Standard Operating Procedure
Acryloyl Chloride
This is an SOP template and is not complete until: 1) lab specific information is entered into the
box below 2) lab specific protocol/procedure is added to the protocol/procedure section and
3) SOP has been signed and dated by the PI and relevant lab personnel.
Print a copy and insert into your
Laboratory Safety Manual and Chemical Hygiene Plan.
Refer to instructions for assistance.
Department:
Chemistry
Date SOP was written:
11/6/2012
Date SOP was approved by PI/lab supervisor:
Principal Investigator:
Richmond Sarpong
Internal Lab Safety Coordinator/Lab Manager:
Lab Phone:
1/13/2013
Rebecca Murphy
510-643-2485
Office Phone:
510-643-6312
Emergency Contact:
Richmond Sarpong 626-644-2407
Location(s) covered by this SOP:
Latimer 834, 836, 837,838, 839, 842, 844, 847, 849,
903
(Name and Phone Number)
(Building/Room Number)
Type of SOP:
☐ Process
☒Hazardous Chemical
☐ Hazardous Class
Purpose
Acryloyl chloride (also known as 2-propenoyl chloride) is a highly flammable liquid that may be fatal if
inhaled and harmful if ingested or absorbed through the skin. It can react with water to form toxic and
corrosive fumes of hydrogen chloride and aqueous hydrochloric acid. It is a corrosive chemical that can
cause severe burns to the digestive tract, respiratory tract, skin, and eyes. Acryloyl chloride is mainly
used as a monomer and an intermediate in the synthesis of acrylate compounds. It is used in the
manufacture of plastics, anti-fog agents, and extended drug release capsules.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 814-68-6
Class: Highly flammable, toxic, corrosive, water reactive
Acryloyl Chloride
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Molecular Formula: C3H3ClO
Form (physical state): Liquid
Color: Colorless, light yellow
Boiling point: 72-76 °C
Flash Point: 14oC (57oF)
Potential Hazards/Toxicity
Acryloyl chloride is a highly flammable liquid and vapor. Contact with moisture or water may release toxic
and corrosive fumes of hydrogen chloride and aqueous hydrochloric acid. Product gradually polymerizes
at room temperature. It may be fatal if inhaled and harmful if ingested or absorbed through the skin. It is
extremely destructive to the tissue of the mucous membranes and upper respiratory tract. It causes skin
and eyes burns with severe damage. Symptoms of exposure include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, spasm, inflammation and edema of the larynx and bronchi,
pneumonitis, pulmonary edema, and central nervous system depression. Repeated exposure may cause
bronchitis and gastritis.
Engineering Controls
Chemical fume hoods must be used. Adequate exhaust and capture filtration if needed must be in place.
Electrically grounded lines and equipment must show no tendency to spark.
Personal Protective Equipment (PPE)
Respirator Protection
NOTE: Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S.
This is a regulatory requirement.
Respirators should be used only under any of the following circumstances:
 As a last line of defense (i.e., after engineering and administrative controls have been
exhausted).
 When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will
be exceeded.
 Regulations require the use of a respirator.
 An employer requires the use of a respirator.
 There is potential for harmful exposure due to an atmospheric contaminant (in the absence of
PEL)
 As PPE in the event of a chemical spill clean-up process
Hand Protection
Handle with gloves. Nitrile gloves are recommended. Sigma-Aldrich recommends as a minimum the use
of 0.6mm chloroprene gloves
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are
compatible with acryloyl chloride.
For glove selection, go to: http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-andusage.html
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Eye Protection
ANSI approved, tight-fitting safety glasses/goggles. Face shields are highly recommended for all handling
of acryloyl chloride.
Skin and Body Protection
Flame-resistant lab coat preferably made of anti-static material, long pants, and closed-toe shoes, closed
heeled are recommended. This recommendation is based on the highly flammable nature of the
compound..
Hygiene Measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the
product.
First Aid Procedures
If inhaled
Move person into fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Consult a physician immediately.
In case of skin contact
Wash off with soap and plenty of water for at least 15 minutes while removing contaminated clothing.
Take victim immediately to hospital.
In case of eye contact
Flush eyes with plenty of water for at least 15 minutes using an emergency eyewash station lifting upper
and lower eyelids and removing contact lenses. Consult a physician. Continue rinsing eyes during
transport to hospital.
If swallowed
Do not induce vomiting. Never give anything by mouth to an unconscious person. If conscious and alert,
rinse mouth with water and give 2-4 cupfuls of milk or water. Consult a physician.
Special Handling and Storage Requirements
Precautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and
ingestion. Use spark-proof tools and explosion-proof equipment. Provide adequate exhaust ventilation.
Keep away from heat and sources of ignition- No smoking. Prevent the build-up of electrostatic charge.
Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated area.
Opened containers must be carefully resealed and kept upright to prevent leakage. Light-sensitive.
Recommended storage temperature is 2-8 °C. Reacts violently with water. Incompatible with strong
bases and oxidizing agents.
Spill and Accident Procedure
Chemical Spill Dial 911 and 510-642-9090
Spill – Assess the extent of danger. Help contaminated or injured persons. Evacuate the spill area.
Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material.
Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
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Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal
protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic
bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 911 (or 310-825-1491 from cell phone) and EH&S at 510-642-9090 for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower
for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S at 510-642-9090
immediately.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water from the
emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention.
Notify supervisor and EH&S at 510-642-9090 immediately.
Medical Emergency Dial 911 and 510-642-9090
Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911 or go to the nearest
emergency room.) Note: All serious injuries must be reported to EH&S within 8 hours. Follow up with a
call to 510-642-9090 to report the incident.
Non-Life Threatening Emergency –. Go to the Occupational Health Facility (Tang Health Center). After
hours go to the nearest emergency room. Note: All serious injuries must be reported to EH&S within 8
hours. Follow up with a call to 510-642-9090 to report the incident.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected
area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the
affected area for 15 minutes using an eyewash station. After hours go to the nearest emergency room.
Note: All needle stick/puncture exposures must be reported to EH&S within 8 hours at 510-642-9090.
Decontamination/Waste Disposal Procedure
Wearing proper PPE, absorb spills with inert material. Do not flush with water. Dispose of the used
chemical and contaminated disposables as hazardous waste following the guidelines below.
General hazardous waste disposal guidelines:
Label Waste
•
Label all containers with the label provided at http://ehs.berkeley.edu/hm/279-new-hazardouswaste-program-hwp.html.
See the EH&S Fact Sheet, “Hazardous Waste Management” for general instructions on procedures for
disposing of hazardous waste.
Dispose of Waste
•
Dispose of regularly generated chemical waste within 6 months.
•
Call EH&S for questions.
Safety Data Sheet (SDS) Location
SDS can be accessed online at http://ucmsds.com
Acryloyl Chloride
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Preparation
Know the location of the nearest spill kit, fire extinguisher, eyewash, and safety shower before beginning work.
Keep water or ignition sources away from procedure area).
Lab-specific
Information
All work with acryloyl chloride must take place in the designated fume hood
Procedure
/Use
1. Use as
an
acrylating
agent
Scale
Up to
10 mL
Engineering
Controls/Equipment
All reactions using
acryloyl chloride
must be performed
in a ventilated
fume hood.
Eliminate ignition
sources such as
open flames, hot
surfaces, steam
baths, static
electricity, and
operation of
mechanical and
electrical
equipment that is
not intrinsically
safe.
Acryloyl Chloride
UCLA- EH&S
PPE
Procedure Steps and Precautions
Eye protection: Wear tightfitting safety goggles or
safety glasses with side
shields.
Where possible, avoid contact
between acryloyl chloride and
water.
Face protection: Wear a
face shield when not
protected by a lab hood
sash.
Gloves: Wear reusable
nitrile gloves.
Do not open container or
secondary container with acryloyl
chloride except in a fume hood.
Add acryloyl chloride slowly to
reaction mixture.
Clothing: Wear fire/flame
resistant lab coat (100%
cotton based); cotton based
clothing/attire; full length
pants or equivalent; and
close-toed and close-heeled
shoes.
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NOTE
Any deviation from this SOP requires approval from PI.
Documentation of Training (signature of all users is required)

Prior to conducting any work with acryloyl chloride, designated personnel must provide training to
his/her laboratory personnel specific to the hazards involved in working with this substance, work
area decontamination, and emergency procedures.

The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a
copy of the SDS provided by the manufacturer.

The Principal Investigator must ensure that his/her laboratory personnel have attended appropriate
laboratory safety training or refresher training within the last one year.
I have read and understand the content of this SOP:
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Acryloyl Chloride
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Date: 9/27/2012
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