Mean value & probability distribution for the non test performance related
parameters in the decision model. (Note: for sources of these parameter values
please see Goodacre et al. [1] )
PROBABILITY OF EVENTS
Variable description
Outcomes of treated proximal DVT
Probability of fatal PE
Probability of non fatal PE
Probability of PTS
Outcomes of untreated proximal DVT
Probability of fatal PE
Probability of non fatal PE
Probability of PTS
Risks of treatment
Mean value Probability
distribution
Parameters
0.004
0.008
0.053
Beta
Beta
Beta
(=4204)
(=4070.6)
(=500)
0.019
0.093
0.33
Beta
Beta
Beta
(=263)
(=243)
(=10.57)
Probability of non-fatal intracranial
haemorrhage
0.001
Dirichlet
Probability of fatal haemorrhage
0.003
Dirichlet
0.021
Dirichlet
(13,37,226,10481) where each
parameter refers to the proportion of
persons in each category. The fourth
category is "no bleeding"
£12.16
£59.36
None
Normal
se = 3.28
8.6
Lognormal
se=5.2
£12.77
4
None
None
£34
None
17.2
£20
None
None
2
£61
£5.46
£1167
£1132
None
None
None
Normal
Normal
se = 35.81
se = 16.34
Normal
Normal
se = 2.53
se = 3.96
Probability of non-fatal, nonintracranial haemorrhage
COSTS
D-Dimer (SimpliRED)
Above knee ultrasound
Treatment of DVT (total)
Based on:
Days of heparin
Unit cost per dose of low molecular
weight heparin (Enoxaparine)
Number of anticoagulant clinic reviews
Unit cost per anticoagulant clinic
review
Number of nursing visits during
anticoagulation
Unit cost per nursing visit
Number of GP visits during
anticoagulation
Unit cost per GP visit
Cost of 90 days warfarin treatment
Treatment of fatal PE
Treatment of non fatal PE
Lifetime costs for post-thrombotic
syndrome
Based on:
Unit cost for new vascular surgery
outpatient
Unit cost for follow-up vascular
£721
£2459
£85
£122
surgery outpatient
GP visits
Treatment of severe bleeding –
lifetime costs
Treatment of fatal bleeding
Treatment of non-IC haemorrhage
QALYS
Normal age specific, discounted
quality adjusted life expectancy
Severe post-thrombotic syndrome
Non fatal intracranial haemorrhage
Non fatal pulmonary embolism
£40
None
£78593
£6600
£569.38
None
None
Normal
9.85
11.58
0.977
0.29
0.94
None
Beta
Beta
Beta
(a=232.64, b=5.48)
(a=8.34, b=20.41)
(a=19.43, b=1.24)
Reference
1. Goodacre, S., Sampson, F., Stevenson, M., Wailoo, A., Sutton, A., Thomas, S.,
Locker, T., Ryan, A. Measurement of the clinical and cost-effectiveness of noninvasive diagnostic testing strategies for deep vein thrombosis. Health
Technology Assessment 2006, 10(15):1-168 (available at
http://www.hta.ac.uk/project.asp?PjtId=1340).