Title: Acute and 3-month effects of calcium carbonate on the calcification propensity of serum and regulators of vascular calcification:
secondary analysis of a randomized controlled trial.
Journal: Osteoporosis International.
Authors: Sarah M Bristow1, Greg D Gamble1, Andreas Pasch2, W. Charles O’Neill3, Angela Stewart1, Anne M Horne1, Ian R Reid1,4
Affiliations: 1. University of Auckland, Auckland, New Zealand
2. Department of Clinical Chemistry, University Hospital Bern, Inselspital, Bern, Switzerland
3. Renal Division, Emory University School of Medicine, Atlanta GA, USA
4. Department of Endocrinology, Auckland District Health Board, New Zealand
Corresponding Author: Ian R Reid (i.reid@auckland.ac.nz)
Supplementary Figure 1
C h a n g e to 8 h o u r s in T 5 0
100
0
-1 0 0
-2 0 0
-3 0 0
r = - 0 .3 4 , P = 0 .0 3 1
-0 .3
-0 .2
-0 .1
0 .0
0 .1
0 .2
C h a n g e in s e r u m P h o s p h a te to 8 h o u r s
Relationship between change in serum phosphate from baseline and change
in the half-maximal transition time of primary to secondary calciprotein
particles (T50) at 8 hours. Data are from both the calcium carbonate and
placebo groups.
Supplementary Figure 2
C h a n g e to 8 h o u r s in F G F 2 3
20
10
0
-1 0
-2 0
r = - 0 .4 8 , P = 0 .0 4 2
-0 .3
-0 .2
-0 .1
0 .0
0 .1
0 .2
C h a n g e in s e r u m P h o s p h a te to 8 h o u r s
Relationship between change in serum phosphate from baseline and change
in FGF23 at 8 hours. Data are from both the calcium carbonate and placebo
groups.