Lecture 6

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Week 6
Particle Based Drug Delivery Systems
References
LANGER, R.S. & PEPPAS, N.A. (1981) Present and future
applications of biomaterials in controlled drug delivery systems.
Biomaterials. 2, 201-214.
Solvent Casting Method
Solvent Casting Method
Double Emulsion Method
PROTEIN
SOLUTION
POLYMER-DCM
SOLUTION
ADD TO PVA IN
WATER & MIX
ULTRA
SONICATION
PRIMARY
EMULSION (W/O)
SECONDARY
EMULSION
(W/O/W)
SOLVENT
EVAPORATION
FILTRATION AND
DRYING
Spray Dried Microspheres
•Inlet temperature
•Polymer concentration
•Pump feed rate
•Aspirator ratio
•Compressed air flow rate
•Drug loadings
F.J. Wang and C.H. Wang, “Sustained Release of Etanidazole from Spray Dried Microspheres Prepared by Non-halogenated Solvents”,
J. Controlled Release, 81 263-280 (2002).
Microsphere surface morphology using different
polymer solution concentrations
A
B
C
D
F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials,
23 3555-3566 (2002)..
Degradation of microspheres
PLGA 50:50
1 month
PLGA 85:15
3 month
PLGA 65:35
1 month
PDLA
3 month
F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”,
Biomaterials, 23 3555-3566 (2002).
Modulation of release by PEG
100
90
100
80
Cumulative Release (%)
Cumulative Release (%)
90
80
70
60
50
PEG 8000, 10%
PEG3350, 10%
40
PEG1145, 5%
30
PEG3350, 5%
70
60
50
PEG8000 10%
40
PEG3350 10%
PEG1145 5%
30
PEG 3350 5%
20
20
10
10
0
0
0
20
40
60
80
100
Release Time (days)
small discs (diameter = 5mm, thickness =1mm)
0
20
40
60
80
Release Time (days)
large discs (diameter =13mm, thickness = 1mm)
100
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