Presentation It is 6pm on a Saturday evening. Liam B, an 18 year old male, is brought to Barcaldine Base Hospital with severe burns to his body. Hypothesis Flames Sun Thermal Radiation Chemical Electrical Friction Scalds Mechanism Functions of skin Barrier (entry of infection, fluid loss) Sweating/Temperature regulation Appearance Sensation Vit D synthesis Fat storage Further info How long Infection? Where? How much? Cause? Mechanism? First aid? Thickness/depth? Pain? Dehydration? Function? Consciousness? Who else? GCS? Airway? Burns in mouth/lungs? Other skin conditions Other injuries FQs Function of skin Types of burns. Grades and severity and degrees. First aid for burns Emergency Management The paramedics state that Liam was at a party when he threw a can of kerosene on a bonfire which exploded, burning himself and five friends. His shirt and jeans caught alight and he ran around for about a minute before the flames were extinguished. Liam denies any loss of consciousness and is alert and oriented on presentation but is clearly in a lot of pain. He states his pain as being worst in his neck and right arm with 8/10 pain. Liam is given IV morphine titrated to effect. He is noted to have cool extremities but all pulses are present. RR: 20/min normal HR: 140bpm regular tachycardia T: 35°C low BP: 140/70 hypertensive/normal SaO2: 94% 6L via mask low (6-8L/min is normal) Wt: 75kg Although Liam is talking in full sentences without stridor, his voice is hoarse and upon indirect laryngoscopy, he is found to have glottic swelling and carbonaceous sputum. He is intubated with a 7.0 endotracheal tube. A central venous line is placed in Liam's right subclavian vein. Blood is taken for investigations. Liam's % total body surface area (%TBSA) of burn is calculated using a Lund-Browder chart to be 62% with 59% full thickness burns, 2% deep dermal and 1% partial thickness burns. Both his arms have suffered circumferential burns from shoulder tip to hands. His neck, back and posterior legs have also been badly burnt with his face sustaining partial thickness burns from nose down. It is quickly realised that Liam's injuries are too severe to be managed in a small rural hospital. Following the ANZBA guidelines, transfer to the Burns Unit in Brisbane is arranged. Liam's burns are covered with gladwrap in preparation for transport. Hypothesis Breathing troubles Near shock Hypothermic Mechanism Further info Alcohol? Drugs? What happened to friends? Clothes? FQs Healing of burns? Foreign bodies? Compartment syndrome? Scarring? Cosmetics? Lungs affected by burns Smoke inhalation ANZBA guidelines for burns management? Clingwrap? Positioning of pt Lund-Browder chart What comprises a burns unit? Trigger 1.3 Liam arrives in Brisbane and handover is given to the burns unit team. He is given morphine stat and the pain team is called to advise on the best way to manage his pain. He is also written up for regular paracetamol. The resident looking after Liam uses the Parkland formula to calculate his fluid requirements as 18.6L over 24hrs. After contemplating which fluid replacement would be best, she decides on Hartmanns and write up orders to have half of this administered in the first 8hrs. Whilst the resident is stabilising Liam, she becomes concerned that his arms and left leg are becoming increasingly oedematous and calls her consultant to advise on performing an escharotomy. She make plans to have Liam admitted to the intensive care unit and checks the blood results that have come through from Barcaldine. Parameter pH PaCO 2 HCO 3K+ Na+ ClAnion gap Glucose Hb Albumin WBC Value 7.32 low 28 low 18 low 4.6 high 142 normal 111 high 17.6 high 8.1 high 160 normal 24 low 8.6 normal Normal Range 7.36-7.44 35-45 mm Hg 22-32 mmol/L 3.4-4.5 mmol/L 135-145 mmol/L 95-110 mmol/L 8-16 mmol/L 3.0-7.7 mmol/L (random) 130-180 g/L 32-45 g/L 4.5-11 x 10 9/L The dietetics team is called to review Liam and a nasogastric tube is placed to facilitate feeding. Hypothesis Compartment syndrome Acidotic. Metabolic. Compensated. Cell damage (K+ high) Urea and creatinine will probably be high Mechanism Further info Kidneys? What is causing metabolic acidosis? MHx Consultant’s thoughts Changes in blood results Monitor Check fluids, O2, vital signs Gladwrap FQs Synergy between paracetamol and opioids. Parkland formula. Fluids for fluid replacement (Hartmanns, Ringers, etc). Principles of fluid balance. Colloid Vs crystalloid. How Glucose released due to adrenaline and cortisol/steroids anti-insulin effect Albumin has leaked due to inflammation (serous fluid) Check for infection Prophylactic a/b much do we need to give. Replacement and maintenance. Silvazine Pain management Problems associated with oedema/compartment syndrome (ischaemia, loss of blood supply, thrombosis, etc) Role of silvazine ICU In the ICU, escharotomies are performed on both of Liam's upper limbs (see photograph) and his right lower limb. For the rest of the evening, the ICU staff keep a very close eye on Liam's urine output, biochemistry and haematology parameters and his wounds are dressed in silver sulfadiazine cream. In the morning, Liam is taken to theatre for debridement of his injuries with split skin grafts applied to his hands, arms, face, neck, back and legs over several days. His scalp and chest are used as donor sites. A skin substitute, Integra, is also utilised. The theatre is kept at a target temperature of 37°C. Two days later, Liam's temperature is 37.9°C and his glucose levels have dropped. There are fears that, despite rigorous infection control procedures, Liam may have developed an infection and a complete septic screen is carried out. On removal of his dressings, it is discovered that the wound on Liam's right lower limb has a greenish tinge and an extremely pungent smell. A chest X-ray, FBC, two sets of paired blood cultures, urine MCS, and line and wound swabs are ordered. Liam is commenced on Timentin (ticarcillin/clavulanate) and given a single dose of vancomycin while his samples are processed. Hypothesis Mechanisms Further info Swab results. FQs Skin grafts. Site of donation. Methods. septic screens. Laboratory results Liam's chest X-ray shows no abnormalities. 12 hours after samples were collected, pathology results reveal that swabs from all his lines and his urine sample are negative for bacterial growth. However the wound swab is positive for Gram-negative rods. In the meantime, Liam's condition is worsening. He develops a temperature of 38.4°C, HR 130, RR 26 and BP 120/50. His WCC has risen to 18.4 x 10 9/L (reference range: 4.5 - 11 x 10 9/L). After a further 12 hours, the lab reports that the wound organism is an isolate of Pseudomonas aeruginosa. It is another 24 hours before sensitivity results are available. These show that the isolate is resistant to Ticarcillin but sensitive to Meropenem. The blood cultures also return positive for the same isolate Hypothesis Septic shock Mechanism Further info FQs Sepsis P. aeruginosa Prescribing antibiotics 1. 2. 3. 4. KISS commonly available first Use the correct a/b for the correct site what organisms do we expect at that location? Eg. Gram negative Vs gram positive Culture wherever possible. want the results asap and not to have to make a second guess. If in doubt, ask Focus Questions: o Skin as a multifunctional organ (revision from year 1) (Skye) Functions of skin. o Assessment and types of burns (Pete) Types of burns. Grades and severity and degrees. Lund-Browder chart. ANZBA guidelines for burns management? o Acute management of burns (Andy) First aid for burns. Synergy between paracetamol and opioids. Parkland formula. Pain management. Role of silvazine o Fluid balance (Arthur) Fluids for fluid replacement (Hartmanns, Ringers, etc). Principles of fluid balance. Colloid Vs crystalloid. How much do we need to give. Replacement and maintenance. o Long-term management and complications (Jackie) Clingwrap? Positioning of pt. What comprises a burns unit? Problems associated with oedema/compartment syndrome (ischaemia, loss of blood supply, thrombosis, etc). Skin grafts. Site of donation. Methods. o Opportunistic and health-care associated infections (Alex) o Factors determining appropriate antibiotic choice (Shannon) o P. aeruginosa SIRS, sepsis and septic shock (Royd) septic screens. Sepsis. Systemic inflammatory response syndrome o Wound healing and scarring (Sonya) Healing of burns? Foreign bodies? Compartment syndrome? Scarring? Cosmetics?