# Chapter 10 Practice Problems

advertisement ```11 February 2014
Chapter 10
Practice Problems
10.1 The effects of genetic hitchhiking are likely to be especially important in populations that
have gone through a bottleneck. Why?
10.2 Can the amount of recombination between two loci be estimated by examining the
genotypic proportions in a population?
10.3 If a population is completely A1B2/A2B1 what is the value of D?
10.4 The number of generations needed for D to go halfway to zero is found by noting when Dt
= 0.5 Do. For a given amount of recombination, we need to solve the equation
(1-r)t = 0.5
t ln(1-r) = ln(0.5)
t = ln(0.5)/ln(1-r)
With unlinked loci, t = ln(0.5)/ln(1-0.5) = 1 and D is therefore halved in a single generation.
Vary the fraction of recombination and evaluate the half-life as a function of r and plot your
results below:
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10.5 What would you consider a small fraction of recombination? Hint: Examine your answer to
the previous problem and Figure 10.2.
10.6 Given heterozygous advantage at one locus (A) and selective neutrality at the other (B) as
shown below. What are the marginal fitness at locus B when D = +0.25 and the allele
frequencies at locus A are at equilibrium? How about if D = -0.25?
AA
Aa
aa
BB w11=0.8
w13=1.0
w33=0.8
Bb
w11=0.8
w13=1.0
w33=0.8
bb
w11=0.8
w13=1.0
w33=0.8
10.7 Given that strong gametic disequilibrium was observed between alleles at two loci in
different populations, how would you design a research program to determine the cause of this
association?
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Assignment Problems
10.8 Several of studies have found a positive correlation between multiple locus heterozygosity
and measures of fitness in a variety of species (Chapman et al. 2009). How can such correlations
be explained? How could you distinguish among alternative possible explanations for such
correlations?
10.9 We saw in Example 10.3 that parental types persisted in a hybrid zone between two
species of field crickets because of assortative mating between parental types. We should be
able to see this by testing for Hardy-Weinberg proportions for the genotype frequencies
presented at three loci in Figure 10.6. For example, at locus pUC5, the genotype numbers are 12
FF, 6 FP, and 7 PP. Test all three loci in this figure for Hardy-Weinberg proportions. Do your
results support the author’s conclusion of assortative mating between parental types?
10.10 Example 10.4 considers hybrid swarms of trout that appear to be mating at random. Test
the two loci shown in Example 10.4 for Hardy-Weinberg proportions. Does the population from
which this sample was taken appear to be mating at random? Estimate D from this genotypic
table using the eight genotypic classes for which gametes can be unambiguously defined. How
does your estimate compare to EM estimate provided in the example?
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