroplasty. Acta Orthop 2014: 85:488-492. Erratum 2014; 85:686. 75. Jørgensen CC, Kjaersgaard-Andersen P, Solgaard S, Kehlet H. Hip dislocations after 2734 elective unilateral fast-track total hip arthroplasties-incidence, circumstances and predisposing factors. Arch Orthop Trauma Surg 2014; 1615-22. 76. Glassou EN, Pedersen AB, Hansen TB. Risk of readmission, reoperation and mortality within 90 days of total hip and knee arthroplasty in fast-track departments in Denmark from 2005-2011. Acta Orthop 2014:85:493-500. 77. Specht K, Kjaersgaard-Andersen P, Kehlet H, Pedersen PD. Nursing in fast-track total hip and knee arthroplasty: a retrospective study. Int J Orthop Trauma Nurs 2014 (in press) 78. Lindberg-Larsen M, Jørgensen CC, Hansen TB, Solgaard S, Odgaard A, Kehlet H. Re-admissions, re-operations and length of stay in hospital after aseptic revision knee replacement in Denmark: a two-year nationwide study. Bone & Joint Journal. 2014; 96B:1649-56. 9 79. Lindberg-Larsen M, Jørgensen CC, Hansen TB, Solgaard S, Kehlet H. Early morbidity after aseptic revision hip arthroplasty in Denmark. A 2-year nationwide study. Bone & Joint Journal 2014:96-B: 1464-71. 80. Jacobsen TL, Kehlet H, Husted H, Petersen J, Bandholm T. Early progressive strength training to enhance recovery after fast-track total knee arthroplasty. A randomized controlled trial. Arthritis Care & Research 2014.1856-1866. 81. Bjerregaard LS, Bogø S, Raaschou S, Troldborg C, Hornum U, Poulsen A, Bagi P, Kehlet H. Incidence and risk factors for postoperative urinary retention in fast-track total hip and knee arthroplasty. Acta Orthop 2015. 86; 183-188. 82. Mikkelsen LR, Mechlenburg I, Søballe K, Jørgensen LB, Mikkelsen S, Bandholm T, Petersen AK. Effect of early supervised progressive resistance training compared to unsupervised home-based exercise after fast-track total hip replacement. A singleblinded randomised controlled trial. Osteoarthritis & Cartilage 2014; 22:2051-8. 83. Harsten A, Kehlet H, Ljung P, Toksvig-Larsen S. Total intravenous general anaesthesia vs spinal anaesthesia for total hip arthroplasty: a randomized controlled trial. Acta Anaesthesiol Scand 2015; 59:298-309. 84. Krenk L, Sørensen G, Kehlet H, Jennum P. Heart rate response during sleep after fast-track arthroplasty. Sleep and Biological Rhythms 2015 (in press) 85. Harsten A, Bandholm T, Kehlet H, Toksvig-Larsen S. Tourniquet versus no tourniquet on knee-extension strength early after fast-track total knee arthroplasty: a randomized controlled trial. The Knee 2015; 126-130. 86. Jørgensen CC, Jans Ø, Kehlet H. Preoperative anaemia and cancer incidence 1 year after elective fast-track total hip and knee arthroplasty. Vox Sang 2015 (e-pub). 87. Jørgensen CC, Madsbad S, Kehlet H. Postoperative morbidity and mortality in Type-2diabetics after fast-track primary total hip and knee arthroplasty. Anesth Analg 2015; 230-238. 88. Husted H, Gromov K, Jørgensen CC, Troelsen A. Low manipulation prevalence following fast-track total knee arthroplasty – a multicenter cohort-study in 3,145 consecutive unselected patients. Acta Orthop 2015; 86:86-91. 10 89. Jørgensen CC, Knop J, Nordentoft M, Kehlet H. Psychiatric disorders and psychopharmacologic treatment as risk factors in elective fast-track total hip and knee arthroplasty. Anesthesiology 2015 (e-pub). 90. Rytter S, Stilling M, Munk S, Hansen TB. Methylprednisolone reduce pain and decrease knee swelling in the first 24 hours after fast-track Oxford unicompartmental knee arthroplasty. Knee Surg Sports Traum Arthrosc 2015 (e-pub). 91. Gromov K, Willendrup F, Palm H, Troelsen A, Husted H. Fast-track pathway for reduction of dislocated hip arthroplasty reduces surgical delay and length of stay. Acta Orthop 2015;3:335-338. 92. Munoz M, Gomez-Ramirez S, Pavia J, Kehlet H, Acheson AG, Richards T, Evans C, Kong R, RaoBaikady R, Shander A, Javidroozi M, Auerbach M, Kozek-Langeneker S. ‘Fit to fly’. Overcoming the barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth 2015 (in press) 93. Kurbegovic S, Andersen J, Krenk L, Kehlet H. Delirium in fast-track colonic surgery. Langenbecks Arch Surg 2015; 4:513-516. 94. Wied C, Thomsen MG, Kallemose T, Myhrmann L, Jensen LS, Husted H, Troelsen A. The risk of manipulation under anesthesia due to unsatisfactory knee flexion after fasttrack total knee arthroplasty. The Knee 2015 (e-pub). 95. Lunn T, Frokjaer VG, Hansen TB, Kristensen PW, Lind T, Kehlet H. Analgesic effect of perioperative Escitalopram in high pain catastrophizing patients after total knee arthroplasty. Anesthesiology 2015:12:884-94. 96. Aasvang E, Luna IE, Kehlet H. Challenges in post-discharge function and recovery – the case of fast-track hip and knee arthroplasty. Br J Anaesth 2015 ( in press) 97. Lindberg-Larsen M, Jørgensen CC, Husted H, Kehlet H. Early morbidity after simultaneous and staged bilateral total knee arthroplasty. KSSTA Journal 2015; 3:831-837. 11 ----------------------------------------------------------------------------------------------------------------------------- -- 98. Kjellberg J, Kehlet H. Long-term socioeconomic outcomes after hip and knee replacement. 2015 (submitted) 99. Mikkelsen EK. Jakobsen TL, Holsgaard-Larsen A, Andersen LL, Bandholm T. Acute effect of strength training with repetitions to contraction failure on central (CNS) activation of the quadriceps muscle shortly following total knee arthroplasty: a cross sectional study. 2015 (submitted) 100. Specht K, Kjaersgaard-Andersen P, Kehlet H, Wedderkopp N, Pedersen B. High patient satisfaction in fast-track primary total hip and knee replacement: a study in 500 patients. 2015 (submitted) 101. Lange J, Pedersen AB, Troelsen A, Søballe K. Does hip prosthesis related infection codes in administrative discharge registers correctly classify periprosthetic hip joint infection? 2015 (submitted) 102. Specht K, Kjaersgaard-Andersen P, Pedersen BP. Patient experience in fast-track total hip and knee arthroplasty – a qualitative study. 2015 (submitted) 103. Lunn TH, Husted H, Laursen MB, Hansen LT; Kehlet H. Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty. A randomized, doubleblind, placebo-controlled, dose-response study. 2015 (submitted) 104. Lange J, Troelsen A, Pedersen A.B., Søballe K. Estimating re-infection rates by competing risk analysis following treatment for chronic periprosthetic hip joint infection in a native sample population. 2015 (submitted) 105. Jans Ø, Brinth L, Kehlet H, Mehlsen J. Abnormal heart rate variability responses during early postoperative mobilization – an observational study 2015 (submitted) 106. Jans Ø, Bandholm T, Solgaard S, Kjærsgaard-Andersen P, Johansson PI, Kehlet H. Postoperative anemia and early functional outcomes after fast-track hip arthroplasty: a prospective cohort study. 2015 (submitted) 107. Jans Ø, Grevstad U, Mandøe H, Kehlet H, Johanson PI. The effect of intraoperative low dose epinephrine infusion on blood loss during total hip arthroplasty – a doubleblind placebo controlled randomized trial. (submitted 2015) 108. Pitter FT, Jørgensen CC, Lindberg-Larsen M, Kehlet H. Postoperative morbidity and discharge destinations after fast-track hip- and knee arthroplasty in patients>85 years. (submitted 2015) 109. Aasvang EK, Lunn TH, Hansen TB, Kristensen PW, Solgaard S, Kehlet H. Chronic pre-operative opioid use and acute pain after fast-track total knee arthroplasty. (submitted 2015) 110. Bjerregaard L.S, Jørgensen CC, Kehlet H. Serious renal and urological complications after fast-track primary total hip and knee arthroplasty. (submitted 2015) 12 111. Jørgensen CC, Petersen MA, Kehlet H. Preoperative prediction of potentially preventable morbidity after fast-track hip and knee arthroplasty. (submitted 2015) 112. Lindberg-Larsen M, Jørgensen CC, Bagger J, Schrøder H.M., Kehlet H. Success rates and failures after infectious revision knee arthroplasty in Denmark. (submitted 2015) 113. Luna IE, Peterson BT, Kehlet H, Aasvang EK. Individualized assessment of postarthroplasty recovery by actigraphy – a methodology study. (submitted 2015) 114. Jørgensen C, Aagaard Petersen M, Kehlet H. Preoperative prediction of potentially preventable morbidity after fast-track hip and knee arthroplasty. (submitted 2015) 115. Jans Ø, Mehlsen J, Kjærsgaard-Andersen P, Husted H, Solgaard S, Josiassen J, Lunn T.H., Kehlet H. Oral midodrine hydrochloride for prevention of orthostatic hypotension during early mobilization after hip arthroplasty – a randomized, double-blind, placebo-controlled trial. (submitted 2015) 13