BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED TWO PAGES.
NAME
Wang, Jia-Yi (
王家儀)
POSITION TITLE
Professor, Graduate Institute of Medical Sciences,
Chair, Department of Physiology,
Taipei Medical University
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of Minnesota, USA
DEGREE
(if applicable)
Ph.D.
YEAR(s)
1983
FIELD OF STUDY
Major: Pharmacology;
Minor: Physiology
National Taiwan University, Taiwan B.Sci 1976 Major: Pharmacy
A. Personal Statement
My research interest is to explore strategies for neuroprotection / therapy in various forms of brain injuries/ degeneration.
Ongoing studies focus on:
1.
Molecular mechanism and time course of neuronal death and survival (apoptosis, autophagy, neurogenesis..etc) following brain injury, repairing, neuroregeneration, and plasticity
2.
Neuron-glia interactions, neuroinflammation and oxidative stress
3.
Biomarkers (proteins and microRNAs) in human cerebrospinal fluid in brain injury and infection
4.
Glioma microenvironment
B. Positions and Honors
1.
Positions and Employment
Chair, Department of Physiology, College of Medicine, Taipei Medical University (2010 to present)
Professor, Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan (2010 to present)
Chair, Department of Physiology, National Defense Medical Center, Taipei, Taiwan (2002-2008)
Professor, Department of Physiology, National Defense Medical Center, Taipei, Taiwan
Council Member, Chinese Physiological Society, Taiwan (2002 to present)
Council Member, Society for Basic Neuroscience, Taiwan (1998- 2012)
Member, Society for Neuroscience, USA
Visiting Research Fellow, National Institute of Drug Abuse, Baltimore, U.S.A (2000-2001)
2.
Honors
Outstanding teacher, National Defense Medical Center, Taipei, Taiwan (2008, & several other years).
Chia-Shing’s Excellent Academic Publications Awards, 1988, Taiwan
C. Selected Peer-reviewed Publications: Publications most relevant to traumatic brain injury:
1.
Yang LY, Chu YH, Tweedie D, Yu QS, Pick CG, Hoffer BJ, Greig NH, d Wang, J.Y.* (2015). Post-trauma administration of the pifithrin-α oxygen analogue improves histological and functional outcomes after experimental traumatic brain injury. Exp. Neurol.
(in press), 2015. doi: 10.1016/j. expneurol.2015.03.015 (online: 24-MAR-2015)
2.
Chen, G. S., Huang, K.F., Huang, C. C. and Wang, J.Y.* (2015) Thaliporphine derivative improves acute lung injury after traumatic brain injury. BioMed Res Int (formerly titled Journal of Biomedicine and Biotechnology) 2015,
729831.
3.
Baratz R, Tweedie D, Wang JY , Rubovitch V, Luo W, , Hoffer BJ, Greig NH, Pick CG. (2015)Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice. J Neuroinflamm 12:45-58
4.
Liu, K.H., Yang, S.T., Lin, Y.K., Lin, J.W., Lee,Y.H., Wang, J.Y.
, Hu, C.J., Lin, E.Y., Chen, S.M., Then, C.K. and
Shen, S.C. (2014). Fluoxetine, an antidepressant, suppresses glioblastoma by evoking AMPAR-mediated calcium dependent apoptosis. Oncotarget. 6: 5088-101. NSC 102-2321-B-038-003.
5.
Lu, K.T., Huang, T.C., Wang, J.Y.
, You, Y.S., Chou, J.L., Chan, M.W., Wo, P.Y., Amstislavskaya, T.G., Tikhonova,
M.A. and Yang, Y.L. (2014). NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through
CREB phosphorylation and HIF-1alpha expression. Pflugers Archiv : European Journal of Physiology. 2014 Sep 9.
[Epub ahead of print] PMID:25201604

6.
Wang, J.Y.
, Lee, C.T., Wang, J.Y. (2014) Nitric oxide plays a dual role in the oxidative injury of cultured rat microglia but not astroglia.
Neuroscience. (281):164-177.
7.
Huang, K.F., Hsu, W.C., Hstao, J.K., Chen, G.S., Wang, J.Y.* (2014) Collagen-Glycosaminoglycan matrix implantation promotes angiogenesis following surgical brain Trauma. BioMed Res Int (formerly titled Journal of
Biomedicine and Biotechnology) 2014:672409.
8.
Huang, Y.N., Lai, C.C., Chiu, C.T., Lin, J.J., Wang, J.Y.* (2014). L-Ascorbate attenuates the endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation and NF-κB translocation in cortical neurons/glia cocultures. PLoS One : 9: e97276.
9.
Hsieh, T. H., Huang, Y. Z., Rotenberg, A., Pascual-Leone, A., Chiang, Y. H., Wang, J. Y.
, Chen, J. J.(2014).
Functional dopaminergic neurons in substantia nigra are required for transcranial magnetic stimulation-induced motor plasticity. Cereb Cortex.
(2014 Jan 22. [Epub ahead of print].
10.
Rachmany, L., Tweedie, D., Rubovitch, V., Yu Q.S., Li, Y., Wang, J-Y.
, Pick, C.G., Greig, N.H. (2014). Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α. PLoS One (8):e79837-e79837.
11.
Tai, Y.T., Lee, W.Y., Lee, F.P., Lin, T.J., Shih, C.L. Wang, J. Y.* , Chiu, W.T., Hung, K.S. (2014). Low dose of valproate improves motor function after traumatic brain injury. BioMed Research International.
(formerly titled
Journal of Biomedicine and Biotechnology) 2014: 980657.
12.
Chang, B.C., Liu, D.H., Chang, J.L., Lee, S.H., Wang, J.-Y.* (2014). Plantar pressure analysis of accommodative insole in older people with metatarsalgia. Gait & Posture , 39(1), 449-454.
13.
Li, C. W., Lin, Y. F., Liu, T. T., and Wang, J.-Y* (2013). Heme oxygenase-1 aggravates heat stress-induced neuronal injury and decreases autophagy in cerebellar Purkinje cells of rats.. Exp Biol Med , 238(7), 744-754.
14.
Ya-Ni Huang, Jiz-Yuh Wang, Ching-Tien Lee, Chih-Hung Lin, Chien-Cheng Lai, Jia-Yi Wang* (2012). l-Ascorbate attenuates methamphetamine neurotoxicity through enhancing the induction of endogenous heme oxygenase-1.
Toxicol Appl Pharmacol , 265(2), 241-252.
15.
Huang, K.F., Hsu, W.C., Chiu, W.T. and Wang, J.Y.* (2012). Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma. B iomaterials , 33(7), 2067-2075.
16.
Chang, B.C., Wang, J.Y.
, Huang, B.S., Lin, H.Y., Winson C.C. Lee (2012). Dynamic impression insole in rheumatoid foot with metatarsal pain. . Clinical Biomechanics , 27(2), 196-201.
17.
Liew H., Peng C.Y., Hsu C.W., Wang M.J., Li T.Y., Kuo J.S. and Wang J.Y.* (2012). Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats. . J
Neuroinflammation , 9, 13-30.
18.
Liew, H.K., Hsu, C.W., Wang, M.J., Kuo, J.S., Li, T.Y., Peng, H.F., Wang, J.Y.* , Pang, C.Y.* (2012).Therapeutic benefit of urocortin in rats with intracerebral hemorrhage. J Neurosurg . 116(1), 193-200.
19.
Chiu, C.C., Wen, L.L. Pao, H.P. and Wang J.-Y* . (2011). Cortistatin is induced in brain tissue and exerts neuroprotection in a rat model of bacterial meningoencephalitis.
J Infectious Dis , 204(10), 1563-1572.
20.
Lui, C.C., Wang, J.-Y , Tain, Y.L., Chen, Y.C., Chang, K.A., Lai, M.C., Huang, L.T. (2011). Prenatal stress in rat causes long-term spatial memory deficit and hippocampus MRI abnormality: Differential effects of postweaning enriched environment. Neurochemistry International , 58(3), 434-441.
21.
Liu, T.T., Hu, C.H., Tsai, C.D., Li, C.W., Lin, Y.F., and Wang, J.Y.* (2010). Heat stroke induces autophagy as a protection mechanism against neurodegeneration in the brain. Shock , 34(6)643-648.
22.
Sheen JM, Huang LT, Hsieh CS, Chen CC en, CC, Wang, J.- Y.
, Tain, YL (2010). Bile duct ligation in developing rats: temporal progression of liver, kidney, and brain damage. J Pediatr Surg , 45(8), 1650-1658.
23.
Huang, Y.N., C. H. Wu, T. C. Lin, and Wang, J.-Y.* (2009). Methamphetamine induces heme oxygenase-1 expression in cortical neurons and glia to prevent its toxicity. Toxicology and Applied Pharmacology , 240(3),
315-326.

24.
Li, C.W., Hu, C.H., and Wang, J.-Y.* (2009). Heat-induced neuronal injury: a review of cellular and animal models.
J Med Sci.
, 29,001-012. (SCI).
25.
Lai, MC, Lui, CC, Yang, Yang, SN, Wang, J.-Y.
and Huang, L.-T. (2009). Epileptogenesis is increased in rats with neonatal isolation and early-life seizure and ameliorated by mk-801: a long-term MRI and histological study.
Pediatric
Res.
, 66(4), 441-447.
26.
Huang, G.S., Lin, T.C., Wang, J.-Y.
, Ku, C.H., Ho, S.T. and Li, C.Y. (2009). Lidocaine priming reduces
ADP-induced P-selectin expression and platelet-leukocyte aggregation. Acta Anaesthesiol Taiwan , 47(2), 56-61.
(SCI).
27.
Lin, T.C., Huang, L.T., Huang, Y.N., Chen, G.S., and Wang, J.Y.* (2009). Neonatal status epilepticus alters prefrontal–striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence.
Epilepsy & Behavior , 14(2), 316-323.
D. Research Support
Current grants:
NSC 99-2320-B-038-006-MY3 (2010 to 2013) Wang, Jia-Yi PI
Roles of autophagy and heme oxygenases (-1, -2) in brain injuries: in vivo and in vitro studies.
NSC 101-2321-B-038-003- (2012 to 2013) Wang, Jia-Yi PI
Therapeutic strategies for traumatic brain injury with novelly desinged drugs. (1/3)
NSC 102-2321-B-038-003 (2013 to 2014) Wang, Jia-YI PI
Therapeutic strategies for traumatic brain injury with novelly desinged drugs. (2/3)
MOST 103-2321-B-038-002-(2014 to 2015) Wang, Jia-Yi PI
Therapeutic strategies for traumatic brain injury with novelly desinged drugs. (3/3)