A. ALEXOPOULOU 1
CURRICULUM VITAE
November 2013
Name: Alexandra Alexopoulou, MD, PhD
Current Position: Assistant Professor in Medicine & Hepatology, Athens University Medical School
(7/1/2013-today), 2nd Department of Internal Medicine, Hippokration General Hospital, 114 Vas.
Sofias, 115 27 Athens, Greece.
Tel: +30 2107774742, Fax: +30 2107706871,
Born: Athens, Greece. July 20, 1961.
Education:
First High School of Hilioupolis 1979.
University of Athens, Medical School, 1979-1985.
University of Athens, Medical Degree, October 1985.
Medical Licence: Ministry of Health & Welfare, Athens, Greece (1985)
Ph.D. Thesis: Role of anti-islet antibodies in secondary failure of anti-diabetic drugs in type II
diabetes mellitus- Excellent (1993).
Speciality of Internal Medicine : Athens 15/1/1993
Member of the Royal College of Physicians
Medical Training:
1. Dept. of Medicine, Athens Amalia Fleming District Hospital (6/1987-1/1989).
2. 2nd Dept. Department of Internal Medicine, Hippokration General Hospital, (01/1989-09/1992).
3. Research Fellow and Honorary Clinical Fellow, Academic Department of Medicine, St Mary’s
Hospital, London, UK (Prof H.C.Thomas 01/10/1993-30/3/1996).
A. ALEXOPOULOU 2
Staff positions:
1. Research Fellow in Medicine and Hepatology 1/10/1992-30/9/1993
1. Senior Registrar in Medicine, 2nd Academic Department of Medicine, Hippokration General
Hospital of Athens (28/6/1996–18/4/2008).
2. Senior Lecturer in Medicine & Hepatology, 2nd Academic Department of Internal Medicine,
Hippokration General Hospital of Athens (18/4/2008-7/1/2013).
3. Assistant Professor in Medicine & Hepatology, 2nd Academic Department of Internal Medicine,
Hippokration General Hospital of Athens (7/1/2013- today).
Society Memberships:
A. Greek
1. Hellenic Association for the Study of Liver –Governing Board Member (2013- today)
2. Society for Medical Studies - Member
3. Athens Medical Society - Member
4. Hellenic Society of Gastroenterology - Member
B. International
1. European Association for the Study of Liver (EASL) - Member (1994 - today)
Editorial Boards:
World Journal of Gastroenterology (2008-2011)
Reviewer:
69 manuscript reviews for 14 international journals
or 47 manuscript reviews for journals with IF >3
(J Hepatol, J Gastroenterol Hepatol, Liver Intern, Expert Opin Biol Ther)
Special Committees
Member (2013) of the Research Committee of the Hellenic Association for the Study of the Liver
A. ALEXOPOULOU 3
Awards:
1. Scholarships for students from Greek Government, 1981-1985.
2. Scholarship from A. Onassis foundation 1993-1996.
3. Scholarship of Hellenic Association for the Study of Liver, 1995-1996.
4. 3 Awards for Presentations in several Greek Meetings
5. Best Researcher Award from American Association for the Study of the Liver meeting
A. ALEXOPOULOU 4
Main Scientific Activities (26/2/2013):
Mostly focused on clinical research in hepatology and Internal Medicine
Full Publications in International Journals: PubMed: 64, Author -1st: 30, 2nd: 18, Last: 3, Other: 13
(corresponding: 50)
Total Impact Factor (IF) (2011): 250
Mean IF (2011) of 171 SCI journals: 4.32
Citations:Scopus 521
H-index: Scopus=13
Full papers in Greek journals: 30
Book chapters: 7 (Greek books: 5, international-english books: 2)
Abstract Presentations in Meetings: International=23, Greek=60
Invited lectures in Meetings: Greek=60
A. ALEXOPOULOU 5
LIST OF PUBLICATIONS IN PUBMED JOURNALS
*after my name denotes corresponding author
1. S.J. HADZIYANNIS, C. PAPAIOANNOU, A. ALEXOPOULOU. The role of the hepatitis delta
virus in acute hepatitis and in chronic liver disease in Greece. Prog Clin Biol Res 1991; 364: 5162.
2. SJ. HADZIYANNIS, S. DOURAKIS, C. PAPAIOANNOU, A. ALEXOPOULOU, E.
HADZIYANNIS and A. GIOUSTOZI. Changing epidemiology and spreading modalities of
Hepatitis Delta Virus infection in Greece. Prog Clin Biolog Research 1993; 382:259-266
3. SJ. HADZIYANNIS, A.S HADZIYANNIS, S. DOURAKIS, A. HORSH, A. ALEXOPOULOU,
and G. HESS. Clinical significance of quantitative anti-HBc IgM assay in acute and chronic HBV
infection. Hepatogastroenterology 1993; 40: 588-592.
4. SJ. HADZIYANNIS, G. GIANNOULIS, E. HADZIYANNIS, E. KAKLAMANI, A.
ALEXOPOULOU, S. DOURAKIS and D. TRICHOPOULOS. Hepatitis C virus infection in
Greece and its role in chronic liver disease and hepatocellular carcinoma. J Hepatol 1993; 17
(Suppl. 3): S72-S77.
5. DOURAKIS SP, A. ALEXOPOULOU, S. J. HADZIYANNIS. Fulminant hepatitis after
flutamide treatment. J Hepatol 1994; 20: 350-353
6. KARAYIANNIS, A. ALEXOPOULOU, S.J. HADZIYANNIS, M. THURSZ, R. WATTS, S.
SEITO, H.C. THOMAS. Fulminant hepatitis associated with hepatitis B virus e antigen negative
infection: importance of host factors. Hepatology 1995; 22: 1628-1634.
7. ALEXOPOULOU A, KARAYIANNIS P., HADZIYANNIS S.J., HOU J., PICKERING J., LUO
K. and THOMAS H.C. Whole genome analysis of hepatitis B virus from four cases of fulminant
hepatitis: Genetic variability and its potential role in disease pathogenicity. J Vir Hepat 1996; 3:
173-181.
8. ALEXOPOULOU A., KARAYIANNIS P., HADZIYANNIS S.J., AIBA N., THOMAS H.C.
Emergence and selection of HBV variants in an anti-HΒe positive patient persistently infected with
quasi-species. J Hepatol 1997; 26: 748-753.
9. SP DOURAKIS, C. MAVROYANNIS, A. ALEXOPOULOU, S.J. HADZIYANNIS. Prolonged
cholestatic jaundice after endoscopic retrograde cholangiography. Hepatogastroenterology 1997;
44: 677-680.
A. ALEXOPOULOU 6
10. ALEXOPOULOU A., OWSIANKA A.M., KAFIRI G., DOURAKIS S.P., CARMAN WF,
HADZIYANNIS S.J. Core variability does not affect response to interferon alpha in HΒeAg
negative chronic hepatitis B. J Hepatol 1998; 29: 345-351.
11. S.P. DOURAKIS, A. ALEXOPOULOU, S.J. HADZIYANNIS. Splenic infarct as a late
complication of liver transplantation. Eur J Gastroenterol Hepatol 1998; 10: 805-808.
12. S. HADZIYANNIS, A. ALEXOPOULOU, A. PAPAKONSTANTINOU, K. PETRAKI, E.
MANESIS. Interferon treatment with or without oral ganciclovir in HΒeAg-negative chronic
hepatitis B: a randomized study. J Vir Hepat 2000; 7: 235-240.
13. ALEXOPOULOU A., MICHAEL A., DOURAKIS S.P. Acute thrombocytopenic purpura in a
patient treated with LibraxR. Arch Intern Med 2001; 161: 1778.
14. DOURAKIS SP, SEBASTIANOS V, ALEXOPOULOU A, DEUTCH M. Toxic, epidermal,
necrolysis-like reaction associated with docetaxel chemotherapy. J Clin Oncol 2002; 20: 30303032.
15. ALEXOPOULOU A, FOURLAS C, DOURAKIS SP. Hyperkalemia in a patient with diabetes
mellitus. Lancet 2002; 359: 628.
16. ALEXOPOULOU A*, DOURAKIS SP, KALOTERAKIS A. Thrombotic thrombocytopenic
purpura in a patient treated with clarithromycin. Eur J Haematol 2002; 69: 191-192.
17. ALEXOPOULOU A, DOURAKIS SP, NOMIKOU E. A case of thrombocytopenic purpura
associated with disseminated gastric cancer. Am J Clin Oncol 2002; 25: 632.
18. ALEXOPOULOU Α, DOURAKIS SP, LOUKA O, MARINAKI O, KALMANTIS T. Hairy cell
leukemia and Lambert-Eaton myasthenic syndrome. Leukemia 2003; 17: 655-6.
19. ALEXOPOULOU A, DEUTSCH M, AGELETOPOULOU J, DELLADETSIMA J, MARINOS
E, KAPRANOS N, DOURAKIS SP. A fatal case of postinfantile giant cell hepatitis in a patient
with chronic lymphocytic leukemia. Eur J Gastroenterol Hepatol 2003; 47: 1125-8 .
20. ALEXOPOULOU A*, DEUTSCH M, DOURAKIS SP. Acute neutrοphilic meningitis treated
successfully with corticosteroids. South Med J 2003; 96: 912-3..
21. DOURAKIS
SP,
ALEXOPOULOU A*, PAPAGEORGIOU C, KALOTERAKIS
A,
HADZIYANNIS SJ. Acute chest syndrome in sickle cell trait. Two case reports in persons of
Mediterranean origin and review of the literature. Eur J Intern Med 2004; 15: 248-250.
22. ALEXOPOULOU Α, ANDRIANAKOS A, DOURAKIS SP. Intestinal pseudo-obstruction and
ureterohydronephrosis as the presenting manifestations of relapse in a lupus patient. Lupus
2004;13: 954-956
A. ALEXOPOULOU 7
23. ALEXANDRA ALEXOPOULOU, SAFFIE JAMMEH, GERASIMOS BALTAYIANNIS,
SPYROS P. DOURAKIS, PETER KARAYIANNIS. Hepatitis B surface antigen variant with
multiple mutations in the ‘a’ determinant in an agammaglobulinemic patient. J Clin Microbiol.
2004;42: 2861-5.
24. ALEXOPOULOU A, DOURAKIS SP Genetic heterogeneity of hepatitis viruses and its clinical
significance. Curr Drug Targets Inflamm Allergy 2005; 4: 47-55.
25. ALEXOPOULOU Α*, DOURAKIS SP, GEORGOUSI KK, ARCHIMANDRITIS AJ.
Intracerebral hematoma following intracerebral administration of methotrexate in a patient with
non-Hodgkin’s lymphoma. Am J Hematol 2005; 78; 159-160.
26. ALEXOPOULOU A*, PAPANIKOLOPOULOS K, THANOS L, DOURAKIS SP. Aneurysmal
dilatation of the portal vein: a rare cause of portal hypertension. Scand J Gastroenterol 2005; 40:
233-235.
27. ALEXOPOULOU A*, DOURAKIS SP, APOSTOLOPOULOU, KANDYLI A, PANTELIDAKI
H, ARCHIMANDRITIS AJ. Light chain multiple myeloma in a patient with long-standing
rheumatoid arthritis. Clin Rheumatol 2005; 24: 669-70.
28. ALEXOPOULOU
Α*,
DOURAKIS
P,
STAMOULIS
ND,
VASSILOPOULOS
D,
ARCHIMANDRITIS AJ. Post-streptococcal reactive arthritis with thoracic spine involvement in
an adult. J Rheumatol 2005;32:2002-5.
29. ALEXOPOULOU A*, MANTZOUKIS D, BROUNTZOS E, DOURAKIS SP. Budd-Chiari
syndrome after in-vitro fertilisation in a patient with latent thrombophilia. J Gastroentrol 2005; 40:
1001-2.
30. DOURAKIS SP, ALEXOPOULOU A, STAMOULIS N, FOUTRIS A, PANDELIDAKI H,
ARCHIMANDRITIS A. Acute Epstein-Barr virus infection in two elderly individuals. Age &
Ageing 2006; 95: 196-8.
31. SOULTATI AS, DOURAKIS SP, ALEXOPOULOU A, DEUTSCH M, BASILIEVA L,
ARCHIMANDRITIS AJ. Predicting utility of a model for end stage liver disease in alcoholic liver
disease. World J Gastroenterol 2006;12: 4020-5.
32. ALEXOPOULOU A*, THEODOROU M, DOURAKIS SP, KARAYIANNIS P, SAGKANA E,
PAPANIKOLOPOULOS K, ARCHIMANDRITIS AJ. Hepatitis B virus reactivation in patients
receiving chemotherapy for malignancies: role of precore stop-codon and basic core promoter
mutations. J Vir Hepat 2006; 13:591-6.
A. ALEXOPOULOU 8
33. GIANNARIS M, DOURAKIS SP, ALEXOPOULOU A*, ARCHIMANDRITIS AJ. Markedly
elevated CA 19-9 in the pus and the serum of a patient with pyogenic liver abscess. J Clin
Gastroenterol 2006;40:657.
34.ALEXOPOULOU Α*, KOSKINAS J, DEUTSCH M, DELLADETSIMA J, KOUNTOURAS D,
DOURAKIS SP. Acute liver failure as the initial manifestation of hepatic infiltration by a solid
tumor; report of 5 cases and review of the literature. Tumori 2006;92(4):354-7.
35. DOURAKIS SP, ALEXOPOULOU A*, METALLINOS G, THANOS L, ARCHIMANDRITIS
AJ. Pubic osteomyelitis due to Klebsiella pneumoniae in a patient with diabetes mellitus. Am J
Med Sci 2006;331:322-4.
36. DOURAKIS SP, TSOCHATZIS E,
ALEXOPOULOU A, ARCHIMANDRITIS AJ.
Pylephlebitis complicating silent diverticulitis. Lancet 2006;368:422.
37. ALEXOPOULOU A*, DOURAKIS SP, PANDELIDAKI H, ARCHIMANDRITIS AJ,
KARAYIANNIS P. Detection of a hepatitis B surface antigen variant emerging in a patient with
chronic lymphocytic leukaemia treated with fludarabine. J Med Virol 2006;78:1043-6.
38. DOURAKIS SP, COKKINOS DD, SOULTATI AS, ALEXOPOULOU A, NEZI V,
ARCHIMANDRITIS AJ. A case of liver sarcoidosis mimicking cirrhosis. Clin Imaging
2007;31:47-9.
39. SOULTATI AS, DOURAKIS SP, ALEXOPOULOU A, DEUTSCH M, ARCHIMANDRITIS
AJ. Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated
with pegylated interferon-alpha for chronic hepatitis C. World J Gastroenterol 2007;13:1292-4.
40. DOURAKIS SP, SARAMADOU R, ALEXOPOULOU A*, KAFIRI G, DEUTSCH M,
KOSKINAS J, ARCHIMANDRITIS AJ. Hepatic granulomas: a 6-year experience in a single
41. SOULTATI
AS,
DOURAKIS
SP,
ASVESTI K,
NEZI
V,
ALEXOPOULOU
A,
ARCHIMANDRITIS AJ. Autoimmune blistering disease in a patient with Graves disease and
vitiligo. Am J Med Sci 2007 333:309-12.
42. DOURAKIS SP, ALEXOPOULOU A*, GEORGOUSI KK, DELLADETSIMA JK, TOLIS G,
ARCHIMANDRITIS AJ. Glucagonoma syndrome: survival 21 years with concurrent liver
metastases. Am J Med Sci 2007;334:225-7.
43. ALEXOPOULOU A*, DOURAKIS SP, ZOVOILIS C, AGAPITOS E, ANDROULAKIS A,
FILIOTOU A, ARCHIMANDRITIS AJ. Dilated cardiomyopathy during the course of hemolytic
uremic syndrome. Int J Hematol. 2007;86:333-6.
A. ALEXOPOULOU 9
44. DOURAKIS S, SAMBATAKOU H, TSIACHRIS D, KITTOU N, ALEXOPOULOU A,
ARCHIMANDRITIS A. A 70-year-old stock-breeder with tricuspid valve and defibrillator lead
brucella endocarditis. Int J Cardiol 2008;126:e47-9.
45. KATSAOUNIS P, ALEXOPOULOU A*, DOURAKIS SP, SMYRNIDIS A, MARINOS L,
FILIOTOU A, ARCHIMANDRITIS AJ. An extranodal NK/T cell lymphoma, nasal type, with
specific immunophenotypic and genotypic features. Int J Hematol. 2008;88:202-5.
46. ALEXOPOULOU A*, SOULTATI A, DOURAKIS SP, VASILIEVA L, ARCHIMANDRITIS
AJ. Cholangiocarcinoma: a 7-year experience at a single center in Greece. World J
Gastroenterol. 2008;14:6213-7.
47. ALEXOPOULOU A*, DOURAKIS SP, MANTZOUKIS D, PITSARIOTIS T, KANDYLI A,
DEUTSCH M, ARCHIMANDRITIS AJ. Adverse drug reactions as a cause of hospital
admissions: a 6-month experience in a single center in Greece. Eur J Intern Med. 2008;19:50510.
48. ALEXOPOULOU A, BALTAYIANNIS G, EROGLU C, NASTOS T, DOURAKIS SP,
ARCHIMANDRITIS AJ, KARAYIANNIS P. Core mutations in patients with acute episodes of
chronic HBV infection are associated with the emergence of new immune recognition sites and
the development of high IgM anti-HBc index values. J Med Virol 2009;81:34-41.
49. ALEXOPOULOU A*, KOSKINAS J, SOULTATI A, KATSAOUNIS P, KILIDIREAS K,
PAPAGEORGIOU C, ANTONIOU C, KATSAMBAS A, ARCHIMANDRITIS A. Acute
bilateral phrenic neuropathy following treatment with adalimumab. Clin Rheumatol. 2009; 28:
1337-40.
50. SOULTATI A, ALEXOPOULOU A*, DOURAKIS SP, DIMOPOULOU H, KATSAOUNIS P,
COKKINOS D, ARCHIMANDRITIS AJ. The burden of incidental findings in clinical practice in
a tertiary care center. Eur J Intern Med. 2010; 21: 123-6.
51. KANELLOPOULOU
T,
ALEXOPOULOU
A*,
TANOULI
MI,
TINIAKOS
D,
GIANNOPOULOS D, KOSKINAS J, ARCHIMANDRITIS AJ. Primary hepatic actinomycosis.
Am J Med Sci 2010;339:362-5.
52. KANELLOPOULOU
T,
ALEXOPOULOU
A*,
TINIAKOS
D,
KOSKINAS
J,
ARCHIMANDRITIS AJ. Primary hepatic actinomycosis mimicking metastatic liver tumor. J
Clin Gastroenterol 2010;44:458-9.
53. KANELLOPOULOU T, ALEXOPOULOU A*, THEODOSSIADES G, KOSKINAS J,
ARCHIMANDRITIS AJ. Pylephlebitis: an overview of non-cirrhotic cases and factors related to
outcome. Scand J Infect Dis. 2010;42:804-11.
A. ALEXOPOULOU 10
54. TZAMOURANIS DG, ALEXOPOULOU A, DOURAKIS SP, STERGIOU GS. Relationship of
24-hour ambulatory blood pressure and heart rate with markers of hepatic function in cirrhotic
patients. BMC Gastroenterol. 2010; 10:143.
55. PAPAGEORGIOU MV, ALEXOPOULOU A*, KONTOPIDOU F, FILIOTOU A, KOSKINAS
J, PECTASIDES D. Concomitant diagnosis of myeloproliferative neoplasm and non-Hodgkin's
lymphoma in a patient with portal vein thrombosis. Anticancer Res. 2011;31:1467-9.
56. KANELLOPOULOU T, ALEXOPOULOU A, KOSKINAS J. JAK2V617F mutation is
ubiquitously present in splanchnic vein thrombosis accompanying myeloproliferative syndromes.
Aliment Pharmacol Ther. 2011; 33:1382-3.
57. POURIKI
S,
ALEXOPOULOU
A*,
CHRYSOCHOOU
C,
RAFTOPOULOS
L,
PAPATHEODORIDIS G, STEFANADIS C, PECTASIDES D. Left ventricle enlargement and
increased systolic velocity in the mitral valve are indirect markers of the hepatopulmonary
syndrome. Liver Int. 2011;31:1388-94.
58. VASILIEVA
L,
ALEXOPOULOU
A*,
PAPADHIMITRIOU
SI,
ROMANOS
A,
XYNOPOULOS D, DOURAKIS SP. Total bilirubin is a good discriminator between benign and
malignant biliary strictures. HPB (Oxford). 2012;14:71.
59. ALEXOPOULOU
A*,
PAPATHEODORIDIS
G,
POURIKI
S,
CHRYSOHOOU
C,
RAFTOPOULOS L, STEFANADIS C, PECTASIDES D. Diastolic myocardial dysfunction does
not affect survival in patients with cirrhosis. Transpl Int. 2012 Nov;25(11):1174-81.
60. NEZI V, DEUTSCH M, GAZOULI M, ALEXOPOULOU A, PAPARRIGOPOULOS T,
LIAPPAS IA, DOURAKIS SP. Polymorphisms of the CD14 Genes are Associated with
Susceptibility to Alcoholic Liver Disease in Greek Patients. Alcohol Clin Exp Res. 2013;37:24451.
61. ALEXOPOULOU A, PAPATHEODORIDIS, G.V. Current progress in the treatment of chronic
hepatitis C. World J Gastroenterol 2012;18:6060-9.
62. ALEXOPOULOU A*, PAPADOPOULOS N, ELIOPOULOS DG, ALEXAKI A, TSIRIGA A,
TOUTOUZA M, PECTASIDES D. Increasing frequency of gram-positive cocci and gramnegative multidrug-resistant bacteria in spontaneous bacterial peritonitis. Liver Int.2013
Aug;33(7):975-81.
63. KANELLOPOULOU T, ALEXOPOULOU A*. Bevacizumab in the treatment of hereditary
hemorrhagic telangiectasia. Expert Opin Biol Ther. 2013 Sep;13(9):1315-23.
64. VASILIEVA
LE,
PAPADHIMITRIOU
SI,
ALEXOPOULOU
A,
PAVLIDIS
D,
KOSTOPOULOS I,GEORGIAKAKI M, XINOPOULOS D, ROMANOS A, DOURAKIS SP. An
A. ALEXOPOULOU 11
extended fluorescence in situ hybridization approach for the cytogenetic study of
cholangiocarcinoma on endoscopic retrograde cholangiopancreatography brushing cytology
preparations. Hum Pathol. 2013 Oct;44(10):2173-9.